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Volumn 2, Issue 2, 1999, Pages 128-134

Metabolic engineering of plants for osmotic stress resistance

Author keywords

[No Author keywords available]

Indexed keywords

BIOACCUMULATION; BIOSYNTHESIS; METABOLIC ENGINEERING; METABOLITE; OSMOPROTECTANT; STRESS TOLERANCE; TRANSGENIC PLANT;

EID: 0033119338     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5266(99)80026-0     Document Type: Article
Times cited : (219)

References (48)
  • 1
    • 0025570130 scopus 로고
    • Drought and salt tolerance: Towards understanding and application
    • 1. McCue KF, Hanson AD: Drought and salt tolerance: towards understanding and application. Trends Biotech 1990, 8:358-362.
    • (1990) Trends Biotech , vol.8 , pp. 358-362
    • McCue, K.F.1    Hanson, A.D.2
  • 2
    • 0000237972 scopus 로고    scopus 로고
    • Molecular genetic improvement of salt tolerance in plants
    • 2. Jain RK, Selvaraj G: Molecular genetic improvement of salt tolerance in plants. Biotechnol Annu Rev 1997, 3:245-267. An excellent review of recent progress towards engineering salt-resistance in plants. It covers the physiological aspects of salt-tolerance and includes a discussion of the adaptive strategies found in nature.
    • (1997) Biotechnol Annu Rev , vol.3 , pp. 245-267
    • Jain, R.K.1    Selvaraj, G.2
  • 5
    • 0031898169 scopus 로고    scopus 로고
    • Plant resistance to environmental stress
    • 5. Smirnoff N: Plant resistance to environmental stress. Curr Opin Biotechnol 1998, 9:214-219.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 214-219
    • Smirnoff, N.1
  • 7
    • 0031603420 scopus 로고    scopus 로고
    • Salinity tolerance-mechanisms, models and the metabolic engineering of complex traits
    • 7. Nelson DE, Shen B, Bohnert HJ: Salinity tolerance-mechanisms, models and the metabolic engineering of complex traits. Genet Engineering 1998, 20:153-176.
    • (1998) Genet Engineering , vol.20 , pp. 153-176
    • Nelson, D.E.1    Shen, B.2    Bohnert, H.J.3
  • 8
    • 0032081990 scopus 로고    scopus 로고
    • Plant stress adaptations - Making metabolism move
    • 8. Bohnert HJ, Sheveleva E: Plant stress adaptations - making metabolism move. Curr Opin Plant Biol 1998, 1:267-274.
    • (1998) Curr Opin Plant Biol , vol.1 , pp. 267-274
    • Bohnert, H.J.1    Sheveleva, E.2
  • 9
    • 0032005868 scopus 로고    scopus 로고
    • Improving stress tolerance in plants by gene transfer
    • 9. Holmberg N, Bülow L: Improving stress tolerance in plants by gene transfer. Trends Plant Sci 1998, 3:61-66.
    • (1998) Trends Plant Sci , vol.3 , pp. 61-66
    • Holmberg, N.1    Bülow, L.2
  • 10
    • 0031810994 scopus 로고    scopus 로고
    • Molecular biology of salt tolerance in the context of whole plant physiology
    • 10. Yeo A: Molecular biology of salt tolerance in the context of whole plant physiology. J Exp Botany 1998, 49:915-929. A whole-plant perspective on molecular approaches to engineering stress tolerance which points out that osmotic stress resistance encompasses a number of mechanisms, many of which are unknown. It cautions against focusing on a single trait such as osmoprotectant synthesis as a solution to introducing resistance, and favors the identification and exploitation of quantitative trait loci associated with stress resistance.
