메뉴 건너뛰기




Volumn 32, Issue 1, 1997, Pages 1-29

Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 2 BUTYL 6 (1 METHOXY 1 METHYLETHYL) 3 [4 [2 (1H TETRAZOL 5 YL)PHENYL]BENZYL] 4(3H) QUINAZOLINONE; 2 ETHYL 4 [2' (1H TETRAZOL 5 YL)BIPHENYL 4 YLMETHOXY]QUINOLINE; 2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; 4 PENTAFLUOROETHYL 2 PROPYL 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 5 METHYL 7 PROPYL 8 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDIN 2(3H) ONE; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CANDESARTAN HEXETIL; CIMETIDINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; EPROSARTAN; FORASARTAN; HYDROCHLOROTHIAZIDE; IRBESARTAN; LOSARTAN POTASSIUM; LRB 081; PHENOBARBITAL; PLASMA PROTEIN; RENIN; SAPRISARTAN; SODIUM; TAK 536; TASOSARTAN; TELMISARTAN; UNCLASSIFIED DRUG; VALSARTAN; WATER;

EID: 0031017235     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199732010-00001     Document Type: Review
Times cited : (98)

References (112)
  • 1
    • 0015333482 scopus 로고
    • Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease
    • Laragh JH, Baer L, Brunner HR, et al. Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med 1972; 52: 633-52
    • (1972) Am J Med , vol.52 , pp. 633-652
    • Laragh, J.H.1    Baer, L.2    Brunner, H.R.3
  • 2
    • 0025325227 scopus 로고
    • Importance of the renin-angiotensin-aldosterone system (RAS) in the physiology and pathology of hypertension: An overview
    • Ferrario CM. Importance of the renin-angiotensin-aldosterone system (RAS) in the physiology and pathology of hypertension: an overview. Drugs 1990; 39 Suppl. 2: 1-8
    • (1990) Drugs , vol.39 , Issue.2 SUPPL. , pp. 1-8
    • Ferrario, C.M.1
  • 3
    • 0029066519 scopus 로고
    • Evolution of the blockade of the renin angiotensin system
    • Johnston CI, Burrell LM. Evolution of the blockade of the renin angiotensin system. Hypertension 1995; 9: 375-80
    • (1995) Hypertension , vol.9 , pp. 375-380
    • Johnston, C.I.1    Burrell, L.M.2
  • 5
    • 0028345075 scopus 로고
    • The clinical potential of renin inhibitors and angiotensin antagonists
    • Cody RJ. The clinical potential of renin inhibitors and angiotensin antagonists. Drugs 1994; 47: 586-98
    • (1994) Drugs , vol.47 , pp. 586-598
    • Cody, R.J.1
  • 6
    • 0026562703 scopus 로고
    • Pharmacokinetic optimisation of angiotensin converting enzyme (ACE) inhibitor therapy
    • Burnier M, Biollaz J. Pharmacokinetic optimisation of angiotensin converting enzyme (ACE) inhibitor therapy. Clin Pharmacokinet 1992; 22: 375-84
    • (1992) Clin Pharmacokinet , vol.22 , pp. 375-384
    • Burnier, M.1    Biollaz, J.2
  • 7
    • 0015165769 scopus 로고
    • A specific competitive antagonist of the vascular action of angiotensin II
    • Pals DT, Masucci FD, Sipos F, et al. A specific competitive antagonist of the vascular action of angiotensin II. Circ Res 1971; 29: 664-72
    • (1971) Circ Res , vol.29 , pp. 664-672
    • Pals, D.T.1    Masucci, F.D.2    Sipos, F.3
  • 8
    • 0015840363 scopus 로고
    • 8-angiotensin II for understanding and treatment of high blood-pressure
    • 8-angiotensin II for understanding and treatment of high blood-pressure. Lancet 1973; II (837): 1045-8
    • (1973) Lancet , vol.2 , Issue.837 , pp. 1045-1048
    • Brunner, H.R.1    Gavras, H.2    Laragh, J.H.3
  • 9
    • 0009739063 scopus 로고
    • Saralasin in human hypertension: The early experience
    • Brunner HR, Laragh JH. Saralasin in human hypertension: the early experience. Kidney Int 1979; 15 Suppl. 9: S36-43
    • (1979) Kidney Int , vol.15 , Issue.9 SUPPL.
    • Brunner, H.R.1    Laragh, J.H.2
  • 10
    • 0029017662 scopus 로고
    • Clinical pharmacokinetics and efficacy of renin inhibitors
    • Rongen GA, Lenders JW, Smits P, et al. Clinical pharmacokinetics and efficacy of renin inhibitors. Clin Pharmacokinet 1995; 29: 6-14
    • (1995) Clin Pharmacokinet , vol.29 , pp. 6-14
    • Rongen, G.A.1    Lenders, J.W.2    Smits, P.3
  • 11
    • 0027536554 scopus 로고
    • Angiotensin II blockade compared with other pharmacological methods of inhibiting the renin-angiotensin system
    • Brunner HR, Nussberger J, Waeber B. Angiotensin II blockade compared with other pharmacological methods of inhibiting the renin-angiotensin system. J Hypertens 1993; 11 Suppl. 3: S532-8
    • (1993) J Hypertens , vol.11 , Issue.3 SUPPL.
