Pharmacokinetics of thiopentone enantiomers following intravenous injection or prolonged infusion of rac-thiopentone

British Journal of Clinical Pharmacology

Volumn 43, Issue 4, 1997, Pages 355-362

  Cordato, D J ^a,b   Gross, A S ^a   Herkes, G K ^a   Mather, L E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Enantiomers; Pharmacokinetics; Thiopentone

Indexed keywords

THIOPENTAL;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; ELECTROENCEPHALOGRAM; ENANTIOMER; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; STEADY STATE; STEREOSPECIFICITY;

EID: 0030941624     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1997.00567.x     Document Type: Article

References (21)

1. Mather LE, Rutten AJ. Stereochemistry and its relevance in anaesthesiology. Curr Opin Anaesthesiol 1991; 4: 473-479.
2. Eichelbaum M, Gross AS. Stereochemical aspects of drug action and disposition. Adv Drug Research 1996; 28: 1-64.
3. Shanks CA, Avram MJ, Krejcie TC, Henthorn TK, Gentry WB. A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental. J Pharmacokin Biopharm 1993; 21: 309-321.
4. Stanksi DR, Maitre PO. Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. Anesthesiology 1990; 72: 412-422.
5. Christensen HD, Lee IS. Anesthetic potency and acute toxicity of optically active disubstituted barbituric acids. Toxicol Appl Pharmacol 1973; 26: 495-503.
6. Haley TJ, Gidley JT. Pharmacological comparison of R (+), S (-) and racemic thiopentone in mice. Eur J Pharmacol 1976; 36: 211-214.
7. Mark LC, Brand L, Perel JM, Carroll FI. II. Barbiturate stereoisomers: Direction for the future? Excerpta Medica. Int Congr Ser 1977; 399: 143-146.
8. Huang JL, Mather LE, Duke C. High-performance liquid chromatographic determination of thiopentone enantiomers in sheep plasma. J Chromatog B: Biomed Applic 1995; 673: 245-250.
9. Jones DJ, Nguyen KT, McLeish MJ, Crankshaw DP, Morgan DJ. Determination of R-(+)- and S-(-)-isomers of thiopentone in plasma by chiral high-performance liquid chromatography. J Chromatog B: Biomed Applic 1996; 675: 174-179.
10. Mather LE, Upton RN, Huang JL, Ludbrook GL, Gray E, Grant C. The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis. J Pharmacol Exp Ther 1996; 279: 291-297.
11. Nguyen KT, Stephens DP, McLeish MJ, Crankshaw DP, Morgan DJ. Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental. Anesth Analg 1996; 83: 552-558.
12. Sharbrough FW. Electrical fields and recording techniques. In Current Practice of Clinical Electroencephalography Second Edition, eds Daly DD, Pedley TA, New York: Raven Press, 1990: 29-49.
13. Sebalt RJ, Kreeft JH. Efficient pharmacokinetic modelling of complex clinical dosing regimens; the universal elementary dosing regimen and computer algorithm EDFAST. J Pharm Sci 1987; 76: 93-100.
14. Burch PG, Stanski DR. The role of metabolism and protein binding in thiopental anesthesia. Anesthesiohgy 1983; 58: 146-152.
15. Carroll FI, Smith D, Mark LC, Brand L, Perel JM. Determination of optically active thiopental, thioamylal, and their metabolites in human urine. Drug Metab Disp 1977; 4: 343-354.
16. Homer TD, Stanski DR. The effect of increasing age on thiopental disposition and anesthetic requirement. Anesthesiology 1985; 62: 714-724.
17. Le Corre P, Mallendant Y, Tanguy M, Le Verge R. Nonlinear disposition of thiopentone following long-term infusion. Eur J Drug Metab Pharmacokin, 1993; 3: 255-259.
18. Turcant A, Delhumeau A, Premel-Cabic A et al. Thiopentone pharmacokinetics under conditions of long-term infusion. Anesthesiology 1985; 63: 50-54.
19. Russo H, Bressolle F, Bres J, Duboin M-P. Nonlinear pharmacokinetics of high-dose thiopental following long term treatment. Clin Drug Invest 1996; 11: 32-42.
20. Avram MJ, Sanghvi R, Henthorn TK, et al. Determinants of thiopental induction dose requirements. Anesth Analg 1993; 76: 10-17.
21. Buhrer M, Maitre PO, Hung OR, Ebling WF, Shafer SL, Stanski DR. Thiopental Pharmacodynamics. 1. Defining the pseudo-steady-state serum concentration-EEG effect relationship. Anesthesiology 1992; 77: 226-236.