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Volumn 61, Issue 25, 1996, Pages 8780-8785

Synthesis of tuckolide, a new cholesterol biosynthesis inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; TUCKOLIDE; UNCLASSIFIED DRUG;

EID: 0030444444     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961686+     Document Type: Article
Times cited : (47)

References (61)
  • 37
    • 33744688762 scopus 로고    scopus 로고
    • note
    • Compounds 4 and 5 were treated separately with dicyanodichloroquinone giving the isomericp-methoxybenzylidine acetals. The 'H NMR J-couplings for the oxygen-bearing methine protons (12 Hz axial, 5 Hz equatorial) were then used to make the synfanti assignments.
  • 39
    • 33947334412 scopus 로고
    • Obtained from the reaction of DIBAL with l-hydroxy-3-butyne followed by trapping with iodine and protection as the TBS ether (30 overall yield, unoptimized). Zweifel, G.; Whitney, C. C. J. Am. Chem. Soc. 1967, 89, 2753.
    • (1967) J. Am. Chem. Soc. , vol.89 , pp. 2753
    • Zweifel, G.1    Whitney, C.C.2
  • 53
    • 33847479032 scopus 로고    scopus 로고
    • P = MOM, R = H. Four isomers where formed with' the approximate ratio: (2:l:l:trace). The stereochemistry was not assigned.
    • P = MOM, R = H. Four isomers where formed with' the approximate ratio: (2:l:l:trace). The stereochemistry was not assigned.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.