Abortive apoptosis as an initiator of chromosomal translocations

Medical Hypotheses

Volumn 52, Issue 5, 1999, Pages 373-376

  Khodarev, N N ^a   Sokolova, I A ^a   Vaughan, A T M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT;

APOPTOSIS; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; DNA DEGRADATION; DNA RECOMBINATION; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0033067835     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1997.0672     Document Type: Article

References (31)

1. Green D. R., Bissonete R. B., Cotter T. G. Apoptosis and cancer. Important Adv Oncol. 1994;37-52.
2. Staunton M. J., Gaffney E. F. Tumor type is a determinant of susceptibility to apoptosis. Am J Clin Pathol. 103:1995;300-307.
3. Nathan B., Gusterson B., Jadayel D. Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype. Ann Oncol. 5:1994;409-414.
4. Fan S., Smith M. L., Rivet D. J. Disruption of p53 functions sensitizes breast cancer MCF7 cells to cisplatin and pentoxifylline. Cancer Res. 55:1995;1649-1654.
5. Thompson C. B. Apoptosis in the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
6. Cohen G. M., Sun X. M., Fearnhead H. A. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J Immunol. 153:1994;507-516.
7. Mogil R. J., Shi Y., Bissonnette R. J ., Bromley P., Yamaguchi I., Green D. R. Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J Immunol. 152:1994;1674-1683.
8. Lindhout E., Mevissen M. L., Kwekkeboom J., Tager J. M., de Groot C. Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis. Clin Exp Immunol. 91:1993;330-336.
9. Smith R. J., Duerksen J. D. Activity of purified and chromatin-associated mouse TLT-hepatoma RNA polymerases on whole chromatin and euchromatin enriched fragments isolated from homologous chromatin. Can J Biochem. 55:1977;227-231.
10. Duerksen J. D., Connor K. W. Periodicity and fragment size of DNA from mouse TLT hepatoma chromatin and chromatin fractions using endogeneous and exogeneous nucleases. Mol Cell Biol. 19:1978;93-112.
11. Stratling W. H., Grade C., Horz W. Ca/Mg-dependent endonuclease from porcine liver. Purification, properties, and sequence specificity. J Biol Chem. 259:1984;5893-5898.
12. Stratling W. H., Klingholz R. Supranucleosomal structure of chromatin: digestion by calcium/magnesium endonuclease proceeds via a discrete size class of particles with elevated stability. Biochemistry. 20:1981;1386-1392.
13. Filipski J., Leblanc J., Youdale T., Sikorska M., Walker P. R. Periodicity of DNA folding in higher order chromatin structures. EMBO J. 9:1990;1319-1327.
14. Oberhammer F., Wilson J. W., Dive C. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb, fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:1993;3679-3684.
15. Luokkamaki M., Servomaa K., Rytaomaa T. Onset of chromatin fragmentation in chloroma cell apoptosis is highly sensitive to UV and begins at non-B DNA conformation. Int J Rad Biol. 63:1993;207-213.
16. Lagarkova M. A., Iarovaia O. V., Razin S. V. Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers. J Biol Chem. 270:1995;20239-20241.
17. Lagarkova M. A., Iarovaia O. V., Razin S. V. Excision of chromosomal DNA loops by treatment of permeabilised cells with Bal 31 nuclease. Mol Gen Genetics. 249:1995;253-256.
18. Stanulla M., Wang J., Chervinsky D. S., Aplan P. D. Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. Leukemia. 11:1997;490-496.
19. Schneider E., Hsiang Y. H., Liu L. F. DNA topoisomerases as anticancer drug targets. Adv Pharmacol. 21:1990;149-183.
20. Schlissel M., Constantinescu A., Morrow T., Baxter M., Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:1993;2520-2532.
21. Staley K., Blaschke A. J., Chun J. Apoptotic DNA fragmentation is detected by a semiquantitative ligation-mediated PCR of blunt DNA ends. Cell Death Differ. 4:1997;66-75.
22. Sokolova I. A., Aleksandrova S. S., Khodarev N. N., Votrin I. I. Isolation and investigation of Ca/Mg-dependent endonuclease from cell nuclei of human spleen lymphocytes. Biochemistry (USSR). 53:1988;1163-1173.
23. Khodarev N. N., Morozov A. I., Sokolova I. A., Aleksandrova S. S., Votrin I. I. Specificity of DNA fragmentation by Ca/Mg-dependent endonuclease from cell nuclei of human lymphocytes. Mol Gen Mikrobiol Virusol (USSR). 9:1998;26-32.
24. Morozov A. I., Urakov D. N., Khodarev N. N., Deev S. M., Polianovskii O. L. Characteristics of the effect of Ca/Mg-dependent endonuclease from cell nuclei of human lymphocytes on J kappa-cluster of immunoglobulin genes. Mol Gen Microbiol Virusol (USSR). 11:1988;26-29.
25. Beere H. M., Chresta C. M., Alejo-Herberg A. Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis. Mol Pharmacol. 47:1995;986-996.
26. Solovyan V. T., Andreev I. Q., Kolotova T. Y., Pogribniy P. V., Tarnavsky D. T., Kunakh V. A. The cleavage of nuclear DNA into high molecular weight DNA fragments occurs not only during apoptosis but also accompanies changes in functional activity of the nonapoptotic cells. Exp Cell Res. 235:1997;130-137.
27. Nossal G. J. Negative selection of lymphocytes. Cell. 76:1994;229-239.
28. Han S., Dillon S. R., Zheng B., Shimoda M., Schlissel M. S., Kelsoe G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:1997;301-305.
29. Tiegs S. L., Russell D. M., Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med. 177:1993;1009-1020.
30. Ramsden D. A., Paull T. T., Gellert M. Cell-free V(D)J recombination. Nature. 388:1997;488-491.
31. Bogue M., Roth D. B. Mechanism of V(D)J recombination. Curr Opin Immunol. 8:1996;175-180.