    • Brunner, H.R.1    Nussberger, J.2    Waeber, B.3
  • 12
    • 85035186734 scopus 로고    scopus 로고
    • Hypotensive imidatide derivatives. US patent 4,340.598.1982
    • Furukawa Y, Kishimoto S, Nishikawa K. Hypotensive imidatide derivatives. US patent 4,340.598.1982
    • Furukawa, Y.1    Kishimoto, S.2    Nishikawa, K.3
  • 13
    • 0029017714 scopus 로고
    • The angiotensin II type I receptor antagonists: A new class of antihypertensive drugs
    • Bauer JH, Reams PG. The angiotensin II type I receptor antagonists: a new class of antihypertensive drugs. Arch intern Med 1995; 155: 1361-8
    • (1995) Arch Intern Med , vol.155 , pp. 1361-1368
    • Bauer, J.H.1    Reams, P.G.2
  • 14
    • 0028822833 scopus 로고
    • Angiotensin receptor antagonists: Focus on losartan
    • Johnston CI. Angiotensin receptor antagonists: focus on losartan. Lancet 1995; 346: 1403-7
    • (1995) Lancet , vol.346 , pp. 1403-1407
    • Johnston, C.I.1
  • 15
    • 0027139232 scopus 로고
    • Angiotensin II receptor blockade: An innovative approach to cardiovascular pharmacotherapy
    • Eberhardt RT, Kevak RM, Kang PM, et al. Angiotensin II receptor blockade: an innovative approach to cardiovascular pharmacotherapy. J Clin Pharmacol 1993; 33: 1023-38
    • (1993) J Clin Pharmacol , vol.33 , pp. 1023-1038
    • Eberhardt, R.T.1    Kevak, R.M.2    Kang, P.M.3
  • 16
    • 0028559534 scopus 로고
    • Angiotensin receptor antagonists as a treatment for hypertension
    • MacFadyen RJ, Reid JL. Angiotensin receptor antagonists as a treatment for hypertension. J Hypertens 1994; 12: 1333-8
    • (1994) J Hypertens , vol.12 , pp. 1333-1338
    • MacFadyen, R.J.1    Reid, J.L.2
  • 17
    • 0029588499 scopus 로고
    • Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans
    • Lo M, Goldberg M, McCrea J, et al. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans. Clin Pharmacol Ther 1995; 58: 641-9
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 641-649
    • Lo, M.1    Goldberg, M.2    McCrea, J.3
  • 18
    • 0028847531 scopus 로고
    • In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: Relationship to in vitro affinities and in vivo pharmacologic potency
    • Beauchamp H, Chang R, Siegl P, et al. In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency. J Pharmacol Exp Ther 1995; 272: 612-8
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 612-618
    • Beauchamp, H.1    Chang, R.2    Siegl, P.3
  • 19
    • 85035183293 scopus 로고    scopus 로고
    • DuP 532 - Initial administration to humans and comparison with losartan of a nonpeptide angiotensin II receptor antagonist
    • In press
    • Goldberg MR, Lo MW, Chiou R, et al. DuP 532 - initial administration to humans and comparison with losartan of a nonpeptide angiotensin II receptor antagonist. Clin Pharm Ther. In press
    • Clin Pharm Ther.
    • Goldberg, M.R.1    Lo, M.W.2    Chiou, R.3
  • 20
    • 0026561612 scopus 로고
    • The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices
    • Stearns RA, Miller RR, Doss GA, et al. The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices. Drug Metab Dispos 1992; 20: 281-7
    • (1992) Drug Metab Dispos , vol.20 , pp. 281-287
    • Stearns, R.A.1    Miller, R.R.2    Doss, G.A.3
  • 21
    • 0028896177 scopus 로고
    • Oxidation of the angiotensin II receptor antagonist losartan (DuP753) in human liver microsomes
    • Yun C, Lee HS, Lee H, et al. Oxidation of the angiotensin II receptor antagonist losartan (DuP753) in human liver microsomes. Drug Metab Dispos 1995; 23: 285-9
    • (1995) Drug Metab Dispos , vol.23 , pp. 285-289
    • Yun, C.1    Lee, H.S.2    Lee, H.3
  • 22
    • 0027509397 scopus 로고
    • Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans
    • Ohtawa M, Takayama F, Saitoh K, et al. Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans. Br J Clin Pharmacol 1993; 35: 290-7
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 290-297
    • Ohtawa, M.1    Takayama, F.2    Saitoh, K.3
  • 23
    • 0026593853 scopus 로고
    • Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist
    • Munafo A, Christen Y, Nussberger J, et al. Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist. Clin Pharmacol Ther 1992; 51: 513-21
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 513-521
    • Munafo, A.1    Christen, Y.2    Nussberger, J.3
  • 24
    • 8044251199 scopus 로고
    • Pharmacokinetics of intravenous losartan (MK-954, DuP 753) in man
    • Lo MW, Wissel PS, Bialy GB, et al. Pharmacokinetics of intravenous losartan (MK-954, DuP 753) in man. J Hypertens 1992; 10 Suppl. 4: S133
    • (1992) J Hypertens , vol.10 , Issue.4 SUPPL.
    • Lo, M.W.1    Wissel, P.S.2    Bialy, G.B.3
  • 25
    • 0029096977 scopus 로고
    • The pharmacokinetics of losartan in renal insufficiency
    • Sica DA, Lo MW, Shaw C, et al. The pharmacokinetics of losartan in renal insufficiency. J Hypertens 1995; 13: S49-52
    • (1995) J Hypertens , vol.13
    • Sica, D.A.1    Lo, M.W.2    Shaw, C.3
  • 26
    • 0011140532 scopus 로고
    • Pharmacokinetics of DuP 753 (MK954) in healthy male volunteers after single oral ascending doses
    • Shum L, Benedek I, Quon C, et al. Pharmacokinetics of DuP 753 (MK954) in healthy male volunteers after single oral ascending doses. Pharm Res 1991; S310
    • (1991) Pharm Res
    • Shum, L.1    Benedek, I.2    Quon, C.3
  • 27
    • 0028849020 scopus 로고
    • Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist
    • Goldberg MR, Lo MW, Bradstreet TE, et al. Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist. Eur J Clin Pharmacol 1995; 49: 115-9
    • (1995) Eur J Clin Pharmacol , vol.49 , pp. 115-119
