Epstein-Barr virus nuclear antigen 2 (EBNA2)-oestrogen receptor fusion proteins complement the EBNA2-deficient Epstein-Barr virus strain P3HR1 in transformation of primary B cells but suppress growth of human B cell lymphoma lines

Journal of General Virology

Volumn 77, Issue 2, 1996, Pages 227-237

  Kempkes, Bettina ^a,d   Zimber Strobl, Ursula ^a   Eissner, Günther ^a   Pawlita, Michael ^b   Falk, Martin ^a,c   Hammerschmidt, Wolfgang ^a   Bornkamm, Georg W ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; ESTROGEN; ESTROGEN RECEPTOR; HYBRID PROTEIN; VIRUS ANTIGEN;

ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; VIRUS GENOME; VIRUS INFECTION; VIRUS TRANSFORMATION;

ANTIGENS, VIRAL; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, VIRAL; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOMA, B-CELL; MOLECULAR SEQUENCE DATA; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS);

HUMAN HERPESVIRUS 4;

EID: 0030020960     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-2-227     Document Type: Article

References (45)

1. ABBOT, S. D., ROWE, M., CADWALLADER, K , RICKSTEN, A., GORDON, J , WANG, F , RYMO, L. & RICKINSON, A. B. (1990). Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein. Journal of Virology 64, 2126-2134.
2. Au, S., METZGER, J., BORNERT, J. M. & CHAMBON, P. (1994). Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor. EMBO Journal 12, 1153-1160.
3. ALLDAY, M. J., CRAWFORD, D. H. & GRIFFIN, B. E. (1989). Epstein-Barr virus latent gene expression during the initiation of B-cell immortalization. Journal of General Virology 70, 1755-1764.
4. BAER, R., BANKIER, A. T., BIGGIN, M. D., DEININGER, P. L., FARRELL, P. J., GIBSON, T. J., HATFULL, G , HUDSON, G. S., SATCHWELL, S. C., SEGUIN, C., TUFNELL, P. S. & BARELL, B. G. (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310, 207-211.
5. L region. Journal of Virology 43, 952-968.
6. CALENDER, A., BILLAUD, M., AUBRY, J. P., BANCHEREAU, J., VUILLAUME, M. & LENOIR, G. M. (1987). Epstein Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells. Proceedings of the National Academy of Sciences. USA 84, 8060-8064.
7. COHEN, J. I., WANG, F., MANNICK, J. & KIEFF, E. (1989) Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte Iransformation. Proceedings of the National Academy of Sciences, USA 86, 9558-9562.
8. CORDIER, M., CALENDER, A., BILLAUD, M., ZIMBER, U., ROUSSELET, G., PAVLISH, O., BANCHEREAU, J., TURSZ, T., BORNKAMM, G. W. & LENOIR, G. M. (1990). Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23. Journal of Virology 64, 1002-1013.
9. COTTER, T. G., LENNON, S. V., GLYNN, J M. & GREEN, D R. (1992). Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Research 52, 997-1005.
10. CRAWFORD, D. H., EPSTEIN, M. A , BORNKAMM, G. W., ACHONG, B G , FINERTY, S & THOMPSON, J. L (1979). Biological and biochemical observations on isolates of EB virus from the malignant epithelial cells of two nasopharyngeal carcinomas. International Journal of Cancer 24, 294-302.
11. CUOMO, L., RAMQUIST, T., TRIVEDI, P., WANG, F., KLEIN, G. & MASUCCI, M. G. (1992). Expression of the Epstein-Barr virus (EBV)-encoded membrane protein LMP1 impairs the in vitro growth, clonability and tumorigenicity of an EBV-negative Burkitt lymphoma line. International Journal of Cancer 51, 949-955.
12. EILERS, M., PICARD, D., YAMAMOTO, K. R. & BISHOP, J M. (1989). Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340, 66-68.
