Bioavailability of timolol and aceclidine after ocular instillation in the rabbit

Research Communications in Molecular Pathology and Pharmacology

Volumn 100, Issue 1, 1998, Pages 35-42

  Matera, M G ^a   Lampa, E ^a   Imperatore, A ^a   Berrino, L ^a   Russo, F ^a   Boldrini, E ^b   Rossi, F ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Farmigea SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACECLIDINE; EYE DROPS; TIMOLOL;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; ARTICLE; DRUG BIOAVAILABILITY; DRUG MIXTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PUPIL; RABBIT;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; AQUEOUS HUMOR; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; EYE; HALF-LIFE; MALE; PARASYMPATHOMIMETICS; PUPIL; QUINUCLIDINES; RABBITS; SPECTROPHOTOMETRY, ULTRAVIOLET; TIMOLOL;

EID: 0031776184     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Alvan, G., Calissendorf, B.M., Seideman, P., Widmark, K., Widemark, G. (1980) Absorption of ocular timolol. Clin. Pharmacokinet. 5: 95-100.
2. Boles Carenini, B., Rolle, T., Brogliatti, B. (1989) Association of aceclidine with timolol in the treatment of POAG. New Trends Ophthalmol. 4:181-186.
3. Ellis, P.P. (1977) In: Handbook of Ocular Therapeutic and Pharmacology, Edited by Mosby, St. Louis, USA. pp 128-129.
4. Hovding, G., Aasved, H. (1987) Timolol/pilocarpine association eye drops in open angle glaucoma and in ocular hypertension. Acta Ophthalmol. Copenh. 65: 594-601.
5. Hurvitz, L.M., Kaufinan, P.L., Robin, AL., Weinreb, R.N., Crawford, K and Shaw, B. (1991) New developments in the drug treatment of glaucoma. Drugs 41: 514-532.
6. Linn, ML., Jones, L.T. (1968) Rate of lacrirnal excretion of ophthalmic vehicles. Am.J. Ophthalmol. 65: 76-78.
7. Mishima, 5. (1981) Clinical pharmacokinetic of eye. Invest. Onhthalmol. 214: 504-541.
8. Moriarty, A.P., Dowd, T.C. (1995) Timolol-pilocarpine fixed ratio combinations in the treatment of chronic open angle glaucoma. Arch. Ophthalmol. 111:1313-1314.
9. Philip, P.P., Wu, P.Y., Reigel, M. (1991)Aqueous humor pilocarpine and timolol levels after instillation of the single drug or in association. Inv. Ophthalmol. 32: 520-522.
10. Phillips, C.I., Bartolomew, R.S., Kazi G., Schmitt C.J., Vogel R. (1981) Penetration of timolol eye drops into human aqueous humor. Br. J. Onhthalmol. 65: 593-595.
11. Smolen, V.F. (1972) Application of a pharmacological method of drug absorption analysis to the study of the bioavailability characteristics of mydriatic drugs. Can. J. Phar. Sci. 7: 7-16.
12. Smolen, V.F. (1978) Bioavailability and phannacokinetic analysis of drug responding systems. Am. Rev. Pharmacol. Toxicol. 18: 495-462.
13. Sondenstrom, M.B., Wallin, O., Grandstrom, P.E., Thorburn, W. (1990) Timololpilocarpine combined vs timolol and pilocarpine given separately. Am. J. Ophthalmol. 197: 465-469.
14. Usitalo, R.J., Palkama, A. (1994) Efficacy and safety of timolol/pilocarpine combination drops in glaucoma patients. Acta Onhthalmol. Copenh. 72: 496-504.
15. Vogel, R. (1989) Ovenview of efficacy and local tolerability of a new timolol/pilocarpine association. Surv. Ophtamol. 33: 467-468.
16. Wu, P.Y., Reigel, M., Ellis, P.P. (1989) High-performance liquid chromatography assay for tirnolol in the aqueous humor of the eye. J. Chromatogr. 494: 368-375.
17. Zadok, D., Geyer, O., Lazar, M., Krakowski, D., Nemet, P. (1994) Combined timolol and pilocarpine vs pilocarpine alone and timolol alone in the treatment of glaucoma. Am. J. Ophthalmol. 117: 728-731.