    • Goldberg, M.R.1    Lo, M.W.2    Bradstreet, T.E.3
  • 28
    • 0029597865 scopus 로고
    • Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide
    • McCrea J, Lo M, Tomasko L, et al. Absence of a pharmacokinetic interaction between losartan and hydrochlorothiazide. J Clin Pharmacol 1995; 35: 1200-6
    • (1995) J Clin Pharmacol , vol.35 , pp. 1200-1206
    • McCrea, J.1    Lo, M.2    Tomasko, L.3
  • 29
    • 8044226303 scopus 로고
    • Pharmacokinetics of intravenous EXP3174, an active metabolite of losartan in man
    • Lo MW, Lu H, Farrell DM, et al. Pharmacokinetics of intravenous EXP3174, an active metabolite of losartan in man [abstract]. Pharm Res 1992; 9: S-308
    • (1992) Pharm Res , vol.9
    • Lo, M.W.1    Lu, H.2    Farrell, D.M.3
  • 30
    • 0028899737 scopus 로고
    • Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers
    • Delacrétaz E, Nussberger J, Biollaz J, et al. Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers. Hypertension 1995; 25: 14-21
    • (1995) Hypertension , vol.25 , pp. 14-21
    • Delacrétaz, E.1    Nussberger, J.2    Biollaz, J.3
  • 31
    • 0028338639 scopus 로고
    • Effects of the angiotensin II antagonist, TCV-116, on blood pressure and the renin-angiotensin system in healthy subjects
    • Ogihara T, Nagano M, Mikami H, et al. Effects of the angiotensin II antagonist, TCV-116, on blood pressure and the renin-angiotensin system in healthy subjects. Clin Ther 1994; 16: 74-86
    • (1994) Clin Ther , vol.16 , pp. 74-86
    • Ogihara, T.1    Nagano, M.2    Mikami, H.3
  • 32
    • 0028117856 scopus 로고
    • Angiotensin II receptor blockade with single doses of valsartan in healthy, normotensive subjects
    • Müller P, Cohen T, De Gasparo M, et al. Angiotensin II receptor blockade with single doses of valsartan in healthy, normotensive subjects. Eur J Clin Pharmacol 1994; 47: 231-45
    • (1994) Eur J Clin Pharmacol , vol.47 , pp. 231-245
    • Müller, P.1    Cohen, T.2    De Gasparo, M.3
  • 33
    • 0012298753 scopus 로고
    • Single- and multiple-dose phase 1 trials with the antagonist valsartan
    • Müller P, Flesch G, De Gasparo M, et al. Single- and multiple-dose phase 1 trials with the antagonist valsartan. J Hypertens 1993; 11: S459-60
    • (1993) J Hypertens , vol.11
    • Müller, P.1    Flesch, G.2    De Gasparo, M.3
  • 34
    • 0343815232 scopus 로고    scopus 로고
    • Absolute oral bioavailability of valsartan in healthy volunteers
    • editors. Proceedings of the 6th European Congress of Biopharmacy and Pharmacokinetics
    • Flesch G, Müller P, Degen P, et al. Absolute oral bioavailability of valsartan in healthy volunteers. Médecine et Hygiène European Journal of Drug Metabolism and Pharmacokinetics, editors. Proceedings of the 6th European Congress of Biopharmacy and Pharmacokinetics, 1996, 163
    • (1996) Médecine et Hygiène European Journal of Drug Metabolism and Pharmacokinetics , pp. 163
    • Flesch, G.1    Müller, P.2    Degen, P.3
  • 35
    • 0028963378 scopus 로고
    • Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension
    • Van den Meiracker AH, Admiraal PJ, Janssen JA, et al. Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension. Hypertension 1995; 25: 22-9
    • (1995) Hypertension , vol.25 , pp. 22-29
    • Van Den Meiracker, A.H.1    Admiraal, P.J.2    Janssen, J.A.3
  • 36
    • 0028960065 scopus 로고
    • Short-term and sustained renal effects of angiotensin II receptor blockade in healthy subjects
    • Burnier M, Hagman M, Nussberger J, et al. Short-term and sustained renal effects of angiotensin II receptor blockade in healthy subjects. Hypertension 1995; 25: 602-9
    • (1995) Hypertension , vol.25 , pp. 602-609
    • Burnier, M.1    Hagman, M.2    Nussberger, J.3
  • 37
    • 0000207241 scopus 로고
    • Angiotensin II (AII) blockade effect of ANA-756 in normal volunteers
    • Steinhäuslin F, Buclin T, Bouissou P, et al. Angiotensin II (AII) blockade effect of ANA-756 in normal volunteers. Clin Pharmacol Ther 1995; 55: 205
    • (1995) Clin Pharmacol Ther , vol.55 , pp. 205
    • Steinhäuslin, F.1    Buclin, T.2    Bouissou, P.3
  • 38
    • 85035182642 scopus 로고    scopus 로고
    • Ascending, single-dose, safety, tolerance and pharmacokinetics (PK) of 5,8-dihydro-2,4-dimethyl-8-[(2-2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]- 4-y 1)methylyl]pyridol[2,3-d]pyrimidin-7(6H)-one (ANA-756)
    • 195
    • Klamerus KJ, Vadiei K, Burghrt P, et al. Ascending, single-dose, safety, tolerance and pharmacokinetics (PK) of 5,8-dihydro-2,4-dimethyl-8-[(2-2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]- 4-y 1)methylyl]pyridol[2,3-d]pyrimidin-7(6H)-one (ANA-756). Clin Pharmacol Ther 195; 57: 203
    • Clin Pharmacol Ther , vol.57 , pp. 203
    • Klamerus, K.J.1    Vadiei, K.2    Burghrt, P.3
  • 39
    • 0002552915 scopus 로고
    • Tolerability, pharmacokinetics and pharmacodynamics of the angiotensin II (Ang II) antagonist TAK-536 in healthy volunteers
    • Buclin T, Biollaz J, Küng S, et al. Tolerability, pharmacokinetics and pharmacodynamics of the angiotensin II (Ang II) antagonist TAK-536 in healthy volunteers. Clin Pharmacol Ther 1995; 57: 204
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 204
    • Buclin, T.1    Biollaz, J.2    Küng, S.3
  • 40
    • 4243205170 scopus 로고
    • Oral administration of SC-52458, a specific angiotensin II receptor antagonist, to healthy male volunteers
    • Naudin R, Hagmann M, Nussberger J, et al. Oral administration of SC-52458, a specific angiotensin II receptor antagonist, to healthy male volunteers. J Hypertens 1994; 12 Suppl. 3: S93
    • (1994) J Hypertens , vol.12 , Issue.3 SUPPL.