    • (1998) J Exp Botany , vol.49 , pp. 915-929
    • Yeo, A.1
  • 11
    • 0028013296 scopus 로고
    • Osmoprotective compounds of the Plumbaginaceae: A natural experiment in metabolic engineering of stress tolerance
    • 11. Hanson AD, Rathinasabapathi B, Rivoal J, Burnet M, Dillon DO, Gage DA: Osmoprotective compounds of the Plumbaginaceae: a natural experiment in metabolic engineering of stress tolerance. Proc Natl Acad Sci USA 1994, 91:306-310.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 306-310
    • Hanson, A.D.1    Rathinasabapathi, B.2    Rivoal, J.3    Burnet, M.4    Dillon, D.O.5    Gage, D.A.6
  • 12
    • 0032212062 scopus 로고    scopus 로고
    • The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase
    • 12. Nuccio ML, Russell BL, Nolte KD, Rathinasabapathi B, Gage DA, Hanson AD: The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase. Plant J 1998, 16:487-496. This paper illustrates the utility of metabolic analysis in the engineering process. It demonstrates that the spinach choline monooxygenase enzyme functions in tobacco, and describes experiments that show how the choline supply limits GlyBet synthesis in these plants. It also suggests engineering steps that may enhance GlyBet synthesis in the next generation of transgenic plants.
    • (1998) Plant J , vol.16 , pp. 487-496
    • Nuccio, M.L.1    Russell, B.L.2    Nolte, K.D.3    Rathinasabapathi, B.4    Gage, D.A.5    Hanson, A.D.6
  • 13
    • 0032076437 scopus 로고    scopus 로고
    • Regulation of cell-specific inositol metabolism and transport on plant salinity tolerance
    • 13. Nelson DE, Rammesmayer G, Bohnert HJ: Regulation of cell-specific inositol metabolism and transport on plant salinity tolerance. Plant Cell 1998, 10:753-764.
    • (1998) Plant Cell , vol.10 , pp. 753-764
    • Nelson, D.E.1    Rammesmayer, G.2    Bohnert, H.J.3
  • 14
    • 0031989203 scopus 로고    scopus 로고
    • Osmotic stress induces expression of choline monooxygenase in sugar beet and amaranth
    • 14. Russell BL, Rathinasabapathi B, Hanson AD: Osmotic stress induces expression of choline monooxygenase in sugar beet and amaranth. Plant Physiol 1998, 116:859-865.
    • (1998) Plant Physiol , vol.116 , pp. 859-865
    • Russell, B.L.1    Rathinasabapathi, B.2    Hanson, A.D.3
  • 15
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • 15. Stephanopoulos G, Vallino JJ: Network rigidity and metabolic engineering in metabolite overproduction. Science 1991, 252:1675-1681.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 16
    • 0345419920 scopus 로고    scopus 로고
    • Sorbitol-6-phosphate dehydrogenase expression in transgenic tobacco: High amounts of sorbitol lead to necrotic lesions
    • 16. Sheveleva EV, Marquez S, Chmara W, Zegeer A, Jensen RG, Bohnert HJ: Sorbitol-6-phosphate dehydrogenase expression in transgenic tobacco: high amounts of sorbitol lead to necrotic lesions. Plant Physiol 1998, 117:831-839. This report highlights a downside in metabolic engineering. It shows that extensive redirection of metabolic flux to sorbitol depletes the myo-inositol pool, and that this correlates with necrosis and growth defects. Clearly, transgene expression created an imbalance in primary metabolism; this could perhaps be corrected through additional rounds of engineering.
    • (1998) Plant Physiol , vol.117 , pp. 831-839
    • Sheveleva, E.V.1    Marquez, S.2    Chmara, W.3    Zegeer, A.4    Jensen, R.G.5    Bohnert, H.J.6
  • 17
    • 0031040536 scopus 로고    scopus 로고
    • Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants
    • 17. Goddijn OJM, Verwoerd TC, Voogd E, Krutwagen RWHH, de Graaf PTHM, Poels J, van Dun K, Ponstein AS, Damm B, Pen J: Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants. Plant Physiol 1997, 113:181-190. The analytical experiments in this paper show that an endogenous trehalase activity is one factor limiting trehalose synthesis in transgenic plants. Specific inhibition of trehalase increased trehalose accumulation. It also reports the expression of trehalose-6-P synthase both alone and with trehalose-6-P phosphatase (tpp), and that the presence of tpp has a small positive effect on trehalose accumulation.
