Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice

Journal of Endocrinology

Volumn 161, Issue 3, 1999, Pages 383-392

  Dominici, F P ^a   Cifone, D ^a   Bartke, A ^b   Turyn, D ^a  

^a Instituto de Quimica y Fisicoquimica Biologicas Buenos Aires   (Argentina)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GROWTH HORMONE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR ANTIBODY; INSULIN RECEPTOR SUBSTRATE 1; LIVER EXTRACT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; RECEPTOR SUBUNIT;

ARTICLE; BETA CHAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBUNIT; FEMALE; GROWTH HORMONE BLOOD LEVEL; HYPERINSULINEMIA; IMMUNOBLOTTING; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIVER; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ENZYME ACTIVATION; GROWTH HORMONE; IMMUNOBLOTTING; INSULIN; LIVER; MICE; MICE, TRANSGENIC; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 0033037104     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1610383     Document Type: Article

References (39)

1. Ader M, Agajanian T, Finegood DT & Bergman RN 1987 Recombinant deoxyribonucleic acid-derived 22K-and 20K-human growth hormone generate equivalent diabetogenic effects during chronic infusion in dogs. Endocrinology 120 725-731.
2. Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun X, Miralpeix M, Hu P, Margolis B, Skolink EY, Schlessinger J & White MF 1992 Phosphatidylinositol 3-kinase is activated by association with 1RS-1 during insulin stimulation. EMBO Journal 11 3469-3479.
3. Balbis A, Bartke A & Turyn D 1996 Overexpression of bovine growth hormone in transgenic mice is associated with changes in hepatic insulin receptors and in their kinase activity. Life Sciences 59 1363-1371.
4. Beck P, Schalch DS, Parker ML, Kipnis DM & Daughaday WH 1965 Correlative studies of growth hormone and insulin plasma concentrations with metabolic abnormalities in acromegaly. Journal of Laboratory and Clinical Medicine 66 366-374.
5. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254.
6. Carvalho CRO, Brenelli SL, Silva AC, Nunes ALB, Velloso LA & Saad MJA 1996 Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. Endocrinology 137 151-159.
7. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J &Kahn CR 1994 Phosphatidylinositol 3-kinase activation is required for insulin stimulation of p70s6-kinase, DNA synthesis and glucose transporter translocation. Molecular and Cellular Biology 14 4902-4911.
8. Chou CK, Dull TJ, Russell DS, Gherzi R, Lebwohl D, Ullrich A & Rosen OM 1987 Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate post-receptor effects of insulin. Journal of Biological Chemistry 262 1842-1847.
9. Chung J, Grammer TC, Lemon KP, Kazlauskas A & Blenis J 1994 PDGF and insulin dependent p70 s6-kinase activation mediated by phosphatidylinositol-3-OH-kinase. Nature 370 71-75.
10. Davidson MB 1987 Effect of growth hormone on carbohydrate and lipid metabolism. Endocrine Reviews 8 115-131.
11. Davidson MB & Melmed S 1983 Hepatocyte insulin binding and action in rats with somatomammotrophic tumors. Diabetologia 25 60-65.
12. Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M & DeFronzo RA 1994 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 37 1025-1035.
13. Dominici FP, Balbis A, Bartke A & Turyn D 1998 Role of hyperinsulinemia on hepatic insulin receptor concentration and autophosphorylation in the presence of high growth hormone levels in transgenic mice overexpressing GH gene. Journal of Endocrinology 159 15-25.
14. Folli F, Saad MJA, Backer JM &Kahn CR 1992 Insulin stimulation of phosphatidylinositol 3-kinase and association with IRS-1 in liver and muscle of the intact rat. Journal of Biological Chemistry 267 22171-22177.
15. Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M & Rizza R 1986 Insulin resistance in acromegaly: defects m both hepatic and extrahepatic insulin action. American Journal of Physiology 250 E269-E273.
