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Volumn 15, Issue 1, 1999, Pages 33-38

Mucosal immunity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FC RECEPTOR; INTEGRIN; LIGAND; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

EID: 0033060325     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199901000-00007     Document Type: Review
Times cited : (3)

References (44)
  • 1
    • 0029665856 scopus 로고    scopus 로고
    • Critical role for β7 integrins in formation of the gut-associated lymphoid tissue
    • 1 Wagner N, Lohler J, Kunkel EJ, Ley K, Leung E, Krissansen G, et al: Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996, 382:366-370.
    • (1996) Nature , vol.382 , pp. 366-370
    • Wagner, N.1    Lohler, J.2    Kunkel, E.J.3    Ley, K.4    Leung, E.5    Krissansen, G.6
  • 2
    • 0030802049 scopus 로고    scopus 로고
    • Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue
    • 2 Briskin M, Winsor-Hines D, Shyjan A, Cochran N, Bloom S, Wilson J, et al: Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 1997, 151:97-110.
    • (1997) Am J Pathol , vol.151 , pp. 97-110
    • Briskin, M.1    Winsor-Hines, D.2    Shyjan, A.3    Cochran, N.4    Bloom, S.5    Wilson, J.6
  • 3
    • 0030940931 scopus 로고    scopus 로고
    • Murine isograft studies of gut immunity: Recirculation and homing of mononuclear cells
    • 3 Okuyama S, Rubin D, Streeter PR, Peters M: Murine isograft studies of gut immunity: recirculation and homing of mononuclear cells. Gastroenterology 1997, 112:1241-1249.
    • (1997) Gastroenterology , vol.112 , pp. 1241-1249
    • Okuyama, S.1    Rubin, D.2    Streeter, P.R.3    Peters, M.4
  • 6
    • 0031945841 scopus 로고    scopus 로고
    • Current concepts in mucosal immunity: III. Ontogeny and function of γδ T cells in the intestine
    • Gastrointest Liver Physiol 37
    • 6 Kagnoff MF: Current concepts in mucosal immunity: III. Ontogeny and function of γδ T cells in the intestine. Am J Physiol 1998, 274(Gastrointest Liver Physiol 37):G455-G458. This is a review of current opinions on the development and function of intestinal γδ IEL and mucosal T cells.
    • (1998) Am J Physiol , vol.274
    • Kagnoff, M.F.1
  • 7
    • 0029854809 scopus 로고    scopus 로고
    • Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7+ Thy1+ lympho-hemopoietic progenitors develop
    • 7 Kanamori Y, Ishimaru K, Nanno M, Maki K, Ikuta K, Nariuchi H, Ishikawa H: Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ iL-7+ Thy1+ lympho-hemopoietic progenitors develop. J Exp Med 1996, 184:1449-1459.
    • (1996) J Exp Med , vol.184 , pp. 1449-1459
    • Kanamori, Y.1    Ishimaru, K.2    Nanno, M.3    Maki, K.4    Ikuta, K.5    Nariuchi, H.6    Ishikawa, H.7
  • 8
    • 0032502836 scopus 로고    scopus 로고
    • Generation of intestinal T cells from progenitors residing in gut cryptopatches
    • 8 Saito H, Kanamori Y, Takemori T, Nariuchi H, Kubota E, Takahashi-Iwanaga H, et al: Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 1998, 280:275-278. These studies indicate that recently described collections of lymphocytes in the crypt area contain precursors of IEL.
    • (1998) Science , vol.280 , pp. 275-278
    • Saito, H.1    Kanamori, Y.2    Takemori, T.3    Nariuchi, H.4    Kubota, E.5    Takahashi-Iwanaga, H.6
  • 9
    • 0032520267 scopus 로고    scopus 로고
    • Generation of intestinal mucosal lymphocytes in SCID mice reconstituted with mature, thymus-derived T cells
    • 9 Camerini V, Sydora BC, Aranda R, Nguyen C, MacLean C, McBride WH, Kronenberg M: Generation of intestinal mucosal lymphocytes in SCID mice reconstituted with mature, thymus-derived T cells. J Immunol 1998, 160:2608-2618.
