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Volumn 19, Issue 3, 1999, Pages 281-298

HIV protease inhibitors: Advances in therapy and adverse reactions, including metabolic complications

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ATORVASTATIN; GEMFIBROZIL; INDINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; ZIDOVUDINE;

EID: 0033019085     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.19.4.281.30937     Document Type: Review
Times cited : (66)

References (115)
  • 1
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • Hammer SM, Squires KE, Hughes ME, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N Engl J Med 1997;337:725-33.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.M.1    Squires, K.E.2    Hughes, M.E.3
  • 2
    • 6844240219 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ritonavir in advanced HIV-I disease
    • Cameron DW, Heath-Chiozzi M, Danner S, et al. Randomized placebo-controlled trial of ritonavir in advanced HIV-I disease. Lancet 1998;351:543-9.
    • (1998) Lancet , vol.351 , pp. 543-549
    • Cameron, D.W.1    Heath-Chiozzi, M.2    Danner, S.3
  • 3
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, AZT and 3TC in adults with HIV and prior antiretroviral therapy
    • Gulick R, Mellors J, Havlir D, et al. Treatment with indinavir, AZT and 3TC in adults with HIV and prior antiretroviral therapy. N EnglJ Med 1997;337:734-9.
    • (1997) N EnglJ Med , vol.337 , pp. 734-739
    • Gulick, R.1    Mellors, J.2    Havlir, D.3
  • 4
    • 0007010412 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1998: Updated recommendations of the international AIDS society
    • Carpenter CC, Fischl MA, Hammer SM, et al. Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society. JAMA 280;1998:78-86.
    • (1998) JAMA , vol.280 , pp. 78-86
    • Carpenter, C.C.1    Fischl, M.A.2    Hammer, S.M.3
  • 5
    • 4243522918 scopus 로고    scopus 로고
    • Report of the NIH panel on principles of therapy of HIV infection and guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
    • Anonymous. Report of the NIH panel on principles of therapy of HIV infection and guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. MMWR 1998;47:RR-5.
    • (1998) MMWR , vol.47
  • 6
    • 0005241362 scopus 로고    scopus 로고
    • Active human immunodeficiency virus protease is required for viral infectivity
    • Kohl NE, Emini EA, Schleif WA, et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA 1998;85(13):4686-90.
    • (1998) Proc Natl Acad Sci USA , vol.85 , Issue.13 , pp. 4686-4690
    • Kohl, N.E.1    Emini, E.A.2    Schleif, W.A.3
  • 7
    • 17344367978 scopus 로고    scopus 로고
    • A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV-1) protease, to treat HIV infection
    • Markowitz M, Conant M, Hurley A, et al. A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV-1) protease, to treat HIV infection. J Infect Dis 1998;177:1533-40.
    • (1998) J Infect Dis , vol.177 , pp. 1533-1540
    • Markowitz, M.1    Conant, M.2    Hurley, A.3
  • 8
    • 10144244674 scopus 로고    scopus 로고
    • A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500/cu cc
    • Hammer S, Katzenstein D, Hughes M, et al. A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500/cu cc. N Engl J Med 1996;335:1081-90.
    • (1996) N Engl J Med , vol.335 , pp. 1081-1090
    • Hammer, S.1    Katzenstein, D.2    Hughes, M.3
  • 11
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ Jr, Delaney K, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-61.
    • (1998) N Engl J Med , vol.338 , pp. 853-861
    • Palella F.J., Jr.1    Delaney, K.2    Moorman, A.C.3
  • 13
    • 0345665169 scopus 로고    scopus 로고
    • Activity of a new formulation of saquinavir in combination with two nucleosides in treatment naive patients
    • Chicago, February 1-5
    • Slater L. Activity of a new formulation of saquinavir in combination with two nucleosides in treatment naive patients [abstr]. In: Program and abstracts of the 5th conference on retroviruses and opportunistic infections, Chicago, February 1-5, 1998
    • (1998) Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Slater, L.1
  • 14
  • 17
    • 0009568853 scopus 로고    scopus 로고
    • Combination 1592/141W94 therapy in HIV-1-infected antiretroviral naive subjects with CD4+ counts >400 cells/ul and viral load > 5000 copies/ml
    • Chicago, February 1-5
    • Bart PA, Rizzardi GP, Gallan S, et al. Combination 1592/141W94 therapy in HIV-1-infected antiretroviral naive subjects with CD4+ counts >400 cells/ul and viral load > 5000 copies/ml [abstr]. In: Program and abstracts of the 5th conference on retroviruses and opportunistic infections, Chicago, February 1-5, 1998.