    • Naudin, R.1    Hagmann, M.2    Nussberger, J.3
  • 41
    • 4243205169 scopus 로고
    • Clinical and hormonal assessment of SC-52458, a new orally active angiotensin II receptor antagonist in normontensive volunteers
    • Hagmann M, Delacrétaz E, Nussberger J, et al. Clinical and hormonal assessment of SC-52458, a new orally active angiotensin II receptor antagonist in normontensive volunteers [abstract]. Am J Hypertens 1994; 7: 57A
    • (1994) Am J Hypertens , vol.7
    • Hagmann, M.1    Delacrétaz, E.2    Nussberger, J.3
  • 42
    • 85035187933 scopus 로고
    • Effect of food on the pharmacokinetics of a capsule formulation of an angiotensin II receptor antagonist
    • Ganes D, Porter S, Kresevic J, et al. Effect of food on the pharmacokinetics of a capsule formulation of an angiotensin II receptor antagonist. Pharm Res 1994; S435
    • (1994) Pharm Res
    • Ganes, D.1    Porter, S.2    Kresevic, J.3
  • 43
    • 0029038511 scopus 로고
    • Comparison of the angiotensin II antagonist UP269-6 with the angiotensin converting enzyme inhibitor enalapril in normotensive volunteers challenged with angiotensin I
    • Inglessis N, Nussberger J, Hagmann M, et al. Comparison of the angiotensin II antagonist UP269-6 with the angiotensin converting enzyme inhibitor enalapril in normotensive volunteers challenged with angiotensin I. J Cardiovasc Pharmacol 1995; 25: 986-93
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 986-993
    • Inglessis, N.1    Nussberger, J.2    Hagmann, M.3
  • 44
    • 0029774383 scopus 로고    scopus 로고
    • Clinical and hormonal effects of the new angiotensin II receptor antagonist LRB081
    • Noël B, Del Re G, Capone P, et al. Clinical and hormonal effects of the new angiotensin II receptor antagonist LRB081. J Cardiovasc Pharmacol 1996; 28: 252-8
    • (1996) J Cardiovasc Pharmacol , vol.28 , pp. 252-258
    • Noël, B.1    Del Re, G.2    Capone, P.3
  • 45
    • 0029068526 scopus 로고
    • Human plasma protein binding of the angiotensin ii receptor antagonist losartan potassium (Dup 753/MK 954) and its pharmacologically active metabolite EXP3174
    • Christ DD. Human plasma protein binding of the angiotensin ii receptor antagonist losartan potassium (Dup 753/MK 954) and its pharmacologically active metabolite EXP3174. J Clin Pharmacol 1995; 35: 515-20
    • (1995) J Clin Pharmacol , vol.35 , pp. 515-520
    • Christ, D.D.1
  • 46
    • 0001055861 scopus 로고    scopus 로고
    • A mutation in CYP2C9 is responsible for decreased metabolism of losartan
    • Spielberg S, McCrea J, Cribb A, et al. A mutation in CYP2C9 is responsible for decreased metabolism of losartan. Clin Pharmacol Ther 1996; 59: 215
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 215
    • Spielberg, S.1    McCrea, J.2    Cribb, A.3
  • 47
    • 0000893433 scopus 로고
    • A rare deficiency of the conversion of losartan to its active metabolite E3174
    • McCrea J, Lo MW, Kong T, et al. A rare deficiency of the conversion of losartan to its active metabolite E3174. Clin Pharmacol Ther 1995; 57: 154
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 154
    • McCrea, J.1    Lo, M.W.2    Kong, T.3
  • 48
    • 0025275076 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent
    • Wong PC, Price Jr WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 1990; 252: 719-25
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 719-725
    • Wong, P.C.1    Price Jr., W.A.2    Chiu, A.T.3
  • 49
    • 0017360659 scopus 로고
    • The binding of drugs to plasma proteins and the interpretation of measurements of plasma concentrations of drugs in patients with poor renal function
    • Reidenberg MM. The binding of drugs to plasma proteins and the interpretation of measurements of plasma concentrations of drugs in patients with poor renal function. Am J Med 1977; 62: 466-70
    • (1977) Am J Med , vol.62 , pp. 466-470
    • Reidenberg, M.M.1
  • 50
    • 0001288467 scopus 로고    scopus 로고
    • Ketoconazole does not effect the systemic conversion of losartan to E-3174
    • McCrea JB, Lo MW, Furtek CI, et al. Ketoconazole does not effect the systemic conversion of losartan to E-3174. Clin Pharmacol Ther 1996; 59: 169
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 169
    • McCrea, J.B.1    Lo, M.W.2    Furtek, C.I.3
  • 51
    • 0029972753 scopus 로고    scopus 로고
    • Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174
    • Goldberg MR, Lo MW, Deutsch PJ, et al. Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174. Clin Pharmacol Ther 1996; 59: 268-74
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 268-274
    • Goldberg, M.R.1    Lo, M.W.2    Deutsch, P.J.3
  • 52
    • 0028847447 scopus 로고
    • Losartan does not affect the pharmacokinetics and pharmacodynamics of warfarin
    • Kong AH, Tomasko L, Waldman SA, et al. Losartan does not affect the pharmacokinetics and pharmacodynamics of warfarin. J Clin Pharmacol 1995; 35: 1008-15
    • (1995) J Clin Pharmacol , vol.35 , pp. 1008-1015
    • Kong, A.H.1    Tomasko, L.2    Waldman, S.A.3
  • 53
    • 0029593383 scopus 로고
    • Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers
    • De Smet M, Schoors D, De Meyer G, et al. Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers. Br J Clin Pharmacol 1995; 40: 571-5
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 571-575
    • De Smet, M.1    Schoors, D.2    De Meyer, G.3
  • 54
    • 0027431141 scopus 로고
    • Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2-2′-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexylcarbonyloxy)-ethyl-2-ethoxy-1-[[2′-(1H-tetrazol- 5-yl)-biphenyl-4-yl]-methyl]-1-benzimidazole-7-carboxylate (TCV-116)
    • Shibouta Y, Inada Y, Ojima M, et al. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2-2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexylcarbonyloxy) -ethyl-2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)-biphenyl-4-yl]-methyl]-1- benzimidazole-7-carboxylate (TCV-116). J Pharmacol Exp Ther 1993; 266: 114-20
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 114-120
    • Shibouta, Y.1    Inada, Y.2    Ojima, M.3
  • 55
    • 0029549912 scopus 로고
    • Valsartan: Pre-clinical and clinical profile of an antihypertensive angiotensin-II antagonist
    • Criscione L, Bradley WA, Buhlmayer P, et al. Valsartan: pre-clinical and clinical profile of an antihypertensive angiotensin-II antagonist. Cardiovasc Drug Rev 1995; 13: 230-50
    • (1995) Cardiovasc Drug Rev , vol.13 , pp. 230-250
    • Criscione, L.1    Bradley, W.A.2    Buhlmayer, P.3
  • 56
    • 0028097103 scopus 로고
    • In vitro N-glucuronidation of SR 47436 (BMS 186295), a new AT1 nonpeptide angiotensin II receptor antagonist, by rat, monkey and human hepatic microsomal fractions
    • Perrier L, Bourrié M, Marti E, et al. In vitro N-glucuronidation of SR 47436 (BMS 186295), a new AT1 nonpeptide angiotensin II receptor antagonist, by rat, monkey and human hepatic microsomal fractions. J Pharmacol Exp Ther 1994; 271: 91-9
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 91-99
    • Perrier, L.1    Bourrié, M.2    Marti, E.3
  • 57
    • 0025906857 scopus 로고
    • Nomenclature for angiotensin receptors: A report of the nomenclature committee of the Council for High Blood Pressure Research
    • Bumpus FM, Catt KJ, Chiu AT, et al. Nomenclature for angiotensin receptors: a report of the nomenclature committee of the Council for High Blood Pressure Research. Hypertension 1995; 720-1
    • (1995) Hypertension , pp. 720-721
    • Bumpus, F.M.1    Catt, K.J.2    Chiu, A.T.3
  • 58
    • 0027208070 scopus 로고
    • Angiotensin II receptors and angiotensin II receptor antagonists
    • Timmermans PBMWM, Wong PC, Chiu AT, et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993; 45: 205-51
    • (1993) Pharmacol Rev , vol.45 , pp. 205-251
    • Timmermans, P.B.M.W.M.1    Wong, P.C.2    Chiu, A.T.3
  • 59
    • 0027412740 scopus 로고
    • How well have animals studies with losartan predicted responses in humans?