    • (1998) J Immunol , vol.160 , pp. 2608-2618
    • Camerini, V.1    Sydora, B.C.2    Aranda, R.3    Nguyen, C.4    MacLean, C.5    McBride, W.H.6    Kronenberg, M.7
  • 10
    • 0031570390 scopus 로고    scopus 로고
    • The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development
    • 10 Holtmeier W, Witthoft T, Hennemann A, Winter HS, Kagnoff MF: The TCR-δ repertoire in human intestine undergoes characteristic changes during fetal to adult development. J Immunol 1997, 158:5632-5641. These studies describe changes in the diversity of the junctional regions of intestinal δ TCR that take place during development from fetal to neonatal to adult life.
    • (1997) J Immunol , vol.158 , pp. 5632-5641
    • Holtmeier, W.1    Witthoft, T.2    Hennemann, A.3    Winter, H.S.4    Kagnoff, M.F.5
  • 11
    • 0029861713 scopus 로고    scopus 로고
    • Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
    • 11 Groh V, Bahram S, Bauer S, Herman A, Beuchamp M, Spies T: Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci U S A 1996, 93:12445-12450.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12445-12450
    • Groh, V.1    Bahram, S.2    Bauer, S.3    Herman, A.4    Beuchamp, M.5    Spies, T.6
  • 12
    • 0032513388 scopus 로고    scopus 로고
    • Recognition of stress-induced MHC molecules by intestinal γδ T cells
    • 12 Groh V, Steinte A, Bauer S, Spies T: Recognition of stress-induced MHC molecules by intestinal γδ T cells. Science 1998, 279:1737-1740. This article describes an MHC-encoded molecule on intestinal epithelial cells that is recognized by γδ T cells expressing a Vδ1 receptor. Because these MHC-encoded molecules may be upregulated by heat stress, it is postulated these antigens allow IEL to recognize damaged, infected, or transformed epithelial cells or stimulate IEL to release growth factors for epithelial cells.
    • (1998) Science , vol.279 , pp. 1737-1740
    • Groh, V.1    Steinte, A.2    Bauer, S.3    Spies, T.4
  • 13
    • 0040077442 scopus 로고    scopus 로고
    • Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180: A candidate molecule mediating T cell-epithelial cell interactions
    • 13 Yio XY, Mayer L: Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180: a candidate molecule mediating T cell-epithelial cell interactions. J Biol Chem 1997, 272:12786-12792. The gp180 molecule described in this article is potentially important for mediating intestinal epithelial cell-IEL interactions.
    • (1997) J Biol Chem , vol.272 , pp. 12786-12792
    • Yio, X.Y.1    Mayer, L.2
  • 14
    • 1842373829 scopus 로고    scopus 로고
    • Defective expression of gp180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease
    • 14 Toy LS, Yio XY, Lin A, Honig S, Mayer L: Defective expression of gp180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease. J Clin Invest 1997, 100:2062-2071.
    • (1997) J Clin Invest , vol.100 , pp. 2062-2071
    • Toy, L.S.1    Yio, X.Y.2    Lin, A.3    Honig, S.4    Mayer, L.5
  • 15
    • 0030747245 scopus 로고    scopus 로고
    • Epithelial cells as sensors for microbial infection
    • 15 Kagnoff MF, Eckmann L: Epithelial cells as sensors for microbial infection. J Clin Invest 1997, 100:6-10. This article reviews an array of intestinal epithelial cell innate immune responses to a spectrum of invasive and minimally invasive enteric pathogens and provides a detailed source of information regarding the expanding role of intestinal epithelial cells in innate immune responses and mucosal immunity.
    • (1997) J Clin Invest , vol.100 , pp. 6-10
    • Kagnoff, M.F.1    Eckmann, L.2
  • 16
    • 0031011849 scopus 로고    scopus 로고
    • Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion
    • 16 Madsen KL, Lewis SA, Tavernini MM, Hibbard J, Fedorak RN: Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology 1997, 113:151-159.
    • (1997) Gastroenterology , vol.113 , pp. 151-159
    • Madsen, K.L.1    Lewis, S.A.2    Tavernini, M.M.3    Hibbard, J.4    Fedorak, R.N.5
  • 17
    • 0030959647 scopus 로고    scopus 로고
    • Ontogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestine
    • 17 Martin MG, Wu SV, Walsh JH: Ontogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestine. Dig Dis Sci 1997, 42:1062-1069.
