Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method

Journal of Microencapsulation

Volumn 15, Issue 4, 1998, Pages 421-430

  Leo, E ^a,b   Pecquet, S ^c   Rojas, J ^a   Couvreur, P ^a   Fattal, E ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Microsphere; Poly(lactide co glycolide); Protein

Indexed keywords

BETA LACTOGLOBULIN; MICROSPHERE; POLYGLACTIN;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; EVAPORATION; ISOELECTRIC POINT; MACROMOLECULE; PH; SOLUBILITY; SURFACE PROPERTY;

EID: 0031809484     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652049809006869     Document Type: Article

References (22)

1. ALEX, R., and BODMEIER, R., 1990, Encapsulation of water soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on the drug entrapment. Journal of Microencapsulation, 7, 347-355.
2. ALLAOUI-ATTARKI, K., PECQUET, S., FATTAL, E., CHACHATY, E., COUVREUR, P., and ANDREMONT, A., 1997, Protective immunity against S. typhimuriium elicited in mice by oral vaccination wth phosphorylcholine encapsulated in poly(D,L-lactide-co-glycolide) microspheres. Infection and Immunity, 65, 853-857.
3. ALONSO, M. J., GUPTA, R. K., MIN, C., SIBER, J. R., and LANGER, R., 1994, Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine, 12, 299-306.
4. BLANCO-PRIETO, M. J., DELIE, F., FATTAL, E., TARTAR, A., PUISIEUX, F., GULIK, A., and COUVREUR, P., 1994, Characterization or V3 BRU peptide-loaded small PLGA microparticles prepared by a (W1/O/W2) emulsion solvent evaporation method. International Journal of Pharmaceutics, 111, 137-154.
5. BLANCO-PRIETO, M. J., LEO, E., DELIE, F., GULIK, A., COUVREUR, P., and FATTAL, E., 1996, Study of the influence of several stabilizing agents on the entrapment and in vitro release of pBC 264 from Poly(lactide-co-glycolide) microspheres prepared by a W/O/W solvent evaporation method. Pharmaceutical Research, 13, 1137-1139.
6. BLANCO-PRIETO, M. J., FATTAL, E., GULIK, A., DEDIEU, J. C., ROQUES, B., and COUVREUR, P., 1997, Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microsphere prepared by a water-in-oil-in-water emulsion solvent evaporation method. Journal of Controlled Release, 43, 81-87.
7. CHALLACOMBE, S. J., RAHMAN, D., JEFFERY, H., DAVIS, S. S., and O'HAGAN, D. T., 1992, Enhanced secretory IgA and IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology, 76, 164-168.
8. COURTHADON, J. L., DICKINSON, E., MATSUMARA, Y., and CLARK, D., 1991, Competitive adsorption of β-lactoglobulin + Tween 20 at the oil-water interface. Colloids and Surfaces, 56, 293-300.
9. ELGERSMA, A. V., and ZSOM, R. L. J., 1990, The adsorption of BSA on positively and negatively charged polystyrene latices. Journal of Colloid and Interface Science, 138, 145-156.
10. GILDING, D., and REED, A. M., 1979, Biodegradable polymers for use in surgery polyglycolic/poly (lactic acid) homo and copolymers: 1. Polymer, 20, 1459-1464.
11. HEYA, T., OKADA, H., TANIOAWARA, Y., OGAWA, Y., and TOGUCHI, H., 1991, Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in water drying method. International Journal of Pharmaceutics, 69, 69-75.
12. HERRMANN, J., and BOUMEIER, R., 1995, Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/ W multiple emulsions. International Journal of Pharmaceutics, 126, 129-138.
13. HORA, M. S., RANA, R. K., NUMMEBERG, J. K., TICE, T. R., GILLEY, R. M., and HUDSON, M. E., 1990, Release of human serum albumin from poly(lactide-co-glycolide) microparticles. Pharmaceutical Research, 7, 1190-1194.
14. JEERY, H., DAVIS, S. S., and O'HAGAN, D. T., 1992, The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharmaceutical Research, 10, 362-368.
15. LENSEN, H. G., and BARGEMAN, D., 1984, HPLC as technique to measure the competitive adsorption of plasma proteins onto latices. Journal of Colloid and Interface Science, 99, 1-8.
16. MCKENZIE, H. A., and SAWER, W. H., 1967, Effect of pH on β Lactoglobulins. Nature, 214, 1101-1104.
17. NIHANT, N., SCHUGENS, C., GRANDFILS, C., JEROME, R., and TEYSSIE, P., 1994, Polylactide microparticles prepared by double emulsion/evaporation technique. 1. Effect of primary emulsion stability. Pharmaceutical Research, 11, 1479-1484.
18. OGAWA, Y., YAMAMOTO, M., OKADA, H., YASHIKI, T., and SHIMAMOTO, T., 1988, A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chemical and Pharmaceutical Bulletin, 36, 1095-1103.
19. RAFATI, H., COOMBES, A. G. A., ADLER, J., HOLLAND, J., and DAVIS, S. S., 1997, Protein-loaded poly(DL-lactide-co glycolide) microparticles for oral administration: formulation, structural and release characteristics. Journal of Controlled Release, 43, 89-102.
20. SAH, H. K., TODDYWALA, R., and CHIEN, Y. W., 1995, Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release. Journal of Microencapsulation, 12, 59-69.
21. SCHUGENS, C. H., LARUELLE, N., NIHANT, N., GRANDFILS, C. H., JEROME, R., and TEYSSIE, P. H., 1994, Effect of the emulsion stability on the morphology and porosity of semicrystalline polylactide microparticles prepared by W/O/W double emulsion-evaporation method. Journal of Controlled Release, 32, 161-176.
22. VERRECHIA, T., HUVE, P., BAZILE, D., VEILLARD, M., SPENLEHAUER, G., and COUVREUR, P., 1993, Adsorption/Desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process. Journal of Biomedical Materials Research, 27, 1019-1028.