Androgen-Induced Oxidative Stress in Human LNCaP Prostate Cancer Cells Is Associated with Multiple Mitochondrial Modifications

Antioxidants and Redox Signaling

Volumn 1, Issue 1, 1999, Pages 71-81

  Ripple, Maureen O ^a,b,c   Hagopian, Kevork ^a,d   Oberley, Terry D ^a,e   Schatten, Heide ^f   Weindruch, Richard ^a,b,d  

^a WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL SUCCINATE; ANTIMYCIN A1; COLORING AGENT; DNA; DRUG DERIVATIVE; FLUORESCEIN DERIVATIVE; FLUORESCENT DYE; HYDROXYL RADICAL; METRIBOLONE; PEROXIDE; ROTENONE; TESTOSTERONE DERIVATIVE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNCOUPLING PROTEIN;

ARTICLE; CELL CULTURE; DRUG EFFECT; ELECTRON TRANSPORT; HUMAN; MALE; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PROSTATE TUMOR; TIME; ULTRASTRUCTURE;

ANTIMYCIN A; COLORING AGENTS; DNA; ELECTRON TRANSPORT; FLUORESCEINS; FLUORESCENT DYES; HUMANS; HYDROXYL RADICAL; MALE; METRIBOLONE; MITOCHONDRIA; OXIDATIVE STRESS; PEROXIDES; PROSTATIC NEOPLASMS; ROTENONE; TESTOSTERONE CONGENERS; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TUMOR CELLS, CULTURED; UNCOUPLING AGENTS; VITAMIN E;

EID: 0033086396     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.1999.1.1-71     Document Type: Article

References (45)

