Liver circulation in the development of portal hypertension

Hepato-Gastroenterology

Volumn 46, Issue SUPPL. 2, 1999, Pages 1429-1433

  Clemens, M G ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATIC ARTERY; LIVER CIRCULATION; PORTAL HYPERTENSION; PRIORITY JOURNAL; REVIEW; VASCULAR RESISTANCE;

ANIMALS; ENDOTHELINS; HEPATIC ARTERY; HUMANS; HYPERTENSION, PORTAL; LIVER CIRCULATION; NITRIC OXIDE SYNTHASE; PORTAL SYSTEM; REGIONAL BLOOD FLOW; VASCULAR RESISTANCE;

EID: 0033042811     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Lautt WW, Greenway CV: Conceptual review of the hepatic vascular bed. Hepatology 1987; 7:952-963.
2. McCuskey RS, Urbaschek R, McCuskey PA, Urbaschek B: In vivo microscopic studies of the responses of the liver to endotoxin. Klin Wochenschr 1982; 60:749-751.
3. Clemens MG, McDonagh PF, Chaudry IH, Baue AE: Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment. Am J Physiol 1985; 248:H804-H811.
4. Sherman IA, Pappas SC, Fisher MM: Hepatic microvascular changes associated with development of liver fibrosis and cirrhosis. Am J Physiol 1990; 258:H460-H465.
5. Clemens MG, Bauer M, Gingalewski C, Miescher E, Zhang JX: Hepatic intercellular communication in shock and inflammation. Shock 1994; 2:1-9.
6. Wake K: Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sìnusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol 1980; 66:303-353.
7. Clemens MG, Bauer M, Pannen BHJ, Bauer I, Zhang JX: Remodeling of hepatic microvascular responsiveness after ischemia/reperfusion. Shock 1997; 8:80-85.
8. Pannen BHJ, Bauer M, Noldge-Schomburg GF, Zhang JX, Robotham JL, Clemens MG, Geiger KK: Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins. Am J Physiol 1997; 272:H2736-H2745.
9. Pannen BHJ, Bauer M, Zhang JX, Robotham JL, Clemens MG: A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol 1996; 271:H1953-H1961.
10. Imakita M, Yamanaka N, Kuroda N, Kitayama Y, Sasaki S, Nakagaki I, Hori S, Okamoto E: Effects of the endothelin receptor antagonist TAK-044 on hepatocyte element alterations in the ischemic-reperfused liver in Beagle dogs. J Hepatol 1998; 28:204-211.
11. Kawamura E, Yamanaka N, Okamoto E, Tomoda F, Furukawa K: Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury. Hepatology 1995; 21:1138-1143.
12. Nakamura S, Nishiyama R, Serizawa A, Yokoi Y, Suzuki S, Konno H, Baba S, Muro H: Hepatic release of endothelin-1 after warm ischemia. Reperfusion injury and its hemodynamic effect. Transplantation 1995; 59:679-684.
13. Liu B, Zhou J, Chen H, Wang D, Hu D, Wen Y, Xiao N: Expression and cellular location of endothelin-1 mRNA in rat liver following endotoxemia. Chin Med J 1997; 110:932-935.
14. Sonin NV, Garcia-Pagán JC, Nakanishi K, Zhang JX, Clemens MG: Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock 1999; 11:175-179.
15. Poo J-L, Jiménez W, Muñoz RM, Bosch-Marcé M, Bordas N, Morales-Ruiz M, Pérez M, Deulofeu R, Solé M, Arroyo V, Rodès J: Chronic blockade of endothelin receptors in cirrhotic rats: hepatic and hemodynamic effects. Gastroenterology 1999; 116:161-167.
16. Rockey DC, Weisiger RA: Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996; 24:233-240.
17. Gandhi CR, Nemoto EM, Watkins SC, Subbotin VM: An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats. Liver 1998; 18:39-48.
18. Gandhi CR, Sproat LA, Subbotin VM: Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats. Life Sci 1996; 58:55-62.
19. Bauer M, Paquette NC, Zhang JX, Bauer I, Pannen BHJ, Kleeberger SR, Clemens MG: Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat. Hepatology 1995; 22:1565-1576.
20. Nanji AA, Khwaja S, Khettry U, Sadrzadeh SM: Plasma endothelin levels in chronic ethanol fed rats: relationship to pathologic liver injury. Life Sci 1994; 54:423-428.
21. Oshita M, Takei Y, Kawano S, Yoshihara H, Hijioka T, Fukui H, Goto M, Masuda E, Nishimura Y, Fusamoto H: Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver. J Clin Invest 1993; 91:1337-1342.
22. Dhar DK, Yamanoi A, Ohmori H, Nakashima Y, Yamamoto A, Osama NE, Kubota H, Kohno H, Nagasue N: Modulation of endothelin and nitric oxide: a rational approach to improve canine hepatic microcirculation. Hepatology 1998; 28:782-788.
23. Ohuchi T, Tada K, Akamatsu K: Endogenous ET-1 contributes to liver injury induced by galactosamine and endotoxin in isolated perfused rat liver. Am J Physiol 1995; 268:G997-G1003.
24. Pannen BHJ, Al-Adili F, Bauer M, Clemens MG, Geiger KK: Role of endothelins and nitric oxide in hepatic reperfusion injury in the rat. Hepatology 1998; 27:755-764.
25. Rockey DC, Chung JJ: Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing. J Clin Invest 1996; 98:1381-1388.
26. Urakami A, Todo S, Zhu Y, Zhang S, Jin MB, Ishizaki N, Shimamura T, Totsuka E, Subbotin V, Lee R, Starzl TE: Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, AwETN40. J Am Coll Surg 1997; 185:358-364.
27. Pannen BHJ, Bauer M, Zhang JX, Robotham JL, Clemens MG: A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol 1996; 271:H1953-H1961.
28. Harbrecht BG, Billiar TR, Stadler J, Demetris AJ, Ochoa J, Curran RD, Simmons RL: Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukoc Biol 1992; 52:390-394.
