Notch-1 expression levels in 3T3-L1 cells influence ras signaling and transformation by oncogenic ras

International Journal of Oncology

Volumn 14, Issue 4, 1999, Pages 777-783

  Ruiz Hidalgo, María José ^a   Garcés, Carmen ^a   Laborda, Jorge ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b Division of Bacterial Products   (United States)

Author keywords

3T3 cells; Adipogenesis; Differentiation; Notch; ras oncogene

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL SURFACE RECEPTOR; INSULIN; MEMBRANE PROTEIN; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN P21; RAS PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; GENETIC TRANSFORMATION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; INSULIN; MEMBRANE PROTEINS; MICE; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMATION, GENETIC;

EID: 0033110998     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.14.4.777     Document Type: Article

References (32)

1. Greenwald I: Structure/function studies of Lin-12/Notch proteins. Curr Opin Genet Dev 4: 556-562, 1994.
2. Artavanis-Tsakonas S, Matsuno K and Fortini ME: Notch signaling. Science 268: 225-232, 1995.
3. Lardelli M, Williams R and Lendahl U: Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Int J Dev Biol 39: 769-780, 1995.
4. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P and Artavanis-Tsakonas S: Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67: 687-699, 1991.
5. Struhl G and Adachi A: Nuclear access and action of Notch in vivo. Cell 93: 649-660, 1998.
6. Schrocter EH, Kisslinger JA and Kopan R: Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain. Nature 393: 382-386, 1998.
7. Lindsell CE, Shawber CJ, Boulter J and Weinmaster G: Jagged: a mammalian ligand that activates Notch-1. Cell 80: 909-917, 1995.
8. Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, Weinmaster G and Barres BA: Notch receptor activation inhibits oligodendrocyte differentiation. Neuron 21: 63-75, 1998.
9. Corbin V, Michelson AM, Abmayr SM, Neel V, Alcamo E, Maniatis T and Young MW: A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67: 311-323, 1991.
10. Garcés C, Ruiz-Hidalgo MJ, Font de Mora J, Park C, Miele L, Goldstein J, Bonvini E, Porras A and Laborda J: Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J Biol Chem 272: 29729-29734, 1997.
11. MacDougald OA and Lane MD: Transcriptional regulation of gene expression during adipocyte differentiation. Ann Rev Biochem 65: 345-373, 1995.
12. Benito M, Porras A, Nebreda AR and Santos E: Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes. Science 253: 565-568, 1991.
13. Porras A, Nebreda AR, Benito M and Santos E: Activation of Ras by insulin in 3T3-L1 cells does not involve GTPase-activating protein phosphorylation. J Biol Chem 267: 21124-21131, 1992.
14. Porras A, Muszynski K, Rapp UR and Santos E: Dissociation between activation of Raf-1 kinase and the 42-KDa mitogen-activated protein kinase/90-KDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3-L1 cells. J Biol Chem 269: 12741-12748, 1994.
15. Raptis L, Brownell HL, Lu Y, Preston T, Narsimhan RP, Anderson S, Schaefer E and Haliotis T: v-Ras and v-Raf block differentiation of transformable C3H10T1/2-derived preadipocytes at lower levels than required for neoplastic transfomation. Exp Cell Res 235: 188-197, 1997.
16. Raptis L, Yang J, Brownell H, Lai J, Preston T, Corbley MJ, Narsimhan RP and Haliotis T: Ras Leu61 blocks differentiation of transformable 3T3-L and C3H10T1/2-derived preadipocytes in a dose- and time-dependent manner. Cell Growth Differ 8: 11-21, 1997.
17. Martin-Zanca D, Oskam R, Mitra G, Copeland T and Barbacid M: Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 9: 24-33, 1989.
18. Sambrook J, Fritsch EF and Maniatis T: Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
19. Harlow E and Lane D: Antibodies. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1988.
20. Hirakawa T, Maruyama K, Kohl NE, Kodama T and Ruley HE: Massive accumulation of neutral lipids in cells conditionally transformed by an activated H-ras oncogene. Oncogene 6: 289-295, 1991.
21. Tontonoz P, Hu E, and Spiegelman M: Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79: 1147-1156, 1994.
22. Kopan R, Schroefer EH, Weintraub H and Nye J: Signal transduction by activated mNotch: importance of proteolitic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 93: 1683-1688, 1996.
23. Axelrod JD, Matsuno K, Artavanis-Tsakonas S and Pcrrimon N: Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 271: 1826-1832, 1996.
24. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA and Hoffman T: T cell leukemia-associated human Notch/ translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med 183: 2025-2032, 1996.
25. Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG and Israel A: The Notch-1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 95: 8108-8112, 1998.
26. Pan MG, Wang YH, Hirsch DD, Labudda K and Stork PJ: The wnt-1 proto-oncogene regulates MAPK activation by multiple growth factors in PC12 cells. Oncogene 11: 2005-2012, 1995.
27. Kuriyama M, Harada N, Kuroda S, Yamamoto T, Nakafuku M, Iwamatsu A, Yamamoto D, Prassad R, Croce C, Canaani E and Kaibuchi K: Identification of AF-6 and Canoe as putative targets for Ras. J Biol Chem 271: 607-610, 1996.
28. Sawamoto K and Okano H: Cell-cell interactions during neural development: multiple types of lateral inhibitions involved in Drosophila eye development. Neurosci Res 26: 205-214, 1996.
29. Ordentlich P, Lin A, Shen C-A, Blaumueller C, Matsuno K, Artavanis-Tsakonas S and Kadesch T: Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol 18: 2230-2239, 1998.
30. Font de Mora J, Porras A, Ahn N and Santos E: Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocyte differentiation. Mol Cell Biol 17: 6068-6075, 1997.
31. Gallego C, Gupta SK, Heasley LE, Qian N-X and Johnson GL: Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH3T3 and Rat1a cells. Proc Natl Acad Sci USA 89: 7355-7359, 1992.
32. Marshall CJ: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185, 1995.