    • Sweet CS, Nelson EB. How well have animals studies with losartan predicted responses in humans? J Hypertens 1993; II Suppl. 3: S63-7
    • (1993) J Hypertens , vol.2 , Issue.3 SUPPL.
    • Sweet, C.S.1    Nelson, E.B.2
  • 60
    • 0028800752 scopus 로고
    • Elucidation of the insurmountable nalure of an angiotensin receptor antagonist, SC-54629
    • Olins G, Chen ST, McMahon EG, et al. Elucidation of the insurmountable nalure of an angiotensin receptor antagonist, SC-54629. Mol Pharmacol 1995; 47: 115-20
    • (1995) Mol Pharmacol , vol.47 , pp. 115-120
    • Olins, G.1    Chen, S.T.2    McMahon, E.G.3
  • 61
    • 0025862043 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists: Insurmountable angiotensin II antagonism of EXP3892 is reversed by the surmountable antagonist DuP 753
    • Wong PC, Timmermans PBMWM. Nonpeptide angiotensin II receptor antagonists: insurmountable angiotensin II antagonism of EXP3892 is reversed by the surmountable antagonist DuP 753. J Pharmacol Exp Ther 1991; 258: 49-57
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 49-57
    • Wong, P.C.1    Timmermans, P.B.M.W.M.2
  • 62
    • 0028658391 scopus 로고
    • Dose-response relationships of ACE inhibitors and angiotensin II blockers
    • Brunner HR, Nussberger J, Waeber B. Dose-response relationships of ACE inhibitors and angiotensin II blockers. Eur Heart J 1994; 15: 123-8
    • (1994) Eur Heart J , vol.15 , pp. 123-128
    • Brunner, H.R.1    Nussberger, J.2    Waeber, B.3
  • 63
    • 0005359161 scopus 로고
    • Does pharmacological profiling of a new drug in normotensive volunteers provide a useful guideline to antihypertensive therapy?
    • Brunner HR, Waeber B, Nussberger J. Does pharmacological profiling of a new drug in normotensive volunteers provide a useful guideline to antihypertensive therapy? Hypertension 1983; 5: 101-7
    • (1983) Hypertension , vol.5 , pp. 101-107
    • Brunner, H.R.1    Waeber, B.2    Nussberger, J.3
  • 64
    • 0025167266 scopus 로고
    • Noninvasive blood pressure monitoring at the finger for studying short lasting pressor responses in man
    • Christen Y, Waeber B, Nussberger J, et al. Noninvasive blood pressure monitoring at the finger for studying short lasting pressor responses in man. J Clin Pharmacol 1990; 30: 711-4
    • (1990) J Clin Pharmacol , vol.30 , pp. 711-714
    • Christen, Y.1    Waeber, B.2    Nussberger, J.3
  • 65
    • 0025858964 scopus 로고
    • Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers: Inhibition of pressor response to exogenous angiotensin I and II
    • Christen Y, Waeber B, Nussberger J, et al. Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers: inhibition of pressor response to exogenous angiotensin I and II. Circulation 1991; 83: 1333-42
    • (1991) Circulation , vol.83 , pp. 1333-1342
    • Christen, Y.1    Waeber, B.2    Nussberger, J.3
  • 66
    • 0029145962 scopus 로고
    • Persistent inhibition of the pressor and aldosterone response to angiotensin-III by TCV-116 in normotensive subjects
    • Ogihara T, Nagano M, Higaki J, et al. Persistent inhibition of the pressor and aldosterone response to angiotensin-III by TCV-116 in normotensive subjects. J Cardiovasc Pharmacol 1995; 26: 490-4
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. 490-494
    • Ogihara, T.1    Nagano, M.2    Higaki, J.3
  • 67
    • 0009670824 scopus 로고
    • The pressor inhibitory effect of angiotensin-II antagonist (Valsartan, CGP 48933) on angiotensin-II infusions in healthy subjects
    • Harb G, Morgan J, Prasad P, et al. The pressor inhibitory effect of angiotensin-II antagonist (Valsartan, CGP 48933) on angiotensin-II infusions in healthy subjects [abstract]. J Invest Med 1995; 43 Suppl. 2: 239
    • (1995) J Invest Med , vol.43 , Issue.2 SUPPL. , pp. 239
    • Harb, G.1    Morgan, J.2    Prasad, P.3
  • 68
    • 0000251269 scopus 로고
    • Effects of the angiotensin II antagonist SR 47436 (BMS 186295) on the pressor response to exogenous angiotensin II and the renin-angiotensin system in sodium replete normal subjects
    • Ribstein J, Sissmann J, Picard A, et al. Effects of the angiotensin II antagonist SR 47436 (BMS 186295) on the pressor response to exogenous angiotensin II and the renin-angiotensin system in sodium replete normal subjects [abstract 2191]. J Hypertens 1994; 12 Suppl. 3: 131
    • (1994) J Hypertens , vol.12 , Issue.3 SUPPL. , pp. 131
    • Ribstein, J.1    Sissmann, J.2    Picard, A.3
  • 69
    • 0028202482 scopus 로고
    • The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) in the dog
    • Christ DD, Wong PC, Wong YN, et al. The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) in the dog. J Pharmacol Exp Ther 1993; 268: 1199-205
    • (1993) J Pharmacol Exp Ther , vol.268 , pp. 1199-1205
    • Christ, D.D.1    Wong, P.C.2    Wong, Y.N.3
  • 71
    • 0027460518 scopus 로고
    • Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers
    • Goldberg MR, Tanaka W, Barchowsky A, et al. Effects of losartan on blood pressure, plasma renin activity, and angiotensin II in volunteers. Hypertension 1993; 21: 704-13
    • (1993) Hypertension , vol.21 , pp. 704-713
    • Goldberg, M.R.1    Tanaka, W.2    Barchowsky, A.3
  • 72
    • 0027162040 scopus 로고
    • Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects
    • Burnier M, Rutschmann B, Nussberger J, et al. Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects. Hypertension 1992; 22: 339-47
    • (1992) Hypertension , vol.22 , pp. 339-347
    • Burnier, M.1    Rutschmann, B.2    Nussberger, J.3
  • 73
    • 3643064761 scopus 로고
    • Haemodynamic and renal response to losartan during salt depletion or salt repletion
    • Doig J, McFadyen R, Sweet CS, et al. Haemodynamic and renal response to losartan during salt depletion or salt repletion. J Hypertens 1993; 11 Suppl.: S419
    • (1993) J Hypertens , vol.11 , Issue.SUPPL.