13. EISSNER, G., KOHLHUBER, F., GRELL, M., UEFFING, M., SCHEURICH, P., HIEKE, A., MULTHOFF, G , BORNKAMM, G. W. & HOLLER, E. (1995). Critical involvement of transmembrane TNF-α in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood 86, 4175-4184.
14. FAHRAEUS, R., JANSSON, A , RICKSTEN, A., SJOBLOM, A. & RYMO, L. (1990). Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element. Proceedings of the National Academy of Sciences, USA 87, 7390-7394.
15. FALK, M. H , HULTNER, L., MILNER, A , GREGORY, C. D. & BORNKAMM, G. W. (1993). Irradiated fibroblasts protect Burkitt lymphoma cells from apoptosis by a mechanism independent of bcl-2. International Journal of Cancer 55, 485-491.
16. GRASSER, F. A , HAISS, P., GOTTEL, S & MUELLER-LANTZSCH, N. (1991). Biochemical characterization of Epstein-Barr virus nuclear antigen 2A Journal of Virology 65, 3779-3788
17. GROSSMAN, S. R., JOHANNSEN, E , TONG, X., YALAMANCHILI, R & KIEFF, E. (1994). The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J Kappa recombination signal binding protein. Proceedings of the National Academy of Sciences, USA 91, 7568-7572.
18. HAMMERSCHMIDT, W. & SUGDEN, B. (1988). Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55, 427-433.
19. HAMMERSCHMIDT, W. & SUGDEN, B. (1989). Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature 340, 393-397.
20. HENKEL, T., LING, P. D., HAYWARD, S. D. & PETERSON, M. G. (1994). Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J. Science 265, 92-95.
21. KEMPKES, B., PICH, D , ZEIDLER, R., SUGDEN, B. & HAMMERSCHMIDT, W. (1995 a). Immortalization of human B lymphocytes by a plasmid containing 71 kbp of Epstein-Barr virus DNA. Journal of Virology 69, 231-238.
22. KEMPKES, B., SPITKOVSKY, D., JANSEN-DÜRR, P., ELLWART, J. W , KREMMER, E., DELECLUSE, H. J., ROTTENBERGER, C., BORNKAMM, G. W., HAMMERSCHMIDT, W (1995 b). B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO Journal 14, 88-96.
23. KLEIN, G., LINDAHL, T., JONDAL, M., LEIBOLD, W., MENEZES, J., NILSSON, K. & SUNDSTROM, C. (1974). Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas. Proceedings of the National Academy of Sciences, USA 71, 3283-3286.
24. KNUTSON, J. C. (1990). The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization. Journal of Virology 64, 2530-2536.
25. KREMMER, E., KRANZ, B. R., HILLE, A., KLEIN, K., EULITZ, M., HOFFMANN-FEZER, G., FEIDEN, W., HERRMANN, K , DELECLUSE, H. J., DELSOL, G., BORNKAMM, G. W., MUELLER-LANTZSCH, N. & GRÄSSER, F. A (1995). Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigen 2A (EBNA2A) and 2B (EBNA2B). Virology 208, 336-342.
26. KUMAR, V., GREEN, S., STAUB, A. & CHAMBON, P. (1986). Localization of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. EMBO Journal 5, 2231-2236.
27. LAUX, G., DUGRILLON, C., ECKERT, B., ADAM, B., ZIMBER-STROBL, U. & BORNKAMM, G. W. (1994). Identification and characterization of an Epstein-Barr virus nuclear antigen 2-responsive element in the bidirectional promoter region of latent membrane protein and terminal protein 2 genes. Journal of Virology 68, 6947-6958.
28. LENOIR, G. M., VUILLAUME, M. & BONNARDEL, C. (1985). The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma. JARC Science Publications 309-318.
29. LING, P. D., RAWLINS, D R. & HAYWARD, S. D (1993) The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein. Proceedings of the National Academy of Sciences, USA 90, 9237-9241