    • (1997) Plant Physiol , vol.113 , pp. 181-190
    • Goddijn, O.J.M.1    Verwoerd, T.C.2    Voogd, E.3    Krutwagen, R.W.H.H.4    De Graaf, P.T.H.M.5    Poels, J.6    Van Dun, K.7    Ponstein, A.S.8    Damm, B.9    Pen, J.10
  • 18
    • 0030029354 scopus 로고    scopus 로고
    • Enhanced NaCI stress tolerance in transgenic tobacco expressing bacterial choline dehydrogenase
    • 18. Lilius G, Holmberg N, Bülow L: Enhanced NaCI stress tolerance in transgenic tobacco expressing bacterial choline dehydrogenase. Biotechnology 1996, 14:177-180.
    • (1996) Biotechnology , vol.14 , pp. 177-180
    • Lilius, G.1    Holmberg, N.2    Bülow, L.3
  • 19
    • 0031194854 scopus 로고    scopus 로고
    • Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycinebetaine and enhanced tolerance to salt and cold stress
    • 19. Hayashi H, Alia, Mustardy L, Deshnium P, Ida M, Murata N: Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycinebetaine and enhanced tolerance to salt and cold stress. Plant J 1997, 12:133-142. This was the first report on the expression of a foreign choline oxidizing gene in chloroplasts. The transformed plants synthesized GlyBet and were slightly more tolerant to salt and cold stress.
    • (1997) Plant J , vol.12 , pp. 133-142
    • Hayashi, H.1    Alia, M.L.2    Deshnium, P.3    Ida, M.4    Murata, N.5
  • 20
    • 0032191255 scopus 로고    scopus 로고
    • Enhancement of the tolerance of Arabidopsis to high temperatures by genetic engineering of the synthesis of glycine betaine
    • 20. Alia, Hayashi H, Sakamoto A, Murata N: Enhancement of the tolerance of Arabidopsis to high temperatures by genetic engineering of the synthesis of glycine betaine. Plant J 1998, 16:155-162.
    • (1998) Plant J , vol.16 , pp. 155-162
    • Alia, H.H.1    Sakamoto, A.2    Murata, N.3
  • 21
    • 0031403567 scopus 로고    scopus 로고
    • Increased salt and drought tolerance by D-ononitol production in transgenic Nicotiana tabacum L
    • 21. Sheveleva EV, Chmara W, Bohnert HJ, Jensen RG: Increased salt and drought tolerance by D-ononitol production in transgenic Nicotiana tabacum L. Plant Physiol 1997, 115:1211-1219. This paper reports the production of D-ononitol in transgenic plants. The myo-inositol pool size increased with stress, which led to greater D-ononitol production and osmotic stress resistance. It illustrates how metabolic engineering can lead to insight into endogenous metabolic characteristics.
    • (1997) Plant Physiol , vol.115 , pp. 1211-1219
    • Sheveleva, E.V.1    Chmara, W.2    Bohnert, H.J.3    Jensen, R.G.4
  • 22
    • 0031933027 scopus 로고    scopus 로고
    • Mathematical modeling and analysis in biochemical engineering: Past accomplishments and future opportunities
    • 22. Bailey JE: Mathematical modeling and analysis in biochemical engineering: past accomplishments and future opportunities. Biotechnol Prog 1998, 14:8-20. A historical discussion of mathematical modeling and its application to metabolic problems. It highlights the importance of modeling complex metabolic networks which, in turn, facilitate the engineering process.
    • (1998) Biotechnol Prog , vol.14 , pp. 8-20
    • Bailey, J.E.1
  • 23
    • 0032066635 scopus 로고    scopus 로고
    • Dimethylsulfonioproprionate biosynthesis in Spartina alterniflora: Evidence that S-methylmethionine and dimethylsulfonio propylamine are intermediates
    • 23. Kocsis MG, Nolte KD, Rhodes D, Shen T-L, Gage DA, Hanson AD: Dimethylsulfonioproprionate biosynthesis in Spartina alterniflora: evidence that S-methylmethionine and dimethylsulfonio propylamine are intermediates. Plant Physiol 1998, 117:273-281.
