The mechanism of cytoprotective action of lazaroids I: Inhibition of reactive oxygen species formation and lethal cell injury during periods of energy depletion

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 3, 1996, Pages 1224-1231

  Taylor, Bruce M ^a   Fleming, William E ^a   Benjamin, Christopher W ^a   Wu, Yankuan ^a   Mathews, W Rodney ^a   Sun, Frank F ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; MESYLIC ACID DERIVATIVE; OXYGEN; SCAVENGER;

ARTICLE; ASTROCYTE; CELL DEATH; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; ENERGY METABOLISM; HUMAN; LIPID PEROXIDATION; METABOLISM; ULTRASTRUCTURE;

ARACHIDONIC ACIDS; ASTROCYTES; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; FREE RADICAL SCAVENGERS; HUMANS; LIPID PEROXIDATION; MESYLATES; MICROSCOPY, ELECTRON; OXYGEN;

EID: 0030111288     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. AUDUS, K. L., GUILLOT, F. L. AND BRAUGHLER, J. M.: Evidence for 21-aminosteroid effects on the molecular packing order of hydrophobic domains in brain microvessel endothelial cells. Free Radical Biol. Med. 11: 361-372, 1991.
2. BAYSAL, E., MONTEIRO, H. P., SULLIVAN, S. G. AND STERN, A.: Desferrioxamine protects human red blood cells from hemin-induced hemolysis. Free Radical Biol. Med. 9: 5-10, 1990.
3. BRAUGHLER, J. M., HALL, E. D., JACOBSEN, E. J., MCCALL, J. M. AND MEANS, E. D.. The 21-aminosteroids: Potent inhibitors of lipid peroxidation for the treatment of central nervous system trauma and ischemia. Drugs Future 14: 143-152, 1989.
4. BRAUGHLER, J. M., PREGENZER, J. F., CHASE, R. L., DUNCAN, L. A., JACOBSEN, E. J. ANT MCCALL, J M.: Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation. J. Biol. Chem. 262: 10438-10440, 1987.
5. CHIEN, K. R., SEN, A., REYNOLDS, R., CHANG, A., KIM, Y., GUNN, M. D., BUJA, L. M. AND WILLERSON, J. T.: Release of arachidonic acid from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. J. Clin. Invest. 75: 1770-1780, 1985.
6. COLEMAN, J. B., CASINI, A. F., SERRONI, A. AND FARBER, J. L.: Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. Toxicol. Appl. Pharmacol. 105: 393-102, 1990.
7. COSTA, A. K., HEFFEL, D. F., SCHIEBLE, T. M. AND TRUDELL, J. R.: Toxicity of t-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation. In Vitro Cell. & Dev. Biol. 23: 501-507, 1987.
8. DI MONTE, D., ROSS, D., BELLOMO, G., EKLOW, L. AND ORRENIUS, S.: Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch. Biochem. Biophys. 235: 334-342, 1984.
9. FARBER, J. L., CHIEN, K. R. AND MITTNACHT, S., JR.: The pathogenesis of irreversible cell injury in ischemia. Am. J. Pathol. 102: 271-281, 1981
10. FARBER, J L., KYLE, M. E. AND COLEMAN, J B.: Biology of disease: Mechanism of cell injury by activated oxygen species. Lab. Invest. 62: 670-679, 1990.
11. GORE, G. J., NIEMINEN, A. L , FLEISHMAN, K. E , DAWSON, T. L., HERMAN, B. AND LEMASTERS, J. J.: Extracellular acidosis delays onset of cell death in ATP depleted hepatocytes. Am J. Physiol. 255: C315-C322, 1988.
12. GORE, G. J., FLEISHMAN, C. E., DAWSON, T. L., NIEMINEN, A. L., HERMAN, B. AND LEMASTERS, J. J.: Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes. Am. J. Physiol. 257: C347-C354, 1989b
13. GORE, G. J , NIEMINEN, A. L , WRAY, B. E., HERMAN, B. AND LEMASTERS, J. J.: Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. J. Clin. Invest. 83: 386-396, 1989a.
14. GUIDO, D. M., MCKENNA, R. AND MATHEWS, W. R.: Quantitation of hydroperoxyeicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometry. Anal Biochem 209: 123-129, 1993.
15. HALL, E. D., YONKERS, P. A., MCCALL, J. M. AND BRAUGHLER, J M.: Effects of 21-aminosteroid U74006F on experimental head injury in mice. J. Neurosurg 68: 456-461, 1988
16. HALL, E. D. AND BRAUGHLER, J. M.: Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Rad Bio. Med. 6: 289-301, 1989a.
17. HALL, E. D : Lazaroids: Efficacy and antioxidant mechanism in experimental cerebral ischemia, In Pharmacology of Cerebral Ischemia, ed. by J. Krieglstein and H. Oberpichler pp. 343-350, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1990.
18. HALL, E. D. AND BRAUGHLER, J. M.: Central nervous system trauma and stroke: H. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation Free Rad. Bio. Med. 6: 303-313, 1989b.
