Pentadecapeptide BPC 157, cimetidine, ranitidine, bromocriptine, and atropine effect in cysteamine lesions in totally gastrectromized rats: A model for cytoprotective studies

Digestive Diseases and Sciences

Volumn 42, Issue 5, 1997, Pages 1029-1037

  Sikirić, Predrag ^a,b   Mikuš, Darko ^a   Seiwerth, Sven ^a   Grabarević, Željko ^a   Ručman, Rudolf ^a   Petek, Marijan ^a   Jagić, Vjekoslav ^a   Turković, Branko ^a   Rotkvić, Ivo ^a   Miše, Stjepan ^a   Zoričić, Ivan ^a   Perić, Josip ^a   Konjevoda, Paško ^a   Perović, Darko ^a   Jurina, Ljubica ^a   Hanževački, Miro ^a   Šeparović, Jadranka ^a   Gjurašin, Miroslav ^a   Jadrijević, Stipislav ^a   Jelovac, Nikola ^a   Miklić, Pavao ^a   Buljat, Gojko ^a   Marović, Anton ^a   more..

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

cysteamine; cytoprotection; duodenal ulcers; pentadecapeptide BPC 157; peptide BPC; standard antiulcer agents; total gastrectomy

Indexed keywords

ANTIULCER AGENT; ATROPINE; BROMOCRIPTINE; CIMETIDINE; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; MERCAPTAMINE; OMEPRAZOLE; RANITAL; RANITIDINE; ULTOP; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DUODENUM MUCOSA; DUODENUM ULCER; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TOTAL STOMACH RESECTION; ULCEROGENESIS;

ANIMALS; ANTI-ULCER AGENTS; ATROPINE; BROMOCRIPTINE; CIMETIDINE; CYSTEAMINE; DUODENAL ULCER; FEMALE; GASTRECTOMY; OMEPRAZOLE; PEPTIDE FRAGMENTS; PROTEINS; RANITIDINE; RATS; RATS, WISTAR;

EID: 8244232500     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018893220943     Document Type: Article

References (62)

