Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock

Shock

Volumn 11, Issue 2, 1999, Pages 127-135

  Oldner, Anders ^a,b   Wanecek, Michael ^a   Weitzberg, Eddie ^a   Rundgren, Mats ^a   Alving, Kjell ^a   Ullman, Johan ^a   Rudehill, Anders ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; ENDOTHELIN 1; ENDOTOXIN; HEMOGLOBIN; LOSARTAN; OXYGEN; RENIN;

ACIDOSIS; ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HEMODYNAMICS; IMMUNOLOGY; INTESTINE MUCOSA; LUNG; LUNG GAS EXCHANGE; MALE; METABOLISM; MICTURITION; SEPTIC SHOCK; SPLANCHNIC BLOOD FLOW; SWINE; VASCULARIZATION;

ACIDOSIS; ANIMALS; ANTIHYPERTENSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTOXINS; FEMALE; HEMODYNAMIC PROCESSES; HEMOGLOBINS; INTESTINAL MUCOSA; LOSARTAN; LUNG; MALE; OXYGEN; PULMONARY GAS EXCHANGE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RENIN; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION; SWINE; URINATION;

EID: 0033072535     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199902000-00010     Document Type: Article

References (43)

1. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL Sibbald WJ: Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638-1652, 1995
2. Doglio GR, Pusajo JF, Egurrola MA, et al: Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 19:1037-1040, 1991
3. Oldner A, Goiny M, Rudehill A, Ungerstedt U, Sollevi A: Tissue hypoxanthine reflects gut vulnerability in porcine endotoxin shock. Crit Care Med 1998. In press.
4. Aranow JS, Fink MP: Determinants of intestinal barrier failure in critical illness. Br J Anaesth 77:71-81, 1996
5. Bailey R, Bulkley G, Hamilton S, Morris J, Smith G: Pathogenesis of nonocclusive ischemic colitis. Ann Surg 203:590-599, 1986
6. Bailey RW, Bulkley GB, Hamilton SR, Morris JB, Haglund UH: Protection of the small intestine from nonocclusive mesenteric ischemic injury due to cardiogenic shock. Am J Surg 153:108-116, 1987
7. Dzau V, Mukoyama M, Pratt R: Molecular biology of angiotensin receptors: Target for drug research? J Hypertension 1994:S1-S5, 1994
8. Pueyo M, Michel J: Angiotensin II receptors in endothelial cells. Gen Pharmacol 29:691-696, 1997
9. Åneman A, Pettersson A, Eisenhofer G, et al: Sympathetic and reninangiotensin activation during graded hypovolemia in pigs: Impact on mesenteric perfusion and duodenal mucosal function. Shock 8:378-384, 1997
10. Kincaid E, Miller PR, Meredith JW, Chang MC: Enaprilat improves gut perfusion in critically injured patients. Shock 9:79-83, 1998
11. Hemsén A: Biochemical and functional characterization of endothelin peptides with special references to vascular effects. Acta Physiol Scand 142:5-61, 1991
12. Flynn W J, Cryer H G, Garrison RN: Pentoxyfylline but not saralasin restores hepatic blood flow after resuscitation from hemorrhagic shock. J Surg Res 50:616-621, 1991
13. Isakson P, Shofer F, McKnight R, Feldhaus R, Raz A, Needleman P: Prostaglandins and the renin-angiotensin system in canine endotoxemia. J Pharmacol Exp Ther 200:614-622, 1977
14. Gardiner S, March J, Kemp P, Bennett T: Enhanced haemodynamic effects of SB209670 and losartan in conscious, endotoxaemic rats. Br J Pharmacol 119:20, 1996
15. Tadros T, Traber DL, Herndon D: Angiotensin II inhibitor DUP753 attenuates burn and endotoxin induced gut ischemia and bacterial translocation. FASEB J 8:A798, 1994
16. Ruokonen E, Takala J, Kari A, Saxen H, Mertsola J, Hansen EJ: Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303, 1993
17. Deitch E: Animal models of sepsis and shock: A review and lesson learned. Shock 9:1-11, 1998
18. Oldner A, Wanecek M, Goiny M, et al: The endothelin receptor antagoinst bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock. Gut 42:696-703, 1998
19. Gardiner SM, Kemp PA, March JE, Bennett T: Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats. Br J Pharmacol 118:1822-1828, 1996
