Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells

Acta Neuropathologica

Volumn 97, Issue 4, 1999, Pages 399-407

  Hinek, Aleksander ^a,b   Jung, Shin ^a   Rutka, James T ^a,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Elastin; Elastin binding protein; Glioma; Proliferation; Suramin

Indexed keywords

CELL SURFACE RECEPTOR; CYCLIN A; CYCLIN DEPENDENT KINASE; DNA; ELASTIN; SURAMIN; TROPOELASTIN;

ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; GLIOMA CELL; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; RADIOASSAY;

CELL DIVISION; CULTURE MEDIA, SERUM-FREE; CYCLIN-DEPENDENT KINASES; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELASTIN; GLIOMA; HUMANS; INTRACELLULAR FLUID; LAMININ; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SURAMIN; THYMIDINE; TRITIUM; TROPOELASTIN; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0033016864     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051004     Document Type: Article

References (79)

1. Anon J (1992) Therapeutic studies of primary central nervous system malignancies in adults. NIH Guide 21:RFA:CA-93-03
2. Baldin V, Lukas J, Marcote MJ, Pegano M, Draetta E (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7:812-821
3. Bellon G, Caulet T, Cam Y (1985) Immunohistolocalisation of macromolecules of the basement membrane and extracellular matrix of human gliomas and meningiomas. Acta Neuropathol (Berl) 66:245-252
4. Berens M, Rief M, Loo M, Giese A (1994) The role of extra-cellular matrix in human glioma migration and proliferation studied in a microliter scale assay. Clin Exp Metastasis 12: 405-415
5. Blood CH, Sasse J, Brodt P, Zetter BR (1988) Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. J Cell Biol 107:1987-1993
6. Cardinali M, Sartor O, Robbins K (1992) Suramin, an experimental chemotherapeutic drug activates the receptor for epidermal growth factor and promotes growth of certain malignant cells. J Clin Invest 89:1242-1247
7. Coffey RJ, Leof EB, Shipley GD, Moses HL (1987) Suramin inhibition of growth factor receptor binding and mutagenicity in AKR 2B cells. J Cell Physiol 132:143-148
8. Danesi R, Del Bianchi S, Soldani P, Campagni A, la Rocca RV, Myers CE, Paparelli A, Del Tacca M (1993) Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane. Br J Cancer 68:932-938
9. Dirks PB, Rutka JT (1997) Current concepts in neuro-oncology: the cell cycle. Neurosurgery 40:1000-1015
10. Dirks PB, Hubbard SL, Murakami M, Rutka JT (1997) Cyclin and cyclin-dependent kinase expression in human glioma cell lines. Neuropathol 56:291-300
11. Eisenberger MA, Reyno LM (1994) Suramin. Cancer Treat Rev 20:259-273
12. Fantini J, Guo X-J, Marvaldi J, Rougon G (1990) Suramin inhibits proliferation of rat glioma cells and alters N-CAM cell surface expression. Int J Cancer 45:554-561
13. Foekens JA, Sieuwerts AM, Stuurman-Aweets EJM, Dorsers LCJ, Berns EMMJ, Klijn JGM (1992) Pleiotropic actions of suramin on the proliferation of human breast cancer cells in vitro. Int J Cancer 51:439-444
14. Giese A, Westphal M (1996) Glioma invasion in the central nervous system. Neurosurgery 39:235-252
15. Giese A, Rief M, Loo M, Berens M (1994) Determinants of human glioma migration. Cancer Res 54:3897-3904
16. Giese A, Loo M, Rief M, Tran N, Berens M (1995) Substrates for glioma invasion. Neurosurgery 37:294-301
17. Gross JL, Morrison RS, Eidsvoog K, Herblin WF, Kornblith PL (1990) Basic fibroblast growth factor: a potential autocrine regulator of human glioma growth. J Neurosci Res 27:689-696