    • (1998) Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Bart, P.A.1    Rizzardi, G.P.2    Gallan, S.3
  • 18
    • 0005920452 scopus 로고    scopus 로고
    • Phase 2 study of amprenavir, a novel protease inhibitor, in combination with zidovudine/3TC
    • Geneva, June 28-July 3
    • Haubrich R. Phase 2 study of amprenavir, a novel protease inhibitor, in combination with zidovudine/3TC [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Haubrich, R.1
  • 24
    • 0030792728 scopus 로고    scopus 로고
    • Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir
    • Lorenzi P, Yerly S, Abderrakim K, et al. Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir. AIDS 1997;11:F95-9.
    • (1997) AIDS , vol.11
    • Lorenzi, P.1    Yerly, S.2    Abderrakim, K.3
  • 26
    • 0008158938 scopus 로고    scopus 로고
    • Open label pilot studies to assess the safety and efficacy of bid dosing regimens of Viracept (nelfinavir mesylate) combined with NRTIs in HIV-infected treatment-naive patients
    • Chicago, February 1-5
    • Sension M, Elion R, Farthing C, et al. Open label pilot studies to assess the safety and efficacy of bid dosing regimens of Viracept (nelfinavir mesylate) combined with NRTIs in HIV-infected treatment-naive patients [abstr]. In: Program and abstracts of the 5th conference on retroviruses and opportunistic infections, Chicago, February 1-5, 1998.
    • (1998) Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Sension, M.1    Elion, R.2    Farthing, C.3
  • 28
    • 85038172593 scopus 로고
    • Potent and convenient Fortovase BID regimens in combination with two nucleosides or nelfinavir plus one nucleoside in HIV-1 infected patients
    • Geneva, June 29-July 3
    • Cohen C, Siemon-Hryczyk P, Pilson R, et al. Potent and convenient Fortovase BID regimens in combination with two nucleosides or nelfinavir plus one nucleoside in HIV-1 infected patients [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 29-July 3, 1988.
    • (1988) Conference Record of the 12th World AIDS Conference
    • Cohen, C.1    Siemon-Hryczyk, P.2    Pilson, R.3
  • 34
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    • Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998;12:F51-8.
    • (1998) AIDS , vol.12
    • Carr, A.1    Samaras, K.2    Burton, S.3
  • 36
    • 85038173568 scopus 로고    scopus 로고
    • Peripheral insulin resistance leading to impaired glucose tolerance in HIV-1 infected patients treated with protease inhibitors
    • Geneva, June 28-July 3
    • Walli RK, Herfort O, Michl GM, et al. Peripheral insulin resistance leading to impaired glucose tolerance in HIV-1 infected patients treated with protease inhibitors. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Walli, R.K.1    Herfort, O.2    Michl, G.M.3
  • 40
    • 0032537042 scopus 로고    scopus 로고
    • Indinavir-associated lipodystrophy
    • Viraben R, Aquilina C. Indinavir-associated lipodystrophy. AIDS 1998;12: F37-9.
    • (1998) AIDS , vol.12
    • Viraben, R.1    Aquilina, C.2
  • 42
    • 0003251876 scopus 로고    scopus 로고
    • Changes in body habitus in HIV(+) women after initiation of protease inhibitor therapy
    • Geneva, June 28-July 3
    • Dong K, Flynn MM., Dickinson BP, et al. Changes in body habitus in HIV(+) women after initiation of protease inhibitor therapy [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Dong, K.1    Flynn, M.M.2    Dickinson, B.P.3
  • 44
    • 17144463863 scopus 로고    scopus 로고
    • Severe premature coronary artery disease with protease inhibitors
    • Henry K, Melroe H, Huebsch J, et al. Severe premature coronary artery disease with protease inhibitors. Lancet 1998;351:1328.