30. MATSUNAMI, N., HAMAGUCHI, Y , YAMAMOTO, Y., KUZE, K., KANGAWA, K., MATSUO, H., KAWAICHI, M. & HONJO, T. (1989). A protein binding to the J kappa recombination sequence of immunoglobutin genes contains a sequence related to the integrase motif Nature 342, 934-937.
31. MEITINGER, C., STROBL, L. J., MARSCHALL, G., BORNKAMM, G W. & ZIMBER-STROBL, U. (1994). Crucial sequences within the Epstein-Barr virus TP1 promoter for EBNA2-mediated transactivation and interaction of EBNA2 with its responsive element. Journal of Virology 68, 7497-7506.
32. MOSMANN, T. (1983). Rapid colorimetric assay for cellular growth and survival : application to proliferation and cytotoxicity assays Journal of Immunological Methods 65, 55-63
33. PICARD, D., SALSER, S. J. & YAMAMOTO, K. R. (1988). A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54, 1073-1080.
34. POLACK, A , HARTL, G., ZIMBER, U., FREESE, U. K , LAUX, G., TAKAKI, K., HOHN, B., GISSMANN, L. & BORNKAMM, G. W. (1984). A complete set of overlapping cosmid clones of M-ABA virus derived from nasopharyngeal carcinoma and its similarity to other Epstein-Barr virus isolates. Gene 27, 279-288.
35. RABSON, M., GRADOVILLE, L., HESTON, L & MILLER, G. (1982) Non-immortalizing P3J-HR-1 Epstein-Barr virus, a deletion mutant of its transforming parent, Jijoye. Journal of Virology 44, 834-844
36. ROONEY, C., HOWE, J. G., SPECK, S. H. & MILLER, G. (1989). Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus. Journal of Virology 63, 1531-1539.
37. SUNG, N. S., KENNEY, S., GUTSCH, D. & PAGANO, J. S. (1991). EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus. Journal of Virology 65, 2164-2169.
38. TORSTEINSDOTTIR, S., ANDERSSON, M. L., AVILA-CARINO. J., EHLIN-HENRIKSSON, B., MASUCCI, M. G., KLEIN, G. & KLEIN, E. (1989). Reversion of tumorigenicity and decreased agarose clonability after EBV conversion of an IgH/myc translocation-carrying BL line International Journal of Cancer 43, 273-278.
39. WALTZER, L., LOGEAT, F., BROU, C., ISRAEL, A., SERGEANT, A. & MANET, E. (1994). The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements. EMBO Journal 13, 5633-5638.
40. WANG, F., GREGORY, C. D., ROWE, M., RICKINSON, A. B., WANG, D., BIRKENBACH, M., KIKUTANI, H., KISHIMOTO, T. & KIEFF, E. (1987). Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proceedings of the National Academy of Sciences, USA 84, 3452-3456.
41. WOISETSCHLAEGER, M.. JIN, X. W., YANDAVA, C. N., FURMANSKI, L. A., STROMINGER, J. L. & SPECK, S. H. (1991). Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection. Proceedings of the National Academy of Sciences, USA 88, 3942-3946.
42. YATES, J., WARREN, N., REISMAN, D. & SUGDEN, B. (1984). A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proceedings of the National Academy of Sciences, USA 81, 3806-3810.
43. ZIMBER-STROBL, U , SUENTZENICH, K. O., LAUX, G., EICK, D., CORDIER, M., CALENDER, A., BILLAUD, M., LENOIR, G. M. & BORNKAMM, G. W. (1991). Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene. Journal of Virology 65, 415-423.
44. ZIMBER-STROBL, U., KREMMER, E., GRASSER, F., MARSCHALL, G., LAUX, G. & BORNKAMM, G. W. (1993). The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter EMBO Journal 12, 167-175.
45. ZIMBER-STROBL, U., STROBL, L. J., MEITINGER, C., HINRICHS, R., SAKAI, T., FURUKAWA, T., HONJO, T. & BORNKAMM, G. W. (1994). The Epstein-Barr virus nuclear antigen 2 exerts its function through interaction with recombination signal binding protein RBP-J Kappa, the homologue of Drosophila suppressor of hairless. EMBO Journal 13, 4973-4982.