    • (1997) Dig Dis Sci , vol.42 , pp. 1062-1069
    • Martin, M.G.1    Wu, S.V.2    Walsh, J.H.3
  • 18
    • 0028960488 scopus 로고
    • A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes
    • 18 Blumberg RS, Koss T, Story CM, Barisani D, Polischuk J, Lipin A, et al: A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest 1995, 95:2397-2402.
    • (1995) J Clin Invest , vol.95 , pp. 2397-2402
    • Blumberg, R.S.1    Koss, T.2    Story, C.M.3    Barisani, D.4    Polischuk, J.5    Lipin, A.6
  • 20
    • 0028864991 scopus 로고
    • A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
    • 20 Jung HC, Eckmann L, Yang S-K, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF: A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 1995, 95:55-65.
    • (1995) J Clin Invest , vol.95 , pp. 55-65
    • Jung, H.C.1    Eckmann, L.2    Yang, S.-K.3    Panja, A.4    Fierer, J.5    Morzycka-Wroblewska, E.6    Kagnoff, M.F.7
  • 21
    • 0030831109 scopus 로고    scopus 로고
    • Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines
    • 21 Laurent F, Eckmann L, Savidge TC, Morgan G, Theodos C, Naciri M, Kagnoff MF: Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect Immun 1997, 65:5067-5073. This article uses polarized cell lines and a novel human intestinal xenograft model to investigate the host's epithelial response to a minimally invasive pathogen.
    • (1997) Infect Immun , vol.65 , pp. 5067-5073
    • Laurent, F.1    Eckmann, L.2    Savidge, T.C.3    Morgan, G.4    Theodos, C.5    Naciri, M.6    Kagnoff, M.F.7
  • 22
    • 0030870251 scopus 로고    scopus 로고
    • Differential and regulated expression of C-X-C, C-C, and C chemokines by human colon epithelial cells
    • 22 Yang S-K, Eckmann L, Panja A, Kagnoff MF: Differential and regulated expression of C-X-C, C-C, and C chemokines by human colon epithelial cells. Gastroenterology 1997, 113:1214-1223. Intestinal epithelial cells participate in innate immune responses by the regulated release of C-X-C and C-C chemokines that appear to provide temporal and spatial chemoattractant gradients for leukocyte populations after stimulation with inflammatory mediators or infection with enteroinvasive bacteria.
    • (1997) Gastroenterology , vol.113 , pp. 1214-1223
    • Yang, S.-K.1    Eckmann, L.2    Panja, A.3    Kagnoff, M.F.4
  • 23
    • 0031954627 scopus 로고    scopus 로고
    • Production of proinflammatory cytokines and inflammatory mediators in human intestinal epithelial cells after invasion by Trichinella spiralis
    • 23 Li CKF, Seth R, Gray T, Bayston R, Mahida YR, Wakelin D: Production of proinflammatory cytokines and inflammatory mediators in human intestinal epithelial cells after invasion by Trichinella spiralis. Infect Immun 1998, 66:2200-2206.
    • (1998) Infect Immun , vol.66 , pp. 2200-2206
    • Li, C.K.F.1    Seth, R.2    Gray, T.3    Bayston, R.4    Mahida, Y.R.5    Wakelin, D.6
  • 24
    • 0031949436 scopus 로고    scopus 로고
    • Cryptosporidium parvum infection of human intestinal xenografts in SCID mice induces production of human tumor necrosis factor alpha and interleukin 8
    • 24 Seydel KB, Zhang T, Champion GA, Fichtenbaum C, Swanson PE, Tzipori S, et al: Cryptosporidium parvum infection of human intestinal xenografts in SCID mice induces production of human tumor necrosis factor alpha and interleukin 8. Infect Immun 1998, 66:2379-2382.
    • (1998) Infect Immun , vol.66 , pp. 2379-2382
    • Seydel, K.B.1    Zhang, T.2    Champion, G.A.3    Fichtenbaum, C.4    Swanson, P.E.5    Tzipori, S.6
  • 25
    • 0029092581 scopus 로고
    • Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin 1α
    • 25 Eckmann L, Reed SL, Smith JR, Kagnoff MF: Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin 1α. J Clin Invest 1995, 96:1269-1279.
