Effects of the group II metabotropic glutamate receptor agonist, LY354740 on schedule-controlled behaviour in rats

Behavioural Pharmacology

Volumn 10, Issue 3, 1999, Pages 319-325

  Moore, N A ^a   Rees, G ^a   Monn, J A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Conflict behaviour; Fixed interval; Fixed ratio; LY354740; Metabotropic glutamate (mGlu) receptors; Rat; Schedule controlled behaviour

Indexed keywords

EGLUMETAD; METABOTROPIC RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONFLICT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EXPLORATORY BEHAVIOR; INSTRUMENTAL CONDITIONING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; REWARD;

EID: 0033040762     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199905000-00008     Document Type: Article

References (11)

1. Conn PJ, Pin JP (1997). Pharmacology and functions of metabotropic glutamate receptors. Ann Rev Pharmacol Toxicol 37:205-237.
2. Dews PB (1977). Rate-dependency hypothesis. Science 198:1182-1183.
3. Geller I, Seifter J (1960). The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally-induced conflict in the rat. Psychopharmacologia 1:482-492.
4. Helton DR, Tizzano JP, Monn JA, Schoepp DD, Kallman MJ (1998). Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J Pharmacol Exp Ther 284:651-660.
5. Moghaddam B, Adams BW (1998). Reversal of phencyclidine effects by a Group II metabotropic glutamate receptor agonist in rats. Science 281:1349-1352.
6. Monn JA, Valli MJ, Massey SM, Wright RA, Salhoff CR, Johnson BG et al. (1997). Design, synthesis, and pharmacological characterization of ( + )-2-aminobicyclo[3,1,0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group II metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J Med Chem 40:528-537.
7. Moore NA, Rees G, Sanger G, Tye NC (1994). Effects of olanzapine and other antipsychotic agents on responding maintained by a conflict schedule. Behav Pharmacol 5:196-202.
8. Robbins TW (1981). Behavioural determinants of drug action: rate dependency revisited. In: Theory in psychopharmacology. Cooper SJ (editor). London: Academic Press, pp. 1-63.
9. Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Mayne NG, Wu S et al. (1997). LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36:1-11.
10. SAS User's Guide (1985). Statistics, 5th ed. Cary, NC: SAS Institute, pp. 433-507.
11. Tye NC, Iversen SD, Green AR (1979). The effects of benzodiazepines and serotonergic manipulations on punished responding. Neuropharmacology 18:689-695.