A Selective Amplifier Gene for Tamoxifen-Inducible Expansion of Hematopoietic Cells

Journal of Gene Medicine

Volumn 1, Issue 4, 1999, Pages 236-244

  Xu, Ruifang ^a,b   Kume, Akihiro ^a,b   Matsuda, Kant M ^a,b   Ueda, Yasuji ^c   Kodaira, Hiroshi ^a,b   Ogasawara, Yoji ^a,b   Urabe, Masashi ^a,b   Kato, Ikunoshin ^d   Hasegawa, Mamoru ^c   Ozawa, Keiya ^a,b  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c DNAVEC Research Inc   (Japan)

^d TAKARA SHUZO CO LTD   (Japan)

Author keywords

Gene therapy; Hematopoietic stem cells; Inducible proliferation; Selective amplifier gene; Tamoxifen

Indexed keywords

MURINAE;

ESTRADIOL; ESTROGEN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HYBRID PROTEIN; PRIMER DNA; TAMOXIFEN;

ANIMAL; ARTICLE; CELL DIVISION; CELL LINE; CHIMERA; CLONOGENIC ASSAY; CYTOLOGY; DRUG EFFECT; GENE AMPLIFICATION; GENE THERAPY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; RETROVIRUS;

ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL LINE; CHIMERA; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; ESTRADIOL; GENE AMPLIFICATION; GENE THERAPY; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; RECEPTORS, ESTROGEN; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; TAMOXIFEN; TRANSDUCTION, GENETIC;

EID: 0033155017     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(199907/08)1:4<236::AID-JGM42>3.0.CO;2-2     Document Type: Article

References (30)

1. Karlsson S. Treatment of genetic defects in hematopoietic cell function by gene transfer. Blood 1991; 78: 2481-2492.
2. Dunbar CE, Emmons RVB. Gene transfer into hematopoietic progenitor and stem cells: Progress and problems. Stem Cells 1994; 12: 563-576.
3. + cells in ADA-deficient SCID neonates. Nat Med 1998; 4: 775-780.
4. Naldini L, Blömer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
5. Pawliuk R, Kay R, Lansdorp P, et al. Selection of retrovirally transduced hematopoieric cells using CD24 as a marker of gene transfer. Blood 1994; 84: 2868-2877.
6. Persons DA, Allay JA, Allay ER, et al. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood 1997; 90: 1777-1786.
7. Sorrentino BP, Brandt SJ, Bodine D, et al. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 1992; 257: 99-103.
8. Hanenberg H, Xiao XL, Dilloo D, et al. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat Med 1996; 2: 876-882.
9. Ito K, Ueda Y, Kokubun M, et al. Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells. Blood 1997; 90: 3884-3892.
10. Avalos BR. Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 1996; 88: 761-777.
11. Mattioni T, Louvion J-F, Picard D. Regulation of protein activities by fusion to steroid binding domains. Methods Cell Biol 1994; 43: 335-352.
12. Ushiroyama T, Yoshikawa M, Saeki M, et al. Hypergonadotropinemia with estradiol secretion in peri-and postmenopausal period. Acta Obstet Gynecol Scand 1989; 68: 139-143.
13. Ushiroyama T, Sugimoto O. Endocrine function of the peri-and postmenopausal ovary. Horm Res 1995; 44: 64-68.
14. Vessey MP. Effect of endogenous and exogenous hormones on breast cancer: epidemiology. Verh Dtsch Ges Path 1997; 81: 493-501.
15. Joles JA, Bijleveld C, van Toi A, et al. Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. J Am Soc Nephrol 1997; 8: 1870-1876.
16. Danielian PS, White R, Hoare SA, et al. Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Mol Endocrinol 1993; 7: 232-240.
17. Littlewood TD, Hancock DC, Danielian PS, et al. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 1995; 23: 1686-1690.
18. Gorman CM, Merlino GT, Willingham MC, et al. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci USA 1982; 79: 6777-6781.
19. Fung MC, Hapel AJ, Ymer S, et al. Molecular cloning of cDNA for murine interleukin-3. Nature 1984; 307: 233-237.
20. Blochlinger K, Diggelmann H. Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells. Mol Cell Biol 1984; 4: 2929-2931.
21. Karasuyama H, Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2,3,4 or 5, using modified cDNA expression vectors. Eur J Immunol 1988; 18: 97-104.
22. Hawley RG, Lieu FH, Fong AZ, et al. Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1994; 1: 136-138.
23. Nakauchi H, Nolan GP, Hsu C, et al. Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: Molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. Proc Natl Acad Sci USA 1985; 82: 5126-5130.
24. Duke GM, Hoffman MA, Palmenberg AC. Sequence and structural elements that contribute to efficient encephalomyo-carditis virus RNA translation. J Virol 1992; 66: 1602-1609.
25. Kodiara H, Kume A, Ogasawara Y, et al. Fas and mutant estrogen receptor chimeric gene: a novel suicide vector for tamoxifenspecific apoptosis. Jpn J Cancer Res 1998; 89: 741-747.
26. Scudiero DA, Shoemaker RH, Paull KD, et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988; 48: 4827-4833.
27. Osborne CK, Hobbs K, Clark GM. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 1985; 45: 584-590.
28. Tsai LC, Hung MW, Yuan CC, et al. Effects of tamoxifen and retinoic acid on cell growth and c-myc gene expression in human breast and cervical cancer cells. Anticancer Res 1997; 17: 4557-4562.
29. Blau CA, Peterson KR, Drachman JG, et al. A proliferation switch for genetically modified cells. Proc Natl Acad Sci U S A 1997; 94: 3076-3081.
30. Jin L, Asano H, Blau CA. Stimulating cell proliferation through the pharmacologic activation of c-kit. Blood 1998; 91: 890-897.