Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug System for Peptides That Utilizes a "Trimethyl Lock"-Facilitated Lactonization Reaction

Journal of Organic Chemistry

Volumn 62, Issue 5, 1997, Pages 1363-1367

  Wang, Binghe ^a,b   Gangwar, Sanjeev ^a,c   Pauletti, Giovanni M ^a   Siahaan, Teruna J ^a   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c Prolinx Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; PRODRUG;

ARTICLE; DRUG STABILITY; HYDROLYSIS; IN VITRO STUDY; METHODOLOGY; PEPTIDE SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030932221     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961778z     Document Type: Article

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