    • Doig, J.1    McFadyen, R.2    Sweet, C.S.3
  • 74
    • 0029133280 scopus 로고
    • Losartan potassium lowers blood pressure measured by ambulatory blood pressure monitoring
    • Byyny RL. Losartan potassium lowers blood pressure measured by ambulatory blood pressure monitoring. J Hypertens 1995; 13 Suppl. 1: S29-33
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL.
    • Byyny, R.L.1
  • 75
    • 0028942349 scopus 로고
    • Blood pressure effects of the angiotensin II receptor blocker, losartan
    • Weber MA, Byyny RL, Pratt JH, et al. Blood pressure effects of the angiotensin II receptor blocker, losartan. Arch Intern Med 1995; 155: 405-11
    • (1995) Arch Intern Med , vol.155 , pp. 405-411
    • Weber, M.A.1    Byyny, R.L.2    Pratt, J.H.3
  • 76
    • 0028558922 scopus 로고
    • Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension
    • Grossman E, Peleg E, Caroll J, et al. Hemodynamic and humoral effects of the angiotensin II antagonist losartan in essential hypertension. Am J Hypertens 1994; 7: 1041-4
    • (1994) Am J Hypertens , vol.7 , pp. 1041-1044
    • Grossman, E.1    Peleg, E.2    Caroll, J.3
  • 77
    • 0028335425 scopus 로고
    • Effects of angiotensin II antagonist losartan in hypertensive patients with renal disease
    • Gansevoort RT, De Zeeuw D, Shahinfar S, et al. Effects of angiotensin II antagonist losartan in hypertensive patients with renal disease. J Hypertens 1994; 12 Suppl. 2: S37-42
    • (1994) J Hypertens , vol.12 , Issue.2 SUPPL.
    • Gansevoort, R.T.1    De Zeeuw, D.2    Shahinfar, S.3
  • 78
    • 0007276493 scopus 로고
    • Safety and antihypertensive effects of losartan (MK-954; DUP753), a new angiotensin II receptor antagonist, in patients with hypertension and renal disease
    • Shaw W, Keane W, Sica D, et al. Safety and antihypertensive effects of losartan (MK-954; DUP753), a new angiotensin II receptor antagonist, in patients with hypertension and renal disease. Clin Pharmacol Ther 1993; 53: 140
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 140
    • Shaw, W.1    Keane, W.2    Sica, D.3
  • 79
    • 0027379394 scopus 로고
    • Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure
    • Gottlieb SS, Dickstein K, Fleck E, et al. Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation 1993; 88: 1602-9
    • (1993) Circulation , vol.88 , pp. 1602-1609
    • Gottlieb, S.S.1    Dickstein, K.2    Fleck, E.3
  • 80
    • 0029065095 scopus 로고
    • A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension
    • Gradman AH, Arcuri KE, Goldberg AI, et al. A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension 1995; 25: 1345-50
    • (1995) Hypertension , vol.25 , pp. 1345-1350
    • Gradman, A.H.1    Arcuri, K.E.2    Goldberg, A.I.3
  • 81
    • 0028924990 scopus 로고
    • Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients
    • Goldberg MR, Bradstreet TE, McWilliams EJ, et al. Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients. Hypertension 1995; 25: 37-46
    • (1995) Hypertension , vol.25 , pp. 37-46
    • Goldberg, M.R.1    Bradstreet, T.E.2    McWilliams, E.J.3
  • 82
    • 0028939701 scopus 로고
    • Renal hemodynamics in essential hypertensives treated with losartan
    • Erley C, Bader B, Scheu M, et al. Renal hemodynamics in essential hypertensives treated with losartan. Clin Nephrol 1995; 43 Suppl. 1: S8-11
    • (1995) Clin Nephrol , vol.43 , Issue.1 SUPPL.
    • Erley, C.1    Bader, B.2    Scheu, M.3
  • 83
    • 0029165196 scopus 로고
    • Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension
    • Mallion JM, Bradstreet DC, Makris L, et al. Antihypertensive efficacy and tolerability of once daily losartan potassium compared with captopril in patients with mild to moderate essential hypertension. J Hypertens 1995; 13 Suppl. 1: S35-41
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL.
    • Mallion, J.M.1    Bradstreet, D.C.2    Makris, L.3
  • 84
    • 0029061433 scopus 로고
    • Effects of losartan on a background of hydrochlorothiazide in patients with hypertension
    • Soffer BA, Wright JT, Pratt JH, et al. Effects of losartan on a background of hydrochlorothiazide in patients with hypertension. Hypertension 1995; 26: 112-7
    • (1995) Hypertension , vol.26 , pp. 112-117
    • Soffer, B.A.1    Wright, J.T.2    Pratt, J.H.3
  • 85
    • 0029103051 scopus 로고
    • Losartan with hydrochlorothiazide in the treatment of hypertension
    • Schoenberger JA, et al. Losartan with hydrochlorothiazide in the treatment of hypertension. J Hypertens 1995; 13 Suppl. 1: S43-7
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL.
