Pulmonary Cytochrome P450 Monooxygenase and Clara Cell Differentiation in Mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 17, Issue 3, 1997, Pages 302-314

  Fanucchi, Michelle Voit ^b   Murphy, Mary E ^b   Buckpitt, Alan R ^b   Philpot, Richard M ^b   Plopper, Charles G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHUS; EUKARYOTA;

CLARA CELL SPECIFIC PROTEIN; CLARA CELL-SPECIFIC PROTEIN; CYTOCHROME P450; ENZYME INHIBITOR; ISOENZYME; OXIDOREDUCTASE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TUBULIN; UTEROGLOBIN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; FEMALE; LUNG; MALE; METABOLISM; MOUSE; PHYSIOLOGY; PREGNANCY;

ANIMALS; CELL DIFFERENTIATION; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; ISOENZYMES; LUNG; MALE; MICE; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; PREGNANCY; PROTEINS; TUBULIN; UTEROGLOBIN;

EID: 0031226836     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.17.3.2774     Document Type: Article

References (39)

1. Buckpitt, A., M. Buonarati, L. B. Avey, A. M. Chang, D. Morin, and C. G. Plopper. 1992. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey. J. Pharmacol. Exp. Ther. 261:364-372.
2. Nagata, K., B. M. Martin, J. R. Gillette, and H. A. Sasame. 1990. Isozymes of cytochrome P-450 that metabolize naphthalene in liver and lung of untreated mice. Drug Metab. Dispos. 18:557-564.
3. Boyd, M. R. 1977. Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung. Nature 269:713-715.
4. Thornton-Manning, J. R., W. K. Nichols, B. W. Manning, G. L. Skiles, and G. S. Yost. 1993. Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages, and subcellular fractions from rabbit lungs. Toxicol. Appl. Pharmacol. 122:182-190.
5. Nocerini, M. R., J. R. Carlson, and G. S. Yost. 1985. Adducts of 3-methylindole and glutathione: species differences in organ-selective bioactivation. Toxicol. Lett. 28:79-87.
6. Chichester, C. H., R. M. Philpot, A. J. Weir, A. R. Buckpitt, and C. G. Plopper. 1991. Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung. Am. J. Respir. Cell Mol. Biol. 4:179-186.
7. Devereux, T. R., J. J. Diliberto, and J. R. Fouts. 1985. Cytochrome P-450 monooxygenase, epoxide hydrolase and flavin monooxygenase activities in Clara cells and alveolar type II cells isolated from rabbit. Cell Biol. Toxicol. 1:57-65.
8. Warren, D. L., D. Brown, Jr., and A. R. Buckpitt. 1982. Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene. Chem. Biol. Interact. 40:287-303.
9. van Bladeren, P. J., J. M. Sayer, D. E. Ryan, P. E. Thomas, W. Levin, and D. M. Jerina. 1985. Differential stereoselectivity of cytochromes P-450b and P-450c in the formation of naphthalene and anthracene 1,2-oxides. The role of epoxide hydrolase in determining the enantiomer composition of the 1,2-dihydrodiols formed. J. Biol. Chem. 260:10226-10235.
10. Nhamburo, P. T., F. J. Gonzalez, O. W. McBride, H. V. Gelboin, and S. Kimura. 1989. Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. Biochemistry 28:8060-8066.
11. Hakkola, J., H. Raunio, R. Purkunen, O. Pelkonen, S. Saarikoski, T. Cresteil, and M. Pasanen. 1996. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem. Pharmacol. 52:379-383.
12. Hakkola, J., M. Pasanen, J. Hukkanen, O. Pelkonen, J. Maenpaa, R. J. Edwards, A. R. Boobis, and H. Raunio. 1996. Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem. Pharmacol. 51:403-411.
13. Plopper, C. G., J. Macklin, S. J. Nishio, D. M. Hyde, and A. R. Buckpitt. 1992. Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene. Lab. Invest. 67:553-565.
14. Plopper, C. G., C. Suverkropp, D. Morin, S. Nishio, and A. Buckpitt. 1992. Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene. J. Pharmacol. Exp. Ther. 261:353-363.
15. Plopper, C. G., A. J. Weir, S. J. Nishio, A. Chang, M. Voit, R. M. Philpot, and A. R. Buckpitt. 1994. Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits. J. Pharmacol. Exp. Ther. 269:867-880.
16. Strum, J. M., T. Ito, R. M. Philpot, A. M. DeSanti, and E. M. McDowell. 1990. The immunocytochemical detection of cytochrome P-450 monooxygenase in the lungs of fetal, neonatal, and adult hamsters. Am. J. Respir. Cell Mol. Biol. 2:493-501.
17. Ji, C. M., W. V. Cardoso, A. Gebremichael, R. M. Philpot, A. R. Buckpitt, C. G. Plopper, and K. E. Pinkerton. 1995. Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats. Am. J. Physiol. 269:L394-L402.
