Contribution of cytochrome P-4502D6 phenotype to the neuromodulatory effects of dextromethorphan

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 607-612

  Desmeules, Jules A ^a,b   Oestreicher, Mitsuko Kondo ^a   Piguet, Valérie ^a   Allaz, Anne Françoise ^a   Dayer, Pierre ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b University Hospital   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DEXTROMETHORPHAN; PLACEBO; QUINIDINE SULFATE;

ADULT; ANTINOCICEPTION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG METABOLISM; GENOTYPE; HUMAN; HYPERALGESIA; MALE; NEUROMODULATION; NEUROPHARMACOLOGY; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; HYPERALGESIA; MALE; NEUROTRANSMITTER AGENTS; NOCICEPTORS; PAIN THRESHOLD; PHENOTYPE; PLACEBOS; QUINIDINE; TISSUE DISTRIBUTION;

EID: 0033061069     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Andersen OK, Gracely RH and Arendt-Nielsen L (1995) Facilitation of the human nociceptive reflex by stimulation of Aβ-fibers in a secondary hyperalgesic area sustained by nociceptive input from the primary hyperalgesic area. Acta Physiol Scand 155:87-97.
2. Besson J-M and Chaouch A (1987) Peripheral and spinal mechanisms of nociception. Physiol Rev 67:67-186.
3. Broly R, Libersa C, Lhermitte M, Bechtel P and Dupuis B (1989) Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver. Br J Clin Pharmacol 28:29-36.
4. Cardinale GJ, Donnerer J, Finck AD, Kantrowitz JD, Oka K and Spector S (1987) Morphine and codeine are endogenous components in human cerebrospinal fluid. Life Sci 40:301-306.
5. Carpenter CL, Mark SS, Watson DL and Greenberg DA (1988) Dextromethorphan and dextrorphan as calcium channel antagonists. Brain Res 439:372-375.
6. Chaplan SR, Malmberg AB and Yaksh TL (1997) Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther 280:829-838.
7. Cook AJ, Woolf CJ, Wall PD and McMahon SB (1987) Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent fibre input. Nature 325:185-187.
8. Dayer P, Desmeules J, Leemann T and Striberni R (1988) Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufl). Biochem Biophys Res Commun 152:411-416.
9. Dayer P, Leemann T and Striberni R (1989) Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450DB1 activity. Clin Pharmacol Ther 45:34-40.
10. DeCoster MA, Klette KL, Knight ES and Tortella FC (1995) σ Receptor-mediated neuro-protection against glutamate toxicity in primary rat neuronal cultures. Brain Res 671:45-53.
11. Desmeules J, Gascon M-P, Dayer P and Magistris M (1991) Impact of environemental and genetic factor on codeine analgesia. Eur J Clin Pharmacol 41:23-26.
12. Desmeules J, Piguet V, Collart L and Dayer P (1996) Contribution of monoaminergic modulation in tramadol analgesic effect. Br J Clin Pharmacol 41:7-12.
13. Dickenson AH and Sullivan AF (1987) Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C-fibre stimulation. Neuropharmacology 26:1235-1238.
14. Grönroos M and Pertovaara A (1993) Capsaicin-induced central facilitation of a nociceptive flexion reflex in human. Neurosci Lett 159:215-218.
15. Idanpaan-Heikkila JE (1994) WHO guidelines for good clinical practice for trials on pharmaceutical products: Responsibilities of investigator. Ann Med 26:89-94.
16. Kauppila T, Grönroos M and Pertovaara A (1995) An attempt to attenuate experimental pain in humans by dextromethorphan an NMDA receptor antagonist. Pharmacol Biochem Behav 52:641-644.
17. Kazis A, Kimiskidis V and Niopas I (1996) Pharmacokinetics of dextromethorphan and dextrorphan in epileptic patients. Acta Neurol Scand 93:94-98.
18. Kenins P (1982) Responses of single nerve fibers applied to the skin. Neurosci Lett 29:83-88.
19. Koltzenburg M, Lundberg LER and Torebjork HE (1992) Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51:207-219.
