Myocardial protection with pinacidil cardioplegia in the blood-perfused heart

Annals of Thoracic Surgery

Volumn 61, Issue 6, 1996, Pages 1680-1688

  Lawton, Jennifer S ^a   Harrington, Gary C ^a   Allen, Cynthia T ^a   Hsia, Peng Wie ^a   Damiano Jr , Ralph J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; APRIKALIM; CARDIOPLEGIC AGENT; CORONARY VASODILATING AGENT; GLIBENCLAMIDE; LEMAKALIM; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; PROCAINE; SODIUM CHANNEL BLOCKING AGENT; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOSE RESPONSE; FEMALE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PERFUSION; HEART PROTECTION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; ISOLATED HEART; MALE; NONHUMAN; PERFUSION PRESSURE; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RABBIT;

EID: 0029942863     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/0003-4975(96)00164-6     Document Type: Article

References (33)

1. Katz AM. The cardiac action potential. In: Physiology of the heart. 2nd ed. New York: Raven Press, 1992:438-9.
2. Damiano RJ. The electrophysiology of ischemia and cardioplegia: implications for myocardial protection. J Cardiac Surg 1995;10(4 Suppl):445-53.
3. Grover GJ, McCullough JR, Henry DE, Conder ML, Sleph PG. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther 1989;251:98-104.
4. + channels protect the myocardium against ischemia/reperfusion damage. Circ Res 1991;69:571-81.
5. Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 1991;261:H1675-86.
6. + channels in cardiac muscle. Nature 1983;305:147-8.
7. Grover GJ. Protective effects of ATP-sensitive potassium channel openers in experimental myocardial ischemia. J Cardiovasc Pharmacol 1994;24:518-27.
8. + channels involves high-energy phosphate preservation. Am J Physiol 1993;265:H1809-18.
9. Cohen NM, Lederer WJ, Nichols CG. Activation of ATP-sensitive potassium channels underlies contractile failure in single human cardiac myocytes during complete metabolic blockade. J Cardiovasc Electrophys 1992;3:56-63.
10. + channel modulator aprikalim (RP 52891): improved cardioprotection in isolated ischemic rabbit hearts. Can J Physiol Pharmacol 1994;72:126-32.
11. Sargent CA, Sleph PG, Dzwonczyk S, Normandin D, Antonaccio MJ, Grover GJ. Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075. J Cardiovasc Pharmacol 1993;22:564-70.
12. 1 on hypothermic injury in immature myocytes. J Surg Res 1995;58:313-20.
13. Mitani A, Kinoshita K, Kukamachi K, et al. Effects of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat hearts. Am J Physiol 1991;261:H1864-71.
14. Galinanes M, Shattock MJ, Hearse DJ. Effects of potassium channel modulation during global ischemia in isolated rat heart with and without cardioplegia. Cardiovasc Res 1992; 26:1063-8.
15. + cardioplegia. Int J Cardiol 1995; 48:11-25.
16. Jerome SN, Akimitsu T, Gute DC, Korthuis RJ. Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion. Am J Physiol 1995;268: H2063-7.
17. Cohen NM, Wise RM, Wechsler AS, Damiano RJ. Elective cardiac arrest with a hyperpolarizing adenosine triphosphate-sensitive potassium channel opener. J Thorac Cardiovasc Surg 1993;106:317-28.
18. Maskal SL, Cohen NM, Hsia PW, Wechsler AW, Damiano RJ. Hyperpolarized cardiac arrest with a potassium-channel opener, aprikalim. J Thorac Cardiovasc Surg 1995;110: 1083-95.
19. Fan Z, Nakayama K, Hiraoka M. Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. J Physiol 1990;430:273-95.
20. Arena JP, Kass RS. Enhancement of potassium-sensitive current in heart cells by pinacidil - evidence for modulation of the ATP-sensitive potassium channel. Circ Res 1989;65: 436-45.
21. + channels in guinea-pig cardiac myocytes. Pflugers Arch 1989;414:669-75.
22. Tseng G, Hoffman BF. Actions of pinacidil on membrane currents in canine ventricular myocytes and their modulation by intracellular ATP and cAMP. Pflugers Arch 1990;415: 414-24.
23. Goto Y, Slinker BK, LeWinter MM. Decreased contractile efficiency and increased nonmechanical energy cost in hyperthyroid rabbit heart. Cire Res 1990;66:999-1011.
24. Moon MR, DeAnda A, Daughters GT, Ingels NB, Miller DC. Experimental evaluation of different chordal preservation methods during mitral valve replacement. Ann Thorac Surg 1994;58:931-44.
25. Fremes SE, Zhang J, Furukawa RD, Mickle DA, Weisel RD. Adenosine pretreatment for prolonged cardiac storage. J Thorac Cardiovasc Surg 1995;110:293-301.
26. Stark PA. Numerical integration. In: Introduction to numerical methods. New York: Macmillan, 1970:196-8.
27. Mirsky I, Parmley WE. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res 1973;33:233-43.
28. Maskal SL, Fields CE, Cohen NM, Damiano RJ. Persistent electrical activity during hyperpolarized cardiac arrest does not affect post ischemic myocardial recovery. Surg Forum 1995;46:222-4.
29. Klocke FJ, Braunwald E, Ross J. Oxygen cost of electrical activity of the heart. Circ Res 1966;18:357-65.
30. Sakamoto S, Liang C, Stone CK, Hood WB. Effects of pinacidil on myocardial blood flow and infarct size after acute left anterior descending coronary artery occlusion and reperfusion in awake dogs with and without a coexisting left circumflex coronary artery stenosis. J Cardiovasc Pharmacol 1989;14:747-55.
31. ATP-channel opening and arrhythmogenesis. J Cardiovasc Pharmacol 1994;24:S35-40.
32. Goto Y, Slinker BK, LeWinter MM. Accuracy of volume measurement of rabbit left ventricle by balloon method. Am J Physiol 1988;255:H394-6.
33. Barner HB. Blood cardioplegia: a review and comparison with crystalloid cardioplegia. Ann Thorac Surg 1991;52: 1354-67.