    • (1995) J Clin Invest , vol.96 , pp. 1269-1279
    • Eckmann, L.1    Reed, S.L.2    Smith, J.R.3    Kagnoff, M.F.4
  • 26
    • 0030931232 scopus 로고    scopus 로고
    • Entamoeba histolytica stimulates interleukin 8 from human colonie epithelial cells without parasite-enterocyte contact
    • 26 Yi Y, Chadee K: Entamoeba histolytica stimulates interleukin 8 from human colonie epithelial cells without parasite-enterocyte contact. Gastroenterology 1997, 112:1536-1547.
    • (1997) Gastroenterology , vol.112 , pp. 1536-1547
    • Yi, Y.1    Chadee, K.2
  • 27
    • 0030950510 scopus 로고    scopus 로고
    • Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis
    • 27 Seydel KB, Li E, Swanson PE, Stanley SL: Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis. Infect Immun 1997, 65:1631-1639.
    • (1997) Infect Immun , vol.65 , pp. 1631-1639
    • Seydel, K.B.1    Li, E.2    Swanson, P.E.3    Stanley, S.L.4
  • 28
    • 0031020373 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
    • 28 Rasmussen SJ, Eckmann L, Quayle AJ, Shen L, Zhang Y-X, Anderson DJ, et al: Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 1997, 99:77-87. This article describes a novel mechanism by which minimally invasive intraepithelial pathogens may activate underlying mucosal inflammation.
    • (1997) J Clin Invest , vol.99 , pp. 77-87
    • Rasmussen, S.J.1    Eckmann, L.2    Quayle, A.J.3    Shen, L.4    Zhang, Y.-X.5    Anderson, D.J.6
  • 30
    • 0030731743 scopus 로고    scopus 로고
    • Paneth cells and innate immunity in the crypt microenvironment
    • 30 Ouellette AJ: Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology 1997, 113:1779-1784.
    • (1997) Gastroenterology , vol.113 , pp. 1779-1784
    • Ouellette, A.J.1
  • 31
    • 15644370080 scopus 로고    scopus 로고
    • Enteric β-defensin: Molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection
    • 31 Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, et al: Enteric β-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun 1998, 66:1045-1056. The authors describe the inducible expression of mRNA for an antimicrobial β-defensin molecule concurrent with infection with the protozoan parasite C. parvum. Expression of this antimicrobial cationic peptide is localized to non-Paneth enterocytes of the small intestinal villi, suggesting that enteric pathogens may up-regulate the expression of antimicrobial peptides in cells other than crypt Paneth cells.
    • (1998) Infect Immun , vol.66 , pp. 1045-1056
    • Tarver, A.P.1    Clark, D.P.2    Diamond, G.3    Russell, J.P.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 33
    • 0031656002 scopus 로고    scopus 로고
    • Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells
    • 33 Witthoft T, Eckmann L, Kim J-M, Kagnoff MF: Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells. Am J Physiol (Gastrointest. and Liver) 1998, 275:G564-571.
    • (1998) Am J Physiol (Gastrointest. and Liver) , vol.275
    • Witthoft, T.1    Eckmann, L.2    Kim, J.-M.3    Kagnoff, M.F.4
  • 34
    • 0030799478 scopus 로고    scopus 로고
    • 2α production
    • 2α production. J Clin Invest 1997, 100:296-309. Intestinal epithelial cells respond to inflammatory mediators and enteric pathogens by the inducible up-regulation of COX II and the release of prostaglandins that may be important in regulating epithelial chloride secretion in an autocrine/paracrine manner.
    • (1997) J Clin Invest , vol.100 , pp. 296-309
    • Eckmann, L.1    Stenson, W.F.2    Savidge, T.C.3    Lowe, D.C.4    Barrett, K.E.5    Fierer, J.6
  • 36
    • 0031253731 scopus 로고    scopus 로고
    • TGF-β production regulates the development of the 2, 4, 6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2 deficient mice
    • 36 Ludvikkisson BR, Ehrhardt RO, Strober W: TGF-β production regulates the development of the 2, 4, 6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2 deficient mice. J Immunol 1997, 159:3622-3628.