29. Harbrecht BG, Wu B, Watkins SC, Marshall HPJ, Peitzman AB, Billiar TR: Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. Shock 1995; 4:332-337.
30. Saetre T, Gundersen Y, Thiemermann C, Lilleaasen P, Aasen AO: Aminoethyl-isothiourea, a selective inhibitor of inducible nitric oxide synthase activity, improves liver circulation and oxygen metabolism in a porcine model of endotoxemia. Shock 1998; 9:109-115.
31. Thiemermann C, Ruetten H, Wu CC, Vane JR: The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 1995; 116:2845-2851.
32. Wray GM, Millar CG, Hinds CJ, Thiemermann C: Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock 1998; 9:329-335.
33. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, Harbrecht BG, Billiar TR: Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1997; 1:404-416.
34. Rockey DC, Chung JJ: Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998; 114:344-351.
35. Rockey DC, Chung JJ: Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J Clin Invest 1995; 95:1199-1206.
36. Zhang JX, Pegoli WJ, Clemens MG: Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266:G624-G632.
37. Macedo MP, Lautt WW: Shear-induced modulation of vasoconstriction in the hepatic artery and portal vein by nitric oxide. Am J Physiol 1998; 274:G253-G260.
38. Shah V, Haddad FG, Garcia-Cardeña G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC: Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997; 100:2923-2930.
39. Lee JW, Filkins JP: Exogenous ATP and hepatic hemodynamics in the perfused rat liver. Circ Shock 1988; 24:99-110.
40. Higuchi H, Satoh T: Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ET(B) receptors in isolated perfused rat liver. Eur J Pharmacol 1997; 328:175-182.
41. Sonin NV, García-Pagán JC, Nakanishi K, Zhang JX, Clemens MG: Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock 1999; 11:175-179.
42. Bauer M, Bauer I, Sonin NV, Kresge N, Baveja R, Harding D, Yokoyama Y, Zhang JX, Clemens MG: Functional significance of endothelin-B receptor expression in endotoxemia. Shock 1999; In press.
43. Suematsu M, Kashiwagi S, Sano T, Goda N, Shinoda Y, Ishimura Y: Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem Biophys Res Commun 1994; 205:1333-1337.
44. Suematsu M, Goda N, Sano T, Kashiwagi S, Egawa T, Shinoda Y, Ishimura Y: Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest 1995; 96:2431-2437.
45. Bauer M, Pannen BHJ, Bauer I, Herzog C, Wanner GA, Hanselmann R, Zhang JX, Clemens MG, Larsen R: Evidence for a functional link between stress response and vascular control in hepatic portal circulation. Am J Physiol 1996; 271:G929-C935.
46. Pannen BH, Bauer M: Differential regulation of hepatic arterial and portal venous vascular resistance by nitric oxide and carbon monoxide in rats. Life Sci 1998; 62:2025-2033.
47. Downard PJ, Wilson MA, Spain DA, Matheson PJ, Siow Y, Garrison RN: Heme oxygenase-dependent carbon monoxide production is a hepatic adaptive response to sepsis. J Surg Res 1997; 71:7-12.
48. Vallance P, Moncada S: Role of endogenous nitric oxide in septic shock. New Horiz 1993; 1:77-86.
49. Jaeschke H, Farhood A: Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991; 260:G355-G362.
50. Liu P, McGuire GM, Fisher MA, Farhood A, Smith CW, Jaeschke H: Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 1995; 3:56-62.
51. Fukatsu K, Saito H, Han I, Furukawa S, Lin MT, Matsuda T, Ikeda S, Inoue T, Yasuhara H, Muto T: Nitric oxide donor decreases neutrophil adhesion in both lung and peritoneum during peritonitis. J Surg Res 1998; 74:119-124.
52. Harbrecht BG, Wu B, Watkins SC, Billiar TR, Peitzman AB: Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats. Shock 1997; 8:415-421.
53. Liu P, Yin K, Nagele R, Wong PY: Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accumulation in hepatic ischemia-reperfusion in rats. J Pharmacol Exp Ther 1998; 284:1139-1146.
54. Liu P, Xu B, Hock CE, Nagele R, Sun FF, Wong PY: NO modulates P-selectin and ICAM-1 mRNA expression and hemodynamic alterations in hepatic I/R. Am J Physiol 1998; 275:H2191-H2198.
55. Farhood A, McGuire GM, Manning AM, Miyasaka M, Smith CW, Jaeschke H: Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J Leukoc Biol 1995; 57:368-374.
56. Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA: Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 1996; 139:213-226.
57. Rockey D: The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997; 25:2-5.
58. Rockey DC, Housset CN, Friedman SL: Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 1993; 92:1795-1804.
59. Yang W, Benjamin IS, Alexander B: The role of nitric oxide in hepatic arterial and portal venous responses to noradrenaline and ATP in rats with secondary biliary cirrhosis. Hepato-Gastroenterol 1999; 46 (Suppl. II); p. 1442. (Abstract)
60. Richter S, Menger MD, Vollmar B: Impact of liver cirrhosis on hepatic blood flow regulation. Hepato-Gastroenterol 1999; 46 (Suppl. II); p. 1441. (Abstract)
61. Kleber G, Steudel N, Behrmann C, Zipprich A, Lotterer E, Fleig WE: Hepatic arterial flow reserve in patients with cirrhosis. Hepato-Gastroenterol 1999; 46 (Suppl. II); 1442. (Abstract)