Relationship between internalization and mRNA decay in down-regulation of recombinant type 1 angiotensin II receptor (AT1) expression in smooth muscle cells

Molecular Pharmacology

Volumn 55, Issue 6, 1999, Pages 1028-1036

  Adams, Brian ^a   Obertone, Tracy S ^a   Wang, Xiaofei ^a   Murphy, T J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; MESSENGER RNA; TETRACYCLINE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELL SURFACE; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RECOMBINANT GENE; RNA SYNTHESIS; STEADY STATE; VASCULAR SMOOTH MUSCLE;

EID: 0033015898     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.6.1028     Document Type: Article

References (34)

1. Anderson KM, Murahashi T, Dostal DE and Peach MJ (1993) Morphological and biochemical analysis of angiotensin II internalization in cultured rat aortic smooth muscle cells. Am J Physiol 264:C179-C188.
2. Bohm SK, Grady EF and Bunnett NW (1997) Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 322:1-18.
3. Boris-Lawrie K and Temin HM (1994) The retroviral vector. Replication cycle and safety considerations for retrovirus-mediated gene therapy. Ann NY Acad Sci 716:59-70.
4. Boss V, Abbott KL, Wang XF, Pavlath GK and Murphy TJ (1998) The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase c-coupled cell surface receptors. J Biol Chem 273:19664-19671.
5. Firulli AB, Han D, Kelly-Roloff L, Koteliansky VE, Schwartz SM, Olson EN and Miano JM (1998) A comparative molecular analysis of four rat smooth muscle cell lines. In Vitro Cell Dev Biol Anim 34:217-226.
6. Gossen M and Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
7. Gossen M and Bujard H (1993) Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells. Nucleic Acids Res 21:4411-4412.
8. Griendling KK, Delafontaine P, Rittenhouse SE, Gimbrone MA Jr and Alexander RW (1987) Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem 262:14555-14562.
9. Griendling KK, Lassegue B, Murphy TJ and Alexander RW (1994) Angiotensin II receptor pharmacology. Adv Pharmacol 28:269-306.
10. Hausdorff WP, Caron MG and Lefkowitz RJ (1990) Turning off the signal: Desensitization of β-adrenergic receptor function. FASEB J 4:2881-2889.
11. Hein L, Meinel L, Pratt RE, Dzau VJ and Kobilka BK (1997) Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: Evidence for selective sorting of receptor and ligand. Mol Endocrinol 11:1266-1277.
12. Hofmann A, Nolan GP and Blau HM (1996) Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette. Proc Natl Acad Sci USA 93:5185-5190.
13. Hunyady L, Bor M, Baukal AJ, Balla T and Catt KJ (1995) A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J Biol Chem 270: 16602-16609.
14. Kimes BW and Brandt BL (1976) Characterization of two putative smooth muscle cell lines from rat thoracic aorta. Exp Cell Res 98:349-366.
15. Koenig JA and Edwardson JM (1997) Endocytosis and recycling of G protein-coupled receptors. Trend Pharmacol Sci 18:276-287.
16. Lassegue B, Alexander RW, Nickenig G, Clark M, Murphy TJ and Griendling KK (1995) Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms. Evidence of homologous and heterologous regulation. Mol Pharmacol 48:601-609.
17. Lefkowitz RJ, Pitcher J, Krueger K and Daaka Y (1998) Mechanisms of beta-adrenergic receptor desensitization and resensitization. Adv Pharmacol 42:416-420.
18. Miller AD and Rosman GJ (1989) Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980-990.
19. Murphy TJ, Alexander RW, Griendling KK, Runge MS and Bernstein KE (1991) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 361:233-236.
20. Murphy TJ, Nakamura Y, Takeuchi K and Alexander RW (1993) A cloned angiotensin receptor isoform from the turkey adrenal gland is pharmacologically distinct from mammalian AT receptors. Mol Pharmacol 44:1-7.
21. Nickenig G and Murphy TJ (1994) Down-regulation by growth factors of vascular smooth muscle angiotensin receptor gene expression. Mol Pharmacol 46:653-659.
22. Nickenig G and Murphy TJ (1996) Enhanced angiotensin receptor type 1 mRNA degradation and induction of polyribosomal mRNA binding proteins by angiotensin II in vascular smooth muscle cells. Mol Pharmacol 50:743-751.
23. Oppermann M, Freedman NJ, Alexander RW and Lefkowitz RJ (1996) Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J Biol Chem 271:13266-13272.
24. Ouali R, Berthelon MC, Begeot M and Saez JM (1997) Angiotensin II receptor subtypes AT1 and AT2 are down-regulated by angiotensin II through AT1 receptor by different mechanisms. Endocrinology 138:725-733.
25. Peach MJ (1977) Renin-angiotensin system: Biochemistry and mechanisms of action. Physiol Rev 57:313-370.
26. Regitz-Zagrosek V, Auch-Schwelk W, Neuss M and Fleck E (1994) Regulation of the angiotensin receptor subtypes in cell cultures, animal models and human diseases. Eur Heart J 15(Suppl D):92-97.
27. Sachs AB, Sarnow P and Hentze MW (1997) Starting at the beginning, middle, and end: Translation initiation in eukaryotes. Cell 89:831-838.
28. Tang H, Guo DF, Porter JP, Wanaka Y and Inagami T (1998) Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. Circ Res 82:523-531.
29. Thomas WG, Thekkumkara TJ, Motel TJ and Baker KM (1995) Stable expression of a truncated AT1A receptor in CHO-K1 cells. The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization. J Biol Chem 270:207-213.
30. Ullian ME and Linas SL (1989) Role of receptor cycling in the regulation of angiotensin II surface receptor number and angiotensin II uptake in rat vascular smooth muscle cells. J Clin Invest 84:840-846.
31. Wang J, Zheng J, Anderson JL and Toews ML (1997) A mutation in the hamster alpha1B-adrenergic receptor that differentiates two steps in the pathway of receptor internalization. Mol Pharmacol 52:306-313.
32. Wang X and Murphy TJ (1998) Inhibition of cyclic AMP-dependent kinase by expression of a protein kinase inhibitor/enhanced green fluorescent fusion protein attenuates angiotensin II-induced type 1 AT1 receptor mRNA down-regulation in vascular smooth muscle cells. Mol Pharmacol 54:514-524.
33. Wang X, Nickenig G and Murphy TJ (1997) The vascular smooth muscle type I angiotensin II receptor mRNA is destabilized by cAMP-elevating agents. Mol Pharmacol 52:781-787.
34. Zhang J, Ferguson SSG, Barak LS, Menard L and Caron MG (1996) Dynamin and beta-arrestin reveal distinct mechanisms for G protein- coupled receptor internalization. J Biol Chem 271:18302-18305.