    • Schoenberger, J.A.1
  • 86
    • 0028934535 scopus 로고
    • Effects of losartan on the renin-angiotensin-aldosterone axis in essential hypertension
    • Bauer HJ, Reams GP, Wu Z, et al. Effects of losartan on the renin-angiotensin-aldosterone axis in essential hypertension. J Hum Hypertens 1995; 9: 237-43
    • (1995) J Hum Hypertens , vol.9 , pp. 237-243
    • Bauer, H.J.1    Reams, G.P.2    Wu, Z.3
  • 87
    • 0029058333 scopus 로고
    • Efficacy and tolerability of losartan potassium and stenolol in patients with mild to moderated essential hypertension
    • Dahlof B, Keller SE, Makris L, et al. Efficacy and tolerability of losartan potassium and stenolol in patients with mild to moderated essential hypertension. Am J Hypertens 1995; 8: 578-83
    • (1995) Am J Hypertens , vol.8 , pp. 578-583
    • Dahlof, B.1    Keller, S.E.2    Makris, L.3
  • 88
    • 0028007334 scopus 로고
    • Effects of an angiotensin II receptor antagonist, TCV-116, on renal haemodynamics in essential hypertension
    • Kawabata M, Takabatake T, Ohta H, et al. Effects of an angiotensin II receptor antagonist, TCV-116, on renal haemodynamics in essential hypertension. Blood Press 1994; 3: 117-21
    • (1994) Blood Press , vol.3 , pp. 117-121
    • Kawabata, M.1    Takabatake, T.2    Ohta, H.3
  • 89
    • 0029027440 scopus 로고
    • Comparison of the oral angiotensin II receptor antagonist UP269-6 or enalapril 20 mg on blood pressure and neurohormonal effects in salt-depleted man
    • McIntyre M, MacFadyen RJ, Meredith PA, et al. Comparison of the oral angiotensin II receptor antagonist UP269-6 or enalapril 20 mg on blood pressure and neurohormonal effects in salt-depleted man. J Cardiovasc Pharmacol 1995; 25: 994-1000
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 994-1000
    • McIntyre, M.1    MacFadyen, R.J.2    Meredith, P.A.3
  • 90
    • 0026527261 scopus 로고
    • Pilot study of the uricosuric effect of DUP-753, a new angiotensin II receptor antagonist, in healthy subjects
    • Nakashima M, Uematsu T, Kosuge K, et al. Pilot study of the uricosuric effect of DUP-753, a new angiotensin II receptor antagonist, in healthy subjects. Eur J Clin Pharmacol 1992; 42: 333-5
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 333-335
    • Nakashima, M.1    Uematsu, T.2    Kosuge, K.3
  • 91
    • 85035189431 scopus 로고
    • Renal effects of angiotensin I receptor blockade and converting enzyme inhibition (CE1) in man
    • Schmitt F, Natov S, Martinez F, et al. Renal effects of angiotensin I receptor blockade and converting enzyme inhibition (CE1) in man. J Hypertens 1994; 12 Suppl. 3: S92
    • (1994) J Hypertens , vol.12 , Issue.3 SUPPL.
    • Schmitt, F.1    Natov, S.2    Martinez, F.3
  • 92
    • 0029018583 scopus 로고
    • Studies of the renal effects of angiotensin II receptor blockade: The confounding factor of acute water loading on the action of vasoactive systems
    • Burnier M, Pechère-Bertschi A, Nussberger J, et al. Studies of the renal effects of angiotensin II receptor blockade: the confounding factor of acute water loading on the action of vasoactive systems. Am J Kidney Dis 1995; 26: 108-15
    • (1995) Am J Kidney Dis , vol.26 , pp. 108-115
    • Burnier, M.1    Pechère-Bertschi, A.2    Nussberger, J.3
  • 93
    • 0000555385 scopus 로고
    • The angiotensin II receptor antagonist SK&F 108566 does not increase uric acid (UA) excretion in healthy men
    • Boike S, Ilson B, Audet P, et al. The angiotensin II receptor antagonist SK&F 108566 does not increase uric acid (UA) excretion in healthy men. J Am Soc Nephrol 1993; 4: 530
    • (1993) J Am Soc Nephrol , vol.4 , pp. 530
    • Boike, S.1    Ilson, B.2    Audet, P.3
  • 94
    • 0027398576 scopus 로고
    • Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension
    • Tsunoda K, Abe K, Hagino T, et al. Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension. Am J Hypertens 1993; 6: 28-32
    • (1993) Am J Hypertens , vol.6 , pp. 28-32
    • Tsunoda, K.1    Abe, K.2    Hagino, T.3
  • 95
    • 0000008942 scopus 로고
    • Efficacy and safety of oral MK-954 (DuP 753) an angiotensin receptor antagonist, in essential hypertension
    • Nelson E, Merrill D, Sweet C, et al. Efficacy and safety of oral MK-954 (DuP 753) an angiotensin receptor antagonist, in essential hypertension. J Hypertens 1991; 9 Suppl. 6: S468-9
    • (1991) J Hypertens , vol.9 , Issue.6 SUPPL.
    • Nelson, E.1    Merrill, D.2    Sweet, C.3
  • 96
    • 0029163199 scopus 로고
    • Angiotensin II antagonism improves the lipoprotein profile in patients with nephrotic syndrome
    • De Zeeuw D, Gansevoort RT, Dullaart RP, et al. Angiotensin II antagonism improves the lipoprotein profile in patients with nephrotic syndrome. J Hypertens 1995; 13 Suppl. 1: S53-8
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL.
