Hypoxic-ischemic brain injury: Advancements in the understanding of mechanisms and potential avenues for therapy

Current Opinion in Pediatrics

Volumn 11, Issue 3, 1999, Pages 223-228

  Biagas, Katherine ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; FREE RADICAL; NITRIC OXIDE; PROTEINASE;

APOPTOSIS; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; INTENSIVE CARE; MORBIDITY; MORTALITY; NEAR DROWNING; NERVE CELL NECROSIS; PERINATAL ASPHYXIA; PRIORITY JOURNAL; RESPIRATORY ARREST; REVIEW; SUDDEN INFANT DEATH SYNDROME;

BRAIN; BRAIN INJURIES; BRAIN ISCHEMIA; CELL DEATH; CHILD; CRITICAL CARE; HUMANS; HYPOXIA, BRAIN; INFANT; MODELS, NEUROLOGICAL; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS;

EID: 0033056021     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199906000-00009     Document Type: Review

References (36)

1. 1 Vannucci RC: Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatr Res 1990, 27:317-326.
2. 2 Martin RL, Lloyd HG, Cowan AI: The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci 1994, 17:251-257.
3. 3 Siesjo BK, Bengtsson F, Grampp W, Theander S: Calcium, excitotoxins, and neuronal death in the brain. Ann N Y Acad Sci 1989, 568:234-251.
4. 4 Choi DW: Excitotoxic cell death. J Neurobiol 1992, 23:1261-1276.
5. 45Ca influx and resultant neuronal injury in cultured cortical neurons [abstract]. Neurology 1989,39:217.
6. 6 Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995, 15:961-973.
7. 7 Siman R, Noszek JC, Kegerise C: Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 1989, 9:1579-1590.
8. 8 Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD: Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 1995, 65:1250-1256.
9. 9 Traystman RJ, Kirsch JR, Koehler RC: Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991, 71:1185-1195.
10. 10 Beckman JK, Howard MJ, Greene HL: Identification of hydroxyalkenals formed from omega-3 fatty acids. Biochem Biophys Res Commun 1990, 169:75-80.
11. 11 Esterbauer H, Schaur RJ, Zollner H: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991, 11:81-128.
12. 12 Chan PH, Epstein CJ, Li Y, Huang TT, Carlson E, Kinouchi H, et al.: Transgenic mice and knockout mutants in the study of oxidative stress in brain injury. J Neurotrauma 1995, 12:815-824.
13. 13 Morikawa E, Huang Z, Moskowitz MA: L-arginine decreases infarct size caused by middle cerebral arterial occlusion in SHR. Am J Physiol 1992, 263:1632-1635.
14. 14 Zhang F, White JG, Iadecola C: Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 1994, 14:217-226.
15. 15 Iadecola C, Zhang F, Xu X: Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 1995, 268:286-292.
16. 16 Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME: Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 1997, 17:9157-9164.
17. 17 Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA: Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994, 265:1883-1885.
18. 18 Grau AJ, Berger E, Sung KL, Schmid-Schonbein GW: Granulocyte adhesion, deformability, and superoxide formation in acute stroke. Stroke 1992, 23:33-39.
19. 19 Dietrich WD: Neurobiology of stroke. Int Rev Neurobiol 1998, 42:55-101. This is an excellent review of the mechanisms of injury in hypoxic-ischemic injury.
20. 20 Leist M, Nicotera P: Apoptosis, excitotoxicity, and neuropathology. Exp Cell Res 1998, 239:183-201. This is a thorough discussion of the mechanisms involved in neuronal apoptosis.
21. 21 Steller H: Mechanisms and genes of cellular suicide. Science 1995, 267:1445-1449.
22. 22 Li Y, Powers C, Jiang N, Chopp M: Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat. J Neurol Sci 1998, 156:119-132.
23. 23 Beilharz EJ, Williams CE, Dragunow M, Sirimanne ES, Gluckman PD: Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Brain Res Mol Brain Res 1995, 29:1-14.
24. 24 Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA: Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 1997, 17:1143-1151.
25. 25 Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, et al.: Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997, 3:1089-1095.
26. 26 Harkness RA: Is post-hypoxic-ischemic cell damage associated with excessive ATP consumption rather than a failure of ATP production? Acta Paediatr 1997, 86:1-5.
27. 27 Kochanek PM, Bell MJ, Fortes ML, Adelson PD, Clark RSB: Pathophysiology. In Traumatic Brain Injury. Edited by Marion DW. New York: Thieme Medical Publishers, Inc; 1999:233-254.
28. 28 Toung TJ, Traystman RJ, Hurn PD: Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 1998, 29:1666-1670.
29. 29 Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD: Gender-linked brain injury in experimental stroke. Stroke 1998, 29:159-165.
30. 30 Gisvold SE, Sterz F, Abramson NS, Bar-Joseph G, Ebmeyer U, Gervais H, et al.: Cerebral resuscitation from cardiac arrest: treatment potentials. Crit Care Med 1996, 24:S69-S80.
31. 31 Zhang RL, Chopp M, Li Y, Zaloga C, Jiang N, Jones ML, et al.: Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology 1994, 44:1747-1751.
32. 32 Gunn AJ, Gluckman PD, Gunn TR: Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 1998, 102:885-892. This safety study on the effects of hypothermia on asphyxial injury in 22 infants serves as the basis for the current and planned multicenter trials.
33. 33 Busto R, Dietrich WD, Globus MY, Valdes I, Scheinberg P, Ginsberg MD: Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987, 7:729-0738.
34. 34 Minamisawa H, Smith ML, Siesjo BK: The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia. Ann Neurol 1990, 28:26-33.
35. 35 Bernard SA, Jones BM, Horne MK: Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med 1997, 30:146-153.
36. 36 Thoresen M, Wyatt J: Keeping a cool head, post-hypoxic hypothermia: an old idea revisited. Acta Paediatr 1997, 86:1029-1033. This paper presents a concise discussion of the reasoning behind the use of hypothermia as rescue therapy for hypoxic-ischemic brain injury. Hypothermia is the most promising new therapy at the present for the treatment of perinatal asphyxia.