1. Thompson J, Greeley GH Jr, Rayford PL, Twonsed CM Jr: Gastrointestinal Endocrinology. New York, McGraw-Hill, 1987
2. Guglietta A: Possible clinical use of peptide growth factors in the GI tract: Perspectives and obstacles. Exp Clin Gastroenterol 3:1-6, 1992
3. Sikiric P, Petek M, Rucman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N: A new gastric juice peptide, BPC-an overview of stomach/stress/ organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87:313-327, 1993
4. 4 administration. A comparative study with dopamine agonists and somatostatin. Life Sci 53:PL291-PL296, 1993
5. Sikiric P, Gyires K, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Udovicic I, Jagic V, Mildner B, Duvnjak M, Danilovic Z: The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology 2:121-127, 1993
6. Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, Rotkvic I, Jagic V, Duvnjak M, Mise S, Djacic S, Separovic J, Veljaca M, Sallmani A, Banic M, Brkic T: The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment on gastric and dudodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H, receptor antagonists, dopamine promotors and gut peptides. Life Sci 54:PL63-PL68, 1994
7. Sikiric P, Rotkvic I, Mise S, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Zjacic-Rotkvic V, Duvnjak M, Jagic V, Suchanek E, Marovic A, Banic M, Brkic T, Hanzevacki M, Separovic J, Djacic S, Simicevic V: Dopamine agents efficacy in peptic ulcer healing and relapse prevention - a further indication for importance of stomach dopamine in the stress organoprotection concept. In Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Volume 2. S Szabo, Y Taché, G Glavin (eds). New York, Plenum Publishing, 1995, pp 221-230
8. Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkvic I, Mise S, Zoricic I, Jurina J, Konjevoda P, Hanzevacki M, Ljubanovic D, Separovic J, Gjurasin M, Bratulic M, Artukovic B, Jelovac N, Buljat G: Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats. Dig Dis Sci 41:1518-1526, 1996
9. Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkvic I, Mise S, Zoricic I, Gjurasin M, Konjevoda P, Separovic J, Ljubanovic D, Artukovic B, Bratulic M, Tisljar M, Jurina Lj, Buljat G, Miklic P, Marovic A: The beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin and capsaicin neurotoxicity. Dig Dis Sci 41:1604-1614, 1996
10. Sikirić P, Mazul B, Seiwerth S, Grabarević Ž, Ručman R, Petek M, Jagić V, Turković B, Rotkvić I, Miše S, Zoričić I, Jurina LJ, Konjevoda P, Hanževački M, Gjurǎsin M, Śeparović J, Ljubanović D, Artuković B, Bratulić M, Tišljar M, Miklić P, Sumajstorčić J: Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress. Dig Dis Sci 42:661-671, 1997
11. Sikirić P, Mikus D, Seiwerth S, Grabarević Z, Ručman R, Petek M, Jagić V, Turković B, Rotkvić I, Miše S, Zoričić I, Konjevoda P, Perović D, Simicevic V, Śeparović J, Hanževački M, Ljubanović D, Artuković B, Bratulić M, Tišljar M, Rekic B, Gurašin M, Miklić P, Buljat G: Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agents-induced gastrointestinal lesions and adjuvant arthritis in rats. J Physiol (Paris), 1997 (in press)
12. Seiwerth S, Sikirić P, Grabarević Ž, Zoričić I, Hanževački M, Ljubanović D, Čorić V, Konjevoda P, Petek M, Ručman R, Turković B, Perović D, Mikuš D, Jandrijević S, Medvidović M, Tadić T, Romac B, Kos J, Perić J, Kolega Ž: BPC 157 effect on healing. J Physiol (Paris), 1997 (in press)
13. Grabarević Z, Tišljar M, Artuković B, Bratulić M, Dzaja P, Seiwerth S, Sikirić P, Perić J, Geres D, Kos J: The influence of BPC 157 on nitric-oxyde agonists and antagonist induced lesions in broiler chicks. J Physiol (Paris), 1997 (in press)
14. Paré W, Klucyznski JM: The effect of new gastric juice peptide BPC on classic stress triad in stress procedure. Exp Clin Gastroenterol 2:234-236, 1992
15. Veljaca M, Pllana R, Lesch CA, Sanchez B, Chan K, Guglietta A: Protective effect of BPC 157 on a rat model of colitis. Gastroenterology 106:789, 1994
16. Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272:417-422, 1994
17. Veljaca M, Lesch CA, Sanchez B, Low J, Guglietta A: Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action. Gastroenterology 108:936, 1995
18. Veljaca M, Chan K, Guglietta A: Digestion of h-EGF, h-TGF alpha, and BPC-15 in human gastric juice. Gastroenterology 108:761, 1995
19. Bosnjak ZJ, Graf BM, Sikiric P, Stowe DF: Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart. FASEB J 8:A129, 1994
20. Sandor Z, Vincze A, Szabo S: The protective effect of a recently isolated gastric peptide in acute and chronic gastroduodenal injury. FASEB J 10:A171, 1996
21. Taché Y, Simard P, Collu R: Prevention by bombesin of coloid-restraint stress induced gastric ulcers in rats. Life Sci 24:1719-1726, 1979
22. Heiling M, Murison R: Intracerebroventricular neuropeptide Y protects against stress-induced gastric lesions in rat. Eur J Pharmacol 137:127-129, 1987
23. Szabo S, Usadel KH: Cytoprotection-organoprotection by somatostatin: Gastric and hepatic lesions. Experientia 38:254-256, 1982
24. Senecic I, Sikiric P, Giljanovic S: The effects of somatostatin on stress-induced gastric lesions in mice. Exp Clin Gastroenterol 1:171-173, 1991
25. Takeuchi K, Johnson LR: Pentagastrin protects against stress ulceration in rats. Gastroenterology 76:788-792, 1979
26. Evangelista S, Renzi D, Guzzi P, Maggi CA: Decrease of gastric calcitonin generated peptide-like immunoreactivity is associated with ulcers induced by water immersion stress in rats. Exp Clin Gastroenterol 1:51-53, 1991
27. Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761-767, 1979
28. Robert A, Lancaster C, Olafsson AS, Gilbertson-Beadling S, Zhang W: Gastric adaptation to the ulcerogenic effect of aspirin. Exp Clin Gastroenterol 1:73-81, 1991
