Cortical load of PHF-tau in Alzheimer's disease is correlated to cholinergic dysfunction

Journal of Neural Transmission

Volumn 106, Issue 5-6, 1999, Pages 513-523

  Arendt, T ^a   Holzer, M ^b   Gertz, H J ^b   Bruckner M K ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NONE

Author keywords

Alzheimer's disease; Cholinergic system; Degeneration; Phosphorylation; Tau

Indexed keywords

CHOLINE ACETYLTRANSFERASE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CHOLINERGIC SYNAPSE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DEAFFERENTATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NERVE ENDING; NEUROFIBRILLARY TANGLE; NEUROPIL THREAD; OLIVARY NUCLEUS; PRIORITY JOURNAL;

EID: 0033017218     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050175     Document Type: Article

References (45)

1. Arendt Th, Bigl V (1986) Alzheimer plaques and cortical cholinergic innervation. Neuroscicnce 17: 227-279
2. Arendt Th, Bigl V, Tennstedt A, Arendt A (1985) Neuronal loss in different parts of the nucleus basalìs is related to neuritic plaque formation in cortical target areas in Alzhcimer's disease. Neuroscience 14: 1-14
3. Arendt Th, Brückner MK, Bigl V, Marcova L (1995) Dendritic reorganization in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease. J Comp Neurol 351: 189-222
4. Arendt Th, Schindler C, Brückner MK, Eschrisch K, Bigl V, Zedlick D, Marcova L (1997) Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein ε4 allele. J Neurosci 17: 516-529
5. Arendt Th, Brückner MK, Certz H-J, Marcova L (1998) Cortical distribution of ncurofibrillary tangles in Alzheimer's disease matches the pattern of neurones that retain their capacity of plastic remodelling in the adult brain. Neuroscience 83: 991-1002
6. Arnold SE, Hyman BT, Flory J, Damasio AR, van Hoesen GW (1991) The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cerebral Cortex 1: 103-116
7. Arriagada PV, Growdon JH, Hedley-White, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
8. Bancher C, Jellinger K, Lassmann H, Fischer P, Leblhuber F (1996) Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia. Eur Arch Psychiatry Clin Neurosci 246: 137-146
9. Bierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, Schmeidler J, Kanof P, Davis KL (1995a) Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J Neurochem 64: 749-760
10. Bierer LM, Hof PR, Purohil DP, Carlin L, Schmeidler J, Davis KL, Perl DP (1995b) Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol 52: 81-88
11. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82: 239-259
12. Brashear HR, Godec MS, Carlsen J (1988) The distribution of neuritic plaques and acetylcholinesterasc staining in the amygdala in Alzheimer's disease. Neurology 38: 1694-1699
13. Brückner M, Bendix U, Hube M, Arendt T, Bigl V (1992) Alzheimer's disease: a monoclonal antibody raised against paired helical filaments. Acta Histochem 41: 143-152
14. Davies P (1979) Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res 171: 319-327
15. DeKosky ST, Harbaugh RE, Schmitt FA, Bakay RAE, Chui HC, Knopman DS, Reeder TM, Shetter AG, Senter HJ, Markesbery WR (1992) Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlates. Ann Neurol 32: 625-632
16. Fonnum F (1969) Radiochemical micro assay for the determination of choline acetyltransferase and acetylcholinesterase activities. Biochem J 115: 465-472
17. Geula C, Mesulam MM (1996) Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease. Cerebral Cortex 6: 165-177
18. Goerdert M, Spillantini MG, Cairns NJ, Crowther RA (1992) Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six isoforms. Neuron 8: 159-168
19. Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83: 4913-4917
20. Henke H, Lang W (1983) Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients. Brain Res 267: 281-291
21. Holzer M, Holzapfel HP, Zedlick D, Brückner MK, Arendt T (1994) Abnormally phosphorylatcd tau protein in Alzheimer's disease: heterogeneity of individual regional distribution and relationship to clinical severity. Neuroscience 63: 499-516
22. Jellinger KA, Bancher C (1998) Neuropathology of Alzheimer's disease: a critical update. J Neural Transm [Suppl 54]: 77-95
23. Khatchaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42: 1097-1105
24. McKee AC, Kosik KS, Kowall NW (1991) Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 30: 156-165
25. McKhann G, Drachmann D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRD A work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34: 939-944
26. Martin EM, Wilson RS, Penn RS, Fox JH, Clasen RA, Savoy RN (1987) Cortical biopsy results in Alzheimer's disease: correlation with cognitive deficits. Neurology 37: 1201-1204
27. Mesulam MM, Mufson EJ, Levey AI, Wainer BH (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the seplal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J Comp Neurol 214: 170-197
28. Monfort JC, Javoy-Agid F, Hauw JJ, Dubois B, Agid Y (1985) Brain glutamate decarboxylase in Parkinson's disease with particular reference to premortem severity index. Brain 108:301-313
29. Mountjoy CQ, Rossor MN, Iverson LL, Roth M (1984) Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain 107: 507-518
30. Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM, McDonald B, Litchfield S, Smith A, Barnetson L, Smith AD (1995) Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia 6: 21-31
31. Perry EK, Gibson PH, Blessed G, Perry RH, Tomlinson BE (1977) Neurotransmitter enzyme abnormalities in senile dementia. J Neurol Sci 34: 247-256
32. Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 2: 1457-1459
33. Perry EK, Blessed G, Tomlinson BE, Perry RH, Crow TJ, Cross AJ, Dockray GJ, Dimaline R, Arragui A (1981) Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes. Neurobiol Aging 2: 251-256
34. Peterson GL (1977) A simplification of the protein assay method of Lowry et al., which is more generally applicable. Anal Biochem 83: 346-356
35. Ransmayr G, Cervera P, Hirsch EC, Berger W, Fischer W, Agid Y (1992) Alzheimer's disease: is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology? Neurosci 47: 843-851
36. Reinikainen KJ, Riekkinen PJ, Paljarvi L, Soininen H, Helkala EL, Jolkkonen J, Laakso M (1988) Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data. Neurochem Res 13: 135-146
37. Reisberg B, Ferris SH, deLeon MJ, Crook T (1982) The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 139: 1136-1139
38. Rossor M, Fahrenkrug J, Emson P, Mountjoy C, Iversen L, Roth M (1980) Reduced cortical choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide. Brain Res 201: 249-253
39. Rossor MN, Garrett NJ, Johnson AL, Mountjoy CO, Roth M, Iversen LL (1982) A postmortem study of the cholinergic and GABA systems in senile dementia. Brain 105: 313-330
40. Sims NR, Bowen DM, Allen SJ, Smith CCT, Neary D, Thomas DJ, Davison AN (1983) Presynaptic cholinergic dysfunction in patients with dementia. J Neurochem 40: 503-509
41. Struble RG, Cork LC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216: 413-414
42. Tomlinson BE, Blessed B, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11: 205-242
43. Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia. A quantitative study. J Neurol Sci 56: 343-356
44. Wilcock GK, Esiri MM, Bowen DM, Smith CCT (1982) Alzheimer's disease: correlation of cortical choline acetyltransferase activity with severity of dementia and histological abnormalities. J Neurol Sci 57: 407-417
45. Zubenko GS, Moossy J, Martinez AJ, Rao GR, Kopp U, Hanin I (1989) A brain regional analysis of morphometric and cholinergic abnormalities in Alzheimer's disease. Arch Neurol 46: 634-638