Synthesis and biological testings as inhibitors of HMGCoA reductase of the seco-acid of tuckolide and its C-7 epimer

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 6, 1999, Pages 1049-1057

  Colle, Stéphane ^a   Taillefumier, Claude ^a   Chapleur, Yves ^a   Liebl, Rex ^b   Schmidt, Arthur ^b  

^a NANCY UNIVERSITÉ   (France)

^b DOW AGROSCIENCES LLC   (United States)

Author keywords

Cholestereol biosynthesis; HMGCoA reductase; Inhibition; Synthesis; Tuckolide

Indexed keywords

DECARESTRICTIN D; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; TUCKOLIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHOLESTEROL SYNTHESIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERCHOLESTEROLEMIA; METHODOLOGY; NONHUMAN;

ALDEHYDES; ANGIOSPERMS; ANIMALS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LACTONES; MICROSOMES, LIVER; PHOSPHONIC ACIDS; PLANTS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

PISUM SATIVUM;

EID: 0033050430     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00020-6     Document Type: Article

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