Differential regulation of p27 and cyclin D1 by TGF-β and EGF in C3H 10T1/2 mouse fibroblasts

Journal of Cellular Physiology

Volumn 168, Issue 3, 1996, Pages 510-520

  Ravitz, Michael J ^a   Yan, Shaochun ^a   Dolce, Calogero ^a   Kinniburgh, Alan J ^a   Wenner, Charles E ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME REGULATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DOWN-REGULATION; EPIDERMAL GROWTH FACTOR; MICE; MICE, INBRED C3H; MICROTUBULE-ASSOCIATED PROTEINS; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 0029784950     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199609)168:3<510::AID-JCP3>3.0.CO;2-S     Document Type: Article

References (45)

1. Brown, K., Kemp, C.J., Burns, P.A., Stoler, A.B., Fowlis, D.J., Akhurst, R.J., and Balmain, A. (1993) Positive and negative growth control in multistage skin carcinogenesis. Recent Results Cancer Res., 128:309-321.
2. Chirgwin, J.M., Przybyla, A.E., McDonald, R.J., and Rutter, W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18:5294-5302.
3. Dulic, V., Lees, E., and Reed, S.I. (1992) Association of human cyclin E with a periodic G1-S phase protein kinase. Science, 257:1958-1961.
4. Dulic, V., Kaufmann, W.K., Wilson, S.J., Tisty, T.D., Lees, E., Elledge, S.J., and Reed, S.I. (1994) p53-dependent inhibition of cyclin-dependent kinase activity in human fibroblasts during radiation-induced G1 arrest. Cell, 76:1013-1023.
5. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., and Vogelstein, B. (1993) Wafl, a potential mediator of of p53 tumor suppression. Cell, 75:817-825.
6. Ewen, M.E., Sluss, H.K., Whitehouse, L.L., and Livingston, D.M. (1993) TGFβ-inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell, 74:1009-1020.
7. Firpo, E., Koff, A., Solomon, M.J., and Roberts, J.M. (1994) Inactivation of a cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell Biol. 14:4889-4901.
8. Flores-Rozas, H., Kelman, Z., Dean, F., Pan, Z.-Q., Harper, J.W., Elledge, S.J., O'Donnell, M., and Hurwitz, J., (1994) Cdk-interacting protein-1 (Cip1, Waf1) directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. U.S.A., 91:8655-8659.
9. Gu, Y., Rosenblatt, J., and Morgan, D.O. (1992) Cell cycle regulation of cdk2 activity by phosphorylation of Thr-160 and Tyr-15. EMBO J., 11:3994-4005.
10. Haddow, S., Fowlis, D.J., Parkinson, K., Akhurst, R.J., and Balmain, A. (1991) Loss of growth control by TGF-β occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation. Oncogene, 6:1465-1470.
11. Halevy, O., Noviotch, B.G., Spicer, D.B., Skapek, S.X., Rhee, J., Hannon, G.J., Beach, D., and Lasser, A.B. (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science, 267:1018-1021.
12. Hannon, G.J., and Beach, D. (1994) p15INK 4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature, 371:257-261.
13. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75:805-816.
14. Hengst, L., Dulic, V., Slingerland, J.M., Lees, E., and Reed, S.I. (1994) A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. U.S.A., 91:5291-5295.
15. Hochstrasser, M. (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol., 7:215-223.
16. Kip1) of cyclin-dependent kinase 4 activation. Cell, 79:487-496.
17. Kim, T.-A., Cutry, A.F., Kinniburgh, A.J., and Wenner, C.E. (1993) Transforming growth factor β1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts. Cancer Lett., 71:125-132.
18. Kim, T.-A., Ravitz, M.J., and Wenner, C.E. (1994) Transforming growth factor-β regulation of retinoblastoma gene product and E2f transcription factor during cell cycle progression in mouse fibro-blasts. J. Cell. Physiol., 160:1-9.
19. Knabble, C., Lippman, M.E., Wakefield, L.M., Flanders, K.C., Kasid, A., Derynck, R., and Dickson, R.B. (1987) Cell, 48:417-428.
20. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S., Nishimoto, T., Morgan, D.O., Franza, B.R., and Roberts, J.M. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science, 257:1689-1694.
21. Koff, A., Ohtsuki, M., Polyak, K., Roberts, J.M., and Massague, J. (1993) Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β. Science, 260:536-539.
22. Laiho, M., DeCaprio, J.A., Ludlow, J.W., Livingston, D.M., and Massague, J. (1990) Growth inhibition of TGF-beta is linked to suppression of retinoblastoma protein phosphorylation. Cell, 62:175-185.
23. Li, Y., Jenkins, C.W., Nichols, M.A., and Xiong, Y. (1994) Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene, 9:2261-2268.
24. Masui, T., Wakefield, L.M., Lechner, J.F., LaVeck, M.A., Sporn, M.B., and Harris, C.C. (1986) Proc. Natl. Acad. Sci. U.S.A., 83:2438-2442.
25. Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., and Kato, J.-Y. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14:2066-2076.
26. McKinney, J.D., and Cross, F.R. (1995) FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae. Mol. Cell. Biol., 15:2509-2516.
27. McKinney, J.D., Chang, F., Heintz, N., and Cross, F.R. (1993) Negative regulation of FAR1 at the start of the yeast cell cycle. Genes Dev., 7:833-843.
28. Meyerson, M., and Harlow, E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol., 14:2077-2086.
29. Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M., and Smith, J.R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211:90-98.
30. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature, 372:570-573.
31. Pagano, M., Tam, S.W., Theodoras, A.M., Beer-Romero, P., Del Sal, G., Chau, V., Yew, P.R., Draetta, G.F., and Rolfe, M. (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269:682-685.
32. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev., 8:9-22.
33. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78:59-66.
34. Quelle, D.E., Ashmun, R.A., Shurtleff, S.A., Kato, J.-Y., Bar-Sagi, D., Roussel, M.F., and Sherr, C.J. (1993) Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7:1559-1571.
35. Kip1 in C3H 10T1/2 mouse fibroblasts. Cancer Res., 55:1413-1416.
36. Ravitz, M.J. (1996) Transforming growth factor-β regulation of cyclin-dependent kinases during G1 phase in C3H 10T1/2 mouse embryonic fibroblasts. Ph.D. dissertation, State University of New York at Buffalo.
37. Resnitzky, D., Gossen, M., Bujard, H., and Reed, S.I. (1994) Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol., 14:1669-1679.
38. Reynisdottir, I., Polyak, K., Iavarone, A., and Massague, J. (1995) Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev., 9:1831-1845.
39. Sic1 controls the G1 to S transition in S. cerevisiae. Cell, 79:233-244.
40. Shipley, G.D., Pittelkow, M.A., Wille, J.J., Scott, R.E., Moses, H.L. (1986) Reversible inhibition of normal human prokeratinocyte proliferation by type beta-transforming growth factor-growth inhibitor in serum-free medium. Cancer Res. 46:2068-2071.
41. Slingerland, J.M., Hengst, L., Pan, C.-H., Alexander, D., Stampfer, M.R., and Reed, S.I. (1994) A novel inhibitor of cyclin-cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol., 14:3684-3694.
42. Toyoshima, H., and Hunter, T. (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell, 78:67-74.
43. Waga, S., Hannon, G.J., Beach, D., and Stillman, B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369:574-78.
44. Xiong, Y., Hannon, G.J., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. (1993) p21 is a universal inhibitor of cyclin kinases. Nature, 366:701-704.
45. Xiong, Y., Xhang, H., and Beach, D. (1992) D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell, 71:505-514.