Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes

Drug Metabolism and Disposition

Volumn 27, Issue 7, 1999, Pages 792-797

  Nakajima, Miki ^a   Ohyama, Katsuhiro ^a   Nakamura, Sumika ^a   Shimada, Noriaki ^b   Yamazaki, Hiroshi ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYAZELASTINE; ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; AZELASTINE; BENZYLOXYRESORUFIN; BUFURALOL; COUMARIN; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE 4 HYDROXYLASE; DIMETHYLNITROSAMINE DEMETHYLASE; DRUG METABOLITE; ETHOXYRESORUFIN; MEPHENYTOIN; NORAZELASTINE; PHENACETIN; PHENACETIN O DEETHYLASE; RESORUFIN DERIVATIVE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN;

ARTICLE; B LYMPHOBLAST; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL;

ANTI-ALLERGIC AGENTS; B-LYMPHOCYTES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; MICROSOMES; OXIDATION-REDUCTION; PHTHALAZINES;

MAMMALIA;

EID: 0033029616     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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