Effects of timolol and of timolol with tamarind seed polysaccharide on intraocular pressure in rabbits

Pharmacy and Pharmacology Communications

Volumn 5, Issue 5, 1999, Pages 361-364

  D'Amico, M ^b   Di Filippo, C ^b   Lampa, E ^b   Boldrini, E ^a   Rossi, Francesoo ^b   Ruggiero, A ^b   Filippelli, A ^b  

^a Farmigea SpA   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; POLYSACCHARIDE; TIMOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MALE; NONHUMAN; RABBIT; SUBCONJUNCTIVAL DRUG ADMINISTRATION;

EID: 0033064452     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080899128734974     Document Type: Article

References (22)

1. Alvan, G., Calissendorf, B. M., Seideman, P., Widmark, K., Widmark, G. (1980) Absorption of ocular timolol. Clin. Pharmacokinet. 5: 95-100
2. Araie, M., Takase, M., Sakaj, Y. (1982) Beta-adrenergic blockers: ocular penetration and binding to uveal pigment. Jpn. J. Ophthalmol. 26: 248-263
3. Bonomi, L. (1978) Experimental corticosteroid and ocular hypertension in the rabbit. Graefes Arch. Clin. Exp. Ophthalmd. 209: 73-82
4. Bonomi, L., Perfetti, S., Noya, E., Belluci, R., Massa, F. (1979) Comparison of the effects of nine beta-adrenergic blocking agents of intraocular pressure of rabbits. Graefes Arch. Clin. Exp. Ophthalmol. 210: 1-8
5. Burgalassi, S., Panichi, L., Saettone, M. F., Jacobsen, J., Rassing, M. R. (1996) Development and in vitro/in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine. Int. J. Pharm. 133: 1-7
6. Burgalassi, S., Panichi, L., Chetoni, P., Saettone, M. F., Boldrini, E. (1999) Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes. Ophthalmic Res. In press
7. Chiang, C. H., Ho, J. I., Chen, J. L. (1996) Pharmacokinetics and intraocular pressure lowering effect of timolol preparations in rabbit eyes. J. Ocul. Pharmacol. Ther. 12: 471-480
8. Chrai, S. S., Makoid, M. C., Eriksen, S. P., Robinson, J. R. (1974) Drop size and initial dosing frequency problems of topically applied ophthalmic drugs. J. Pharm. Sci. 63: 333-338
9. Keats, E.D. (1979) Evaluation of timolol maleate combination therapy in chronic open angle glaucoma. Am. J. Ophthalmol. 88: 565-571
10. Liu, J. H. K., Bartels, S. P., Neufeld, A. H. (1983) Effects of L- and D-timolol on cyclic-AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. Invest. Ophthalmol. Vis. Sci. 24: 1276-1281
11. Matera, M. G., Lampa, E., Imperatore, A., Berrino, L., Russo, F., Boldrini, E., Rossi, F. (1998) Bioavailability of timolol and aceclidine after ocular instillation in the rabbit. Res. Comm. Mol. Path. Pharmacol. 100: 35-42
12. Mishima, S. (1981) Clinical pharmacokinetic of eye. Invest. Ophthalmol. 214: 504-541
13. Moriarty, A. P., Dowd, T. C. (1995) Timolol-pilocarpine fixed ratio in the treatment of chronic open angle glaucoma. Arch. Ophthalmol. 111: 1313-1314
14. Novack, G. D. (1987) Ophthalmic beta-blockers since timolol. Surv. Ophthalmol. 31: 307
15. Sondenstrom, M. B., Wallin, O., Grandstrom, P. E., Thorburn, W. (1990) Timolol-pilocarpine combined vs timolol and pilocarpine given separately. Am. J. Ophthalmol. 197: 465-469
16. Sugrue, M. F., Gautheron, P., Grove, J., Mallorga, P., Viader, M. P., Baldwin, J. J., Ponticello, G. S., Varga, S. L. (1988) L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity. Invest. Ophthalmol. Vis Sci. 29: 776-779
17. Tagawa, H., Okada, A., Furukawa, H., Konishi, N., Fujii, H. (1995) Effect of topical timolol on the blood velocity of the iris microcirculation and the aqueous veins in human subjects. Nippo Ganka Gakkai Zasshi 99: 435-439
18. Tamaki, Y., Araie, M., Tomita, K., Tomidokoro, A. (1997) Effect of topical timolol on tissue circulation in optic nerve. Jpn. J. Ophthalmol. 41: 297-304
19. Usitalo, R. J., Palkama, A. (1994) Efficacy and safety of timolol/pilocarpine combination drops in glaucoma patients. Acta Ophthalmol. (Copenh.) 72: 496-504
20. Vareilles, P., Silvestrone, D., Plazonnet, B., le Douarec, J. C., Sears, M. L., Stone, C. A. (1977) Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. Invest. Ophthalmol 16: 987-991
21. Vareilles, P., Conquet, P., Lotti, V. J. (1980) Intraocular pressure responses to antiglaucoma agents in spontaneously buphthalmic rabbits. Ophthalmic. Res. 12: 296
22. Zadok, D., Geyer, O., Lazar, M., Krakowski, D., Nemet, P. (1994) Combined timolol and pilocarpine vs pilocarpine alone and timolol alone in the treatment of glaucoma. Am. J. Ophthalmol. 117: 728-731