Diverse binding site structures revealed in homology models of polyreactive immunoglobulins

Journal of Computer-Aided Molecular Design

Volumn 11, Issue 5, 1997, Pages 453-461

  Ramsland, Paul A ^a   Guddat, Luke W ^b   Edmundson, Allen B ^c   Raison, Robert L ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Chronic B lymphocytic leukaemia; Natural (auto)antibodies; Polyreactive IgM; Template based models

Indexed keywords

BINDING ENERGY; BINDING SITES; MOLECULAR DYNAMICS; X RAY CRYSTALLOGRAPHY;

BINDING-SITES; CHRONIC B LYMPHOCYTIC LEUKEMIA; CHRONIC LYMPHOCYTIC LEUKEMIAS; COMPLEMENTARITY-DETERMINING REGIONS; COMPUTER ASSISTED; HOMOLOGY MODELING; LYMPHOCYTIC LEUKEMIA; NATURAL (AUTO)ANTIBODY; POLYREACTIVE IGM; TEMPLATE-BASED MODELING;

ANTIBODIES;

IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN FV; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN MU CHAIN;

AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHRONIC LYMPHATIC LEUKEMIA; HUMAN; HYDROGEN BOND; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR GENETICS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031228928     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007932211514     Document Type: Article

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