Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia

European Journal of Pharmacology

Volumn 376, Issue 1-2, 1999, Pages 179-187

  Tang, Tianlai ^a   Dong, Christine ^a   Duffield, Rose ^a   Ho, Andrew K S ^a  

^a Division of Clinical Pharmacology   (United States)

Author keywords

Cardiomyocyte; Cardioprotection; Cyanide; Hyperkalemia; K(ATP) channel opener; Pinacidil; Ca2+ (i) transient

Indexed keywords

BEPRIDIL; CREATINE KINASE; CYANIDE; GLIBENCLAMIDE; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CHICKEN; CONCENTRATION RESPONSE; DRUG MECHANISM; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HYPERKALEMIA; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033064706     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00366-0     Document Type: Article

References (39)

1. Arena J.P., Kass R.S. Enhancement of potassium-sensitive current in heart cells by pinacidil: evidence for modulation of the ATP-sensitive potassium channel. Circ. Res. 65:1989;436-445.
2. ATP channel openers protect against increased cytosolic calcium during ischemia and reperfusion. J. Mol. Cell. Cardiol. 27(9):1995;1809-1817.
3. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ. Res. 75:1993;379-385.
4. 2+ loading in cardiomyocytes. Eur. J. Pharmacol. 308:1996;343-349.
5. Cavaro I., Djellas Y., Guillon J.M. Ischemic myocardial cell protection conferred by the opening of ATP-sensitive potassium channels. Cardiovasc. Drugs Ther. 9(suppl. 2):1995;245-255.
6. Cheung J.V., Bonventre J.V., Malis C.D., Leaf A. Calcium and ischemic injury. N. Engl. J. Med. 314:1986;1670-1676.
7. + channels protect the myocardium against ischemia/reperfusion damage. Circ. Res. 69(3):1991;571-581.
8. + channels and protects against simulated ischemia in rabbit myocytes. J. Mol. Cell. Cardiol. 29(4):1997;1123-1130.
9. Feher J.J., LeBolt W.R., Manson N.H. Differential effect of global ischemia on the ryanodine-sensitive and ryanodine-insensitive calcium uptake of cardiac sarcoplasmic reticulum. Circ. Res. 65:1989;1400-1408.
10. Fletcher A.E., Battersby C., Adnitt P., Underwood N., Jurgensen H.J., Bulpitt C.J. Quality of life on antihypertensive therapy: a double-blind trial comparing quality of life on pinacidil and nifedipine in combination with thiazide diuretic. J. Cardiovasc. Pharmacol. 20:1992;108-114.
11. Friedel H.A., Brodgen R.N. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension. Drugs. 39:1990;929-967.
12. Galinanes M., Shatock M.M., Hearse D.J. Effects of potassium channel modulation during global ischemia in isolated rat heart with and without cardioplegia. Cardiovasc. Res. 26:1992;1063-1068.
13. ATP opener cromakalim is not correlated with ischemic myocardial action potential duration. J. Cardiovasc. Pharmacol. 26:1995;145-152.
14. Grover G.J., D'Alonza A.J., Hess T., Sleph P.G., Darbensiio R.B. Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening. Cardiovasc. Res. 30:1995;731-738.
15. Hearse D.J. Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection? Cardiovasc. Res. 30:1995;1-17.
16. Jovanovic A., Alekseev A.E., Lopez J.R., Shen W.K., Terzic A. Adenosine prevents hyperkalemia-induced calcium loading in cardiac cells: relevance for cardioplegia. Ann. Thorac. Surg. 63:1997;153-161.
17. + loss and arrhythmias in rat hearts: effect of glibenclamide, a sulfonylurea. Circ. Res. 66:1990;478-485.
18. 2+ cycling. Am. J. Physiol. 271:1996;H643-H650.
19. Labrid C., Grossel A., Dureng G., Mironneau J., Duchene-Marullaz P. Some membrane interactions with bepridil, a new antianginal agent. J. Pharmacol. Exp. Ther. 211:1979;546-554.
20. Lawton J.S., Harrington G.C., Allen C.T., Hsia P.W., Damiano R.J. Jr. Myocardial protection with pinacidil cardioplegia in the blood-perfused heart. Ann. Thorac. Surg. 61(6):1996;1680.
21. 2+ waves: a laser confocal microscopy study. Am. J. Physiol. 39:1996;H1384-H1389.
22. Lopez J.R., Jahangir R., Jahangir A., Shen W.K., Terzic A. Potassium channel openers prevent potassium-induced calcium loading of cardiac cells: possible implications in cardioplegia. J. Thorac. Cardiovasc. Surg. 112(3):1996;820-831.
23. 2+-ATPase on cytoplasmic calcium and enzyme secretion in pancreatic acini. Biochim. Biophys. Acta. 13(1220(2)):1994;199-208.
24. Noma A. ATP-regulated K channels in cardiac muscle. Nature. 305:1983;147-148.
25. Opie L.D., Du Tit E.F. Postischemic stunning: the two-phase model for the role of calcium as pathogen. J. Cardiovasc. Pharmacol. 20:1992;S1-S4.
26. Powell T., Tatham P.E.R., Twist V.W. Cytoplasmic free calcium measured by QUIN2 fluorescence in isolated ventricular myocytes at rest and during potassium depolarization. Biochem. Biophys. Res. Commun. 122:1984;1012-1020.
27. 2+ in anoxic rat ventricular myocytes. Effects of glibenclamide. Pflug. Arch. 432(1):1996;75-80.
28. Schwartz A., Matlib M.A., Balwierczak J., Lathrop D.A. Pharmacology of calcium antagonists. Am. J. Cardiol. 55:1985;3C-7C.
29. Steenbergen C., Murphy E., Levy L., London R.E. Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ. Res. 60:1997;700-707.
30. 2+ loading induced by metabolic inhibition and hyperkalemia in cardiomyocytes. Eur. J. Pharmacol. 360:1998;205-211.
31. 2+ overload in reperfused ischemic myocardium. Annu. Rev. Physiol. 52:1990;543-559.
32. + loss during hypoxia, ischemia and metabolic inhibition in mammalian ventricles. Circ. Res. 69:1991;623-637.
33. Vigne P., Breittmayer J.P., Frelin C. Thapsigargin, a new inotropic agent, antagonizes action of endothelin-1 in rat atrial cells. Am. J. Physiol. 263(6):1992;H1689-H1694. pt. 2.
34. Watanabe I., Johnson T.A., Buchanan J., Engle C.L., Gettes C. Effect of graded coronary flow reduction on ionic, electrical, and mechanical indexes of ischemia in the pig. Circulation. 76:1987;1127-1134.
35. i in mammalian ventricle: dynamic control by cellular processes. Annu. Rev. Physiol. 52:1990;467-485.
36. o accumulation and electrophysiological alterations during early myocardial ischemia. Am. J. Physiol. 243:1982;H318-H327.
37. Wickenden A.D., Kaprielian R., Kassiri Z., Tsoporis J.N., Tsushima R., Fishman G.I., Backx P.H. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure. Cardiovasc. Res. 37:1998;312-323.
38. Wilde A.A.M., Escande D., Schumacher C.A., Thuringer D., Meestre M., Fiolet J.W.T., Jance M.J. Potassium accumulation in the globally ischemic mammalian heart: a role for the ATP-sensitive potassium channel. Circ. Res. 67:1990;835-843.
39. 2+ transport. Circ. Res. 77:1995;88-97.