A flow cytometric study of N-methyl-D-aspartate effects on dissociated cerebellar cells

Brain Research

Volumn 723, Issue 1-2, 1996, Pages 110-114

  Sureda, Francesc X ^a   Camins, Antoni ^a   Trullas, Ramon ^b   Camarasa, Jordi ^a   Escubedo, Elena ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

calcium; cerebellum; flow cytometry; granule cell; Indo 1; MK 801; NMDA; oxidative stress

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADOLESCENT; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CEREBELLUM; CONTROLLED STUDY; FLOW CYTOMETRY; GRANULE CELL; INTRACELLULAR RECORDING; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

EID: 0029940994     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00230-2     Document Type: Article

References (19)

1. Bas, D.A., Parce, J.W., Dechatelet, L.R., Szejda, P., Seeds, M.C. and Thomas, M., Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J. Immunol., 130 (1983) 1910-1917.
2. Bondy, S.C. and Lee, D.K., Oxidative stress induced by glutamate receptor agonists. Brain Res., 610 (1993) 229-233.
3. 2+ influx, Exp. Brain. Res., 76 (1989) 281-291.
4. Burgoyne, R.D., Pearce, I.A. and Cambray-Deakin, M., N-MethylD-aspartate raises cytosolic calcium concentration in rat cerebellar granule cells in culture, Neurosci. Lett., 91 (1988) 47-52.
5. Choi, D.W., Excitotoxic cell death, J. Neurobiol., 23 (1992) 1261-1276.
6. Coyle, J.T. and Puttfarcken, P., Oxidative stress, glutamate, and neurodegenerative disorders, Science, 262 (1993) 689-695.
7. 2+ in dissociated brain cells, Brain Res., 499 (1989) 383-387.
8. Domenici, M.R., Longo, R., Scotti de Carolis, A., Frank, C. and Sagratella, S., Protective actions of 21-aminosteroids and MK-801 on hypoxia-induced electrophysiological changes in rat hippocampal slices. Eur. J. Pharmacol., 233 (1993) 291-293.
9. Fagni, L., Lafon-Cazal, M., Lerner-Natoli, M., Rondouin, G. and Bockaert, J., Role of nitric oxide and free-radicals in the glutamate mediated neurotoxicity, J. Pharm. Belg., 50 (1995) 204-212.
10. Hammer, B., Parker, W.D. and Bennet, J.P., NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C, NeuroReport, 5 (1993) 72-74.
11. Harman, A.W. and Maxwell, M.J., An evaluation of the role of calcium in cell injury. Annu. Rev. Pharmacol. Toxicol., 35 (1995) 129-144.
12. Jesberger, J.A. and Richardson, J.S., Oxygen free radicals and brain dysfunction. Int. J. Neuroscience. 57 (1991) 1-17.
13. Lafon-Cazal, M., Culcasi, M., Gaven, F., Pietri, S. and Bockaert, J., Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells, Neuropharmacology, 32 (1993) 1259-1266.
14. Lafon-Cazal, M., Pietri, S., Culcasi, M. and Bockaert, J., NMDA-dependent superoxide production and neurotoxicity. Nature, 364 (1993) 535-537.
15. Monyer, H., Hartley, D.M. and Choi, D.W., 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures, Neuron, 5 (1990) 121-126.
16. Oyama, Y., Hayashi, A., Ueha, T. and Maekawa, K., Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide, Brain Res., 635 (1994) 113-117.
17. Parks, T.N., Artman, L.D., Alasti, N. and Nemeth, E.F., Modulation of N-methyl-D-aspartate receptor-mediated increases in cytosolic calcium in cultured rat cerebellar granule cells, Brain Res., 552 (1991) 13-22.
18. Pazdernik, T.L., Layton, M., Nelson, S.R. and Samson, F.E., The osmotic/calcium stress theory of brain damage: are free radicals involved? Neurochem. Res., 17 (1992) 11-21.
19. Pellegrini-Giampietro, D.E., Cherici, G., Alesiani, M., Carla, V. and Moroni, F., Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage, J. Neurosci., 10 (1990) 1035-1041.