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Volumn 31, Issue 4, 1999, Pages 1115-1124

A single amino acid, outside the AlcR zinc binuclear cluster, is involved in DNA binding and in transcriptional regulation of the alc genes in Aspergillus nidulans

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMINO ACID; DNA BINDING PROTEIN; FUNGAL DNA; MUTANT PROTEIN; TRANSCRIPTION FACTOR;

EID: 0033026766     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01250.x     Document Type: Article
Times cited : (24)

References (38)
  • 1
    • 0040874534 scopus 로고    scopus 로고
    • First experimental evidence of a zinc binuclear cluster in AlcR protein, mutational and x-ray absorption studies
    • Ascone, I., Lenouvel, F., Sequeval, D., Dexpert, H., and Felenbok, B. (1997) First experimental evidence of a zinc binuclear cluster in AlcR protein, mutational and X-ray absorption studies. Biochim Biophys Acta 1343: 211-220.
    • (1997) Biochim Biophys Acta , vol.1343 , pp. 211-220
    • Ascone, I.1    Lenouvel, F.2    Sequeval, D.3    Dexpert, H.4    Felenbok, B.5
  • 2
    • 0026475162 scopus 로고
    • A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger
    • Camier, S., Kacherovski, N., and Young, E.T. (1992) A mutation outside the two zinc fingers of ADR1 can suppress defects in either finger. Mol Cell Biol 12: 5758-5767.
    • (1992) Mol Cell Biol , vol.12 , pp. 5758-5767
    • Camier, S.1    Kacherovski, N.2    Young, E.T.3
  • 4
    • 0031011233 scopus 로고    scopus 로고
    • The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: An NMR study
    • Cerdan, R., Collin, D., Lenouvel, F., Felenbok, B., and Guittet, E. (1997) The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: an NMR study. FEBS Lett 408: 235-240.
    • (1997) FEBS Lett , vol.408 , pp. 235-240
    • Cerdan, R.1    Collin, D.2    Lenouvel, F.3    Felenbok, B.4    Guittet, E.5
  • 6
    • 0014011862 scopus 로고
    • The induction and repression of nitrate reductase in the fungus Aspergillus nidulans
    • Cove, D.J. (1966) The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim Biophys Acta 113: 51-56.
    • (1966) Biochim Biophys Acta , vol.113 , pp. 51-56
    • Cove, D.J.1
  • 7
    • 0026026830 scopus 로고
    • The ethanol utilization regulon of Aspergillus nidulans: The alcA-alcR system as a tool for the expression of recombinant proteins
    • Felenbok, B. (1991) The ethanol utilization regulon of Aspergillus nidulans: the alcA-alcR system as a tool for the expression of recombinant proteins. J Biotechnol 17: 11-18.
    • (1991) J Biotechnol , vol.17 , pp. 11-18
    • Felenbok, B.1
  • 8
    • 0028315108 scopus 로고
    • Alcohol metabolism
    • Martinelli, S., and Kinghorn, J.R. (eds). Amsterdam, London, New York, Tokyo: Elsevier Scientific
    • Felenbok, B., and Sealy-Lewis, H.M. (1994) Alcohol metabolism. In Genetics and Physiology of Aspergillus nidulans, Vol. 29. Martinelli, S., and Kinghorn, J.R. (eds). Amsterdam, London, New York, Tokyo: Elsevier Scientific, pp. 141-179.
    • (1994) Genetics and Physiology of Aspergillus Nidulans , vol.29 , pp. 141-179
    • Felenbok, B.1    Sealy-Lewis, H.M.2
  • 9
    • 0024232197 scopus 로고
    • The ethanol regulon in Aspergillus nidulans: Characterization and sequence of the positive regulatory gene alcR
    • Felenbok, B., Sequeval, D., Mathieu, M., Sibley, S., Gwynne, D.I., and Davies, R.W. (1988) The ethanol regulon in Aspergillus nidulans: characterization and sequence of the positive regulatory gene alcR. Gene 73: 385-396.
