Effects of U-83836E on glutamate-induced neurotoxicity in dissociated rat cerebellar granule cells

Toxicology and Applied Pharmacology

Volumn 156, Issue 1, 1999, Pages 1-5

  Sureda, Francesc X ^a   Gabriel, Cecília ^a   Pubill, David ^a   Pallàs, Mercè ^a   Escubedo, Elena ^a   Camarasa, Jorge ^a   Camins, Antonio ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; ALPHA TOCOPHEROL; ANTIOXIDANT; CALCIUM ION; DIZOCILPINE; GLUTAMIC ACID; REACTIVE OXYGEN METABOLITE; TRILAZAD; TROLOX C; U 83836F; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; GRANULE CELL; MEMBRANE STEADY POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALIA;

EID: 0033118571     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8613     Document Type: Article

References (35)

1. Ankarcrona M., Dypbukt J. M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S. A., Nicotera P. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
2. Bast A. Antioxidant pharmacotherapy. Drug News Perspect. 8:1994;465-472.
3. Bowling A. C., Beal M. F. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sci. 56:1995;1151-1171.
4. Camins A., Gabriel C., Aguirre L., Sureda F. X., Pubill D., Pallàs M., Escubedo E., Camarasa J. U-83836E prevents kainic acid-induced neuronal damage. Naunyn-Schmiedebergs Arch. Pharmacol. 357:1998;413-418.
5. Campo G. M., Squadrito F., Campo S., Altavilla D., Avenoso A., Ferlito M., Squadrito G., Caputi A. P. Antioxidant activity of U-83836E, a second generation lazaroid, during myocardial ischemia/reperfusion injury. Free Radical Res. Commun. 27:1997;577-590.
6. Chan P. H. Role of oxidants in ischemic brain damage. Stroke. 27:1996;1124-1129.
7. Clark W. M., Hazel J. S., Coull B. M. Lazaroids. CNS pharmacology and current research. Drugs. 50:1995;971-983.
8. Dawson R., Beal M. F., Bondy S. C., Di Monte D. A., Isom G. Excitotoxins, aging, and environmental neurotoxins: Implications for understanding human neurodegenerative diseases. Toxicol. Appl. Pharmacol. 134:1995;1-17.
9. Frodl E. M., Nakao N., Brundin P. Lazaroids improve the survival of cultured rat embryonic mesencephalic neurons. Neuroreport. 5:1994;2393-2396.
10. Hall E. D. Inhibition of lipid peroxidation in central nervous system trauma and ischemia. J. Neurol. Sci. 134:1996;79-83.
11. Hall E. D., Braughler J. M., Yonkers P. A., Smith S. L., Linseman K. L., Means E. D., Scherch H. M., Von Voigtlander P. F., Lahti R. A., Jacobsen E. J. U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J. Pharmacol. Exp. Ther. 258:1991;688-694.
12. Hall E. D., McCall J. M. Antioxidant action of lazaroids. Methods Enzymol. 234:1994;548-555.
13. Ishizaki N., Zhu Y., Zhang S., Nemoto A., Kobayashi Y., Subbotin V. M., Lee R. G., Starzl T. E., Todo S. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation. 29:1997;1333-1334.
14. Lafon-Cazal M., Pletri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
15. Lethem R., Orrel M. Antioxidants and dementia. Lancet. 349:1997.
16. Mattana A., Bennardini F., Juliano C., Picci V., Marceddu S., Sciola L., Pippia P., Franconi F. Cytotoxicity of lazaroid U-75412E in human epithelial cell line (wish). Biochem. Pharmacol. 48:1994;259-265.
17. Miyamoto M., Murphy T. H., Schnaar R. L., Coyle J. T. Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. J. Pharmacol. Exp. Ther. 250:1989;1132-1140.
18. Monyer H., Hartley D. M., Choi D. W. 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures. Neuron. 5:1990;121-126.
19. Müller U., Krieglstein J. Inhibitors of lipid peroxidation protect cultured neurons against cyanide-induced injury. Brain Res. 678:1995;265-268.
20. Nakao N., Frodl E. M., Duan W. M., Widner H., Brundin P. Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc. Natl. Acad. Sci. USA. 91:1994;12408-12412.
21. Niederau C., Schulz H. U., Klonowski H. Lazaroids protect isolated rat pancreatic acinar cells against damage induced by free radicals. Pancreas. 11:1995;107-121.
22. Oyama Y., Hayashi A., Ueha T., Maekawa K. Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: Estimation on intracellular content of hydrogen peroxide. Brain Res. 635:1994;113-117.
23. Pakala R., Pakala R., Benedict C. R. Novel 21-aminosteroidlike compounds prevent iron-induced free radical-mediated injury to vascular endothelial cells. J. Cardiovasc. Pharmacol. 25:1995;871-879.
24. Patel M., Day B. J., Crapo J. D., Fridovich I., McNamara J. O. Requirement for superoxide in excitotoxic cell death. Neuron. 16:1996;345-355.
25. Pereira C. M., Oliveira C. R. Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress. Free Radical Biol. Med. 23:1997;637-647.
26. Puttfarcken P. S., Getz R. L., Coyle J. T. Kainic acid lipid peroxidation: Protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells. Brain Res. 624:1993;223-232.
27. Reynolds I. J., Hastings T. G. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15:1995;3318-3327.
28. Simonian N. A., Coyle J. T. Oxidative stress neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36:1996;83-106.
29. Smith M. A., Perry G. Free radical damage, iron, and Alzheimer's disease. J. Neurol. Sci. 134:1995;92-94.
30. Sureda F. X., Camins A., Trullas R., Camarasa J., Escubedo E. A flow cytometric study ofNd. Brain Res. 723:1996a;110-114.
31. Sureda F. X., Escubedo E., Gabriel C., Camarasa J., Camins A. Effect of glutamate receptor ligands on mitochondrial membrane potential in rat dissociated cerebellar cells. Naunyn-Schmiedebergs Arch. Pharmacol. 354:1996b;420-423.
32. Sureda F. X., Escubedo E., Gabriel C., Comas J., Camarasa J., Camins A. Mitochondrial membrane potential measurement in rat cerebellar neurons by flow cytometry. Cytometry. 28:1997;74-80.
33. Taylor B. M., Fleming W. E., Benjamin C. W., Wu Y., Matews W. R., Sun F. F. The mechanism of cytoprotective action of lazaroids I: Inhibition of reactive oxygen species formation and lethal cell injury during periods of energy depletion. J. Pharmacol. Exp. Ther. 276:1996;1224-1231.
34. Villa R. F., Gorini A. Pharmacology of lazaroids and brain energy metabolism: A review. Pharmacol. Rev. 49:1997;99-136.
35. Zhao W., Richardson J. S., Mombourquette M. J., Weil J. A., Ijaz S., Shuaib A. Neuroprotective effects of hypothermia and U-78517F in cerebral ischemia are due to reducing oxygen-based free radicals: An electron paramagnetic resonance study with gerbils. J. Neurosci. Res. 45:1996;282-288.