Suppression of immediate and late responses to antigen by a non- anaphylactogenic anti-IgE antibody in a murine model of asthma

European Respiratory Journal

Volumn 13, Issue 5, 1999, Pages 961-969

  Haile, S ^a   Lefort, J ^a   Eum, S Y ^a   Dumarey, C ^a   Huerre, M ^a   Heusser, C ^b   Vargaftig, B B ^a,c  

^a INSTITUT PASTEUR   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c U de Pharmacologie Cell   (France)

Author keywords

Basophils; Bronchopulmonary hyperreactivity; Eosinophils; Immunoglobulin E; Interleukin 4

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 4;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BASOPHIL; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EOSINOPHIL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ASTHMA; BASOPHILS; BRONCHIAL HYPERREACTIVITY; EOSINOPHILS; IMMUNOGLOBULIN E; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; OVALBUMIN; RATS; TIME FACTORS;

EID: 0033037430     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3003.1999.13e06.x     Document Type: Article

References (41)

1. Metzger WJ, Zavala D, Richerson HB, et al. Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation. Am Rev Respir Dis 1987; 135: 433-440.
2. Sunyer J, Anto JM, Sabria J, et al. Relationship between serum IgE and airway responsiveness in adults with asthma. J Allergy Clin Immunol 1995; 95: 699-706.
3. Brunner T, Heusser CH, Dahinden CA. Human peripheral blood basophils primed by IL-3 produce IL-4 in response to IgE receptor stimulation. J Exp Med 1993; 177:605-611.
4. Galli SJ. The mast cell: a versatile effector cell for a challenging world. Int Arch Allergy Immunol 1997; 113: 14-22.
5. Stingl G, Maurer D. IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting, cells. Int Arch Allergy Immunol 1997; 113: 24-29.
6. Stadler BM, Nakajima K, Yang X, Week ALd. Potential role of anti-IgE antibodies in vivo. Int Arch Allergy Appl Immunol 1989; 88: 206-208.
7. Eum SY, Haile S, Lefort J, Huerre M, Vargaftig BB. Eosinophil recruitment into respiratory epithelium following antigenic challenge in hyper-IgE mice accompanied by interleukin 5-dependent bronchial hyperreactiveness. Proc Natl Acad Sci USA 1995; 92: 12290-12294.
8. Lefort J, Bachelet CM, Leduc D, Vargaftig BB. Effect of antigen provocation of IL-5 transgenic mice on eosinophil mobilization and bronchial hyperresponsiveness. J Allergy Clin Immunol 1996; 97: 788-799.
9. Coyle AJ, Wagner K, Bertrand C, Tsuyuki S, Bews J, Heusser C. Central role of immunoglobulin (Ig)E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 1996; 183: 1303-1310.
10. Heusser CH, Wagner K, Bews JPA, et al. Demonstration of the therapeutic potential of non-anaphylactogenic anti-IgE antibodies in murine models of skin reaction, lung function and inflammation. Int Arch Allegy Immunol 1997; 113: 231-235.
11. Fahy JV, Fleming HE, Wong HH, et al. The effect of an anti-IgE monoclonal antibody on the early and late responses to allergen inhalation in asthmatic subjects. Am Respir J Crit Care Med 1997; 155: 1828-1834.
12. Helm BA. Is there a link between the agent nature of the agents that trigger mast cells and the induction of immunoglobulin (IG)E synthesis? Adv Exp Med Biol 1994; 347: 1-10.
13. Chvatchko Y, Kosco-Vilbois MH, Herren S, Lefort J, Bonnefoy JY. Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge. J Exp Med 1996; 184:2353-2360.
14. Eum SY, Créminon C, Haile S, Lefort J, Vargaftig BB. Inhibition of airway inflammation by dexamethasone is followed by reduced bronchial hyperreactivity in BP2 mice. Clin Exp Allergy 1996; 26: 971-979.
15. Hamelmann E, Schwarze J, Takeda K, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997; 156: 766-775.
16. Ten RM, Pearce LR, McKean DJ, Bell MP, Gleich GJ. Molecular cloning of the human eosinophil peroxidase: evidence for the existence of a peroxidase multigene family. J Exp Med 1989; 169: 1757-1769.