    • (1988) Gene , vol.73 , pp. 385-396
    • Felenbok, B.1    Sequeval, D.2    Mathieu, M.3    Sibley, S.4    Gwynne, D.I.5    Davies, R.W.6
  • 10
    • 0029974525 scopus 로고    scopus 로고
    • A newly identified gene cluster in Aspergillus nidulans comprises five novel genes localized in the alc region that are controlled both by the specific transactivator AlcR and the general carbon-catabolite repressor CreA
    • Fillinger, S., and Felenbok, B. (1996) A newly identified gene cluster in Aspergillus nidulans comprises five novel genes localized in the alc region that are controlled both by the specific transactivator AlcR and the general carbon-catabolite repressor CreA. Mol Microbiol 20: 475-488.
    • (1996) Mol Microbiol , vol.20 , pp. 475-488
    • Fillinger, S.1    Felenbok, B.2
  • 11
    • 0029121414 scopus 로고
    • The basal level of transcription of the alc genes in the ethanol regulon in Aspergillus nidulans is controlled both by the specific transactivator AlcR and the general carbon catabolite repressor CreA
    • Fillinger, S., Panozzo, C., Mathieu, M., and Felenbok, B. (1995) The basal level of transcription of the alc genes in the ethanol regulon in Aspergillus nidulans is controlled both by the specific transactivator AlcR and the general carbon catabolite repressor CreA. FEBS Lett 368: 547-550.
    • (1995) FEBS Lett , vol.368 , pp. 547-550
    • Fillinger, S.1    Panozzo, C.2    Mathieu, M.3    Felenbok, B.4
  • 12
    • 0028905902 scopus 로고
    • Sequence specific DNA binding by NIT4, the pathway-specific regulatory protein that mediates nitrate induction in Neurospora
    • Fu, Y.M., Feng, B., Evans, S., and Marzluf, G.A. (1995) Sequence specific DNA binding by NIT4, the pathway-specific regulatory protein that mediates nitrate induction in Neurospora. Mol Microbiol 15: 935-942.
    • (1995) Mol Microbiol , vol.15 , pp. 935-942
    • Fu, Y.M.1    Feng, B.2    Evans, S.3    Marzluf, G.A.4
  • 13
    • 0023189082 scopus 로고
    • Comparison of the cis-acting control regions of two coordinately controlled genes involved in ethanol utilization in Aspergillus nidulans
    • Gwynne, D.I., Buxton, F.P., Sibley, S., Davies, R.W., Lockington, R.A., Scazzocchio, C., et al. (1987) Comparison of the cis-acting control regions of two coordinately controlled genes involved in ethanol utilization in Aspergillus nidulans. Gene 51 (2): 205-216.
    • (1987) Gene , vol.51 , Issue.2 , pp. 205-216
    • Gwynne, D.I.1    Buxton, F.P.2    Sibley, S.3    Davies, R.W.4    Lockington, R.A.5    Scazzocchio, C.6
  • 14
    • 0024284648 scopus 로고
    • Structure of the lambda complex at 2.5A resolution: Details of the repressor-operator interactions
    • Jordan, S.R., and Pabo, C.O. (1988) Structure of the lambda complex at 2.5A resolution: details of the repressor-operator interactions. Science 242: 893-899.
    • (1988) Science , vol.242 , pp. 893-899
    • Jordan, S.R.1    Pabo, C.O.2
  • 15
    • 0026582055 scopus 로고
    • Structure of the DNA-binding domain of zinc GAL4
    • Kraulis, P.J., Raine, A.R.C., Gadhavi, P.L., and Laue, E.D. (1992) Structure of the DNA-binding domain of zinc GAL4. Nature 356: 448-453.
    • (1992) Nature , vol.356 , pp. 448-453
    • Kraulis, P.J.1    Raine, A.R.C.2    Gadhavi, P.L.3    Laue, E.D.4
  • 17
    • 0026061154 scopus 로고
    • Correct intron splicing generates a new type of a putative Zn-binding domain in a transcriptional activator of Aspergillus nidulans
    • Kulmburg, P., Prangé, T., Mathieu, M., Sequeval, D., Scazzocchio, C., and Felenbok, B. (1991) Correct intron splicing generates a new type of a putative Zn-binding domain in a transcriptional activator of Aspergillus nidulans. FEBS Lett 280: 11-16.