    • (1998) Plant Physiol , vol.117 , pp. 273-281
    • Kocsis, M.G.1    Nolte, K.D.2    Rhodes, D.3    Shen, T.-L.4    Gage, D.A.5    Hanson, A.D.6
  • 24
    • 0029126437 scopus 로고
    • Prospects of manipulating plant metabolism
    • 24. ap Rees T: Prospects of manipulating plant metabolism. Trends Biotech 1995, 13:375-378.
    • (1995) Trends Biotech , vol.13 , pp. 375-378
    • Ap Rees, T.1
  • 25
    • 0004277661 scopus 로고    scopus 로고
    • London: Portland Press
    • 25. Fell DA: Understanding the Control of Metabolism. London: Portland Press; 1997. This book provides a thorough and highly readable introduction to metabolic control analysis (MCA). It bridges the gap between traditional enzymology and MCA, and demonstrates how MCA overcomes some of the descriptive limitations of traditional enzymology.
    • (1997) Understanding the Control of Metabolism
    • Fell, D.A.1
  • 26
    • 0031051302 scopus 로고    scopus 로고
    • Finite change analysis of glycolytic intermediates in tuber tissue of lines of transgenic potato (Solanum tuberosum) overexpressing phosphofructokinase
    • 26. Thomas S, Mooney PJF, Burrell MM, Fell DA: Finite change analysis of glycolytic intermediates in tuber tissue of lines of transgenic potato (Solanum tuberosum) overexpressing phosphofructokinase. Biochem J 1997, 322:111-117. An instructive demonstration of the use of MCA. Phosphofructokinase has been traditionally thought of as a 'rate-limiting' enzyme in glycolysis. However, overexpressing it in transgenic plants does not result in an increase in glycolytic flux. The authors use MCA to show that flux control is shared by the many steps between fructose-6-P and the Krebs cycle.
    • (1997) Biochem J , vol.322 , pp. 111-117
    • Thomas, S.1    Mooney, P.J.F.2    Burrell, M.M.3    Fell, D.A.4
  • 27
    • 0030669030 scopus 로고    scopus 로고
    • Exploring the metabolic and genetic control of gene expression on a genomic scale
    • 27. DeRisi JL, Iyer VR, Brown PO: Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 1997, 278:680-686. DNA micro-array technology enables the expression of many genes to be measured at once. This paper is the first to report bringing this analytical procedure to the genomic scale, in yeast. The experiments clearly demonstrate how alterations in growth, mutations and genetic manipulations can affect the expression of many genes.
    • (1997) Science , vol.278 , pp. 680-686
    • DeRisi, J.L.1    Iyer, V.R.2    Brown, P.O.3
  • 28
    • 0032169549 scopus 로고    scopus 로고
    • Towards Arabidopsis genome analysis: Monitering expression profiles of 1400 genes using cDNA microarrays
    • 28. Ruan Y, Gilmore J, Conner T: Towards Arabidopsis genome analysis: monitering expression profiles of 1400 genes using cDNA microarrays. Plant J 1998, 15:821-833.
    • (1998) Plant J , vol.15 , pp. 821-833
    • Ruan, Y.1    Gilmore, J.2    Conner, T.3
  • 29
    • 0001296314 scopus 로고    scopus 로고
    • Transport, compartmentation, and metabolism of homoserine in higher plant cells: Carbon-13-and phosphorus-31-nuclear magnetic resonance studies
    • 31P-NMR were used to monitor the uptake and metabolism of homoserine. The experiments demonstrate how metabolite pool size data and enzymatic rate data can be derived from NMR spectra. An experiment to determine the distribution of phosphohomoserine between the cytosol and the vacuole is also described.