29. Sikiric P, Rotkvic I, Mise S, Krizanac S, Gjuris V, Jukic J, Suchanek E, Petek M, Udovicic I, Kalogjera L, Geber J, Tucan-Foretic M, Duvnjak M, Philipp M, Balen I, Anic T: The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats. Eur J Pharmacol 158:61-67, 1988
30. Moron F, Pena C, Cuesta E, Mozsik G, Javor T: Comparative study of the cytoprotective effects of anticholinergic agents on the gastric mucosal lesions produced by intragastric administration of 0.6 M HCl in rats. In Recent Advances in Gastrointestinal Cytoprotection. G Mózsik, A Pár, A Bertelli (eds). Budapest, Akedémiai Kiadó, 1984, pp 61-66
31. Clissold SP, Campoli-Richards DM: Omeprazole. An updated review. Drugs 32:15-47, 1986
32. Kim KH, Kim HY, Lee GY, Hong SS: Involvement of histamine release in the mechanism of cysteamine induced gastric acid hypersecretion. Arch Int Pharmacodyn Ther 276:279-286, 1985
33. Poulsen SS, Kirkegaard P, Skov-Olsen P, Christiansen J: Brunner's glands of the rat during cysteamine ulceration. Scand J Gastroenterol 16:459-464, 1981
34. Ohe K, Okada Y, Fujiwara T, Inoue M, Miyoshi A: Cysteamine-induced inhibition of acid neutralization and the increase in hydrogen ion back-diffusion in duodenal mucosa. Dig Dis Sci 27:250-256, 1982
35. Tanaka H, Ueki S, Takeuchi K, Okabe S: Effects of indomethacin on the duodenal mucosa of rats: Comparative study with cysteamine. Jpn J Pharmacol 42:539-548, 1986
36. Gallagher GT, Szabo S: Direct measurement of duodenal acid-pepsin exposure at site of ulceration in rats. Am J Physiol 246:G660-G665, 1984
37. Szabo S: Dopamine disorder in duodenal ulceration. Lancet 2:880-882, 1979
38. Robert A, Nezamis JE, Lancaster C, Badalamenti JN: Cysteamine-induced duodenal ulcers: A new model to test antiulcer agents. Digestion 11:199-214, 1974
39. Hernandez DE, Adcock JW, Nemeroff CB, Prange AJ: The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats. Eur J Pharmacol 84:205-209, 1982
40. Szabo S, Neumeyer JL: Dopamine agonists and antagonists in duodenal ulcer disease. In ACS Symposium Series 224. C Kaiser, W Kebabian (eds). Washington, DC, American Chemical Society, 1983, pp 175-196
41. Szabo S, Reichlin S: Somatostatin in rat tissues is depleted by cysteamine administration. Endocrinology 109:2255-2257, 1981
42. 2-beta stimulate rat gastric mucin release. Gastroenterology 84:306-313, 1983
43. Konturek SJ, Brzozowski T, Piastucki I, Radecki T, Dupuy D, Szabo S: Gastric mucosal protection by agents altering gastric mucosal sulfhydryls. Role of endogenous prostaglandins. Digestion 37:67-71, 1987
44. Utley RJ, Salim ASM, Carter DC: Effect of cimetidine and omeprazole on aspirin- and taurocholate-induced gastric mucosal damage in the rat. Gut 26:770-775, 1985
45. McComb DJ, Kovacs K, Horner HC, Gallagher GT, Schwedes U, Usadel KH, Szabo S: Cysteamine-induced adrenocortical necrosis in rats. Exp Mol Pathol 35:422-434, 1981
46. Millard WJ, Sagar SM, Landis DM, Martin JB: Cysteamine: A potent and specific depletor of pituitary prolactin. Science 217:452-454, 1982
47. McComb DJ, Cairns PD, Kovacs K, Szabo S: Effects of cysteamine on the hypothalamic-pituitary axis in the rat. Fed Proc 44:2551-2555, 1985
48. Cook LL, Bissette G, Dole K, Nemeroff CB: A critical evaluation of cysteamine as a tool to deplete somatostatin in the rat central nervous system. Endocrinology 124:855-861, 1989
49. Briden S, Flemstrom G, Kivilaakso E: Cysteamine and propionitrile inhibit the rise of duodenal mucosal alkaline secretion in response to luminal acid in rats. Gastroenterology 88:295-302, 1985
50. Szabo S, Haith LR Jr, Reynolds ES: Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile: Influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones. Dig Dis Sci 24:471-477, 1979
51. Spina G, Fox U, Glasser AU: Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat. Pharmacol Res Commun 14:679-686, 1982
52. Pihan G, Gallagher GT, Szabo S: Biliary and pancreatic secretions influence experimental duodenal ulcer without affecting gastric secretion in the rat. Dig Dis Sci 30:240-246, 1985
53. Olsen PS, Poulsen SS, Kirkegaard P, Nexo E: Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 87:103-108, 1984
54. Scalabrino G, Monzio-Compagnoni B, Ferioli ME, Lorenzini EC, Chiodini E, Candiani R: Subacute combined degeneration and induction of ornithine decarboxylase in spinal cords of totally gastrectomized rats. Lab Invest 62:297-304, 1990
55. Axelson J, Persson P, Gagnemo-Persson R, Hakanson R: Importance of the stomach in maintaining calcium homoeostasis in the rat. Gut 32:1298-1302, 1991
56. Sugiyama M, Hsu-Chang CY, Sato Y, Katamura H, Tsuchiya S: Pathophysiology of bone disorder after total gastrectomy. Nippon Geka Gakkai Zasshi 89:1410-1413, 1988
57. Poulsen SS, Kirkegaard P, Olsen PS, Jensen KK, Christiansen J: Role of delayed gastric emptying in the pathogenesis of cysteamine-induced duodenal ulcer in the rat. Scand J Gastroenterol 17:325-330, 1982
58. Seiler M, Szabo S, Ourieff S, McComb DJ, Kovacs K, Reichlin S: The effect of the duodenal ulcerogen cysteamine on somatostatin and gastrin cells in the rat. Exp Mol Pathol 39:207-218, 1983
59. Boesby S, Man WK, Mendez Diaz R, Spencer J: Effect of cysteamine on gastroduodenal mucosal histamine in rat. Gut 24:935-939, 1983
60. Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228-236, 1985
61. Szabo S: Experimental basis for a role for sulfhydryls and dopamine in ulcerogenesis: A primer for cytoprotection - organoprotection. Klin Wochenschr 64(suppl 7):116-122, 1986
62. Sikiric P, Zoricic I, Sewerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkvic I, Mise S: Pentadecapeptide BPC 157 beneficially influences the healing of colon-colon anastomoses in rats. Inflammopharmacology 4: (in press), 1997