    • (1998) Lancet , vol.351 , pp. 1328
    • Henry, K.1    Melroe, H.2    Huebsch, J.3
  • 47
    • 0005404114 scopus 로고    scopus 로고
    • Lipid abnormalities associated with use of protease inhibitors: Prevalence, clinical sequelae, and treatment
    • Geneva, June 28-July 3
    • Henry K. Lipid abnormalities associated with use of protease inhibitors: prevalence, clinical sequelae, and treatment [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3.
    • Conference Record of the 12th World AIDS Conference
    • Henry, K.1
  • 48
    • 0030793476 scopus 로고    scopus 로고
    • Crystalluria and urinary tract abnormalities associated with indinavir
    • Kopp JB, Miller KD, Mican AM, et al. Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med 1997;127:119-25.
    • (1997) Ann Intern Med , vol.127 , pp. 119-125
    • Kopp, J.B.1    Miller, K.D.2    Mican, A.M.3
  • 50
    • 0031026640 scopus 로고    scopus 로고
    • Unusual occurrence of spontaneous hematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment
    • Ginsburg C, Salmon-Ceron D, Vassilief D, et al. Unusual occurrence of spontaneous hematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment. AIDS 1997;11:388-9.
    • (1997) AIDS , vol.11 , pp. 388-389
    • Ginsburg, C.1    Salmon-Ceron, D.2    Vassilief, D.3
  • 51
    • 0030636396 scopus 로고    scopus 로고
    • HIV protease inhibitors and increased bleeding in hemophilia?
    • Helal A. HIV protease inhibitors and increased bleeding in hemophilia? Can Med Assoc J 1997;156(1):90.
    • (1997) Can Med Assoc J , vol.156 , Issue.1 , pp. 90
    • Helal, A.1
  • 53
    • 0030775097 scopus 로고    scopus 로고
    • Protease inhibitors and unusual bleeding in haemophiliacs
    • Yee TT, Amrolia PJ, Lee CA, et al. Protease inhibitors and unusual bleeding in haemophiliacs. Haemophilia 1997;3(3):220-1.
    • (1997) Haemophilia , vol.3 , Issue.3 , pp. 220-221
    • Yee, T.T.1    Amrolia, P.J.2    Lee, C.A.3
  • 55
    • 0031963566 scopus 로고    scopus 로고
    • Severe hyperglycemia in an HIV clinic: Preexisting versus drug-associated diabetes mellitus
    • Kilby JM, Tabereaux PB. Severe hyperglycemia in an HIV clinic: preexisting versus drug-associated diabetes mellitus. J Acquir Hum Immune Defic Syndr Hum Retrovir 1998;17:46-50.
    • (1998) J Acquir Hum Immune Defic Syndr Hum Retrovir , vol.17 , pp. 46-50
    • Kilby, J.M.1    Tabereaux, P.B.2
  • 62
    • 0026534161 scopus 로고
    • The role of the cytokines interferon alpha and tumor necrosis factor in the hypertriglyceridemia and wasting of AIDS
    • Grunfeld C, Feingold KR. The role of the cytokines interferon alpha and tumor necrosis factor in the hypertriglyceridemia and wasting of AIDS. J Nutr 1992;122:749-53.
    • (1992) J Nutr , vol.122 , pp. 749-753
    • Grunfeld, C.1    Feingold, K.R.2
  • 63
    • 0027167664 scopus 로고
    • The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprolein subclass B
    • Feingold KR, Krauss RM, Pang M, Doerrler W, Jensen P, Grunfeld C. The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprolein subclass B. J Clin Endocrinol Metab 1993;76:1423-7.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1423-1427
    • Feingold, K.R.1    Krauss, R.M.2    Pang, M.3    Doerrler, W.4    Jensen, P.5    Grunfeld, C.6
  • 64
    • 0023220709 scopus 로고
    • Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo
    • Feingold KR, Grunfeld C. Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. J Clin Invest 1987;80:184-90.
    • (1987) J Clin Invest , vol.80 , pp. 184-190
    • Feingold, K.R.1    Grunfeld, C.2
  • 66
    • 0023232216 scopus 로고
    • Helsinki heart study: Primary prevention trial with gemfibrozil in middle aged men with dyslipidemia
    • Frick MH, Elo O, Haapa K, et al. Helsinki heart study: primary prevention trial with gemfibrozil in middle aged men with dyslipidemia. N EnglJ Med 1987;317:1237-45.
