Osmolarity in renal medulla of transgenic mice regulates transcription via 5'-flanking region of canine BGT1 gene

American Journal of Physiology - Renal Physiology

Volumn 272, Issue 5 41-5, 1997, Pages

  Kaneko, Tetsuya ^a   Takenaka, Masaru ^a   Okabe, Masaru ^b   Yoshimura, Yasuhide ^b   Yamauchi, Atsushi ^a   Horio, Masaru ^c   Kwon, H Moo ^d   Handler, Joseph S ^d   Imai, Enyu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Kidney; Osmolyte; Tonicity responsive enhancer

Indexed keywords

BETAINE; CARRIER PROTEIN;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; DOG; GENE CONTROL; GENE EXPRESSION REGULATION; KIDNEY MEDULLA; MOUSE; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSGENE; TRANSGENIC MOUSE;

EID: 0030808468     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.272.5.f610     Document Type: Article

References (26)

1. Blau, S., L. Daly, A. Fienberg, G. Teitelman, and M. E. Ehrlich. DARPP-32 promoter directs transgene expression to renal thick ascending limb of loop of Henle. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F564-F570, 1995.
2. Borden, L. A., K. E. Smith, E. L. Gustafson, T. A. Branchek, and R. L. Weinshank. Cloning and expression of a betaine/ GABA transporter from human brain. J. Neurochem. 64: 977-984, 1995.
3. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
4. Eisenberger, C. L., H. Nechushtan, H. Cohen, M. Shani, and L. Reshef. Differential regulation of the rat phosphoenolpyruvate carboxykinase gene expression in several tissues of transgenic mice. Mol. Cell. Biol. 12: 1396-1403, 1992.
5. Ferraris, J. D., C. K. Williams, K. Jung, J. J. Bedford, M. B. Burg, and A. Garcia-Perez. ORE, a eukaryotic minimal essential osmotic response element. J. Biol. Chem. 271: 18318-18321, 1996.
6. Garcia-Perez, A., and M. B. Burg. Renal medullary organic osmolytes. Physiol. Rev. 72: 1081-1115, 1992.
7. Halmekytö, M., J. M. Hyttinen, R. Sinervirta, M. Utriainen, S. Myöhänen, H. M. Viopio, J. Wahlfors, S. Syrjänen, K. Syrjänen, L. Alhönen, and J. Jänne. Transgenic mice aberrantly expressing human ornithine decarboxylase gene. J. Biol. Chem. 266: 19746-19751, 1991.
8. Harats, D., H. Kurihara, P. Belloni, H. Oakley, A. Ziober, D. Ackley, G. Cain, Y. Kurihara, R. Lawn, and E. Sigal. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J. Clin. Invest. 95: 1335-1344, 1995.
9. Kelley, K. A., N. Agarwal, S. Reeders, and K. Herrup. Renal cyst formation and multifocal neoplasia in transgenic mice carrying the simian virus 40 early region. J. Am. Soc. Nephrol. 2: 84-97, 1991.
10. Kopp, J. B., and P. E. Klotman. Transgenic animal models of renal development and pathogenesis. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F601-F620, 1995.
11. Lopez-Corcuera, B., Q. R. Liu, S. Mandiyan, H. Nelson, and N. Nelson. Expression of a mouse brain cDNA encoding novel γ-amino-butyric acid transporter. J. Biol. Chem. 267: 17491-17493, 1992.
12. Miyai, A., A. Yamauchi, T. Moriyama, T. Kaneko, M. Takenaka, T. Sugiura, H. Kitamura, A. Ando, S. Shimada, M. Tohyama, E. Imai, and T. Kamada. Expression of betaine transporter: its unique localization and rapid regulation in rat kidney. Kidney Int. 50: 819-827, 1996.
13. Nakanishi, T., O. Uyama, H. Nakahama, Y. Takamitsu, and M. Sugita. Determinants of relative amounts of medullary organic osmolytes: effects of NaCl and urea differ. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F472-F479, 1993.
14. Rasola, A., L. J. V. Galietta, V. Barone, G. Romeo, and S. Bagnasco. Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney. FEBS Lett. 373: 229-233, 1995.
15. Ruepp, B., K. M. Bohren, and K. H. Gabbay. Characterization of the osmotic response element of the human aldose reductase gene promoter. Proc. Natl. Acad. Sci. USA 93: 8624-8629, 1996.
16. Semenza, G. L., S. T. Kouy, M. K. Nejfelt, J. D. Gearhart, and S. E. Antonarakis. Cell-type specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc. Natl. Acad. Sci. USA 88: 8725-8729, 1991.
17. Sigmund, C. D., C. A. Jones, J. R. Fabian, J. J. Mullins, and K. W. Gross. Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice. Biochem. Biophy. Res. Commun. 170: 344-350, 1990.
18. Takenaka, M., S. M. Bagnasco, A. S. Preston, S. Uchida, A. Yamauchi, H. M. Kwon, and J. S. Handler. The canine betaine γ-amino-n-butyric acid transporter gene: diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. Proc. Natl. Acad. Sci. USA 92: 1072-1076, 1995.
19. Takenaka, M., A. S. Preston, H. M. Kwon, and J. S. Handler. The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. J. Biol. Chem. 269: 29379-29381, 1994.
20. Thorey, I. S., G. Cecena, W. Reynolds, and R. G. Oshima. Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice. Mol. Cell. Biol. 13: 6742-6751, 1993.
21. --dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene. J. Clin. Invest. 91: 1604-1607, 1993.
22. Walker, R. L., and M. E. Olson. Renal function in the laboratory rat: a student exercise. Am. J. Physiol. 268 (Adv. Physiol. Educ. 13): S49-S55, 1995.
23. Yamada, K., T. Noguchi, J. Miyazakl, T. Matsuda, M. Takenaka, K. Yamamura, and T. Tanaka. Tissue-specific expression of rat pyruvate kinase L/chloramphenicol acetyltransferase fusion gene in transgenic mice and its regulation by diet and insulin. Biochem. Biophy. Res. Commun. 171: 243-249, 1990.
24. +/myo-inositol cotransporter in rat kidney. J. Clin. Invest. 96: 1195-1201, 1995.
25. --dependent betaine transporter that is regulated by hypertonicity. J. Biol. Chem. 267: 649-652, 1992.
26. Yancy, P. H., M. E. Clark, S. C. Hand, R. D. Bowlus, and G. N. Somero. Living with water stress: evolution of osmolyte systems. Science 217: 1214-1222, 1982.