    • (1991) FEBS Lett , vol.280 , pp. 11-16
    • Kulmburg, P.1    Prangé, T.2    Mathieu, M.3    Sequeval, D.4    Scazzocchio, C.5    Felenbok, B.6
  • 18
    • 0026693313 scopus 로고
    • Identification of the promoter region involved in the autoregulation of the transcriptional activator ALCR in Aspergillus nidulans
    • Kulmburg, P., Sequeval, D., Lenouvel, F., Mathieu, M., and Felenbok, B. (1992a) Identification of the promoter region involved in the autoregulation of the transcriptional activator ALCR in Aspergillus nidulans. Mol Cell Biol 12: 1932-1939.
    • (1992) Mol Cell Biol , vol.12 , pp. 1932-1939
    • Kulmburg, P.1    Sequeval, D.2    Lenouvel, F.3    Mathieu, M.4    Felenbok, B.5
  • 19
    • 0026657596 scopus 로고
    • Specific binding sites for the activator protein, ALCR, in the alcA promoter of the ethanol regulon of Aspergillus nidulans
    • Kulmburg, P., Judewicz, N., Mathieu, M., Lenouvel, F., Sequeval, D., and Felenbok, B. (1992b) Specific binding sites for the activator protein, ALCR, in the alcA promoter of the ethanol regulon of Aspergillus nidulans. J Biol Chem 267: 21146-21153.
    • (1992) J Biol Chem , vol.267 , pp. 21146-21153
    • Kulmburg, P.1    Judewicz, N.2    Mathieu, M.3    Lenouvel, F.4    Sequeval, D.5    Felenbok, B.6
  • 20
    • 0023613953 scopus 로고
    • Rapid and efficient site-specific mutagenesis without phenotypic selection
    • Kunkel, T.A., Roberts, J.D., and Zabour, R.A. (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154: 367-382.
    • (1987) Methods Enzymol , vol.154 , pp. 367-382
    • Kunkel, T.A.1    Roberts, J.D.2    Zabour, R.A.3
  • 21
    • 0030982139 scopus 로고    scopus 로고
    • In vitro recognition of specific DNA targets by AlcR, a zinc binuclear cluster activator different from the other proteins of this class
    • Lenouvel, F., Nikolaev, I., and Felenbok, B. (1997) In vitro recognition of specific DNA targets by AlcR, a zinc binuclear cluster activator different from the other proteins of this class. J Biol Chem 272: 15521-15526.
    • (1997) J Biol Chem , vol.272 , pp. 15521-15526
    • Lenouvel, F.1    Nikolaev, I.2    Felenbok, B.3
  • 22
    • 0023445125 scopus 로고
    • Regulation of alcR, the positive regulatory gene of the ethanol utilization regulon of Aspergillus nidulans
    • Lockington, R.A., Scazzocchio, C., Sequeval, D., Mathieu, M., and Felenbok, B. (1987) Regulation of alcR, the positive regulatory gene of the ethanol utilization regulon of Aspergillus nidulans. Mol Microbiol 1: 275-281.
    • (1987) Mol Microbiol , vol.1 , pp. 275-281
    • Lockington, R.A.1    Scazzocchio, C.2    Sequeval, D.3    Mathieu, M.4    Felenbok, B.5
  • 24
    • 0026547747 scopus 로고
    • DNA recognition by GAL4: Structure of a protein-DNA complex
    • Marmorstein, R., Carey, M., Ptashne, M., and Harrison, S.C. (1992) DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356: 408-414.
