Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma

Cancer Research

Volumn 59, Issue 3, 1999, Pages 516-520

  Parris, Christopher N ^a   Harris, Julian D ^a   Griffin, Darren K ^a   Cuthbert, Andrew P ^a   Silver, Andrew J R ^a,b   Newbold, Robert F ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 10; CHROMOSOME 9P; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE ISOLATION; HUMAN; HUMAN CELL; MELANOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN CARCINOGENESIS; TUMOR SUPPRESSOR GENE;

AGAR; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 9; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENES, P16; GENES, TUMOR SUPPRESSOR; HUMANS; MELANOMA; MICE; MICE, NUDE; PHENOTYPE; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR STEM CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033082457     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Rivers, J. K. Melanoma. Lancet, 347: 803-806, 1996.
2. Cowan, J. M., Halabam, R., and Franke, U. Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. J. Natl. Cancer Inst. (Bethesda), 80: 1159-1164, 1988.
3. Walker, G. J., Palmer, J. M., Walters, M. K., and Hayward, N. K. A genetic model of melanoma tumorigenesis based on allelic losses. Genes Chromosomes Cancer, 12: 134-141, 1995.
4. Cannon-Albright, L., Goldgar, D., Meyer, L., Lewis, C., Anderson, D., Fountain, J., Hegi, M., Wiseman, R., Petty, E., Bale, S., Olopade, O., Diaz, M., Kwiatkowski, D., Piepkom, M., Zone, J., and Skolnick, M. Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-22. Science (Washington DC), 258: 1148-1152, 1992.
5. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in the genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
6. Kamb, A., Shattuck-Eidens, D., Eeles, R., Liu, Q., Gruis, N. A., Ding, W., Hussey, C., Tran, T., Miki, Y., Weaver-Feldhaus, J., McClure, M., Aitken, J. F., Anderson, D. E., Bergman, W., Frants, R., Goldgar, D. E., Green, A., MacLennan, R., Martin, N. G., Meyer, L. J., Youl, P., Zone, J. J., Skolnick, M. H., and Cannon-Albright, L. A. Analysis of the p16 gene (CDKN2) as a candidate for the 9p melanoma susceptibility locus. Nat. Genet., 8: 22-26, 1994.
7. Puig, S., Ruiz, A., Lazaro, C., Castel, Lynch, M., Palou, J., Vilalta, A., Weissenbach, J., Mascaro, J. M., and Estivill, X. Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene. Am. J. Hum. Genet., 57: 395-402, 1995.
8. Ohta, M., Nagai, H., Shimizu, M., Rasio, D., Berd, D., Mastrangelo, M., Singh, A. D., Shields, J. A., Shields, C. L., Croce, C. M., and Huebner, K. Rarity of somatic and germ-line mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK41, in melanoma. Cancer Res., 54: 5269-5272, 1994.
9. Healy, E., Sikkink, S., and Rees, J. L. Infrequent mutation of CDKN2A in sporadic melanoma. J. Invest. Dermatol., 107: 318-321, 1996.
10. INK4) mutations in sporadic melanoma in vivo J. Invest. Dermatol., 108: 950, 1997.
11. Tsao, H., Zhang, X., Benoit, E., and Halsuka, F. G. Identification of PTEN/MMACI alterations in uncultured melanomas and melanoma cell lines. Oncogene, 16: 3397-3402, 1998.
12. Walker, G. J., Flores, J. F., Glendening, J. M., Lin A., Markl, I. D. C., and Fountain, J. W. Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets. Genes Chromosomes Cancer, 22: 157-163, 1998.
13. Trent, J. M., Stanbridge, E. J., McBride, H. L., Messe, E. U., Casey, G., Araujo, D. E., Witkowski, C. M., and Nagle, R. B. Tumorigenicity in human melanoma lines controlled by the introduction of human chromosome 6. Science (Washington DC), 247: 568-571, 1990.
14. Ray, M. E., Su, Y. A., Meltzer, P. S., and Trent, J. M. Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma. Oncogene, 12: 2527-2533, 1996.
15. Robertson, G. P., Coleman, A. B., and Lugo, T. G. Mechanisms of human melanoma cell growth and tumor suppression by chromosome 6. Cancer Res., 56: 1635-1641, 1996.
16. Miele, M. E., Robertson, G., Lee, J-H., Coleman, A., McGary, C. T., Fisher, P. B., Lugo, T. G., and Welch, D. R. Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosome 1 or 6. Mol. Carcinog., 15: 284-299, 1996.
17. Cuthbert, A. P., Trott, D. A., Ekong, R. M., Jezzard, S., England, N. L., Themis, M., Todd, C. M., and Newbold, R. F. Construction and characterization of a highly stable human:rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet. Cell Genet., 71: 68-76, 1995.
18. Lupton, S., Brunton, L. L., Kalberg, V. A., and Overall, R. W. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol. Cell. Biol., 11: 3374-3378, 1991.
19. Lugo, T. G., and Witte, O. N., The BCR-ABL oncogene transforms rat-1 cells and cooperates with. v-myc. Mol. Cell. Biol., 9: 1263-1270, 1989.
20. Plumb, J. A., Wishart, G. C., Setanoians, A., Morrison, J. G., Hamilton, T., Bicknell, S. R., and Kaye, S. B. Identification of a multidrug resistance modulator with clinical potential by analysis of synergistic activity in vitro, toxicity in vivo and growth delay in a solid human tumour xenograft. Biochem. Pharmacol., 47: 257-266, 1994.
21. Trent, J. M., and Thompson, F. H., Methods for chromosome banding of human and experimental tumors in vitro. Methods Enzymol., 151: 267-279, 1987.
22. Griffin, D. K., Sanoudou, D., Adamski, E., McGiffert, C., O'Brien, P., Weinberg, J., and Ferguson-Smith, M. A. Chromosome specific comparative genome hybridisation for determining the origin of intrachromosomal duplications. J. Med. Genet., 35: 37-41, 1998.
23. INK4A). Carcinogenesis (Lond.), 17: 1567-1575, 1996.
24. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Pue, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
25. Steck, P. A., Pershouse, M. A., Jasser, S. A., Alfred-Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMACI, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.