18. Plopper, C. G., A. J. Weir, D. Morin, A. Chang, R. M. Philpot, and A. R. Buckpitt. 1993. Postnatal changes in the expression and distribution of pulmonary cytochrome P450 monooxygenases during Clara cell differentiation in rabbits. Mol. Pharmacol. 44:51-61.
19. Filler, R., and K. J. Lew. 1981. Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos. Proc. Natl. Acad. Sci. USA 78:6991-6995.
20. Juchau, M. R., C. M. Giachelli, A. G. Fantel, J. C. Greenaway, T. H. Shepard, and E. M. Faustman-Watts. 1985. Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis. Toxicol. Appl. Pharmacol. 80:137-146.
21. Yang, H. Y., M. J. Namkung, and M. R. Juchau. 1995. Expression of functional cytochrome P4501AI in human embryonic hepatic tissues during organogenesis. Biochem. Pharmacol. 49:717-726.
22. Palmer, K. C. 1985. Clara cell adenomas of the mouse lung. Interaction with alveolar type 2 cells. Am. J. Pathol. 120:455-463.
23. Cardoso, W. V., L. G. Stewart, K. E. Pinkerton, C. Ji, G. E. Hook, G. Singh, S. E. Katyal, W. M. Thurlbeck, and C. G. Plopper. 1993. Secretory product expression during Clara cell differentiation in the rabbit and rat. Am. J. Physiol. 264:L543-L552.
24. Strum, J. M., G. Singh, S. E. Katyal, and E. M. McDowell. 1990. Immunochemical localization of Clara cell protein by light and electron microscopy in conducting airways of fetal and neonatal hamster lung. Anat. Rec. 227:77-86.
25. Plopper, C. G., J. L. Alley, C. J. Serabjitsingh, and R. M. Philpot. 1983. Cytodifferentiation of the nonciliated bronchiolar epithelial (Clara) cell during rabbit lung maturation: an ultrastructural and morphometric study. Am. J. Anat. 167:329-357.
26. Lee, R. M. K. W., and J. B. Forrest. 1991. Structure and function of cilia. In The Lung: Scientific Foundations. R. G. Crystal and J. B. West, editors. Raven Press, New York, 169-181.
27. Wu, R., E. Nolan, and C. Turner. 1985. Expression of tracheal differentiated functions in serum-free hormone-supplemented medium. J. Cell Physiol. 125:167-181.
28. Serabjit-Singh, C. J., S. J. Nishio, R. M. Philpot, and C. G. Plopper. 1988. The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization. Mol. Pharmacol. 33:279-289.
29. Singh, G., S. L. Katyal, and M. L. Wong-Chong. 1986. A quantitative assay for a Clara cell-specific protein and its application in the study of development of pulmonary airways in the rat. Pediatr. Res. 20:802-805.
30. Van Winkle, L. S., A. R. Buckpitt, S. J. Nishio, J. M. Isaac, and C. G. Plopper. 1995. Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. Am. J. Physiol. 269:L800-L818.
31. Plopper, C. G., A. M. Chang, A. Pang, and A. R. Buckpitt. 1991. Use of microdissected airways to define metabolism and cytotoxicity in murine bronchiolar epithelium. Exp. Lung Res. 17:197-212.
32. Buckpitt, A., A. M. Chang, A. Weir, L. Van Winkle, X. Duan, R. Philpot, and C. Plopper. 1995. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol. Pharmacol. 47:74-81.
33. Lowry, O. H., N. J. Rosebrough, A. Lewis Farr, and R. J. Randall. 1951. Protein measurement with the Polin phenol reagent. J. Biol. Chem. 193:265-275.
34. Buckpitt, A. R., N. Castagnoli, Jr., S. D. Nelson, A. D. Jones, and L. S. Bahnson. 1987. Stereoselectivity of naphthalene epoxidation by mouse, rat, and hamster pulmonary, hepatic, and renal microsomal enzymes. Drug Metab. Dispos. 15:491-498.
35. Have-Opbrock, A. A. W. T., and E. C. P. D. Vries. 1993. Clara cell differentiation in the mouse: ultrastructural morphology and cytochemistry for surfactant protein A and Clara cell 10 kD protein. Microscopy Res. Technique 26:400-411.
36. Evans, M. J., L. J. Cabral-Anderson, and G. Freeman. 1978. Role of the Clara cell in renewal of the bronchiolar epithelium. Lab. Invest. 38:648-653.
37. Plopper, C. G., S. J. Nishio, J. L. Alley, P. Kass, and D. M. Hyde. 1992. The role of the nonciliated bronchiolar epithelial (Clara) cell as the progenitor cell during bronchiolar epithelial differentiation in the perinatal rabbit lung. Am. J. Respir. Cell Mol. Biol. 7:606-613.
38. Lakritz, J., A. Chang, A. Weir, S. Nishio, D. Hyde, R. Philpot, A. Buckpitt, and C. Plopper. 1996. Cellular and metabolic basis of Clara cell tolerance to multiple doses of P450 activated cytotoxicants: I. Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene. J. Pharmacol. Exp. Therapeut. 278:1408-1418.
39. Fanucchi, M. V., A. R. Buckpitt, M. E. Murphy, and C. G. Plopper. 1997. Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice. Toxicol. Appl. Pharmacol. (In press)