Transforming growth factor-β-induced collagen synthesis by human liver myofibroblasts is inhibited by α2-macroglobulin

Journal of Hepatology

Volumn 26, Issue 6, 1997, Pages 1220-1228

  Tiggelman, Anke M B C ^a   Linthorst, Christiaan ^a   Boers, Willem ^a   Brand, Henk S ^b   Chamuleau, Robert A F M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Collagen; Fat storing cell; Fibrosis; Human; Liver; Myofibroblast; TGF ; 2 Macroglobulin

Indexed keywords

ALPHA 2 MACROGLOBULIN; ALPHA ACTIN; COLLAGEN; METHYLAMINE; PROLINE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL; MYOFIBROBLAST; PRIORITY JOURNAL;

EID: 0030795961     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80455-2     Document Type: Article

References (62)

1. Annoni G, Weiner FR, Zern MA. Increased transforming growth factor-β1 gene expression in human liver disease. J Hepatol. 14:1992;259-264.
2. Nagy P, Schaff Z, Lapis K. Immunohistochemical detection of transforming growth factor-β1 in fibrotic liver diseases. Hepatology. 14:1991;269-273.
3. Castilla A, Prieto J, Fausto N. . Transforming growth factors β1 and α in chronic liver disease. Effects of interferon alpha therapy N Engl J Med. 324:1991;933-940.
4. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L, Zern MA. In vitro and in vivo association of transforming growth factor-β1 with hepatic fibrosis. J Cell Biol. 108:1989;2477-2482.
5. Armendariz-Borunda J, Seyer JM, Kang AH, Baghow R. Regulation of TGFβ gene expression in rat liver intoxicated with carbon tetrachloride. FASEB J. 4:1990;215-221.
6. Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D, Rotella CM, Surrenti C. Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells. Gastroenterology. 105:1993;245-253.
7. Tiggelman AMBC, Boers W, Linthorst C, Sala M, Chamuleau RAFM. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1β, IL-4, TGFβ and IFNgamma. J Hepatol. 23:1995;307-317.
8. Matsuoka M, Pham NT, Tsukamoto H. Differential effects of interleukin-1α, tumor necrosis factor α, and transforming growth factor β1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 9:1989;71-78.
9. Armendariz-Borunda J, Katayama K, Seyer JM. Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1β, tumor necrosis factor α, and transforming growth factor β in Ito cells. J Biol Chem. 267:1992;14316-14321.
10. Ramadori G. The Stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Archiv B Cell Pathol. 61:1991;147-158.
11. Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med. 328:1993;1828-1835.
12. Milan S, Herbst H, Schuppan D, Grappone C, Heinrichs OE. Cellular sources of extracellular matrix proteins in normal and fibrotic liver. Studies of gene expression by in situ hybridization. J Hepatol. 22:1995;71-76.
13. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther. 66:1995;387-412.
14. Bedossa P, Paradis V. Transforming growth factor-β (TGF-β): a key role in liver fibrogenesis. J Hepatol. 22:1995;37-42. (suppl 2).
15. Meyer DH, Bachem MG, Gressner AM. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type β1 and type α Biochem Biophys Res Commun. 171:1990;1122-1129.
16. Meyer DH, Bachem MG, Gressner AM. Transformed fat-storing cells inhibit the proliferation of hepatocytes by secretion of transforming growth factor-β J Hepatol. 11:1990;86-91.
17. Weiner FR, Giambrone MA, Czaja MJ, Shah A, Annoni G, Takahashi S, Eghbali M, Zern MA. Ito-cell gene expression and collagen regulation. Hepatology. 11:1990;111-117.
18. Bachem MG, Meyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest. 89:1992;19-27.
19. Attisano L, Wrana JL, López-Casillas F, Massagué L. TGF-β receptors and actions. Biochim Biophys Acta. 1222:1994;71-80.
20. Lawrence DA. Transforming growth factor-β: an overview. Kidney Int. 47:1995;S19-S23.
21. Miyazono K, Ichijo H, Heldin CH. Transforming growth factors-β: latent forms, binding proteins and receptors. Growth Factors. 8:1993;11-22.
22. 4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells. Hepatology. 21:1995;1429-1437.
23. Kingsley DM. The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8:1994;133-146.
24. Border WA, Ruoslahti E. Transforming growth factor-β in disease: the dark site of tissue repair. J Clin Invest. 90:1992;1-7.
25. 2-Macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J. 6:1992;3345-3353.