    • (1987) N EnglJ Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 68
    • 0031924315 scopus 로고    scopus 로고
    • Atorvastatin: A potent new HMG-CoA reductase inhibitor
    • Hilleman DE, Seyedroubari A. Atorvastatin: a potent new HMG-CoA reductase inhibitor. Cardiovasc Rev Rep 1998;19(5):32-48.
    • (1998) Cardiovasc Rev Rep , vol.19 , Issue.5 , pp. 32-48
    • Hilleman, D.E.1    Seyedroubari, A.2
  • 70
    • 0000685377 scopus 로고    scopus 로고
    • Atorvastatin pharmacokinetic interactions with other CYP3A4 substrates: Erythromycin and ethinyl estradiol
    • Yang B-B, Smithers JA, Siedlik PH, et al. Atorvastatin pharmacokinetic interactions with other CYP3A4 substrates: erythromycin and ethinyl estradiol [abstr]. Pharm Res 1996;13(9suppl):S347.
    • (1996) Pharm Res , vol.13 , Issue.9 SUPPL.
    • Yang, B.-B.1    Smithers, J.A.2    Siedlik, P.H.3
  • 71
    • 0027215838 scopus 로고
    • Myopathies associated with human immunodeficiency virus and zidovudine: Can their effects be distinguished?
    • Simpson DM, Citak KA, Godfrey E, Godbold J, Wolfe DE. Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished? Neurology 1993;43:971-6.
    • (1993) Neurology , vol.43 , pp. 971-976
    • Simpson, D.M.1    Citak, K.A.2    Godfrey, E.3    Godbold, J.4    Wolfe, D.E.5
  • 72
    • 0028154543 scopus 로고
    • Second report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults
    • National Cholesterol Education Program. Second report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Circulation. 1994;90:1329-1445.
    • (1994) Circulation , vol.90 , pp. 1329-1445
  • 74
    • 0032551258 scopus 로고    scopus 로고
    • Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance
    • Carr A, Samaras K, Chisholm DJ, Cooper DA. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 1998;352:1881-3.
    • (1998) Lancet , vol.352 , pp. 1881-1883
    • Carr, A.1    Samaras, K.2    Chisholm, D.J.3    Cooper, D.A.4
  • 75
    • 0009932759 scopus 로고    scopus 로고
    • Treatment of dorsocervical fat pads and truncal adiposity with serostim (recombinant human growth hormone) in patients with AIDS maintained on HAART
    • Geneva, June 28-July 3
    • Torres R. Treatment of dorsocervical fat pads and truncal adiposity with serostim (recombinant human growth hormone) in patients with AIDS maintained on HAART [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Torres, R.1
  • 76
    • 0032565098 scopus 로고    scopus 로고
    • A randomized, double blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients
    • Montaner JS, Reiss P, Cooper D, Vella S, Harris H. A randomized, double blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients. JAMA 1998;279:930-7.
    • (1998) JAMA , vol.279 , pp. 930-937
    • Montaner, J.S.1    Reiss, P.2    Cooper, D.3    Vella, S.4    Harris, H.5
  • 77
    • 0003322084 scopus 로고    scopus 로고
    • A phase II, multicenter, randomized, open-label study to compare the antiretroviral activity and tolerability of efavirenz + indinavir, versus efavirenz + zidovudine + lamivudine, versus indinavir + zidovudine + lamivudine at 24 weeks [DMP 266-006]
    • Geneva, June 28-July 3
    • Staszewski S, Morales-Ramirez J, Flanigan T, et al. A phase II, multicenter, randomized, open-label study to compare the antiretroviral activity and tolerability of efavirenz + indinavir, versus efavirenz + zidovudine + lamivudine, versus indinavir + zidovudine + lamivudine at 24 weeks [DMP 266-006] [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Staszewski, S.1    Morales-Ramirez, J.2    Flanigan, T.3
  • 78
    • 0003326086 scopus 로고    scopus 로고
    • Safety and activity of abacavir (1592, ABC) with 3TC/ZDV in antiretroviral naive subjects
    • Geneva, June 28-July 3
    • Fischl M, Greenberg S, Clumeck N, et al. Safety and activity of abacavir (1592, ABC) with 3TC/ZDV in antiretroviral naive subjects [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Fischl, M.1    Greenberg, S.2    Clumeck, N.3
  • 79
    • 0030027918 scopus 로고    scopus 로고
    • Insulin resistance and body fat distribution: Contribution of visceral fat accumulation to the development of insulin resistance and atherosclerosis
    • Yamashita S, Nakamura T, Shimomura I, et al. Insulin resistance and body fat distribution: contribution of visceral fat accumulation to the development of insulin resistance and atherosclerosis. Diabetes Care 1996;19(3):287-91.
