Redefining the therapeutic goals in chronic lymphocytic leukemia: Towards an evidence-based, risk-adapted therapy

Annals of Oncology

Volumn 10, Issue 5, 1999, Pages 505-509

  Wendtner, C M ^a   Schmitt, B ^a   Wilhelm, M ^b   Dreger, P ^c   Montserrat, E ^d   Emmerich, B ^a   Hallek, M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

CLL; Cytogenetics; Infection; Pathogenesis; Therapy

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; BRYOSTATIN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLAVOPIRIDOL; FLUDARABINE; MITOXANTRONE; RITUXIMAB;

AUTOIMMUNITY; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; HUMAN; INFECTION; MOLECULAR GENETICS; NOTE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS;

BACTERIAL INFECTIONS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; PROGNOSIS; VIDARABINE;

EID: 0033044207     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1023/A:1026481430446     Document Type: Note

References (16)

1. Dohner H, Stilgenbauer S, Dohner K. et al. Chromosome aberrations in B-cell chronic lymphocytic leukemia: Reassessment based on molecular cytogenetic analysis. J Mol Med 1999; 77: 266-81.
2. Molica S, Vitelli G, Levato D et al. CD27 in B-cell chronic lymphocytic leukemia. Cellular expression, serum release and correlation with other soluble molecules belonging to nerve growth factor receptors (NGFr) superfamily. Haematologica 1998; 83: 398-402.
3. Romano MF, Lamberti A, Tassone P et al. Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B-chronic lymphocytic leukemia cells. Blood 1998; 92: 990-5.
4. Vrhovac R, Delmer A, Tang R et al. Prognostic significance of the cell cycle inhibitor p27Kipl in chronic B-cell lymphocytic leukemia. Blood 1998; 91: 4694-700.
5. Caligaris-Cappio F. Relationship between autoimmunity and immunodeficiency in CLL. Hematol Cell Ther 1997; 39: 13-6.
6. Diehl LF, Ketchum LH. Autoimmune disease and chronic lymphocytic leukemia: Autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia. Semin Oncol 1998; 25: 80-97.
7. Lambe CV, Averett DR, Paff MT et al. 2-Amino-6-methoxypurine arabinoside: An agent for T-cell malignancies. Cancer Res 1995; 55: 3352-6.
8. Gandhi V, Plunkett W, Rodriguez COJ et al. Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response. J Clin Oncol 1998; 16: 3607-15.
9. Arguello F, Alexander M, Sterry JA et al. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood 1998; 91: 2482-90.
10. Senderowicz AM, Headlee D, Stinson SF et al. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 1998; 16: 2986-99.
11. Osterborg A, Dyer MJ, Bunjes D et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H treatment in chronic lymphocytic leukemia. J Clin Oncol 1997; 15: 1567-74.
12. Kato K, Cantwell MJ, Sharma S et al. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998; 101: 1133-41.
13. Khouri IF, Keating M, Korbling M et al. Transplantation-lite: Induction of graft-verjuj-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 1998; 16: 2817-24.
14. Morrison VA. The infectious complications of chronic lymphocytic leukemia. Semin Oncol 1998; 25: 98-106.
15. Sudhoff T, Arming M, Schneider W. Prophylactic strategies to meet infectious complications in fludarabine-treated CLL. Leukemia 1997; 11 (Suppl 2): S38-1.
16. Persico M, De Renzo A, Persico E et al. Chronic liver disease and lymphoproliferative disorders in HCV-positive patients: A working hypothesis. J Hepatol 1998; 29: 857-8.