1. ANGEL, P., and KARIN, M. (1991). The role of Fos, Jun and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157.
2. BERRIDGE, M.V., and TAN, A.S. (1993). Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch. Biochem. Biophys. 303, 474-482.
3. BIRCH-MACHIN, M., JACKSON, S., KLER, R.S., and TURNBULL, D.M. (1993). Study of skeletal muscle mitochondrial dysfunction. In Methods in Toxicology: Mitochondrial Dysfunction. L.H. Lash and D.P. Jones, eds. (Academic Press, New York) pp. 51-69.
4. CERUTTI, P.A. (1985). Prooxidant states and tumor promotion. Science 227, 375-381.
5. CLARK, L.C., DALKIN, B., KRONGRAD, A., COMBS, G.F., TURNBULL, B.W., SLATE, E.H., WITHERINGTON, R., HERLONG, J.H., JANOSKO, J.E., CARPENTER, D., BOROSSO, C., FALK, S., and ROUNDER, J. (1998). Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 81, 730-734.
6. COSTELLO, L.C., and FRANKLIN, R.B. (1994). Bioenergetic theory of prostate malignancy. Prostate 25, 162-166.
7. COSTELLO, L.C., and FRANKLIN, R.B. (1997). Citrate metabolism of normal and malignant prostate epithelial cells. Urology 50, 3-12.
8. COSTELLO, L.C., LIU, Y., and FRANKLIN, R.B. (1995). Testosterone stimulates the biosynthesis of m-aconitase and citrate oxidation in prostate epithelial cells. Mol. Cell. Endocrinol. 112, 45-51.
9. DARGEL, R. (1992). Lipid peroxidation - a common pathogenetic mechanism? Exp. Toxic. Pathol. 44, 169-181.
10. DOEG, K.A. (1968). Control of mitochondrial lipid biosynthesis by testosterone in male sex accessory gland tissue and liver of castrate rats. Endocrinology 82, 535-539.
11. DOEG, K.A., POLOMSKI, L.L., DOEG, L.H., and DUBOS, P.M. (1971). Androgen control of mitochondrial protein biosynthesis in male sex accessory tissue and liver of rats. Endocrinology 89, 338-346.
12. DOEG, K.A., POLOMSKI, L.L., and DOEG, L.H. (1972). Androgen control of mitochondrial and nuclear DNA synthesis in male sex accessory tissue of castrate rats. Endocrinology 90, 1633-1638.
13. FINKEL, T. (1998). Oxygen radicals and signaling. Curr. Opin. Cell. Biol. 10, 248-253.
14. FUJII, H., CODY, S.H., SEYDEL, U., PAPDIMITRIOU, J.M., WOOD, D.J., and ZHENG, M. (1997). Recording of mitochondrial transmembrane potential and volume in cultured rat osteoclasts by confocal laser scanning microscopy. Histochem. J. 29, 571-581.
15. GIOVANNUCCI, E., ASCHERIO, A., RIMM, E.B., STAMPFER, M.J., COLDITZ, G.A., and WILLETT, W.C. (1995). Intake of carotenoids and retinol in relation to risk of prostate cancer. J. Natl. Cancer Inst. 87, 1767-1776.
16. GOTOH, Y., and COOPER, J.A. (1998). Reactive oxygen species-and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. J. Biol. Chem. 273, 17277-17282.
17. GRAY, A., FELDMAN, H.A., McKINLAY, J.B., and LONGCOPE, C. (1991). Age, disease, and sex hormone levels in middle-aged men: results of the Massacheusetts male aging study. J Clin. Endocrinol. Metab. 73, 1016-1025.
18. HARKONEN, P. (1981). Androgenic control of glycolysis, the pentose cycle and pyruvate dehydrogenase in the rat ventral prostate. J. Steroid Biochem. 14, 1075-1084.
19. HEINONEN, O.P., ALBANES, D., VIRTAMO, J., TAYLOR, P.R., HUTTUNEN, J.K., HARTMAN, A.M., HAAPAKOSKI, J., MALILA, N., RAUTALAHTI, M., RIPATTI, S., MAENPAA, H., TEERENHOVI, L., KOSS, L., VIROLAINEN, M., and EDWARDS, B.K. (1998). Prostate cancer and supplementation with a-tocopherol and β-carotene: Incidence and mortality in a controlled trial. J. Natl. Cancer Inst. 90, 440-446.
20. IRANI, K., YONG, X., Zweier, J.L., SOLLOTT, S.J., DER, C.J., FEARON, E.R., SUNDARESAN, M., FINKEL, T., and GOLDSCHMIDT-CLERMONT, P.J. (1997). Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275, 1649-1652.
21. KANE, D.J., SARAFIAN, T.A., ANTON, R., HAHN, H., GRALLA, E.B., VALENTINE, J.S., ORD, T., and BREDESEN, D.E. (1993). Bcle-inhibition of neural death: Decreased generation of reactive oxygen species. Science 262, 1274-1277.
22. LANDIS, S.H., MURRAY, T., BOLDEN, S., and WINGO, P.A. (1998). Cancer Statistics, 1998. CA Cancer J. Clin. 48, 6-29.