20. Koltzenburg M, Torebjork HE and Wahren LK (1994) Nociceptor modulated central sensitization causes hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain 117:579-591.
21. Kupfer A, Schmid B and Pfaff G (1986) Pharmacogenetics of dextromethorphan O-demethylation in man. Xenobiotica 16:421-433.
22. Leemann T, Dayer P and Meyer UA (1986) Single-dose quinidine treatment inhibits metoprolol oxydation in extensive metabolizers. Eur J Clin Pharmacol 29:739-741.
23. Llerena A, Edman, G. Cobaleda J, Benitez J, Schalling D and Bertillson L (1993) Relationship between personality and debrisoquine hydroxylation capacity: Suggestion of an endogenous neuroactive substrate or product of cytochrome P-4502D6. Acta Psychiatr Scand 87:23-28.
24. Löscher W and Hönack D (1993) Differences in anticonvulsant potency and adverse effects between dextromethorphan and dextrorphan in amygdala-kindled and nonkindled rats. Eur J Pharmacol 238:191-200.
25. McQuay HJ, Carroll D, Jadad AR, Glynn CJ, Jack T, Moore RA and Wiffeh PJ (1994) Dextromethorphan for the treatment of neuropathic pain: A double-blind randomised controlled crossover trial with integral n-of-1 design. Pain 59:127-133.
26. Nelson KA, Park KM, Robinovitz E, Tsigos C and Max MB (1997) High-dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia. Neurology 48:1212-1218.
27. Netzer R, Pflimlin P and Trube G (1993) Dextromethorphan blocks N-methyl D aspartate-induced currents and voltage operated inwards currents in cultured cortical neurons Eur J Pharmacol 238:209-216.
28. Porchet HC, Piletta P and Dayer P (1990) Objective assessment of clonidine analgesia in man and influence of naloxone. Life Sci 46:991-998.
29. Price DD, Mao J, Frenk H and Mayer DJ (1994) The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain 59:165-174.
30. Sindrup SH and Brosen K (1995) The pharmacogenetics of codeine hypoalgesia Pharmacogenetics 5:335-346.
31. Sindrup SH, Poulsen L, Brosen K, Arendt-Nielsen L and Gram LF (1993) Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers? Pain 53:335-349.
32. Steinberg GK, Bell TE and Yenari MA (1996) Dose escalation safety and tolerance study of the N-methyl-D-aspartate antagonist dextromethorphan in neurosurgery patients. J Neurosurg 84:860-866.
33. Székély JI, Sharpe LG and Jaffe JH (1991) Induction of phencyclidine-like behaviour in rats by dextrorphan but not dextromethorphan. Pharmacol Biochem Behav 40:381-386.
34. Szolcsanyi J, Anton F, Reeh PW and Handwercker HO (1988) Selective activation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res 446:262-268.
35. Tal M and Bennett GJ (1994) Neuropathic pain sensations are differentially sensitive to dextrorphan. Neuroreport 5:1438-1440.
36. Torebjörk HE, Lundberg LER and LaMotte RH (1992) Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 448:765-780.
37. Willer JC (1977) Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 3:69-80.
38. Willer JC (1990) Exploration clinique de la nociception par des techniques de réflex-ologie. Neurophysiol Clin 20:335-256.
39. Wong BY, Coulter DA, Choi DW and Pince DA (1988) Dextrorphan and dextrometho-rphan common antitussives are antiepileptic and antagonize N-methyl-D-Aspartate in brain slices. Neurosci Lett 85:261-266.
40. Woodworth JR, Dennis SRK, Hinsvark ON, Amsel LP and Rotenberg KS (1987) Bioavailability evaluation of a controlled release dextromethorphan liquid. J Clin Pharmacol 27:133-138.
41. Woolf CJ and Thompson SW (1991) The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic receptor activation: Implications for the treatment of postinjury pain hypersensitivity states Pain 44:293-299.
42. Wu D, Otton V, Kalow W and Seller EM (1995) Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat. J Pharmacol Exp Ther 274:1431-1437.