18. Henesey C, Boscoboinik D, Assi A (1998) Suramin, anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A. FEBS Lett 258:156-158
19. Hinek A (1994) Nature and the multiple functions of the 67-kD elastin-laminin binding protein. Cell Adhes Commun 3: 185-193
20. Hinek A (1995) The spliced variant of β-galactosidase serves as a reusable protective chaperone for tropoelastin. CIBA Found Symp 192:185-196
21. Hinek A (1996) Biological roles of the non-integrin elastin/ laminin receptor. Biol Chem 377:471-480
22. Hinek A, Rabinovitch M (1994) 67-kD elastin binding protein is a protective companion of extracellular insoluble elastin and intracellular soluble tropoelastin. J Cell Biol 126:563-574
23. Hinek A, Boyle J, Rabinovitch M (1992) Vascular smooth muscle cell detachment from elastin and migration through elastin is promoted by the chondroitin sulfate-induced shedding of the 67 kD elastin binding protein. Exp Cell Res 203: 344-353
24. Hinek A, Boyle J, Rabinovitch M (1992) Vascular smooth muscle cell detachment from elastin and migration through elastin is promoted by the chondroitin sulfate-induced shedding of the 67 kD elastin binding protein. Exp Cell Res 203: 344-353
25. Hinek A, Rabinovitch M, Keeley F, Okamura-Oho J, Callahan JW (1993) The 67 kD elastin laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of β-galactosidase. J Clin Invest 91:1198-1205
26. Hinek A, Keeley F, Callahan JW (1995) Recycling of the 67-kD reusable shuttle protein for tropoelastin is imperative for proper deposition of insoluble elastin by vascular smooth muscle cells. Exp Cell Res 220:1-13
27. Hoffman R (1993) Carrageenans inhibit growth factor binding. Biochem J 289:31-334
28. Hoffman R, Burns WW, Paper DH (1995) Selective inhibition of cell proliferation and DNA synthesis by the polysulfated carbohydrate λ-carrageenan. Cancer Chemother Pharmacol 36: 325-334
29. Hosang M (1985) Suramin binds to platelet-derived growth factor and inhibits its biological activity. J Cell Biochem 29: 265-273
30. Jung S, Rutka JT, Hinek A (1998) Tropoelastin and elastin degradation products promote proliferation of human glioma cell lines. J Neuropathol Exp Neurol 57:439-448
31. Krishnan R, Cleary EG (1990) Elastin gene expression in elastotic human breast cancers and epithelial cell lines. Cancer Res 50:2164-2171
32. Koochekpour S, Merzak A, Pilkington G (1995) Extracellular matrix proteins inhibit proliferation, upregulate migration and induce morphological changes in human glioma cell lines. Eur J Cancer 31A:375-380
33. Kuratsu J-I, Kurino M, Fukanaga K, Miyamoto E, Ushi Y (1995) Stimulatory effect of suramin on the proliferation of human glioma cells. Anticancer Res 15:1263-1268
34. Larsen AK (1993) Suramin: an anticancer drug with unique biological effects. Cancer Chemother Pharmacol 32:96-98
35. LaRocca RV, Stein CA, Myers CE (1990) Suramin: prototype of a new generation of antitumor compounds. Cancer Cells 2: 106-115
36. LaRocca RV, Stein CA, Danesi R, Coopoer MR, Uhrich M, Myers CE (1991) A pilot study of suramin in the treatment of metastatic renal carcinoma. Cancer 67:1509-1513
37. Lopez R, Peters GJ, Loenen van AC, Piazao PE, Rijswijk REN van, Wagstaff J, Pinedo HM (1992) The effect of schedule, protein binding and growth factors on the activity of suramin. Int J Cancer 51:921-926
38. Maxwell M, Galanopoulos T, Antoniades HN (1996) Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas. Int J Oncol 9:493-4-97