    • (1992) Nature , vol.356 , pp. 408-414
    • Marmorstein, R.1    Carey, M.2    Ptashne, M.3    Harrison, S.C.4
  • 25
    • 0030983924 scopus 로고    scopus 로고
    • The zinc binuclear cluster activator AlcR is able to bind to single sites, but requires multiple repeated sites for synergistic activation of the alcA gene in Aspergillus nidulans
    • Panozzo, C., Capuano, V., Fillinger, S., and Felenbok, B. (1997) The zinc binuclear cluster activator AlcR is able to bind to single sites, but requires multiple repeated sites for synergistic activation of the alcA gene in Aspergillus nidulans. J Biol Chem 272: 22859-22865.
    • (1997) J Biol Chem , vol.272 , pp. 22859-22865
    • Panozzo, C.1    Capuano, V.2    Fillinger, S.3    Felenbok, B.4
  • 27
    • 0031013081 scopus 로고    scopus 로고
    • Conservation of a putative inhibitory in the GAL4 family members
    • Poch, O. (1997) Conservation of a putative inhibitory in the GAL4 family members. Gene 184: 229-235.
    • (1997) Gene , vol.184 , pp. 229-235
    • Poch, O.1
  • 29
    • 0029803121 scopus 로고    scopus 로고
    • Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators
    • Schjerling, P., and Holmberg, S. (1996) Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators. Nucleic Acids Res 24: 4599-4607.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4599-4607
    • Schjerling, P.1    Holmberg, S.2
  • 30
    • 0027953395 scopus 로고
    • Relationships between zinc content and DNA-binding activity of the DNA-binding motif of the transcription factor ALCR in Aspergillus nidulans
    • Sequeval, D., and Felenbok, B. (1994) Relationships between zinc content and DNA-binding activity of the DNA-binding motif of the transcription factor ALCR in Aspergillus nidulans. Mol Gen Genet 242: 33-39.
    • (1994) Mol Gen Genet , vol.242 , pp. 33-39
    • Sequeval, D.1    Felenbok, B.2
  • 33
    • 0031164761 scopus 로고    scopus 로고
    • Evolution of a fungal regulatory gene family: The Zn(II)2Cys6 binuclear cluster DNA binding motif
    • Todd, R.B., and Andrianopoulos, A. (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21: 388-405.
    • (1997) Fungal Genet Biol , vol.21 , pp. 388-405
    • Todd, R.B.1    Andrianopoulos, A.2
  • 34
    • 0026646156 scopus 로고
    • HAP1 positive control mutants specific for one of two binding sites
    • Turcotte, B., and Guarente, L. (1992) HAP1 positive control mutants specific for one of two binding sites. Genes Dev 6: 2001-2009.
    • (1992) Genes Dev , vol.6 , pp. 2001-2009
    • Turcotte, B.1    Guarente, L.2
  • 35
    • 85047673784 scopus 로고    scopus 로고
    • Regulation of transcription factor localization: Fine-tuning of gene expression
    • Vandromme, M., Gauthier-Rouvière, C., Lamb, N., and Fernandez, A. (1996) Regulation of transcription factor localization: fine-tuning of gene expression. Trends Biochem Sci 21: 59-64.
    • (1996) Trends Biochem Sci , vol.21 , pp. 59-64
    • Vandromme, M.1    Gauthier-Rouvière, C.2    Lamb, N.3    Fernandez, A.4
  • 36
    • 0027331505 scopus 로고
    • 6' proteins distinguish between similar upstream activation sites?
    • 6' proteins distinguish between similar upstream activation sites? J Biol Chem 268: 24699-24706.
    • (1993) J Biol Chem , vol.268 , pp. 24699-24706
    • Vashee, S.1    Xu, H.2    Johnston, S.A.3    Kodadek, T.4
  • 38
    • 0026002757 scopus 로고
    • Crystal structure of a MAT α2 homeodomain operator complex suggests a general model for homeodomain DNA interactions
    • Wolberger, C., Vershon, A.K., Lin, B., Johnson, A.D., and Pabo, C.O. (1991) Crystal structure of a MAT α2 homeodomain operator complex suggests a general model for homeodomain DNA interactions. Cell 67: 517-528.
    • (1991) Cell , vol.67 , pp. 517-528
    • Wolberger, C.1    Vershon, A.K.2    Lin, B.3    Johnson, A.D.4    Pabo, C.O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.