16. Kasuga M, Karlsson FA & Kahn CR 1982 Insulin stimulates the phosphorylation of the 95 000 dalton subunit of its own receptor. Science 215 185-187.
17. Kelly PA, Djiane J, Postel Vinay M-C & Edery M 1991 The prolactin/growth hormone receptor family. Endocrine Review 12 235-251.
18. s6k pathways. Biochemical Journal 315 517-522.
19. Le Marchand-Brustel Y, Gautier N, Cormont M & Van Obberghem E 1995 Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. Endocrinology 136 3564-3570.
20. McGrane MM, de Vente J, Yun J, Bloom J, Park E, Wynshaw-Boris A, Wagner T, Rottman FM & Hanson RW 1988 Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice. Journal of Biological Chemistry 263 11443-11451.
21. Moller N, Moller J, Jorgensen JO, Ovesen P, Schmitz O, Alberti KG & Christiansen JS 1993 Impact of 2 weeks high dose growth hormone treatment on basal and insulin stimulated substrate metabolism in humans. Clinical Endocrinology 5 575-581.
22. Morgan DO, Ho L, Korn LJ & Roth RA 1986 Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proceedings of the National Academy of Sciences of the USA 83 328-332.
23. Myers MG Jr & White MF 1995 New frontiers in insulin receptor substrate signalling. Trends in Endocrinology and Metabolism 6 209-215.
24. Ng SF, Storlien LH, Kraegen EW, Stuart MC, Chapman GE & Lazarus L 1990 Effect of biosynthetic human growth hormone on insulin action in individual tissues of the rat in vivo. Metabolism 39 264-268.
25. Ridderstrale M, Degerman E & Tornqvist 1995 Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. Journal of Biological Chemistry 270 3471-3474.
26. Rizza RA, Mandarino LJ & Gerich JE 1982 Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 31 663-669.
27. Rizza RA, Mandarino LJ, Genest J, Baker BA & Gerich JE 1985 Production of insulin resistance by hyperinsulinaemia in man. Diabetologia 28 70-75.
28. Ruderman NB, Kapeller R, White MF & Cantley LC 1990 Activation of phosphatidylinositol 3-kinase by insulin. Proceedings of the National Academy of Sciences of the USA 87 1411-1415.
29. Saad MJA, Araki E, Miralpeix M, Rothemberg PL, White MF & Kahn CR 1992 Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. Journal of Clinical Investigation 90 1839-1849.
30. Shepherd PR, Navé BT & O'Rahilly S 1996 The role of phosphoinositide 3-kinase in insulin signalling. Journal of Molecular Endocrinology 17 175-184.
31. Souza SC, Frick GP, Yip R, Raysildo BL, Tai L-R & Goodman HM 1994 Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1. Journal of Biological Chemistry 269 30085-30088.
32. Sun XJ, Rothemberg P, Kahn CR, Backer JM, Araki E, Wilden P, Cahill DA, Goldstein BJ & White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352 73-77.
33. Thirone ACP, Carvalho RO, Brenelli SL, Velloso LA & Saad MJA 1997 Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues. Molecular and Cellular Endocrinology 130 33-42.
34. Tobe K, Koshio O, Tashiro-Hashimoto Y, Takaku F, Akanuma Y & Kasuga M 1990 Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection. Diabetes 39 528-533.
35. Trimble ER, Atkinson AB, Buchanan KD & Hadden DR 1980 Plasma glucagon and insulin concentrations in acromegaly. Journal of Clinical Endocrinology and Metabolism 51 626-631.
36. Valera A, Rodriguez-Gil JE, Yun JS, McGrane MM, Hanson RW & Bosch F 1993 Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone. FASEB Journal 7 791-800.
37. Venkatesan N & Davidson MB 1995 Insulin resistance in rats harbouring growth hormone-secreting tumors: decreased receptor number but increased kinase activity in liver. Metabolism 44 75-84.
38. White MF & Kahn CR 1994 The insulin signalling system. Journal of Biological Chemistry 269 1-4.
39. Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, Kazaki Y & Kadowaki T 1998 Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly P13-kinase activation via JAK2 kinase. Journal of Biological Chemistry 273 15719-15726.