20. Kampp M, Lundgren O, Nilsson N: Extravascular short-circuiting of oxygen indicating countercurrent exchange in the intestinal villi of the cat. Experienta 23:197-198, 1967
21. Granger DN: Role of xanthine oxidase and granulocytes in ischemiareperfusion injury. Am J Physiol 255:H1269-1275, 1988
22. Gennari R, Alexander JW, Boyce ST, Lilly N, Babcock GF, Cornaggia M: Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge. Shock 6:95-100, 1996
23. VanderMeer TJ, Wang H, Fink MP: Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Car Med 23:1217-1226, 1995
24. Revelly J-P, Ayuse T, Brienza N, Fessier HE, Robotham JL: Endotoxic shock alters distribution of blood flow within the intestestinal wall. Crit Care Med 24:1345-1351, 1996
25. Szabö C: Activation of poly-(ADP-ribose) synthetase by peroxynitrite. In Vincent J-L (ed): Yearbook of Intensive Care and Emergency Medicine, New York, NY: Springer, 1997, pp 217-229.
26. Gross SS, Wolin MS: Nitric oxide: pathophysiological mechanisms. Ann Rev Physiol 57:737-769, 1995
27. Walley K: Mechanisms of decreased cardiac function in sepsis. In Vincent J-L (ed): Yearbook of Intensive Care and Emergency Medicine, New York, NY: Springer, 1997, pp 243-255.
28. Wanecek M, Oldner A, Rudehill A, Sollevi A, Alving K, Weitzberg E: Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan. Shock 7:364-370, 1997
29. Ji Y, Ren X, Zhao Y, Dong L, Wu L, Su J: Role of intracardiac angiotensin II in cardiac dysfunction of rat during septic shock. Chinese Med J 109:864-867, 1996
30. Wanecek M, Rudehill A, Hemsén A, Lundberg JM, Weitzberg E: The endothelin receptor antagonist bosentan in combination with the cyclooxygenase inhibitor diclofenac counteracts pulmonary hypertension in porcine endotoxin shock. Crit Care Med 25:848-857, 1996
31. Schaller MD, Waeber B, Nussberger J. Brunner HR: Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia. Am J Physiol 249:H1086-1092, 1985
32. Gardiner S, March J, Kemp P, Bennett T: Influence of captopril and losartan on the haemodynamic responses to endotoxaemia in conscious rats. Br J Pharmacol 119:106P, 1996
33. Csajka C, Buclin T, Brunner H, Biollaz J: Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists. Clin Pharmacokin 32:1-29, 1997
34. Pittet JF, Morel DR, Hemsen A, et al: Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 213:261-264, 1991
35. Imai T, Hirata Y, Emori T, Yanagisawa M, Masaki T, Marumo F: Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension 19:753-757, 1992
36. Di Pasquale P, Valdes L, Albano V, et al: Early captopril treatment reduces plasma endothelin concentrations in acute and subacute phases of myocardial infarction: A pilot study. J Cardiovasc Pharmacol 29:202-208, 1997
37. Abassi Z, Klein H, Golomb E, Keiser H: Regulation of the urinary excretion of endothelin in the rat. Am J Hypertension 1993
38. Sacerdote A, Cosenzi A, Bocin E, et al: Effects of chronic treatment with losartan on blood pressure, endothelin-like immunoreactivity and nitric oxide in normotensive rats. J Hypertension 13:1670-1673, 1995
39. Buyukgebiz O, Aktan AO, Yegen C, et al: Captopril increases endothelin serum concentrations and preserves intestinal mucosa after mesenteric ischemia-reperfusion injury. Res Exp Med 194:339-348, 1994
40. Rasetti C, Vicaut E: Short exposure to endotoxin increases the constriction induced by angiotensin II in rat aorta. J Appl Physiol 79:2094-2100, 1995
41. Gray GA, Furman BL, Parratt JR: Endotoxin-induced impairment of vascular reactivity in the pithed rat: Role of arachidonic acid metabolites. Circ Shock 31:395-406, 1990
42. Burnier M, Centeno G, Waeber G, Centeno C, Burki E: Effect of endotoxin on the angiotensin II receptor in cultured vascular smooth muscle cells. Br J Pharmacol 116:2524-2530, 1995
43. Gardiner S, Kemp P, March J, Bennett T: Temporal differences between the involvment of angiotensin II and endothelin in the cardiovascular responses to endotoxaemia in conscious rats. Br J Pharmacol 1619-1627: 1996