39. McComb RD, Bigner DD (1985) Immunolocalization of laminin in neoplasms of the central and peripheral nervous systems. J Neuropathol Exp Neurol 44:242-253
40. McComb RD, Moul JM, Bigner DD (1987) Distribution of type IV collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein. J Neuropathol Exp Neurol 46:623-633
41. McKeever PE, Fliegel SEG, Varani J (1986) Products of cells cultured from gliomas IV: extracellular matrix proteins of gliomas. Int J Cancer 37:867-874
42. McKeever PE, Varani J, Papadoupolos SM, Wang M, McCoy P (1995) Products of cells from gliomas IX: evidence that two fundamentally different mechanisms change extracellular matrix expression by gliomas. J Neurooncol 24:267-280
43. Mecham RP, Hinek A (1995) Non-integrin laminin receptors. In: Timpl R (ed) Laminins. Academic Press, New York, pp 159-183
44. Mecham RP, Hinek A, Cleary EG, Kucich U, Rosenbloom J (1988) Development of immunoreagents to ciliary zonules that react with protein components of elastic fibers microfibrils and with elastin producing cells. Biochem Biophys Res Commun 151:822-826
45. Mecham RP, Hinek A, Entwistle R, Wrenn D, Griffin G, Senior R (1989) Elastin binds to a multifunctional 67-kilodalton peripheral membrane protein. Biochemistry 28:3716-3722
46. Mecham RP, Hinek A, Griffin G, Senior RM, Liotta LR (1989) 67kD elastin binding protein is homologous to the tumor cell 67-kD laminin receptor. J Biol Chem 264:16652-16657
47. Mecham RP, Whitehouse L, Hay M, Hinek A, Sheetz MP (1991) Visualization of elastin/laminin receptor complexes with gold-tagged ligands: modulation by carbohydrate and cytoskeleton attachment. J Cell Biol 113:187-194
48. Middaugh CR, Mach H, Burke CJ, Volkin DB, Dabora JM, Tsai PK, Bruner MW, Ryan JA, Marfia KE (1992) Nature of the interaction of the growth factors with suramin. Biochemistry 31:9016-9024
49. Morgan DO (1995) Principles of CDK regulation. Nature 374: 512-515
50. Nakajima M, DeChavigny A, Johnson CE, Hamada J, Stein CA (1990) Suramin, a potent inhibitor of melanoma heparanase invasion. J Biol Chem 266:9661-9666
51. Okamura N, Takimoto K, Okada M, Nakagawa H (1989) C6 glioma cells produce basic fibroblast growth factor that can stimulate their own proliferation. J Biochem 106:904-909
52. Oliver S, Formento P, Fischel JL, Etienne MC, Milano G (1990) Epidermal growth factor expression and suramin cytotoxicity in vitro. Eur J Cancer 26:867-871
53. Privitera S, Prody CA, Callahan JW, Hinek A (1998) The 67-kDa enzymatically inactive alternatively spliced variant of β-galactosidase is identical to the elastin/laminin binding protein. J Biol Chem 273:6319-6326
54. Prosser IW, Whitehouse LA, Parks WC, Hinek A, Park PW, Mecham RP (1991) Polyclonal antibodies to tropoelastin and the specific detection and measurement of tropoelastin in vitro. Connect Tissue Res 25:265-279
55. Reith A, Bjerkvig R, Rucklidge G (1994) Laminin: a potential inhibitor of rat glioma cell invasion in vitro. Anticancer Res 14: 1071-1076
56. Ruoslahti E (1996) Brain extracellular matrix. Glycobiology 6: 489-492
57. Russell DS, Rubinstein LJ (1989) Glioblastomas. In: Arnold E (ed) Pathology of tumors of the nervous system, 5th edn. Williams and Wilkins, London, pp 219-247
58. Rutka JT, Giblin JR, Hoifoldt HK, Dougherty DV, Bell CW (1986) Establishment and characterization of a cell line from a human gliosarcoma. Cancer Res 46:5893-5902
59. Reference deleted
