Generalized autoimmunity of the nervous system (GANS) induced by a recombinant protein composed of major pathogenic determinants of MBP, IRBP, and P2 protein: Suppression of inflammation by a monoclonal antibody against activated rat T line cells

Journal of Neuroscience Research

Volumn 45, Issue 3, 1996, Pages 303-307

  Schluesener, Hermann ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

encephalomyelitis; inflammation; neuritis; tolerance; uveoretinitis

Indexed keywords

INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; MONOCLONAL ANTIBODY; MYELIN BASIC PROTEIN; PROTEIN P21; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; ENCEPHALOMYELITIS; GENE INDUCTION; GENETIC CODE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INFLAMMATION; MOLECULAR CLONING; NEURITIS; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION; TARGET CELL; UVEORETINITIS;

EID: 0029744693     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960801)45:3<303::AID-JNR12>3.0.CO;2-4     Document Type: Article

References (19)

1. Al-Sabbagh A, Miller A, Santos LM, Weiner HL (1994): Antigen-driven tissue-specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol 24:2104-2109.
2. Barton K, McLauchlan MT, Calder VL, Lightman S (1995): The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis. Cell Immunol 164:133-140.
3. Caspi RR (1995): Experimental autoimmune uveoretinitis-rat and mouse. In Cohen ER, Miller A (eds):: "Autoimmune Disease Models." San Diego: Academic Press.
4. Cohen K, Miller A (1995): "Autoimmune Disease Models" San Diego: Academic Press.
5. Gautam AM (1995): Self and non-self peptides treat autoimmune encephalomyelitis: T cell anergy or competition for major histocompatibility complex class II binding ? Eur J Immunol 25:2059-2063.
6. Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW (1993): Microglial involvement in experimental autoimmune inflammation of the central and peripheral nervous system. Glia 7:50-59.
7. Gould KE and Swanborg RH (1993): T and B cell responses to myelin basic protein and encephalitogenic epitopes. J Neuroimmunol 46:193-198.
8. Gregorian SK, Clark L, Heber-Katz E, Amento EP, Rostami A (1993): Induction of peripheral tolerance with peptide-specific-anergy in experimental autoimmune neuritis. Cell Immunol 150:298-310.
9. Inoue H, Takeuchi T, Tanaka M, Usui S, Taguchi O (1994): Analysis of the uveitogenic determinant in repeat structure of retinal interphotoreceptor retinoid-binding protein (IRBP). Clin Exp Immunol 97:219-225.
10. Kobayashi Y, Kawai K, Honda H, Tomida S, Niimi N, Tamatani T, Miyasaka M, Yoshikai Y (1995): Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis. Cell Immunol 164:295-305.
11. Kunz J, Krause D, Gehrmann J, Dermietzel R (1995): Changes in the expression pattern of blood-brain barrier-associated pericytic aminopeptidase N (pAPN) in the course of acute experimental autoimmune encephalomyelitis. J Neuroimmunol 59:41-55.
12. Mesri M, Liversidge J, Forrester JV (1994): ICAM-1/LFA-1 interactions in T-lymphocyte activation and adhesion to cells of the blood-retina barrier in the rat. Immunology 83:52-57.
13. Schluesener HJ (1987): T cell line mediated EAE: Prevention and therapy by a monoclonal antibody specific for T lymphoblasts. J Neuroimmunol 14:339-343.
14. Schluesener HJ, Brunner C, Vass K, Lassmann (1986): Therapy of rat autoimmune disease by a monoclonal antibody specific for T lymphoblasts. J Immunol 137:3814-3820.
15. Sun D, Le J, Coleclough C (1993): Diverse T cell receptor chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein. Eur J Immunol 23:494-498.
16. Takeuchi HI, Tanaka T, Usui M, Ando S, Taguchi O (1994): Analysis of the uveitogenic determinant repeat structure of retinal interphotoreceptor retinoid-binding protein (IRBP). Clin Exp Immunol 97:219-225.
17. Wadhwani KC, Rapoport SI (1994): Transport properties of vertebrate blood-nerve barrier: Comparison with blood-brain barrier. Prog Neurobiol 43:235-279.
18. Wildner G, Thurau SR (1995): Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye. Eur J Immunol 25:1292-1297.
19. Zhang XM, Esch TR, Clark L, Gregorian S, Rostami A, Otvos L, Heber-Katz E (1994): Neuritogenic Lewis rat T cells use Tcrb chains that include a new Tcr-V8 family member. Immunogenetics 40:266-270.