    • (1997) J Immunol , vol.159 , pp. 3622-3628
    • Ludvikkisson, B.R.1    Ehrhardt, R.O.2    Strober, W.3
  • 37
    • 0030752587 scopus 로고    scopus 로고
    • Mice lacking transforming growth factor a have an increased susceptibility to dextran sulfate-induced colitis
    • 37 Egger B, Procaccino F, Lakshmanan J, Reinshagen M, Hoffman P, Patel A, et al: Mice lacking transforming growth factor a have an increased susceptibility to dextran sulfate-induced colitis. Gastroenterology 1997, 113:825-832.
    • (1997) Gastroenterology , vol.113 , pp. 825-832
    • Egger, B.1    Procaccino, F.2    Lakshmanan, J.3    Reinshagen, M.4    Hoffman, P.5    Patel, A.6
  • 38
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor factor alpha for Crohn's disease. Crohn's disease cA2 study group
    • 38 Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, et al: A short-term study of chimeric monoclonal antibody cA2 to tumor factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997,337:1029-1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    Van Deventer, S.J.3    Mayer, L.4    Present, D.H.5    Braakman, T.6
  • 39
    • 0029832930 scopus 로고    scopus 로고
    • Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice
    • 39 Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK: Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice. J Exp Med 1996, 184:707-715.
    • (1996) J Exp Med , vol.184 , pp. 707-715
    • Mizoguchi, A.1    Mizoguchi, E.2    Chiba, C.3    Bhan, A.K.4
  • 40
    • 0030802981 scopus 로고    scopus 로고
    • Appendectomy and the risk of developing ulcerative colitis or Crohn's disease: Results of a large case-control study
    • 40 Russel MG, Dorant E, Brummer R-JM, Van de Kruijs MA, Muris JW, Bergers JM, et al: Appendectomy and the risk of developing ulcerative colitis or Crohn's disease: Results of a large case-control study. Gastroenterology 1997, 113:377-382.
    • (1997) Gastroenterology , vol.113 , pp. 377-382
    • Russel, M.G.1    Dorant, E.2    Brummer, R.-J.M.3    Van De Kruijs, M.A.4    Muris, J.W.5    Bergers, J.M.6
  • 41
    • 0032540266 scopus 로고    scopus 로고
    • Fulminant jejuno-ileitis following ablation of enteric glial cells in adult transgenic mice
    • 41 Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, et at: Fulminant jejuno-ileitis following ablation of enteric glial cells in adult transgenic mice. Cell 1998, 93:189-201. These authors genetically ablated neuronal glial cells and determined that the affected mice develop intestinal inflammation, suggesting that enteric glial cells and neurons participate in modulating intestinal inflammation.
    • (1998) Cell , vol.93 , pp. 189-201
    • Bush, T.G.1    Savidge, T.C.2    Freeman, T.C.3    Cox, H.J.4    Campbell, E.A.5    Mucke, L.6
  • 42
    • 0030838044 scopus 로고    scopus 로고
    • Identification of tissue transglutaminase as the autoantigen of celiac disease
    • 42 Dietrich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D: Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997, 3:797-801. This study provides evidence that the target antigen for antiendomysium autoantibody in celiac disease is a tissue transglutaminase.
    • (1997) Nat Med , vol.3 , pp. 797-801
    • Dietrich, W.1    Ehnis, T.2    Bauer, M.3    Donner, P.4    Volta, U.5    Riecken, E.O.6    Schuppan, D.7
  • 43
    • 0031779478 scopus 로고    scopus 로고
    • Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    • 43 Molberg O, Mcadam SN, Komer R, Quarsten H, Kristiansen C, Madsen L, et al: Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998, 4:713-717. This study presents the novel concept that tissue transglutaminase, the target of antiendomysium antibody in celiac disease, can alter glutamine residues in gliadin peptides and render them better binders to the celiac disease-associated HLA-DQ2 molecule as well as more immunogenic for antigliadin T cells.
    • (1998) Nat Med , vol.4 , pp. 713-717
    • Molberg, O.1    Mcadam, S.N.2    Komer, R.3    Quarsten, H.4    Kristiansen, C.5    Madsen, L.6


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