Synthesis and evaluation of the physicochemical properties of esterase- sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker

Journal of Peptide Research

Volumn 53, Issue 4, 1999, Pages 393-402

  Bak, A ^a   Siahaan, T J ^b   Gudmundsson, O S ^b,d   Gangwar, S ^b,c   Friis, G J ^a   Borchardt, Ronald T ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF KANSAS   (United States)

^c Coulter Pharmaceuticals Inc ^*  (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

Leu5 enkephalin; Cyclic prodrug (acyloxy)alkoxy; DADLE; Peptide delivery

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ESTERASE; GLYCOPROTEIN P; LEUCINE ENKEPHALIN; OPIATE PEPTIDE; PRODRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; SYNTHESIS;

AMINO ACID SEQUENCE; CHEMISTRY, PHYSICAL; ENKEPHALIN, LEUCINE; ENKEPHALIN, LEUCINE-2-ALANINE; ESTERASES; OPIOID PEPTIDES; PEPTIDES, CYCLIC; PRODRUGS;

EID: 0033040559     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00070.x     Document Type: Article

References (17)

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