    • De Zeeuw, D.1    Gansevoort, R.T.2    Dullaart, R.P.3
  • 97
    • 3643090779 scopus 로고
    • The angiotensin II receptor antagonist SB 203220 does not increase uric acid (UA) excretion in healthy men
    • Ilson B, Boike S, Larouche J, et al. The angiotensin II receptor antagonist SB 203220 does not increase uric acid (UA) excretion in healthy men [abstract]. J Am Soc Nephrol 1994; 5: 562
    • (1994) J Am Soc Nephrol , vol.5 , pp. 562
    • Ilson, B.1    Boike, S.2    Larouche, J.3
  • 98
    • 0028798758 scopus 로고
    • Losartan in heart failure: Hemodynamic effects and tolerability
    • Crozier I, Ikram H, Awan N, et al. Losartan in heart failure: hemodynamic effects and tolerability. Circulation 1995; 91: 691-7
    • (1995) Circulation , vol.91 , pp. 691-697
    • Crozier, I.1    Ikram, H.2    Awan, N.3
  • 99
    • 0028918486 scopus 로고
    • Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: A pilot study
    • Shand B, Gilchrist N, Nicholls M, et al. Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study. J Hum Hypertens 1995; 9: 233-5
    • (1995) J Hum Hypertens , vol.9 , pp. 233-235
    • Shand, B.1    Gilchrist, N.2    Nicholls, M.3
  • 100
    • 0028593665 scopus 로고
    • Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension
    • Sweet CS, Bradstreet D, Berman RS, et al. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994; 7: 1035-40
    • (1994) Am J Hypertens , vol.7 , pp. 1035-1040
    • Sweet, C.S.1    Bradstreet, D.2    Berman, R.S.3
  • 101
    • 0010749763 scopus 로고
    • Angiotensin II blockade in healthy volunteers: Tolerability and impact on renin angiotensin system components of single and repeated doses of a new angiotensin II receptor antagonist SR 47436 (BMS 186295)
    • Sissmann J, Bouroudian M, Armagnac C, et al. Angiotensin II blockade in healthy volunteers: tolerability and impact on renin angiotensin system components of single and repeated doses of a new angiotensin II receptor antagonist SR 47436 (BMS 186295). J Hypertens 1994; 12 Suppl. 3: S92
    • (1994) J Hypertens , vol.12 , Issue.3 SUPPL.
    • Sissmann, J.1    Bouroudian, M.2    Armagnac, C.3
  • 102
    • 0027272498 scopus 로고
    • Pilot study of a new angiotensin II receptor antagonist, TCV-116: Effects of a single oral dose on blood pressure in patients with essential hypertension
    • Ogihara T, Higashimori K, Masuo K, et al. Pilot study of a new angiotensin II receptor antagonist, TCV-116: effects of a single oral dose on blood pressure in patients with essential hypertension. Clin Ther 1993; 15: 684-91
    • (1993) Clin Ther , vol.15 , pp. 684-691
    • Ogihara, T.1    Higashimori, K.2    Masuo, K.3
  • 103
    • 0028004615 scopus 로고
    • Open clinical studies on a new angiotensin II receptor antagonist, TCV 116
    • Ogihara T, Arakawa K, Limura O, et al. Open clinical studies on a new angiotensin II receptor antagonist, TCV 116. J Hypertens 1994; 12 Suppl. 1: S35-8
    • (1994) J Hypertens , vol.12 , Issue.1 SUPPL.
    • Ogihara, T.1    Arakawa, K.2    Limura, O.3
  • 104
    • 0343511829 scopus 로고
    • Renal hemodynamic effects of SK&F 108566, a nonpeptide selective angiotensin (AII) receptor AT1 antagonist
    • Ilson B, Boike S, Audet P, et al. Renal hemodynamic effects of SK&F 108566, a nonpeptide selective angiotensin (AII) receptor AT1 antagonist. Clin Pharmacol Ther 1995; 57: 206
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 206
    • Ilson, B.1    Boike, S.2    Audet, P.3
  • 105
    • 0029135039 scopus 로고
    • Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough
    • Ramsay LE, Yeo WW. Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough. J Hypertens 1995; 13 Suppl. 1: S73-6
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL.
    • Ramsay, L.E.1    Yeo, W.W.2
  • 106
    • 0028829712 scopus 로고
    • Angioedema induced by the angiotensin II blocker losartan
    • Acker CG, Greenberg A. Angioedema induced by the angiotensin II blocker losartan. N Engl J Med 1995; 333: 1572
    • (1995) N Engl J Med , vol.333 , pp. 1572
    • Acker, C.G.1    Greenberg, A.2
  • 107
    • 0028935595 scopus 로고
    • Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension
    • Golberg AI, Dunlay MC, Sweet CS. Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. Am J Cardiol 1995; 75: 792-5
    • (1995) Am J Cardiol , vol.75 , pp. 792-795
    • Golberg, A.I.1    Dunlay, M.C.2    Sweet, C.S.3
  • 109
    • 0021737469 scopus 로고
    • An overview of the clinical pharmacology of enalapril
    • Davies RO, Gomez HJ, Irvin JD, et al. An overview of the clinical pharmacology of enalapril. Br J Clin Pharmacol 1984; 18 Suppl. 2: 215S-29S
    • (1984) Br J Clin Pharmacol , vol.18 , Issue.2 SUPPL.
    • Davies, R.O.1    Gomez, H.J.2    Irvin, J.D.3
  • 110
    • 8044256182 scopus 로고
    • Dose-response study of lisinopril efficacy in hypertension
    • Nelson EB, Chrysant SG, Gradman AH, et al. Dose-response study of lisinopril efficacy in hypertension [abstract]. Br J Clin Pharmacol 1985; 25: 470
    • (1985) Br J Clin Pharmacol , vol.25 , pp. 470
    • Nelson, E.B.1    Chrysant, S.G.2    Gradman, A.H.3
  • 111
    • 0027437840 scopus 로고
    • Enalapril clinical pharmacokinetics and pharmacokinetic-pharmacodynamic relationships
    • MacFadyen RJ, Meredith PA, Elliott HL. Enalapril clinical pharmacokinetics and pharmacokinetic-pharmacodynamic relationships. Clin Pharmacokinet 1993; 25: 274-82
    • (1993) Clin Pharmacokinet , vol.25 , pp. 274-282
    • MacFadyen, R.J.1    Meredith, P.A.2    Elliott, H.L.3
  • 112
    • 0026663431 scopus 로고
    • Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development
    • Peck CC, Barr WH, Benet LZ, et al. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Pharm Res 1992; 9: 826-33
    • (1992) Pharm Res , vol.9 , pp. 826-833
    • Peck, C.C.1    Barr, W.H.2    Benet, L.Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.