Effects of thiopental on regional blood flows in the rat

Anesthesiology

Volumn 84, Issue 3, 1996, Pages 596-604

  Wada, D Russell ^a   Harashima, Hideyoshi ^a,b   Ebling, William F ^a,c   Osaki, Eileen W ^a   Stanski, Donald R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Anesthetics, intravenous: thiopental; Animals: rat; Drug effects: regional blood flows; Hemodynamics: drug effects

Indexed keywords

THIOPENTAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD GAS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFECT; HEART OUTPUT; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHETICS, INTRAVENOUS; ANIMALS; CARDIAC OUTPUT; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; THIOPENTAL;

EID: 0029879738     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199603000-00015     Document Type: Article

References (36)

1. Avram MJ, Sanghvi R, Henthorn TK, Krejcie TC, Shanks CA, Fragen RJ, Howard KA, Kaczynski DA: Determinants of thiopental induction dose requirements. Anesth Analg 1993; 76:10-17
2. Ahlgren I, Aronsen KF, Björkman I, Wetterlin S: Hemodynamics during superficial thiopental anesthesia in the dog. Acta Anaesthesiol Scand 1978; 22:76-82
3. Runciman WB, Mather LE, Selby DG: Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. Br J Anaesth 1990; 65:353-9
4. Haberer JP, Audibert G, Saunier CG, Muller C, Laxenaire MC, Hartemann D: Effect of propofol and thiopentone on regional blood flow in brain and peripheral tissues during normoxia and hypoxia in the dog. Clin Physiol 1993; 13:197-207
5. Priano LL: Alteration of renal hemodynamics by thiopental, diazepam, and ketamine in conscious dogs. Anesth Analg 1982; 61: 853-62
6. Björkman S, Nilsson F, Åkeson J, Messeter K, Rosén I: The effect of thiopental on cerebral blood flow, and its relation to plasma concentration, during simulated induction of anaesthesia in a porcine model. Acta Anaesthesiol Scand 1994; 38:473-8
7. Gerlowski LE, Jain RK: Physiologically based pharmacokinetic modeling: Principles and applications. J Pharm Sci 1983; 72:1103-27
8. Flaim SF, Nellis SH, Toggart EJ, Drexler H, Kanda K, Newman ED: Multiple simultaneous determinations of hemodynamics and flow distribution in conscious rat. J Pharmacol Methods 1984; 11:1-39
9. Ebling WF, Mills-Williams L, Harapat SR, Stanski DR: High-performance liquid chromatographic method for determining thiopental concentrations in twelve rat tissues: Application to physiologic modeling of disposition of barbiturate. J Chromatogr 1989; 490:339-53
10. Ebling WF, Danhof M, Stanski DR: Pharmacodynamic characterization of the electroencephalographic effects of thiopental in rats. J Pharmacokinet Biopharm 1991; 19:123-43
11. Ebling WF, Wada DR, Stanski DR: From piecewise to full physiologic pharmacokinetic modeling: Applied to thiopental disposition in the rat. J Pharmacokinet Biopharm 1994; 22:259-92
12. Buckberg GD, Luck JC, Payne DB, Hoffman JIE, Archie JP, Fixler D: Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 1971; 31:598-604
13. Ishise S, Pegram BL, Yamamoto J, Kitamura Y, Frohlich ED: Reference sample microsphere method: Cardiac output and blood flows in conscious rat. Am J Physiol 1980; 239:H443-9
14. Kawasaki T, Carmichael FJ, Saldivia V, Roldan L, Orrego H: Relationship between portal venous and hepatic arterial blood flows: Spectrum of response. Am J Physiol 1990; 259:G1010-8
15. Kawaue Y, Iriuchijima J: Changes in cardiac output and peripheral flows on pentobarbital anesthesia in the rat. Jpn J Physiol 1984; 34:283-94
16. Salgado MCO, Krieger EM: Cardiac output in unrestrained conscious rats. Clin Exp Pharmacol Physiol 1976; S3:165-7
17. Seyde WC, McGowan L, Lund N, Duling B, Longnecker DE: Effects of anesthetics on regional hemodynamics in normovolemic and hemorrhaged rats. Am J Physiol 1985; 249:H164-73
18. Tuma RF, Irion GL, Vasthare US, Heinel LA: Age-related changes in regional blood flow in the rat. Am J Physiol 1985; 249:H485-91
19. Conway CM, Ellis DB: The haemodynamic effects of short-acting barbiturates. Br J Anaesth 1969; 41:534-42
20. Manders WT, Vatner SF: Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ Res 1976; 39:512-7
21. Eckstein JW, Hamilton WK, McCammond JM: The effect of thiopental on peripheral venous tone. ANESTHESIOLOGY 1961; 22:525-8
22. Häggendal J: On the patterns of blood pressure, heart rate, and blood levels of noradrenaline and adrenaline during haemorrhage in the rat. Acta Physiol Scand 1986; 127:513-22
23. Altura BT, Altura BM: Barbiturates and aortic and venous smooth-muscle function. ANESTHESIOLOGY 1975; 43:432-44
24. Ebert TJ, Kanitz DD, Kampine JP: Inhibition of sympathetic neural outflow during thiopental anesthesia in humans. Anesth Analg 1990; 71:319-26
25. Teranishi Y, Iriuchijima J: Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of rats. Jpn J Physiol 1992; 42:171-8
26. Thomson WJ: The effect of induction of anaesthesia on peripheral haemodynamics. Br J Anaesth 1967; 39:210-4
27. Delp MD, Manning RO, Bruckner JV, Armstrong RB: Distribution of cardiac output during diurnal changes of activity in rats. Am J Physiol 1991; 261:H1487-93
28. Grände PO, Gustafsson D, Lindberg L: Effects of thiopental on resistance vessels in cat skeletal muscle. Intensive Care Med 1990; 16:399-404
29. Brickner EW, Dowds EG, Willitts B, Selkurt EE: Mesenteric blood flow as influenced by progressive hypercapnia. Am J Physiol 1956; 184:275-81
30. Epstein RM, Wheeler HO, Frumin MJ, Habif DV, Papper EM, Bradley SE: The effect of hypercapnia on estimated hepatic blood flow, circulating splanchnic blood volume, and hepatic sulfobrom-ophthalein clearance during general anesthesia in man. J Clin Invest 1961; 40:592-8
31. Michenfelder JD: The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. ANESTHESIOLOGY 1974; 41:231-6
32. Onarheim J, Tyssebotn I: Effect of high ambient pressure and oxygen tension on organ blood flow in the anesthetized rat. Undersea Biomed Res 1980; 7:47-60
33. Cullen DJ, Eger EI: Cardiovascular effects of carbon dioxide in man. ANESTHESIOLOGY 1974; 41:345-9
34. Kuwahira I, Gonzalez NC, Heisler N, Piiper J: Regional blood flow in conscious resting rats determined by microsphere distribution. J Appl Physiol 1993; 74:203-10
35. Price HL, Kovnat PJ, Safer JN, Conner EH, Price ML: The uptake of thiopental by body tissues and its relation to the duration of narcosis. Clin Pharmacol Ther 1960; 1:16-22
36. Björkman S, Wada DR, Stanski DR, Ebling WF: Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based upon parametric single-tissue models. J Pharmacokinet Biopharm 1994; 22:381-410