60. Rutka JT, Giblin JR, Apodaca G (1987) Inhibition of growth and induction of differentiation in a malignant human glioma cell line by normal leptomeningeal extracellular matrix proteins. Cancer Res 47:3515-3522
61. Rutka JT, Giblin JR, Dougherty DV, Liu HC, McCulloch JR (1987) Establishment and characterization of five cell lines derived from human malignant gliomas. Acta Neuropathol 75: 92-103
62. Rutka JT, Myatt CA, Giblin J (1987) Distribution of extracellular matrix proteins in primary human brain tumours: an immunohistochemical analysis. Can J Neurol Sci 14:25-30
63. Rutka J, Aprodaca G, Stern R, Rosenblum M (1988) The extracellular matrix of the central and peripheral nervous systems: structure and function. J Neurosurg 69:155-170
64. Rutka JT, Hubbard SL, Fukuyamu K, Matsuzawa K, Dirks PB, Becker LE (1994) Effects of antisense glial fibrillary acidic protein complementary DNA on the growth, invasion, and adhesion of human glioma cells. Cancer Res 54: 3267-3272
65. Shin R, Naomoto Y, Kamikawa Y, Tanaka N, Orita K (1997) Effect of suramin on human esophageal cancer cells in vitro and in vivo. Scand J Gastroeterol 32:824-828
66. Sjolund M, Thyberg J (1989) Suramin inhibits binding and degradation of platelet-derived growth factor in arterial smooth muscle cells but does not interfere with autocrine stimulation of DNA synthesis. Cell Tissue Res 256: 35-43
67. Stein CA (1993) Suramin: a novel antineoplastic agent with multiple potential mechanisms of action. Cancer Res 53: 2239-2248
68. Stein CA, Larocca R, McAtee N, Thomas R, Home M, Myers CE (1988) Suramin - an anticancer drug with a unique mechanism of action. J Clin Oncol 7:499-508
69. Strassman G, D'Alessandro F, Fong M, Nordan RP, Nickel P, Chizzonite R (1994) Suramin blocks the binding of interleukin-1 to its receptor and neutralizes IL-1 biological activities. Int J Immunopharmacol 16:931-939
70. Takano S, Gatley S, Engelhard H, Tsanaclis AMC, Brem S (1994) Suramin inhibits cell proliferation in vitro and in the brain. J Neurooncol 21:189-201
71. Tysnes B, Larsen L, Ness G, Mahesparan R, Edvardsen K (1996) Stimulation of glioma-cell migration by laminin and inhibition by anti-alpha3 and anti-betal integrin antibodies. Int J Cancer 67:777-784
72. Van Oosterom AT, De Smedt EA, Denis LJ (1990) Suramin for prostatic cancer: a Phase I/II study in advanced extensively pretreated disease. Eur J Cancer 26:422-428
73. Varga Z, Jacob MP, Robert L, Fulop T (1989) Identification and signal transduction mechanism of elastin peptide receptor in human leukocytes. FEBS Lett 258:5-8
74. Venstrom K, Reichardt L (1993) Extracellular matrix 2: role of extracellular matrix molecules and their receptors in the nervous system. FASEB J 7:996-1003
75. Ventimiglia JB, Wikstrand CJ, Ostrowski LE (1992) Tenascin expression in human glioma cell lines and normal tissues. J Neuroimmunol 36:41-55
76. Voogd TE, Vansterkenburg ELM, Wilting J, Janssen LHM (1993) Recent research on the biological activity of suramin. Pharmacol Rev 45:177-303
77. Westphal M, Ackermann E, Hoppe J, Herrmann H-D (1991) Receptors for platelet derived growth factor in human glioma cell lines and influence of suramin on cell proliferation. J Neurooncol 11:207-213
78. Wrenn DS, Hinek A, Mecham RP (1988) Kinetics of receptor mediated binding of tropoelastin to ligament fibroblasts. J Biol Chem 238:2280-2284
79. Yusa T, Blood CH, Zetter BR (1989) Tumor cell interaction with elastin: implications for pulmonary metastasis. Am Rev Respir Dis 140:1458-1462