23. MADESH, M., and BALASUBRAMANIAN, K.A. (1998). Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian J. Biochem. Biophys. 35, 184-188.
24. MALINS, D.C., POLISSAR, N.L., and GUNSELMAN, S.J. (1997). Models of DNA structure achieve almost perfect discrimination between normal prostate, benign prostatic hyperplasia (BPH), and adenocarcinoma and have a high potential for predicting BPH and prostate cancer. Proc. Natl. Acad. Sci. USA 94, 259-264.
25. MATTHEWS, J.L., and MARTIN, J.H., eds. (1971). Atlas of Human Histology and Ultrastructure. (Lea and Febiger, Philadelphia).
26. MEIKLE, A.W. (1989). The endocrinology of the prostate and benign prostatic hyperplasia. In Endocrinology, 2nd ed. L.J. DeGroot, ed. (W.B. Saunders Company, Philadelphia) pp. 2152-2160.
27. MIGNOTTE, B., and VAYSSIERE, J.L. (1998). Mitochondria and apoptosis. Eur. J. Biochem. 252, 1-15.
28. MOSLEN, M.T. (1994). Reactive oxygen species in normal physiology, cell injury and phagocytosis. In Free Radicals in Diagnostic Medicine. D. Armstrong, ed. (Plenum Press, New York) pp. 17-26.
29. NARAYAN, P. (1995). Neoplasms of the prostate gland. In Smith's General Urology. E.A. Tanagho and J.W. McAninch, eds. (Appleton and Lange, CT) pp. 392-433.
30. NYDEN, S.J., and WILLIAMS-ASSMAN, A.G. (1953). Influence of androgens on synthetic reactions in venteral prostate tissue. Endocrinology 172, 588-600.
31. OBERLEY, T.D., and OBERLEY, L.W. (1993). Oxygen radicals and cancer. In Free Radicals in Aging. B.P. Yu, ed. (CRC Press, Ann Arbor, MI) pp. 247-267.
32. OESTERLING, J.E., FUKS, Z., LEE, C.T., and SCHER, H.I. (1998). Cancer of the prostate. In Cancer Principles and Practice of Oncology, 5th ed. V.T. DeVita, Jr., S. Hellman, and S.A. Rosenberg, eds. (Lippincott-Raven Publishers, Philadelphia, PA) pp. 1322-1386.
33. RAGO, R., MITCHEN, J., and WILDING, G. (1990). DNA fluormetric assay in 96-well tissue culture plates using Hoeschst33258 after cell lysis by freezing in distilled water. Anal. Biochem. 191, 31-34.
34. RICHTER, C. (1988). Do mitochondria DNA fragments promote cancer and aging? FEBS Lett. 241, 1-5.
35. RICKWOOD, D., WILSON, M.T., and DARLEY-USMAR, V.M. (1987). Isolation and characteristics of intact mitochondria. In Mitochondria A Practical Approach. V.M. Darley-Usmar, D. Rickwood, and M.T. Wilson, eds. (IRL Press, Oxford, UK) pp. 1-16.
36. RIPPLE, M.O., and WILDING, G. (1995). Alteration of glyceraldehyde-3-phosphate dehydrogenase activity and messenger RNA content by androgen in human prostate carcinoma cells. Cancer Res. 55, 4234-4236.
37. RIPPLE, M.O., HENRY, W.F., RAGO, R.P., and WILDING, G. (1997). Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J. Natl. Cancer Inst. 89, 40-48.
38. SCHUUR, E.R., HENDERSON, G.A., KMETEC, L.A., MILLER, J.D., LAMPARSKI, H.G., and HENDERSON, D.R. (1996). Prostate-specific antigen expression is regulated by an upstream enhancer. J. Biol. Chem. 271, 7043-7051.
39. SEN, C., and PACKER, L. (1996). Antioxidant and redox regulation of gene transcription. FASEB J. 72, 709-720.
40. SLATER, T.F., SAWYER, B., and STRAULI, U. (1963). Studies on succinate-tetrazolium reductase systems III. Points of coupling of four different tetrazolium salts. Biochim. Biophys. Acta 77, 383-393.
41. SOHAL, R., and WEINDRUCH, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
42. STARKOV, A.A. (1997). "Mild" uncoupling of mitochondria. Biosci. Rep. 17, 273-279.
43. VERCESI, A.E., KOWALTOWSKI, A.J., GRIJALBA, M.T., MEINICKE, A.R., and CASTILHO, R.F. (1997). The role of reactive oxygen species in mitochondrial permeability transition. Bioscience Rep., 17, 43-52.
44. YORK, J.L., MADDOX, L.C., ZIMNIAK, P., McHUGH, T.E., and GRANT, D.F. (1998). Reduction of MTT by glutathione S-transferase. Biotechniques 25, 626-628.
45. ZIEGLER, D.M. (1985). Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. Annu. Rev. Biochem. 54, 305-329.