26. 2-macroglobulin receptors, cellular synthesis and aspects of function in relation to immunology. Dan Med Bull. 40:1993;409-446.
27. 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. Lab Invest. 71:1994;792-812.
28. Sottrup-Jensen L. α-Macroglobulins: structure, shape and mechanism of proteinase complex formation. J Biol Chem. 264:1989;11539-11542.
29. Sottrup-Jensen L. Role of internal thiol esters in the α-macroglobulin-proteinase binding mechanism. Ann NY Acad Sci. 737:1994;172-187.
30. 2-macroglobulin following reaction with methylamine and trypsin. Biochim Biophys Acta. 705:1982;306-314.
31. 2-macroglobulin by primary amines. J Biol Chem. 256:1981;9016-9022.
32. 2-macroglobulin molecule. Biochem J. 181:1979;401-418.
33. 2-macroglobulin-trypsin complex in the rat is mainly accounted for by uptake into hepatocytes. Biochim Biophys Acta. 846:1985;85-92.
34. 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissues Res. 269:1992;375-382.
35. 2-Macroglobulin. A multifunctional binding and targeting protein with possible roles in immunity and autoimmunity. Ann NY Acad Sci. 737:1994;267-272.
36. 2-macroglobulins. Lab Invest. 65:1991;3-14.
37. 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-β1 in mice. J Clin Invest. 87:1991;39-44.
38. 2-macroglobulin. Immunol Today. 11:1990;163-169.
39. 2-Macroglobulin and serum preferentially counteract the mitoinhibitory effect of transforming growth factor-β2 in rat hepatocytes. Lab Invest. 62:1990;545-551.
40. 2-macroglobulin. J Biol Chem. 265:1990;6973-6977.
41. 2-macroglobulin-proteinase complexes. Biochem J. 281:1992;569-575.
42. 2-macroglobulin and TGFβ1. Its putative role in liver fibrogenesis. Knook DL, Wisse E. Cells of the Hepatic Sinusoid. 4:1993;218-221 Kupffer Cell Foundation, Leiden.
43. 2-macroglobulin and transforming growth factor-β1 induce a synergistic smooth muscle cell proliferative response. J Biol Chem. 268:1993;18340-18344.
44. 2-macroglobulin. J Biol Chem. 262:1987;14090-14099.
45. Hiramatsu S, Kojima J, Okada TT, Inai S, Ohmori K. The serum protein profile in chronic hepatitis, cirrhosis and liver cancer. Acta Hepato-Gastroenterol. 23:1976;177-182.
46. Meliconi R, Parracino O, Facchini A, Morselli-Labate AM, Bortolotti F, Tremolada F, Martuzzi M, Miglio F, Gasbarrini G. Acute phase proteins in chronic and malignant liver diseases. Liver. 8:1988;65-74.
47. Naveau S, Poynard T, Banattar C, Bedossa P, Chaput JC. Alpha-2-macroglobulin and hepatic fibrosis. Diagnostic interest. Dig Dis Sci. 39:1994;2426-2432.
48. 1-protease inhibitor, and neutral protease-antiprotease complexes within liver granulomas of Schistosoma mansoni-infected mice. Am J Pathol. 130:1988;281-288.
49. 2-macroglobulin within Schistosoma mansoni egg-granulomas. Hepatology. 23:1996;1260-1267.
50. 2-macroglobulin cleaved during proteinase complex formation. FEBS Lett. 121:1980;275-279.
51. Lonberg-Holm K, Reed DL, Roberts RC, Hebert RR, Hillman MC, Kutney RM. Three high molecular weight protease inhibitors of rat plasma. Isolation, characterization, and acute phase changes. J Biol Chem. 262:1987;438-445.
52. 2-macroglobulin. Biochem J. 171:1978;27-38.
53. Peterkofsky B, Chojkier M, Bateman J. Determinations of collagen synthesis in tissue and cell culture systems. Furthmayer H. Immunocytochemistry of the Extracellular Matrix. 2:1981;19-47 Boca Raton, CRC.
54. 2-macroglobulin complex is a latent form of transforming growth factor β J Biol Chem. 263:1988;1535-1541.
55. 2-macroglobulin conformation. Biochem J. 293:1993;443-450.
56. Marra F, Bonewald LF, Park-Snyder S, Park I-S, Woodruff KA, Abboud HE. Characterization and regulation of the latent transforming growth factor-β complex secreted by vascular pericytes. J Cell Physiol. 166:1996;537-546.
57. 2-Macroglobulin production by cultured human fibroblasts. Somat Cell Genet. 8:1982;289-305.
58. 2-macroglobulin by cultured adherent cells. Ann NY Acad Sci. 421:1983;327-331.
59. 2-macroglobulin gene. Eur J Biochem. 168:1987;641-646.
60. 2-macroglobulin and apolipoprotein E gene expression in cultured rat liver fat-storing (Ito) cells. Hepatology. 14:1991;875-882.
61. Tiggelman AMBC, Boers W, Linthorst C, Brand HS, Sala M, Chamuleau RAFM. Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1β, and TNFα J Hepatol. 23:1995;295-306.
62. Rosenbaum J, Blazejewski S. Regulation of Ito cell proliferation by soluble factors. J Hepatol. 22:1995;65-70. (suppl 2).