Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein

Mechanisms of Development

Volumn 82, Issue 1-2, 1999, Pages 171-179

  Sedkov, Yurii ^a   Benes, Judith J ^b   Berger, Joseph R ^b   Riker, Karen M ^b   Tillib, Sergei ^a   Jones, Richard S ^b   Mazo, Alexander ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

ALL 1; ALR; Chromatin; Chromosomal proteins; Drosophila; Embryonic expression; Larval expression; Maintenance; Mutagenesis; PHD domain; Polycomb; Polycomb group; Regulation; SET domain; Silencing; Tr ithorax group; Transcript; Transcription; Trithorax; TRR

Indexed keywords

ANTERIOR POSTERIOR AXIS; ARTICLE; DROSOPHILA; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA PRIMERS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; HUMANS; INSECT PROTEINS; MALE; MOLECULAR BIOLOGY; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0033016615     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00246-9     Document Type: Article

References (34)

1. Aasland R., Gibson T.J., Stewart A.F. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 20:1995;56-59.
2. Adamson A.L., Shearn A. Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation. Genetics. 144:1996;621-633.
3. Bienz M., Müller J. Transcriptional silencing of homeotic genes in Drosophila. BioEssays. 17:1995;775-784.
4. Campbell R.B., Sinclair D.A., Couling M., Brock H.W. Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Molec. Gen. Genet. 246:1995;291-300.
5. Campos-Ortega, J.A., Hartenstein, V., 1985. The Embryonic Development of Drosophila melanogaster. Springer, Berlin.
6. Cavener D.R. Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucl. Acids Res. 15:1987;1353-1361.
7. Dingwall A.K., Beek S.J., McCallum C.M., Tamkun J.W., Kalpana G.V., Goff S.P., Scott M.P. The Drosophila SNR1 and Brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. Mol. Biol. Cell. 6:1995;777-791.
8. Dingwall C., Laskey R.A. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16:1991;478-481.
9. Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C.M., Canaani E. The t(4:11) chromosome translocation of human acute leukemias fuse the ALL-1 gene, related to Drosophila trithorax to the AF-4 gene. Cell. 71:1992;701-708.
10. Jenuwein T., Laible G., Dorn R., Reuter G. SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell. Mol. Life Sci. 54:1998;80-93.
11. Jones R.S., Gelbart W.M. The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13:1993;6357-6366.
12. Kennison J.A., Tamkun J.W. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. USA. 85:1988;8136-8140.
13. Kennison J.A. The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu. Rev. Genet. 29:1995;289-303.
14. Kramer H., Zipursky L. Whole mount in situ hybridization to imaginal discs using digoxygenin labeled DNA probes. Drosophila Information Service. 71:1992;147.
15. Lindsley, D.L., Zimm, G.G., 1992. The genome of Drosophila melanogaster. Academic Press, San Diego, CA.
16. Lonie A., D'Andrea R., Paro R., Saint R. Molecular characterization of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development. 120:1994;2629-2636.
17. Mazo A.M., Huang D.H., Mozer B.A., Dawid I.B. The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc. Natl. Acad. Sci. USA. 87:1990;2112-2116.
18. Orlando V., Paro R. Chromatin multiprotein complexes involved in the maintenance of transcription patterns. Curr. Opin. Genet. Dev. 5:1995;174-179.
19. Peterson C.L., Tamkun J.W. The SWI/SNF complex - a chromatin remodeling machine. Trends Bioch. Sci. 20:1995;143-146.
20. Pirrotta V. PcG complexes and chromatin silencing. Curr. Opin. Gen. Dev. 7:1997;249-258.
21. Prasad R., Zhadanov A.B., Sedkov Y., Rallapalli R., Druck T., Bullrich F., Croce C.M., Huebner K., Mazo A., Canaani E. Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 and Drosophila trithorax. Oncogene. 15:1997;549-560.
22. Rechsteiner M. PEST sequences are signals for rapid intranuclear proteolysis. Sem. Cell. Biol. 1:1990;433-440.
23. Reuter G., Wolff I. Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogaster. Mol. Gen. Genet. 182:1981;516-519.
24. Riggleman B., Wieschaus E., Schedl P. Molecular analysis of armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene. Gen. Dev. 3:1989;96-113.
25. Savant-Bhonsale S., Montell D.J. torso-like encodes the localized determinant of Drosophila terminal pattern formation. Gen. Dev. 7:1993;2548-2555.
26. Sedkov Yu., Tillib S., Mizrokhi L., Mazo A. The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts. Development. 120:1994;1907-1917.
27. Shearn A. The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related. Genetics. 121:1989;517-525.
28. Simon J. Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7:1995;376-385.
29. Tamkun J.W., Deuring R., Scott M.P., Kissinger M., Pattatucci A.M., Kaufman T.C., Kennison J.A. Brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell. 68:1992;561-572.
30. Tautz D., Pfeifle C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma (Berlin). 98:1989;81-85.
31. Tillib S., Sedkov Yu., Mizrokhi L., Mazo A. Conservation of structure and expression of the trithorax gene between Drosophila virilis and Drosophila melanogaster. Mech. Dev. 53:1995;113-122.
32. Tkachuk D.C., Kohler S., Cleary M.L. Involvement of homolog of Drosophila trithorax by 11q23 chromosome translocations in acute leukemias. Cell. 71:1992;691-700.
33. Tripoulas N., LaJeunesse D., Gildea J., Shearn A. The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger. Genetics. 143:1996;913-928.
34. Tschiersch B., Hofmann A., Krauss V., Dorn R., Korge G., Reuter G. The protein encoded by the Drosophila position-effect variegation gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13:1994;3822-3831.