Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1

British Journal of Pharmacology

Volumn 127, Issue 2, 1999, Pages 441-448

  Vellenga, Edo ^a   Tuyt, Leonore ^a   Wierenga, Bart Jan ^a   Müller, Michael ^a   Dokter, Wim ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

IL 6 secretion; Leukotrienes; MK 571; Monocytes; MRP1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; PYRROLIDINE DITHIOCARBAMATE; VERLUKAST;

ARTICLE; CYTOKINE PRODUCTION; DNA BINDING; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL;

ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, NORTHERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; IMIDAZOLES; INTERLEUKIN-6; LEUKOTRIENE C4; LIPOPOLYSACCHARIDES; MONOCYTES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROPIONATES; PROTO-ONCOGENE PROTEINS C-JUN; PYRIDINES; QUINOLINES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL; UP-REGULATION;

EID: 0033036735     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702577     Document Type: Article

References (29)

1. Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T. & Saltiel, A.R. (1995). PD98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270, 27489-27494.
2. Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J.C., Haegeman, G., Cohen, P. & Fiers, W. (1996). The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J., 15, 1914-1917.
3. waf1/CIP1 via C/EBPβ. Nature Medicine, 3, 1233-1239.
4. Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. & Lee, J.C. (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229-234.
5. Dokter, W.HA., Dukstra, A.J., Koopmans, S.B., Stulp, B.K., Keck, W., Halie, M.R. & Vellenga, E. (1994). G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes. A study of the molecular mechanisms involved in inflammatory cytokine expression. J. Biol. Chem., 269, 4201-4207.
6. Dokter, W.H.A., Koopmans, S.B. & Vellenga, E. (1996). Effects of IL-10 and IL-4 on LPS-2 induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation. Leukemia. 10, 1308-1313.
7. 2 from human monocytes stimulated with aggreated IgG, IgA and IgE, J. Immunology, 136, 4188-4195.
8. Gekeler, V., Ise, W., Sanders, K.H., Ulrich, W.R. & Beck, J. (1995). The leukotriene LTD4 receptor antagonist MK-571 specifically modulates MRP associated multidrug resistance. Biochem. Biophys. Res. Commun., 208, 345-349.
9. 4 receptor antagonist. Can. J. Physiol. Pharmacol., 67, 17-31.
10. Keppler, D. (1992). Leukotrienes: biosynthesis, transport, inactivation, and analysis. Rev. Physiol. Biochem. Pharmacol., 121, 1-12.
11. Kyriakis, J.M., Banerjee P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.F., Avruch, J. & Woodgett, J.R. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156-161.
12. Leier, J., Jedlitschky, G., Buchholz, U., Cole, S.P.C., Deeley, R.G. & Keppler, D. (1994). The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugtes. J. Biol. Chem., 269, 27807-27811.
13. Libermann, T.A. & Baltimore, D. (1990). Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell Biol., 10, 2327-2331.
14. 4 and chemotherapeutic agents in membrane vesicles. J. Biol. Chem., 271, 9675-9677.
15. Marshall, C.J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-187.
16. 2 does not alter leukotriene formation. J. Biol. Chem., 72, 759-765.
17. Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T. & Akira, S. (1993). Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin. Proc. Natl. Acad. Sci. U.S.A., 90, 10193-10197.
18. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B., Davis, R.J., Johnson, G.L. & Karin, M. (1994). Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-I and MEKK. Science, 266, 1719-1723.
19. Muller, M., Meijer C., Zaman, G.J.R., Borst, P., Scheper, R.J., Mulder, N.H., De Vries, E.G.E. & Jansen, P.L.M. (1994). Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. U.S.A., 91, 13033-13037.
20. Müller, M., De Vries, E.G.E. & Jansen, P.L.M. (1996). Role of multidrug resistance protein (MRP) in glutathione s-conjugate transport in mammalian cells. J. Hepatology, 24, 1-6.
21. Roelofsen, H., Vos, T.A., Schippers, I.J., Kuipers, F., Koning, H., Moshage, H., Jansen, P.L.M. & Müller, M. (1997). Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology, 112, 511-516.
22. 4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Blood, 80, 1004-1008.
23. Rosette, C. & Karin, M. (1996). Ultraviolet light and osmotic-stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science, 274, 1194-1199.
24. Samuelsson, B. Dahlen, S.E., Lindgren, C.A., Rouzer, C. & Serhan, C.N. (1987). Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science, 237, 1171-1175.
25. Schaub, T., Ishikawa, T. & Keppler, D. (1991). ATP-dependent leukotriene export form mastocytoma cells. FEBS Lett., 279, 83-94.
26. Stankova, J. & Rola-Leszczynski, M. (1992). Interleukin 6 production by mononuclear phagocytes can be stimulated by leukotrienes. Archivum. Imm. et Th., 40, 17-25.
27. Sulciner, D.J., Irani, K., Yu, Z-X., Ferrans, V.J., Goldsmidt-Clermont, P. & Finkel, T. (1996). RAC1 regulates a cytokine-stimulated redox-dependent pathway necessary for NF-κB activation. Mol. Cell Biol., 16, 7115-7121.
28. + peripheral blood cells. Clin. Cancer Res., 4, 1727-1736.
29. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y. & Shimizu, T. (1992). A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature, 387, 620-624.