Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 23, Issue 2, 1999, Pages 277-287

  Baptista, Trino ^a,c   Alvarez, Lisette ^a   Lacruz, Anny ^a   De Mendoza, Soaira ^b   Hernández, Luis ^a  

^a UNIVERSIDAD DE LOS ANDES   (Venezuela)

^b Metabolism Center   (Venezuela)

^c NONE   (Venezuela)

Author keywords

Antipsychotic drugs; Glucose; Insulin sensitivity; Obesity; Prolactin; Rats

Indexed keywords

GLUCOSE; HALOPERIDOL; INSULIN; NEUROLEPTIC AGENT; PROLACTIN; SULPIRIDE; THIORIDAZINE; TRIFLUOPERAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG INDUCED DISEASE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; NONHUMAN; OBESITY; PROLACTIN BLOOD LEVEL; RAT; WEIGHT GAIN;

EID: 0033081842     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(98)00096-7     Document Type: Article

References (32)

1. Ammon, H.P.T., Orci, L. and Steinke, J. (1973) Effect of chlorpromazine (CPZ) on insulin release in vivo and in vitro in the rat. J Pharmacol Exp Ther. 187: 423-429.
2. 2 dopamine receptors involved? Pharmacol. Biochem. Behav. 27: 399-405.
3. Baptista, T., Parada, M.A. and Murzi, E. (1988) Puberty modifies sulpiride effects on body weight in rats. Neurosci. Lett. 92: 161-164.
4. 2 dopamine receptors supersensitivity? Med Hypoth. 30: 5-8.
5. Baptista, T., Hernandez, L. and Hoebel, B.G. (1990) Systemic sulpiride increases dopamine metabolites in the lateral hypothalamus. Pharmacol. Biochem. Behav. 37: 227-229
6. Baptista, T., Murzi, E., Hernández, L., Burguera, J.L., and De Burguera, M. (1991) Mechanism of the sex-dependent effect of lithium on body weight in rats. Pharmacol. Biochem. Behav. 38: 533-537.
7. Baptista, T., Tened, L. Hernández, L. (1993) Enhancement of amphetamine anorexia after chronic administration of sulpiride. Pharmacol. Biochem. Behav. 45: 45-49.
8. Baptista, T., López, M.A., Teneud, L., Contreras, Q., Alastre, T., Paez, X., Musseo, E., Altemus, M., Weiss, S.R.B. and Hernández, L. (1997 a) Amantadine in the treatment of neuroleptic-induced obesity in female rats: behavioral, endocrine and neurochemical correlates. Pharmacopsychiat. 30: 43-54.
9. Baptista, T., Araujo De Baptista, E., Weiss, S.R.B., Altemus, M. and Hernández, L. (1997 b) Tamoxifen prevents sulpiride-induced weight gain in female rats. Pharmacol. Biochem. Behav. 57: 215-222.
10. Baptista, T., Molina, M. G., Martinez, J. L., Quijada, M., Acosta, A., Martinez, J.M. and Hernández, L. (1997 c) Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: relationship with body weight regulation. Pharmacopsychiat. 30: 256-262.
11. Baptista, T., Contreras, Q., Teneud, L., Quijada, M., Acosta, A., La Cruz, A. and Hernández, L. (1998 a) Mechanism of the neuroleptic-induced obesity in female rats. Prog. Neuro Psychopharmacol. & Biol. Psychiat. 22: 187-198.
12. Baptista, T., Lacruz, A. and Hernández, L. (1998 b) Naltrexone does not prevent neuroleptic-induced obesity in rats. Neurosci. Soc. Ann. Meet. Pp 796.
13. Bernstein, J.G. (1992) Management of psychotropic drug-induced obesity. In: Obesity. P. Bjorntrop. and B.N. Brodoff (Eds.), pp. 445-453, J.B. Lippincott Company, Philadelphia.
14. Beumont, P.J.V. and Bergen, J. (1982) Neuroendocrine effects of neuroleptics. In: Handbook of Psychiatry and Endocrinology. P.J.V. Beumont, and G.D. Burrows (Eds.), pp. 157-182. Elsevier, Asterdam.
15. Cabrera, R., Mayor, P., Fernández-Ruiz, J. and Calle, C. (1988) Insulin binding and action on adipocytes from female rats with experimentally induced chronic hyperprolactinemia. Mol. Cell Endocrinol. 58: 167-173.
16. Correa, N., Opler L. A., Kay, S.R. and Birmaher, B. (1987) Amantadine in the treatment of neuroendocrine side effects of neuroleptics. J. Clin. Psychopharmacol. 7: 91-95.
17. Dorrington, J. and Gore-Langton, R.E. (1981) Prolactin inhibits oestrogen synthesis in the ovary. Nature. 290: 600-602.
18. Erle, G., Basso, M., Federspil, G., Sicolo, N. and Scandellari, C. (1977) Effect of chlorpromazine on blood glucose and plasma insulin in man. Eur. J. Clin. Pharmacol. 11: 15-18.
19. Figlewicz, D.P., Schwartz, M.W., Seeley, R.J., Chavez, M., Baskin, D.G., Woods, S.C. and Porte, D. (1996) Endocrine regulation of food intake and body weight. J Lab Clin Med. 127: 328-332.
20. Foss, M.C., Paula, F.J., Paccola, G.M and Piccinato, C.E. (1995) Peripheral glucose metabolism in human hyperprolactinemia. Clin Endocrinol. 43: 721-726.
21. Ganong, W. (1994) Fisiología Médica. pp. 359-384. El Manual Moderno, México.
22. Kissebah, A.H. and Krakover, G.R. (1994) Regional adiposity and morbidity. Physiol. Rev. 74: 761-798.
23. Matsuda, M. and Mori, T. (1996) Effect of estrogen on hyperprolactinemia-induced glucose intolerance in SHN mice. Proc Soc Exp Biol Med. 212: 243-247.
24. Murzi, E., Baptista, T and Hernandez, L. (1991) Hypothalamic sites affecting masticatory neurons in rats. Brain. Res. Bull. 26: 321-325.
25. Parada, M.A., Hernández, L., Páez, X., Baptista, T., Puig De Parada, M. and De Quijada, M. (1989) Mechanism of the sulpiride-induced obesity in rats. Pharmacol. Biochem. Behav. 33: 45-50.
26. Parada, M.A., Hernández, L. and Hoebel, B.G. (1988) Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats. Pharmacol. Biochem.Behav. 30: 917-923.
27. Reiss, F.M., Ribeiro-De-Oliveira., Guerra, R.M., Reiss, A.M. and Coimbra, C.C. (1996) Blood glucose and prolactin in hyperprolactinemic rats exposed to restraint and surgical stress. Life Sci. 58: 155-161.
28. 2 receptor antagonist sulpiride. Exp. Clin. Endocrinol. 96: 25-29.
29. Schwartz, M. W., Boyki, E.J., Kahn, S.E., Ravussin, E. and Bogardus, C. (1995) Reduced insulin secretion: an independent predictor of body weight gain. J, Clin. Endocrinol. Met. 80: 1571-1576.
30. Wade G.N. and Schneider, J.E. (1992) Metabolic fuels and reproduction in female mammals. Neurosci. Biobehav. Rev. 16: 235-272.
31. Wagstaff, A.J., Fitton, A. and Benfield, P. (1994) Sulpiride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in schizophrenia. CNS Drugs. 2: 313-333.
32. Woods, S.C., Seeley, R.J., Porte, D. and Schwartz, M.W. (1998) Signals that regulate food intake and energy homeostasis. Science. 280: 1378-1383.