Intravesical capsaicin therapy: A Review

Journal of Spinal Cord Medicine

Volumn 22, Issue 2, 1999, Pages 114-118

  Ozawa, Hideo ^a,b   Jung, Suk Young ^a,b   Fraser, Matthew O ^a,b   Rivas, David A ^a,b   Chancellor, Michael B ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; DRUG RECEPTOR;

ANIMAL; DECEREBRATION; DRUG EFFECT; HUMAN; INTRAVESICAL DRUG ADMINISTRATION; MICTURITION; NEUROGENIC BLADDER; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PHYSIOLOGY; REFLEX; REVIEW; SENSORY NERVE CELL;

ADMINISTRATION, INTRAVESICAL; ANIMALS; CAPSAICIN; DECEREBRATE STATE; HUMANS; NEURONS, AFFERENT; PERIPHERAL NERVES; RECEPTORS, DRUG; REFLEX; URINARY BLADDER, NEUROGENIC; URINATION;

EID: 0033140028     PISSN: 10790268     EISSN: None     Source Type: Journal    
DOI: 10.1080/10790268.1999.11719556     Document Type: Article

References (31)

1. Chancellor MB, Blaivas JG. Urinary incontinence and neurological implication. In; Chancellor MB, Blaivas JG, eds. Practical Neuro-urology: Genitourinary Complications in Neurologic Disease. Boston, MA; Butterworth-Heinemann, 1995:259-74.
2. de Groat WC, Kawatani M, Hisamitsu T, et al. Mechanisms underlying the recovery of urinary bladder function following spinal cord injury. J Auto Nerv System 1990;30:S71-7.
3. Fowler CJ, Jewkes D, McDojiald WI, et al. Intravesical capsaicin for neurogenic bladder dysfunction. Lancet 1992;339:1239.
4. Lembeck F. Columbus, capsicum and capsaicin: past, present and future. Acta Physiol Hung 1987;691:265-73.
5. Szolcsanyi J. Capsaicin type pungent agents producing pyrexia. In; Milton LA, ed. Pyretics and antipyretics. Handbook of Experimental Pharmacology. Berlin; Springer-Verlag, 1982:437-78.
6. Jancsâo N. Role of the nerve terminals in the mechanism of inflammatory reactions. Bull Millard Fillmore Hasp 1960;7:53-77.
7. Jancsâo N, Jancsâo GA, Szolcsânyi J. The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol 1968;33:32-41.
8. Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991;43:143-201.
9. Lewis R. Why red-hot peppers are red-hot. Biophoto Int J, 1998:40-1.
10. Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997;389:816-24.
11. Clapham DE. Some like it hot: Spicing up ion channels. Nature 1997;389:783-4.
12. Szolcsânyi J, Jancsâo-Gâbor A, Joâo F. Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin. NaunynSchmiedebergs Arch Pharmacol 1975;287:157-69.
13. Maggi CA, Santicioli P, Patacchini R, et al. Regional differences in the motor response to capsaicin in the guinea-pig urinary bladder: Relative role of pre- and postjunctional factors related to neuropeptide-containing sensory nerves. Neurosci 1988;27:675-88.
14. Buck SH, Burks TF. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 1986;38:179-226.
15. Jessell TM, Iversen LL, Cuello AC. Capsaicininduced depletion of substance P from primary sensory neurons. Brain Res 1978;152:183-8.
16. Mallory B, Steers WD, de Groat WC. Electrophysiological study of micturition reflexes in rats. AmJPhysiol 1989;257,R410-21.
17. Cheng CI, Ma CP, de Groat WC. Effects of capsaicin on micturition and associated reflexes in rats. AmJPhysiol 1993;265:R132-8.
18. Cheng CI, Ma CP, de Groat WC. .Effect of capsaicin on micturition and associated reflexes in chronic spinal rats. Brain Res 1995;678:40-8.
19. Yoshimura N, Erdman SL, Snider NW, de Groat WC. Effects of spinal cord injury on neurofilament immunoreactivity and capsaicin sensitivity in rat dorsal root ganglion neurons innervating the urinary bladder. Neurosci 1998;83:633-43.
20. Kawatani, M, Whitney T, Booth AM, de Groat WC. Excitatory effect of substance P in parasympathetic ganglia of the cat urinary bladder. Am JPhysiol 1989;257:R1450-6.
21. Maggi CA, Barbanti G, Santicioli P, et al. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex of humans. J Urol 1989;142:150-4.
22. Fowler CJ, Beck RO, Gerrard S, et al. Intravesical capsaicin for treatment of detrusor hyperreflexia. J Neural Neurosurg Psych 1994;57:169-73.
23. Geirsson G, Fall M, Sullivan L. Clinical and urodynamic effects of intravesical capsaicin treatment in patients with chronic traumatic spinal detrusor hyperreflexia. J Urol 1995;154:1825-9.
24. Das A, Chancellor MB, Watanabe T, et al. Intravesical capsaicin in heurogenic impaired patients with detrusor hyperreflexia. J Spinal Cord Medl996;19:190-3.
25. De Ridder DD, Chandiramani V, Dasgupta P, et al. Intravesical capsaicin as a treatment for refractory detrusor hyperreflexia: A dual center study with long-term follow-up. J Urol 1997;158:2087-92. s
26. Igawa Y, Komiyama I, Nishizawa S, Ogawa A. Intravesical capsaicin for treatment of autonomie dysreflexia in patients with spinal cord injury. J Urol 1996;155:591A.
27. Cruz F, Guimaräes M, Suva C, et al. Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction. J Urol 1997;157:585-9.
28. Flood H, Ireland L, Byrne DS, et al. Intravesical capsaicin for interstitial cystitis. J Urol 1997;157:254A
29. Maggi CA. Capsaicin and primary afferent neurons: From basic science to human therapy. J Auto Nerv System 1991;33:1-14.
30. Cruz F, Guaraes M, Suva C, Reis M. Intravesical resiniferatoxin represses bladder hyperreflexia without evoking significant acute discomfort. Lancet 1997;350:640-1.
31. Lazzeri M, Beneforti P, Turini D. Urodynamic effects of intravesical resiniferatoxin in humans: Preliminary results in stable and unstable detrusor. J Urol 1997;158:2093-6.