17. Bancroft JD, Cook HC, Stirling RW, eds. Enzyme histochemistry. In: Manual of Histological Techniques and their Diagnostic Application. London, Churchil Livingstone, 1994; pp. 289-322.
18. Davis EM, Gosset LA, Pinkston KL, et al. Can anti-IgE be used to treat allergy? Semin Immunopathol 1993; 15: 51-73.
19. Daniel WW. Biostatistics: a Foundation for Analysis in the Health Sciences. 5 Edn. Singapore; John Wiley & Sons, 1991; p. 740.
20. Galli SJ, Costa JJ. Mast-cell-leukocyte cytokine cascades in allergic inflammation. Allergy 1995; 50: 851-862.
21. Huntley JF, Newlands GF, Gibson S, Ferguson A, Miller HR. Histochemical demonstration of chymotrypsin-like serine esterases in mucosal mast cells in four species including man. J Clin Pathol 1985; 38: 375-384.
22. Bradding P, Roberts JA, Britten KM, et al. Interleukin-4, -5, -6 and tumor necrosis factor-a in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994; 10: 471-480.
23. Gavett SH, O'Heam J, Karp CL, et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am J Physiol 1997; 272: L253-L261.
24. Seder RA, Paul WE, Dvorak AM, et al. Mouse splenic and bone marrow cell populations that express high-affinity Fcε receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci USA 1991; 88: 2835-2839.
25. de-Andres B, Rakasz E, Hagen M, et al. Lack of Fc-epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infections. Blood 1997; 89: 3826-3836.
26. Koshino T, Arai Y, Miyamoto Y, et al. Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness. J Asthma 1996; 33: 89-95.
27. Haile S, Lefort J, Joseph D, Gounon P, Huerre P, Vargaftig BB. Mucous-cell metaplasia and inflammatory-cell recruitment are dissociated in allergic mice after antibody- and drug-dependent cell depletion in a murine model of asthma. Am J Respir Cell Mol Biol 1999 (in press).
28. Gershwin LJ, Osebold JW, Zee YC. Immunoglobulin E-containing cells in mouse lung following allergen and ozone exposure. Int Archs Allergy Appl Immunol 1981; 65: 266-277.
29. Schroeder JT, Lichtenstein LM, MacDonald SM. An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils. J Exp Med 1996; 183: 1265-1270.
30. Yamaguchi M, Lantz CS, Oettgen HC, et al, IgE enhanced mouse mast cell FceRI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med 1997; 185: 663-672.
31. Yanagihara Y, Kajiwara K, Basaki Y, et al. Cultured basophils but not cultured mast cells induce human IgE synthesis in B cells after immunologic stimulation. Clin Exp Immunol 1998; 111: 136-143.
32. Jeffery PK. Comparative morphology of the airways in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994; 150: S6-13.
33. Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med 1997; 186: 1737-1747.
34. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282: 2258-2261.
35. Granig G, Warnock M, Wakil AE, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282: 2261-2263.
36. Heusser C, Jardieu P. Therapeutic potential of anti-IgE antibodies. Curr Opin Immunol 1997; 9: 805-814.
37. Rudolf MP, Furukawa K, Miescher S, Vogel M, Kricek F, Stadler BM. Effect of anti-IgE antibodies on FcεRI-bound IgE. J Immunol 1996; 157: 5646-5652.
38. Ben-Sasson SZ, Gros GL, Conrad DH, Finkeman FD, Paul WE. Cross-linking Fe receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci USA 1990; 87: 1421-1425.
39. Mehlhop PD, Rijn Mvd, Goldberg AB, et al. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci USA 1997; 94: 1344-1349.
40. Dombrowicz D, Flamand V, Miyajima I, Ravetch JV, Galli SJ, Kinet JP. Absence of FcεRI alpha chain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between FcεRI and FcγRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 1997; 99: 915-925.
41. MacClashan DW, Bochner BS, Adelman DC, et al. Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997; 158: 1438-1445.