    • (1998) Plant Physiol , vol.116 , pp. 547-557
    • Aubert, S.1    Curien, G.2    Bligny, R.3    Gout, E.4    Douce, R.5
  • 30
    • 0032566703 scopus 로고    scopus 로고
    • Unidirectional steady state rates of central metabolism enzymes measured simultaneously in a living plant tissue
    • 30. Roscher A, Emsley L, Raymond P, Roby C: Unidirectional steady state rates of central metabolism enzymes measured simultaneously in a living plant tissue. J Biol Chem 1998, 273:25053-25061. This paper describes how in vivo NMR spectroscopy can be used to measure the flux of phosphate from substrates to products. The methods to monitor four enzymatic reactions in central metabolism are described and used to show how each reaction responds to changes in external stimuli.
    • (1998) J Biol Chem , vol.273 , pp. 25053-25061
    • Roscher, A.1    Emsley, L.2    Raymond, P.3    Roby, C.4
  • 31
    • 0032478635 scopus 로고    scopus 로고
    • Arabidopsis CBF1 overexpression induces COR genes and enhances freezing tolerance
    • 31. Jaglo-Ottosen KR, Gilmour SJ, Zarka DG, Schabenberger O, Thomashow MF: Arabidopsis CBF1 overexpression induces COR genes and enhances freezing tolerance. Science 1998, 280:104-106. This is the first report to demonstrate 'regulon engineering' in a plant stress context. CBF1 had been shown to interact with a number of cold-reponsive genes during the 'cold-acclimation' process, which leads to an increase in freezing tolerance. The experiments show that overexpressing CBF1 induces the acclimation effect and enhances freezing tolerance.
    • (1998) Science , vol.280 , pp. 104-106
    • Jaglo-Ottosen, K.R.1    Gilmour, S.J.2    Zarka, D.G.3    Schabenberger, O.4    Thomashow, M.F.5
  • 33
    • 0032144961 scopus 로고    scopus 로고
    • Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis
    • 33. Liu Q, Kasuga M, Sakuma Y, Abe H, Miura S, Yamaguchi-Shinozaki K, Shinozaki K: Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought-and low-temperature-responsive gene expression, respectively, in Arabidopsis. Plant Cell 1998, 10:1391-1406.
    • (1998) Plant Cell , vol.10 , pp. 1391-1406
    • Liu, Q.1    Kasuga, M.2    Sakuma, Y.3    Abe, H.4    Miura, S.5    Yamaguchi-Shinozaki, K.6    Shinozaki, K.7
  • 34
    • 0032560462 scopus 로고    scopus 로고
    • Eskimo1 mutants of Arabidopsis are constitutively freezing tolerant
    • 34. Xin Z, Browse J: eskimo1 mutants of Arabidopsis are constitutively freezing tolerant. Proc Natl Acad Sci USA 1998, 95:7799-7804. This paper describes the identification and characterization of an Arabidopsis mutant that is defective in a key regulatory gene. It is a new locus, distinct from other cold-acclimation pathways. The data show that, in proline metabolism, this gene can simultaneously upregulate synthesis genes and downregulate degradative genes, implying that it is near the top of a signaling cascade.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7799-7804
    • Xin, Z.1    Browse, J.2
  • 35
    • 0028835509 scopus 로고
    • Overexpression of Δ1-pyrroline-5-carboxylate synthetase increases proline production and confers osmotolerance in transgenic plants
    • 35. Kavi Kishor PB, Hong Z, Miao G-H, Hu C-AA, Verma DPS: Overexpression of Δ1-pyrroline-5-carboxylate synthetase increases proline production and confers osmotolerance in transgenic plants. Plant Physiol 1995, 108:1387-1394.