19. HALL, E. D. PAZARA, K. E , BRAUGHLER, J. M., LINEMAN, K. L. AND JACOBSEN, E. J.: Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Stroke, 21: suppl. III, 83-87, 1990.
20. HALL, E. D., BRAUGHLER, J. M., YONKERS, P. A., SMITH, S. L., LINEMAN, K. L., MEANS, E. D., SCHERCH, H. M., VON VOIGTLANDER, P. F., LAHTI, R. A. AND JACOBSEN, E. J.: U78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia J. Pharmacol. Exp. Ther. 258: 688-694, 1991.
21. HALL, E. D., MCCALL, J. M AND MEANS, E. D.: Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage. Adv. Pharmacol. 28: 221-268, 1994.
22. HERMAN, B., GORES, G. J., NIEMINEN, A. L., KAWANISHI, T., HARMAN, A AND LEMASTERS, J. J : Calcium and pH in anoxic and toxic injury. Critical Reviews in Toxicology 21: 127-148, 1990.
23. JENNINGS, R B. AND REIMER, K. A.. Lethal myocardial ischemic injury. Am. J. Pathol. 102: 241-255, 1981.
24. JONES, R. L., MILLER, J. C., HAGLER, H. K., CHIEN, K. R., WILLERSON, J T. AND BUJA, L. M.: Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am. J. Pathol. 135: 541-556, 1989.
25. KILLINGER, JR., W. A., DOROFI, D. B., KEAGY, B. A AND JOHNSON, G.: Improvement of endothelial cell viability at 4°C by addition of lazaroid U74500A to preservation solutions. Transplantation 53: 983-986, 1992.
26. KUZUYA, M., NAITO, M., FUNAKI, C., HAYASHI, T., ASAI, K. AND KUZUYA, F.: Probucol prevents oxidative injury to endothelial cells. J. Lipid Res. 32: 197-204, 1991.
27. KYLE, M. E., SERRONI, A. AND FARBER, J. L.: The inhibition of lipid peroxidation by disulfiram prevents the killing of cultured hepatocytes by allyl alcohol, tert-butyl hydroperoxide, hydrogen hydroperoxide and diethyl maleate. Chem. Biol. Interactions 72: 269-275, 1989.
28. LEBEL, C. P., ISCHIROPOULOS, H. AND BONDY, S. C.: Evaluation of the probe 2′,7′-dichlorofluorescinas an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5: 227-231, 1992.
29. LIWNICZ, B. H., ARCHER, G., SOUKUP, S. W. AND LIWNICZ, R. G.: Continuous human glioma derived cell lines UC-11MG and UC-302MG J. Neuro-Oncol. 3: 373-385, 1986.
30. MASAKI, N., KYLE, M. E. AND FARBER, J. L.: tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch. Biochem. Biophys. 269: 390-399, 1989.
31. MASSEY, K. D. AND BURTON, K. P.: Free radical damage in neonatal rat cardiac myocyte cultures: Effect of alpha-tocopherol, trolox and phytol. Free Rad. Biol. Med. 8: 449-458, 1990.
32. MITCHELL, D. B., ACOSTA, D. AND BRUCKNER, J. V.: Role of glutathione depletion in the cytotoxicity of acetaminophen in a primary culture system of rat hepatocytes. Toxicology 37: 127-146, 1985.
33. MOORE, M., THOR, H., MOORE, G., NELSON, S., MOLDEUS, S. AND ORRENIUS, S.: The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated rat hepatocytes is associated with thiol depletion and increased cytosolic calcium. J Biol. Chem. 260: 13035-13040, 1985.
34. RAICHLE, M. E.: The pathophysiology of brain ischemia. Ann. Neurol. 13: 2-10, 1983.
35. RICE-EVANS, C. A. AND DIPLOCK, A. T.: Current status of antioxidant therapy. Free Rad. Biol. Med. 15: 77-96, 1993.
36. RUBIN, R. AND FARBER, J. L.: Mechanism of the killing of cultured hepatocytes by hydrogen peroxide. Arch. Biochem. Biophys. 228: 450-459, 1984.
37. RUSH, G. F., GORSKI, J. R., RIPPLE, M. G , SOWINSKI, J., BUGELSKI, P. AND HEWITT, W. R.: Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol. Appl Pharmacol. 78: 473-483, 1985.
38. SEDMAK, J. J. AND GROSSBERG, S. E.: A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. Anal Biochem. 79: 544-552, 1977.
39. SLEZAK, S. E AND HOEAN, P. K.: Cell-mediated cytotoxicity: A highly sensitive and informative flow cytometric assay. J. Immunol. Methods 117: 205-214, 1989.
40. SUN, F. F., FLEMING, W. E. AND TAYLOR, B. M.: Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochem. Pharmacol. 45: 1149-1155, 1993.
41. TAYLOR, B. M., YANKUAN WU AND SUN, F. F.: The effect of Hpophilic antioxidants on the physiological changes occuring in ATP depletion induced lethal cell injury: A fluorescence analysis. FASEB J. 8: A408, 1994.
42. WERNS, S. W., SHEA, M. J. AND LUCHESI, B. R.: Free radicals in ischemic myocardial injury. Free Rad. Bio. Med. 1: 103-110, 1985.
43. WU, Y., TAYLOR, B. M. AND SUN, F. P.: Membrane property changes during energy depletion induced cell injury: Studies with fluorescence microscopy. FASEB J. 8: A128, 1994