CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design

Journal of Immunology

Volumn 157, Issue 3, 1996, Pages 1000-1005

  Chen, Weisan ^a   Ede, Nicholas J ^b   Jackson, David C ^c   McCluskey, James ^a   Purcell, Anthony W ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

^b Mimotopes Pty Ltd   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; AUTOANTIGEN; H 2KB PROTEIN, MOUSE; H-2KB PROTEIN, MOUSE; H2 ANTIGEN; HLA ANTIGEN CLASS 1; RIBONUCLEOPROTEIN; SS B ANTIGEN; SS-B ANTIGEN; SUCCINIMIDE; SUCCINIMIDE DERIVATIVE; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; ARTICLE; CELL CULTURE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ASPARAGINE; AUTOANTIGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RIBONUCLEOPROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIMIDES; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0030209791     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. + T cells. Nature 372:691.
2. b-restricted TNP epitopes. J. Immunol. 151:678.
3. Haurum, J. S., G. Arsequell, A. C. Lellouch, S. Y. C. Wong, R. A. Dwek, A. J. McMichael, and T. Elliott. 1994. Recognition of carbohydrate by major histocompatibility complex class I restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180:739.
4. Deck, B., M. Elofsson, J. Kihlberg, and E. R. Unanue. 1995. Specificity of glycopeptide-specific T cells. J. Immunol. 155:1074.
5. Kohler, J., S. Martin, U. Pflugfelder, H. Ruh, J. Vollmer, and H. U. Weltzien. 1995. Cross-reactive trinitrophenylated peptides as antigens for class II major histocompatibility complex-restricted T cells and inducers of contact sensitivity in mice: limited T cell receptor repertoire. Eur. J. Immunol. 25:92.
6. Romagnoli, P., A. M. Labhart, and F. Sinigaglia. 1991. Selective interaction of Ni with an MHC-bound peptide. EMBO J. 10:1303.
7. Aswad, D. W. 1995. Deamidation and Isoaspartate Formation in Peptides and Proteins. CRC Press, Boca Raton.
8. Ede, N. J., W. Chen, J. McCluskey, D. C. Jackson, and A. W. Purcell. 1995. Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen. Biomed. Peptides Proteins Nucleic Acids 1:231.
9. Chen, W., J. McCluskey, S. Rodda, and F. R. Carbone. 1993. Changes at peptide residues buried in the MHC class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J. Exp. Med. 177:869.
10. Catipovic, B., J. D. Porto, M. Mage, T. E. Johansen, and J. P. Schneck. 1992. Major histocompatibility complex conformational epitopes are peptide specific. J. Exp. Med. 176:1611.
11. Jones, B., and C. A. Janeway Jr. 1981. Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted. Nature 292:547.
12. Anderson, K., P. Cresswell, M. Gammon, J. Hermes, A. Williamson, and H. Zweerink. 1991. Endogenously synthesised peptide with an endoplasmic reticulum signal sequence sensitizes antigen-processing mutant cells to class I-restricted cell-mediated lysis. J. Exp. Med. 174:489.
13. Chu, G. H., H. Hayakawa, and P. Berg. 1987. Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res. 15:1311.
14. Chen, W., S. Khilko, J. Fecondo, D. H. Margulies, and J. McCluskey. 1994. Determinant selection of MHC class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by non-dominant anchor residues. J. Exp. Med. 180:1471.
15. Chen, W., F. R. Carbone, and J. McCluskey. 1993. Electroporation and commercial liposomes efficiently deliver soluble protein into MHC class I presentation pathway: priming in vitro and in vivo for class I-restricted recognition of soluble antigen. J. Immunol. Meth. 160:49.
16. + T cell fusion partner. J. Exp. Med. 170:1887.
17. Chambers, J. C., D. Kenan, B. Martin, and J. D. Keene. 1988. Genomic structure and amino acid sequence of human La autoantigen. J. Biol. Chem. 263:18043.
18. Falk, K., O. Rötzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-speciflc motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
19. b. Science 257:919.
20. d-restricted cloned CTL specific for a photoreactive peptide derivative. Immunity 3:51.
21. + T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J. Immunol. 155:462.
22. Brander, C., D. Mauri-Hellweg, F. Bettens, H. Rolli, M. Goldman, and W. J. Pichler. 1995. Heterogeneous T cells responses to β-lactam-modified self-structures are observed in penicillin-allergic individuals. J. Immunol. 155(5):2670.
23. Robson, V. M. J., I. D. Rae, and F. M. Ng. 1990. Identification of the aspartimide structure in a previously reported peptide. Biol. Chem. Hoppe-Seyler 371:423.
24. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. Vanpel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, T. Boon, D. F. Hunt, and V. H. Engelhard. 1996. An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. J. Exp. Med. 183:527.
25. Teshima, G. T., J. T. Stults, V. Ling, and E. Canova-Davies. 1991. Isolation and characterization of a succinimide variant of methionyl growth hormone. J. Biol. Chem. 266:13544.
26. Violand, B. N., M. R. Schittler, E. W. Kolodziej, P. C. Toren, M. A. Cabonce, N. R. Siegel, K. L. Duffin, J. F. Zobel, C. E. Smith, and J. S. Tou. 1992. Isolation and characterization of porcine somatotropin containing a succinimide residue in place of aspartate 129. Protein Sci. 1:1634.
27. Bischoff, R., P. Lepage, M. Jaquinod, G. Cauet, M. Acker-Klein, D. Cleese, M. Laporte, A. Bayol, A. Van Dorsselar, and C. Roitsch. 1993. Sequence specific deamidation: isolation and biochemical characterization of succinimide intermediates of recombinant hirudin. Biochemistry 32:725.
28. Toney, K., A. Bateman, C. Gagon, and H. P. Bennett. 1993. Aspartimide formation in the joining sequence of porcine and mouse pro-opiomelanocortin. J. Biol. Chem. 268(2):1024.
29. Battersby, J. E., V. R. Mukku, R. G. Clark, and W. S. Hancock. 1995. Affinity purification and microcharacterization of recombinant DNA-derived human growth hormone isolated from an in vivo model. Anal. Chem. 67:447.