    • (1995) Plant Physiol , vol.108 , pp. 1387-1394
    • Kavi Kishor, P.B.1    Hong, Z.2    Miao, G.-H.3    Hu, C.-A.A.4    Verma, D.P.S.5
  • 36
    • 0026552614 scopus 로고
    • Expression of a bacterial mtID gene in transgenic tobacco leads to production and accumulation of mannitol
    • 36. Tarczynski MC, Jensen RG, Bohnert HJ: Expression of a bacterial mtID gene in transgenic tobacco leads to production and accumulation of mannitol. Proc Natl Acad Sci USA 1992, 89:2600-2604.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2600-2604
    • Tarczynski, M.C.1    Jensen, R.G.2    Bohnert, H.J.3
  • 37
    • 0027464813 scopus 로고
    • Stress protection of transgenic tobacco by production of the osmolyte mannitol
    • 37. Tarczynski MC, Jensen RG, Bohnert HJ: Stress protection of transgenic tobacco by production of the osmolyte mannitol. Science 1993, 259:508-510.
    • (1993) Science , vol.259 , pp. 508-510
    • Tarczynski, M.C.1    Jensen, R.G.2    Bohnert, H.J.3
  • 38
    • 0028801439 scopus 로고
    • Enhancement of seed germination in high salinity by engineering mannitol expression in Arabidopsis thaliana
    • 38. Thomas JC, Sepahi M, Arendall B, Bohnert HJ: Enhancement of seed germination in high salinity by engineering mannitol expression in Arabidopsis thaliana. Plant Cell Environ 1995, 18:801-806.
    • (1995) Plant Cell Environ , vol.18 , pp. 801-806
    • Thomas, J.C.1    Sepahi, M.2    Arendall, B.3    Bohnert, H.J.4
  • 40
    • 0029278053 scopus 로고
    • Sorbitol synthesis in transgenic tobacco with apple cDNA encoding NADP-dependent sorbitol-6-phosphate dehydrogenase
    • 40. Tao R, Uratsu SL, Dandekar AM: Sorbitol synthesis in transgenic tobacco with apple cDNA encoding NADP-dependent sorbitol-6-phosphate dehydrogenase. Plant Cell Physiol 1995, 36:525-532.
    • (1995) Plant Cell Physiol , vol.36 , pp. 525-532
    • Tao, R.1    Uratsu, S.L.2    Dandekar, A.M.3
  • 43
    • 0030956438 scopus 로고    scopus 로고
    • Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants: Pleiotropic phenotypes include drought tolerance
    • 43. Romero C, Bellés JM, Vayá JL, Serrano R, Culiáñez-Macià FA: Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants: pleiotropic phenotypes include drought tolerance. Planta 1997, 201:293-297.
    • (1997) Planta , vol.201 , pp. 293-297
    • Romero, C.1    Bellés, J.M.2    Vayá, J.L.3    Serrano, R.4    Culiáñez-Macià, F.A.5
  • 44
    • 0003147202 scopus 로고
    • Polyol accumulation and metabolism during water deficit
    • Edited by Smirnoff N. Oxford: Bios Scientific Publishers Limited
    • 44. Popp M, Smirnoff N: Polyol accumulation and metabolism during water deficit. In Environment and Plant Metabolism: Flexibility and Acclimation. Edited by Smirnoff N. Oxford: Bios Scientific Publishers Limited; 1995:199-215.
    • (1995) Environment and Plant Metabolism: Flexibility and Acclimation , pp. 199-215
    • Popp, M.1    Smirnoff, N.2
  • 45
    • 0001004483 scopus 로고
    • Salt stress and comparative physiology in the Gramineae. II: Glycinebetaine and proline accumulation in two salt-and water-stressed barley cultivars
    • 45. Storey R, Wyn Jones RG: Salt stress and comparative physiology in the Gramineae. II: glycinebetaine and proline accumulation in two salt-and water-stressed barley cultivars. Aust J Plant Physiol 1978, 5:817-829.
    • (1978) Aust J Plant Physiol , vol.5 , pp. 817-829
    • Storey, R.1    Wyn Jones, R.G.2
  • 48
    • 0001272298 scopus 로고
    • The glycerolipid composition of leaves
    • 48. Roughan PG, Batt RD: The glycerolipid composition of leaves. Phytochemistry 1969, 8:363-369.
    • (1969) Phytochemistry , vol.8 , pp. 363-369
    • Roughan, P.G.1    Batt, R.D.2


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