    • (1996) Diabetes Care , vol.19 , Issue.3 , pp. 287-291
    • Yamashita, S.1    Nakamura, T.2    Shimomura, I.3
  • 80
    • 0029073966 scopus 로고
    • pH-Dependent oral absorption of L-734, 524, a potent HIV protease inhibitor, in rats and dogs
    • Lin JH, Chen IW, Wastag KJ, Ostovic D. pH-Dependent oral absorption of L-734, 524, a potent HIV protease inhibitor, in rats and dogs. Drug Metab Dispos 1995;23:730-5.
    • (1995) Drug Metab Dispos , vol.23 , pp. 730-735
    • Lin, J.H.1    Chen, I.W.2    Wastag, K.J.3    Ostovic, D.4
  • 81
    • 0028868234 scopus 로고
    • Metabolites of L-735,524, a potent HIV-I protease inhibitor, in human urine
    • Balani SH, Arison BH, Mathai L, et al. Metabolites of L-735,524, a potent HIV-I protease inhibitor, in human urine. Drug Metab Dispos 1995;23:266-70.
    • (1995) Drug Metab Dispos , vol.23 , pp. 266-270
    • Balani, S.H.1    Arison, B.H.2    Mathai, L.3
  • 84
    • 0032582422 scopus 로고    scopus 로고
    • Prevention and treatment of tuberculosis among patients infected with human immunodeficiency virus: Principles of therapy and revised recommendations
    • Anonymous. Prevention and treatment of tuberculosis among patients infected with human immunodeficiency virus: principles of therapy and revised recommendations. MMWR 1998;47:RR-20.
    • (1998) MMWR , vol.47
  • 96
    • 0013472220 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ketoconazole and the HIV protease inhibitor 141W94 after a single dose administration to normal volunteers
    • Toronto, Canada. September 28-October 1
    • Polk RE, Israel DS, Pastor A, et al. Pharmacokinetic interaction between ketoconazole and the HIV protease inhibitor 141W94 after a single dose administration to normal volunteers [abstr]. In: Abstracts of the 37th interscience conference on antimicrobial agents and chemotherapy, Toronto, Canada. September 28-October 1, 1997.
    • (1997) Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Polk, R.E.1    Israel, D.S.2    Pastor, A.3
  • 97
    • 0344511140 scopus 로고    scopus 로고
    • Study of protease inhibitor combination in Europe (SPICE); saquinavir soft gel capsule (SQV-SGC) and nelfinavir in HIV infected individuals
    • Chicago, February 1-5
    • Opravil M. Study of protease inhibitor combination in Europe (SPICE); saquinavir soft gel capsule (SQV-SGC) and nelfinavir in HIV infected individuals [abstr]. In: Program and abstracts of the 5th conference on retroviruses and opportunistic infections, Chicago, February 1-5, 1998.
    • (1998) Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Opravil, M.1
  • 104
    • 0030792728 scopus 로고    scopus 로고
    • Toxicity, efficacy, plasma drug concentration and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir
    • Lorenzi P, Yerly S, Abderrakim K, et al. Toxicity, efficacy, plasma drug concentration and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir. AIDS 1997;11:F95-9.
    • (1997) AIDS , vol.11
    • Lorenzi, P.1    Yerly, S.2    Abderrakim, K.3
  • 105
    • 0032537171 scopus 로고    scopus 로고
    • The antiviral effect of ritonavir and saquinavir in combination amongst HIV-infected adults: Results from a community-based study
    • Rhone S, Hogg RS, Yip B, et al. The antiviral effect of ritonavir and saquinavir in combination amongst HIV-infected adults: results from a community-based study. AIDS 1998;12:619-24.
