Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme

Molecular Pharmacology

Volumn 55, Issue 3, 1999, Pages 508-514

  D'Amours, Marc R ^a   Granovsky, Alexey E ^b   Artemyev, Nikolai O ^b   Cote, Rick H ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [6 CHLORO 4 (3,4 METHYLENEDIOXYBENZYLAMINO) 2 QUINAZOLINYL] 4 PIPERIDINECARBOXYLIC ACID; CYCLIC GMP; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; ZAPRINAST;

ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CYCLIC GMP; ENZYME ACTIVATION; HOLOENZYMES; ISOENZYMES; PHOSPHODIESTERASE INHIBITORS; PHOTORECEPTORS, VERTEBRATE; PIPERIDINES; QUINAZOLINES; RANIDAE;

EID: 0033054952     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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