    • (1998) AIDS , vol.12 , pp. 619-624
    • Rhone, S.1    Hogg, R.S.2    Yip, B.3
  • 106
    • 85038184641 scopus 로고
    • Efficacy and durability of ritonavir/saquinavir as salvage therapy after failure of initial protease inhibitor regimen
    • Geneva, June 29-July 3
    • Gallant JE, Barnett S, Raines C, Hall C. Efficacy and durability of ritonavir/saquinavir as salvage therapy after failure of initial protease inhibitor regimen [abstr]. In: Conference record of the 12th World AIDS Conference. Geneva, June 29-July 3, 1988.
    • (1988) Conference Record of the 12th World AIDS Conference
    • Gallant, J.E.1    Barnett, S.2    Raines, C.3    Hall, C.4
  • 108
    • 0003203027 scopus 로고    scopus 로고
    • Salvage therapy using ritonavir/saquinavir with a non-nucleoside reverse transcriptase inhibitor after prolonged failure with indinavir or ritonavir
    • Geneva, June 28-July 3
    • Ruane PJ, Tam JT, Libraty DH, Sokolov RT, Uman SJ, Zakowski PC. Salvage therapy using ritonavir/saquinavir with a non-nucleoside reverse transcriptase inhibitor after prolonged failure with indinavir or ritonavir [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Ruane, P.J.1    Tam, J.T.2    Libraty, D.H.3    Sokolov, R.T.4    Uman, S.J.5    Zakowski, P.C.6
  • 110
    • 0005920601 scopus 로고    scopus 로고
    • Potent and convenient Fortovase (SQV) SGC BID regimens in combination with 2 nucleosides or nelfinavir (NFV) plus 1 nucleoside in HIV-1 infected patients
    • Geneva, June 28-July 3
    • Cohen C, Siemon-Hryczk P, Pilson R, et al. Potent and convenient Fortovase (SQV) SGC BID regimens in combination with 2 nucleosides or nelfinavir (NFV) plus 1 nucleoside in HIV-1 infected patients [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Cohen, C.1    Siemon-Hryczk, P.2    Pilson, R.3
  • 111
    • 0005954285 scopus 로고    scopus 로고
    • Combined nelfinavir/saquinavir protease inhibitor treatment in a BID regimen as salvage therapy in advanced HIV disease
    • Geneva, June 28-July 3
    • Lohmeyer J, Selhorst J, Friese G, Teichmann J, Discher T. Combined nelfinavir/saquinavir protease inhibitor treatment in a BID regimen as salvage therapy in advanced HIV disease [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Lohmeyer, J.1    Selhorst, J.2    Friese, G.3    Teichmann, J.4    Discher, T.5
  • 112
    • 0003299441 scopus 로고    scopus 로고
    • Twenty-week HIV RNA response and correlation with baseline phenotypic drug susceptibility during treatment with a novel quadruple salvage regimen after failure of indinavir combination therapy
    • Geneva, June 28-July 3
    • Decks S. Twenty-week HIV RNA response and correlation with baseline phenotypic drug susceptibility during treatment with a novel quadruple salvage regimen after failure of indinavir combination therapy [abstr]. In: Conference record of the 12th World AIDS Conference. Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Decks, S.1
  • 113
    • 0007561021 scopus 로고    scopus 로고
    • Co-administration of indinavir (IDV) and nelfinavir (NFV) in a twice daily regimen: Preliminary safety, pharmacokinetics and anti-viral activity results
    • Chicago, February 1-5
    • Havlir DV, Riddler S, Squires K, et al. Co-administration of indinavir (IDV) and nelfinavir (NFV) in a twice daily regimen: preliminary safety, pharmacokinetics and anti-viral activity results [abstr]. In: Program and abstracts of the 5th conference on retroviruses and opportunistic infections, Chicago, February 1-5, 1998.
    • (1998) Program and Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Havlir, D.V.1    Riddler, S.2    Squires, K.3
  • 115
    • 0005426641 scopus 로고    scopus 로고
    • Novel double protease combinations combining indinavir (IDV) with ritonavir (RTV): Results from first study
    • Geneva, June 28-July 3
    • Workman C, Musson R, Dyer W, Sullivan J. Novel double protease combinations combining indinavir (IDV) with ritonavir (RTV): results from first study [abstr]. In: Conference record of the 12th World AIDS Conference, Geneva, June 28-July 3, 1998.
    • (1998) Conference Record of the 12th World AIDS Conference
    • Workman, C.1    Musson, R.2    Dyer, W.3    Sullivan, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.